877
Views
40
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Respiratory Effects of Insulin Sensitisation with Metformin: A Prospective Observational Study

, &

References

  • American Diabetes Association. Standards of medical care in diabetes-2010. Diabetes Care 2010; 33 Suppl 1:S11–S61.
  • van den Borst B, Gosker HR, Zeegers MP, Schols AMWJ. Pulmonary function in diabetes: a meta-analysis. Chest 2010; 138:393–406.
  • Innocenti F, Fabbri A, Anichini R, Tuci S, Pettina G, Vannucci F, De Giorgio LA, Seghieri G. Indications of reduced pulmonary function in type 1 (insulin-dependent) diabetes mellitus. Diabetes Res Clin Pract 1994; 25:161–168.
  • Kodolova IM, Lysenko LV, Saltykov BB. (Changes in the lungs in diabetes mellitus). Arkh Patol 1982; 44:35–40.
  • Fariña J, Furió V, Fernandez-Aceñero MJ, Muzas MA. Nodular fibrosis of the lung in diabetes mellitus. Virchows Arch 1995; 427:61–63.
  • McKeever TM, Weston PJ, Hubbard R, Fogarty A. Lung function and glucose metabolism: an analysis of data from the Third National Health and Nutritio n Examination Survey. Am J Epidemiol 2005; 161:546–556.
  • Yeh HC, Punjabi NM, Wang NY, Pankow JS, Duncan BB, Cox CE, Selvin E, Brancati FL. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 2008; 31:741–746.
  • Lazarus R, Sparrow D, Weiss ST. Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metabolism 1997; 46:1266–1269.
  • Mannino DM, Thorn D, Swensen A, Holguin F. Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur Respir J 2008; 32:962–969.
  • Song Y, Klevak A, Manson JE, Buring JE, Liu S. Asthma, chronic obstructive pulmonary disease, and type 2 diabetes in the Women's Health Study. Diabetes Res Clin Pract 2010; 90:365–371.
  • Niranjan V, McBrayer DG, Ramirez LC, Raskin P, Hsia CC. Glycemic control and cardiopulmonary function in patients with insulin-dependent diabetes mellitus. Am J Med 1997; 103:504–513.
  • Terzano C, Morano S, Ceccarelli D, Conti V, Paone G, Petroianni A, Graziani E, Carnovale A, Fallarino M, Gatti A, Effect of insulin on airway responsiveness in patients with type 2 diabetes mellitus: a cohort study. J Asthma 2009; 46:703–707.
  • Kim HJ, Lee JY, Jung HS, Kim D-K, Lee S-M, Yim J-J, Yang S-C, Yoo C-G, Chung HS, Kim YW, The impact of insulin sensitisers on lung function in patients with chronic obstructive pulmonary disease and diabetes. Int J Tuberc Lung Dis 2010; 14:362–367.
  • Spears M, Donnelly I, Jolly L, Brannigan M, Ito K, McSharry C, Lafferty J, Chaudhuri R, Braganza G, Bareille P, Bronchodilatory effect of the PPAR-gamma agonist rosiglitazone in smokers with asthma. Clin Pharmacol Ther 2009; 86:49–53.
  • Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Standardisation of spirometry. Eur Resp J 2005; 26:319–338.
  • Jones PW: St. George's Respiratory Questionnaire: MCID. COPD 2005; 2:75–79.
  • Mahler DA, Witek TJ: The MCID of the transition dyspnea index is a total score of one unit. COPD 2005; 2:99–103.
  • Stewart AL, Mills KM, King AC, Haskell WL, Gillis D, Ritter PL. CHAMPS physical activity questionnaire for older adults: outcomes for interventions. Med Sci Sports Exerc 2001; 33:1126–1141.
  • Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 2001; 108:1167–1174.
  • Libby G, Donnelly LA, Donnan PT, Alessi DR, Morris AD, Evans JM. New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 2009; 32:1620–1625.
  • Salpeter SR, Greyber E, Pasternak GA, Salpeter EE. Risk of fatal and nonfatal lactic acidosis with metformin use in type 2 diabetes mellitus. Cochrane Database of Systematic Reviews 2010, Issue 4. Art. No.: CD002967. DOI: 10.1002/14651858.CD002967.pub4.
  • Eiser N, Willsher D, Doré CJ. Reliability, repeatability and sensitivity to change of externally and self-paced walking tests in COPD patients. Respir Med 2003; 97:407–414.
  • Gartner M. Exhaled Breath Analysis of Emergency Room Patients with Diabetes and Respiratory Diseases. University of California, 2011 PhD thesis.
  • Gosens R, Nelemans SA, Hiemstra M, Grootte Bromhaar MM, Meurs H, Zaagsma J. Insulin induces a hypercontractile airway smooth muscle phenotype. Eur J Pharmacol 2003; 481: 125–131.
  • Piccioni M, Manfrini S. Bronchial responsiveness to methacholine in insulin-dependent diabetic patients with autonomic neuropathy. Chest 1994; 105:644–645.
  • Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med 1996; 153:454–457.
  • Simoneau JA, Kelley DE. Altered glycolytic and oxidative capacities of skeletal muscle contribute to insulin resistance in NIDDM. J Appl Physiol 1997; 83:166–171.
  • Wanke T, Formanek D, Auinger M, Popp W, Zwick H, Irsigler K. Inspiratory muscle performance and pulmonary function changes in insulin-dependent diabetes mellitus. Am Rev Respir Dis 1991; 143:97–100.
  • Frayn KN, Adnitt PI. Effects of metformin on glucose uptake by isolated diaphragm from normal and diabetic rats. Biochem Pharmacol 1972; 21:3153–3162.
  • Hill K, Jenkins SC, Philippe DL, Cecins N, Shepherd KL, Green DJ, Hillman DR, Eastwood PR. High-intensity inspiratory muscle training in COPD. Eur Respir J 2006; 27: 1119–1128.
  • De Troyer A. Effect of hyperinflation on the diaphragm. Eur Respir J 1997; 10:708–713.
  • Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA, Nathan DM, Group DPPR. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346:393–403.
  • Keech AC, Mitchell P, Summanen PA, O'Day J, Davis TME, Moffitt MS, Taskinen M-R, Simes RJ, Tse D, Williamson E, Effect of fenofibrate on the need for laser treatment for diabetic retinopathy (FIELD study): a randomised controlled trial. Lancet 2007; 370:1687–1697.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.