15
Views
4
CrossRef citations to date
0
Altmetric
Research Article

Continuous Deep Intravenous Infusion in Rat Embryotoxicity Studies: The Effects of Infusion Volume and two Different Infusion Fluids on Pregnancy

&
Pages 61-67 | Received 12 Nov 1994, Accepted 14 Dec 1994, Published online: 27 Sep 2008

References

  • Francis P C, Hawkins B L, Houchins J O, et al. Continuous intravenous infusion in Fischer 344 rats for six months: a feasibility study. Toxicol Methods 1992; 2: 1–13
  • Brown D F, Burr R E. Customized vascular catheters for rodents. Lab Anim Sci 1985; 35: 515–6
  • Hodge D D, Shalev M. Dual cannulation: a method for continuous intravenous infusion and repeated blood sampling in unrestrained mice. Lab Anim Sci 1992; 42: 320–2
  • Wyman J F, Moore T J, Buring M S. Simple procedure for jugular vein cannulation of rats. Toxicol Methods 1994; 4: 12–18
  • Barrow M V, Taylor W J. A rapid method for detecting malformations of rat foetuses. J Morphol 1967; 127: 291–306
  • Barrow P. Technical procedures in reproduction toxicology. Laboratory animals handbooks 11. Royal Society of Medicine, London 1990
  • Manson J M, Kang Y J. Test methods for assessing female reproductive and developmental toxicology. Principles and methods of toxicology, 2d ed., W Hayes. Raven, New York 1989
  • EEC Council recommendations of 26.10.1983 concerning tests relating to the placing on the market of proprietary medicinal products. Official Journal of the European Communities 1983; L 332/20-2
  • Ministry of Health and Welfare, Japan. Guidelines for toxicity of drugs manual. Yakuji Nippo, Tokyo 1991
  • Food and Drug Administration (USA). Guidelines for reproduction studies for safety evaluation of drugs for human use. 1966
  • ICH (1994) . Step 4 tripartite harmonised guidelines: detection of toxicity to reproduction for medicinal products. Proceedings of the second international conference on harmonisation, Orlando, 1993, P F D'Arcy, D WG Harron. Queen's University, Belfast, 557–78
  • O'Flaherty E J, Clarke D O. Pharmacokinetic/pharmacodynamic approaches for developmental toxicity. Developmental toxicology, 2d ed., C A Kimmel, Buelke-Sam. Raven, New York 1994; 215–44

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.