C-Reactive Protein at Discharge, Diabetes Mellitus and ≥1 Hospitalization During Previous Year Predict Early Readmission in Patients with Acute Exacerbation of Chronic Obstructive Pulmonary Disease

References

• Buist AS, McBurnie MA, Vollmer WM, et al. on behalf of BOLD Collaborative Research Group: International variation in the prevalence of COPD (the BOLD Study): a population-based prevalence study. Lancet 2007; 370:741–750.
   PubMed Web of Science ®Google Scholar
• Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 2006; 3:e442.
   PubMed Web of Science ®Google Scholar
• Donaldson GC, Seemungal TA, Bhowmik A, Wedzicha JA. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57:847–852.
   PubMed Web of Science ®Google Scholar
• Donaldson GC, Wilkinson TMA, Hurst JR, et al. Exacerbations and time spent outdoors in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2005; 171:446–452.
   PubMed Web of Science ®Google Scholar
• Seemungal TA, Donaldson GC, Paul EA, et al. Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 157:1418–1422.
   PubMed Web of Science ®Google Scholar
• Soler-Cataluña JJ, Martínez-García MA, Román Sánchez P, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005; 60:925–931.
   PubMed Web of Science ®Google Scholar
• Hurst JR, Vestbo J, Anzueto A, et al. on behalf of Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010; 363:1128–1138.
   PubMed Web of Science ®Google Scholar
• Hurst JR, Donaldson GC, Quint JK, et al. Temporal clustering of exacerbations in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2009; 179(5):369–74.
   PubMed Web of Science ®Google Scholar
• Baker CL, Zou KH, Su J. Risk assessment of readmissions following an initial COPD-related hospitalization. Int J Chron Obstruct Pulmon Dis 2013; 8:551–559.
   PubMed Web of Science ®Google Scholar
• Nantsupawat T, Limsuwat C, Nugent K. Factors affecting chronic obstructive pulmonary disease early rehospitalization. Chron Respir Dis 2012; 9(2):93–98.
   PubMedGoogle Scholar
• Strassels SA, Smith DH, Sullivan SD, Mahajan PS. The cost of treating COPD in the United States. Chest 2001; 119:344–352.
   PubMed Web of Science ®Google Scholar
• FitzGerald JM, Haddon JM, Bradly-Kennedy C, et al. Resource use study in COPD (RUSIC): a prospective study to quantify the effects of COPD exacerbations on health care resource use among COPD patients. Can Respir J 2007; 14:145–152.
   PubMed Web of Science ®Google Scholar
• Elixhauser A, Au DH, Podulka J. Readmissions for Chronic Obstructive Pulmonary Disease, 2008: Statistical Brief #121. Healthcare Cost and Utilization Project (HCUP) Statistical Briefs (Internet). Rockville, MD: Agency for Health Care Policy and Research; 2006–2011.
   Google Scholar
• Garcia-Aymerich J, Farrero E, Félez MA, et al. on behalf of Estudi del Factors de Risc d’Agudització de la MPOC investigators. Risk factors of readmission to hospital for a COPD exacerbation: a prospective study. Thorax 2003; 58:100–105.
   PubMed Web of Science ®Google Scholar
• Gudmundsson G, Gislason T, Janson C, et al. Risk factors for rehospitalisation in COPD: role of health status, anxiety and depression. Eur Respir J 2005; 26:414–419.
   PubMed Web of Science ®Google Scholar
• Almagro P, Cabrera FJ, Diez J, et al. on behalf of Working Group on COPD, Spanish Society of Internal Medicine. Comorbidities and short-term prognosis in patients hospitalized for acute exacerbation of COPD: the EPOC en Servicios de medicina interna (ESMI) study. Chest 2012; 142:1126–1133.
   PubMed Web of Science ®Google Scholar
• Steer J, Norman EM, Afolabi OA, et al. Dyspnoea severity and pneumonia as predictors of in-hospital mortality and early readmission in acute exacerbations of COPD. Thorax 2012; 67:117–121.
   PubMed Web of Science ®Google Scholar
• González C, Servera E, Marín J. Importance of noninvasively measured respiratory muscle overload among the causes of hospital readmission of COPD patients. Chest 2008; 133:941–947.
   PubMed Web of Science ®Google Scholar
• Almagro P, Barreiro B, Ochoa de Echaguen A, et al. Risk factors for hospital readmission in patients with chronic obstructive pulmonary disease. Respiration 2006; 73:311–317.
   PubMed Web of Science ®Google Scholar
• Vilaró J, Ramirez-Sarmiento A, Martínez-Llorens JM et al. Global muscle dysfunction as a risk factor of readmission to hospital due to COPD exacerbations. Respir Med 2010; 104:1896–1902.
   PubMed Web of Science ®Google Scholar
• Coventry PA, Gemmell I, Todd CJ. Psychosocial risk factors for hospital readmission in COPD patients on early discharge services: a cohort study. BMC Pulm Med 2011; 11:49.
   PubMedGoogle Scholar
• de Batlle J, Mendez M, Romieu I, et al. on behalf of PAC-COPD Study Group. Cured meat consumption increases risk of readmission in COPD patients. Eur Respir J 2012; 40:555–560.
   PubMed Web of Science ®Google Scholar
• McGhan R, Radcliff T, Fish R, et al. Predictors of rehospitalization and death after a severe exacerbation of COPD. Chest 2007; 132:1748–1755.
   PubMed Web of Science ®Google Scholar
• Wong AW, Gan WQ, Burns J, et al. Acute exacerbation of chronic obstructive pulmonary disease: influence of social factors in determining length of hospital stay and readmission rates. Can Respir J 2008; 15:361–364.
   PubMed Web of Science ®Google Scholar
• Cao Z, Ong KC, Eng P, et al. Frequent hospital readmissions for acute exacerbation of COPD and their associated factors. Respirology 2006; 11:188–195.
   PubMed Web of Science ®Google Scholar
• Bhatt SP, Khandelwal P, Nanda S, et al. Serum magnesium is an independent predictor of frequent readmissions due to acute exacerbation of chronic obstructive pulmonary disease. Respir Med 2008; 102:999–1003.
   PubMed Web of Science ®Google Scholar
• Vestbo J, Hurd SS, Agustí AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2013; 187:347–365.
   PubMed Web of Science ®Google Scholar
• Anthonisen NR, Manfreda J, Warren CP, et al. Antibiotic therapy in exacerbations of chronic obstructive pulmonary disease. Ann Intern Med 1987; 106:196–204.
   PubMed Web of Science ®Google Scholar
• Rana JS, Mittleman MA, Sheikh J, et al. Chronic obstructive pulmonary disease, asthma, and risk of type 2 diabetes in women. Diabetes Care 2004; 27:2478–2484.
   PubMed Web of Science ®Google Scholar
• Spranger J, Kroke A, Möhlig M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 2003; 52:812–817.
   PubMed Web of Science ®Google Scholar
• Yeh HC, Punjabi NM, Wang NY, et al. Cross-sectional and prospective study of lung function in adults with type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) study. Diabetes Care 2008; 31:741–746.
   PubMed Web of Science ®Google Scholar
• Isotani H, Nakamura Y, Kameoka K, et al. Pulmonary diffusing capacity, serum angiotensin-converting enzyme activity and the angiotensin-converting enzyme gene in Japanese non-insulin-dependent diabetes mellitus patients. Diabetes Res Clin Pract 1999; 43:173–177.
   PubMed Web of Science ®Google Scholar
• Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther 2002; 96(1):23–43.
   PubMed Web of Science ®Google Scholar
• Perera WR, Hurst JR, Wilkinson TM, et al. Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur Respir J 2007; 29:527–534.
   PubMed Web of Science ®Google Scholar
• Sethi S, Wrona C, Eschberger K, et al. Inflammatory profile of new bacterial strain exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2008; 177(5):491–497.
   PubMed Web of Science ®Google Scholar
• Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004; 59(7):574–580.
   PubMed Web of Science ®Google Scholar
• Dahl M, Vestbo J, Lange P, et al. C-reactive protein as a predictor of prognosis in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2007; 175(3):250–5.
   PubMed Web of Science ®Google Scholar
• Agustí A, Edwards LD, Rennard SI, et al. on behalf of Evaluation of COPD Longitudinally to Identify Predictive Surrogate Endpoints (ECLIPSE) Investigators. Persistent systemic inflammation is associated with poor clinical outcomes in COPD: a novel phenotype. PLoS One 2012; 7(5):e37483.
   PubMed Web of Science ®Google Scholar
• Thomsen M, Ingebrigtsen TS, Marott JL, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013; 309:2353–2361.
   PubMed Web of Science ®Google Scholar