Mefloquine Blockade of Pannexin1 Currents: Resolution of a Conflict

REFERENCES

• Bao L, Locovei S, Dahl G (2004). Pannexin membrane channels are mechanosensitive conduits for ATP. FEBS Lett. 572: 65–68.
   PubMed Web of Science ®Google Scholar
• Barbe MT, Monyer H, Bruzzone R (2006). Cell-cell communication beyond connexins: the pannexin channels. Physiology (Bethesda). 21: 103–114.
   PubMed Web of Science ®Google Scholar
• Bargiotas P, Monyer H, Schwaninger M (2009). Hemichannels in cerebral ischemia. Curr Mol Med. 9: 186–194.
   Google Scholar
• Brocks DR, Mehvar R (2003). Stereoselectivity in the pharmacodynamics and pharmacokinetics of the chiralantimalarial drugs. Clin Pharmacokinet. 42: 1359–1382.
   PubMed Web of Science ®Google Scholar
• Bruzzone R, Barbe MT, Jakob NJ, Monyer H (2005). Pharmacological properties of homomeric and heteromeric pannexin hemichannels expressed in Xenopus oocytes. J Neurochem. 92: 1033–1043.
   PubMed Web of Science ®Google Scholar
• Contreras JE, Sánchez HA, Véliz LP, Bukauskas FF, Bennett MV, Sáez JC (2004). Role of connexin-based gap junction channels and hemichannels in ischemia-induced cell death in nervous tissue. Brain Res Brain Res Rev. 47: 290–303.
   PubMed Web of Science ®Google Scholar
• Cruikshank SJ, Hopperstad M, Younger M, Connors BW, Spray DC, Srinivas M (2004). Potent block of Cx36 and Cx50 gap junction channels by mefloquine. Proc Natl Acad Sci U S A. 101: 12364–12369.
   PubMed Web of Science ®Google Scholar
• Del Corsso C, Srinivas M, Urban-Maldonado M, Moreno AP, Fort AG, Fishman GI, Spray DC (2006). Transfection of mammalian cells with connexins and measurement of voltagesensitivity of their gap junctions. Nat Protoc. 4: 1799–809.
   Google Scholar
• Iglesias R, Dahl G, Qiu F, Spray DC, Scemes E (2009). Pannexin 1: The molecular substrate of astrocyte “hemichannels.” J Neurosci. 29: 7092–7097.
   PubMed Web of Science ®Google Scholar
• Iglesias R, Locovei S, Roque A, Alberto AP, Dahl G, Spray DC, Scemes E (2008). P2X7 receptor-Pannexin1 complex: Pharmacology and signaling. Am J Physiol Cell Physiol. 295: C752–C760.
   PubMed Web of Science ®Google Scholar
• Kanneganti TD, Lamkanfi M, Kim YG, Chen G, Park JH, Franchi L, Vandenabeele P, Núñez G (2007). Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity. 26: 433–443.
   PubMed Web of Science ®Google Scholar
• Kimelberg HK (2005). Astrocytic swelling in cerebral ischemia as a possible cause of injury and target for therapy [review]. Glia. 50: 389–397.
   PubMed Web of Science ®Google Scholar
• Locovei S, Wang J, Dahl G (2006). Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. FEBS Lett. 580: 239–244.
   PubMed Web of Science ®Google Scholar
• Ma W, Hui H, Pelegrin P, Surprenant A (2009). Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. J Pharmacol Exp Ther. 328: 409–418.
   PubMed Web of Science ®Google Scholar
• Nilius B, Droogmans G. (2003). Amazing chloride channels: An overview. Acta Physiol. Scand. 177: 119–147.
   PubMedGoogle Scholar
• Panchin YV (2005). Evolution of gap junction proteins—The pannexin alternative. J Exp Biol. 208(Pt 8): 1415–1419.
   PubMed Web of Science ®Google Scholar
• Pelegrin P, Barroso-Gutierrez C, Surprenant A (2008). P2X7 receptor differentially couples to distinct release pathways for IL-1beta in mouse macrophage. J Immunol. 180: 7147–7157.
   PubMed Web of Science ®Google Scholar
• Silverman WR, de Rivero Vaccari JP, Locovei S, Qiu F, Carlsson SK, Scemes E, Keane RW, Dahl G (2009). The pannexin 1 channel activates the inflammasome in neurons and astrocytes. J Biol Chem. 284: 18143–18151.
   PubMed Web of Science ®Google Scholar
• Skals M, Jorgensen NR, Leipziger J, Praetorius HÁ (2009). Alpha-hemolysin from Escherichia coli uses endogenous amplification through P2X receptor activation to induce hemolysis. Proc Natl Acad Sci U S A. 106: 4030–4035.
   PubMed Web of Science ®Google Scholar
• Spray DC, Ye ZC, Ransom BR (2006). Functional connexin “hemichannels”: A critical appraisal. Glia. 54: 758–773.
   PubMed Web of Science ®Google Scholar
• Suadicani SO, Brosnan CF, Scemes E (2006). P2X7 receptors mediate ATP release and amplification of astrocytic intercellular Ca2+ signaling. J Neurosci. 26: 1378–1385.
   PubMed Web of Science ®Google Scholar
• Thompson RJ, Zhou N, MacVicar BA (2006). Ischemia opens neuronal gap junction hemichannels. Science. 312: 924–927.
   Google Scholar
• White TW, Deans MR, O’Brien J, Al-Ubaidi MR, Goodenough DA, Ripps H, Bruzzone R (1999). Functional characteristics of skate connexin35, a member of the gamma subfamily of connexins expressed in the vertebrate retina. Eur J Neurosci. 11: 1883–1890.
   PubMed Web of Science ®Google Scholar
• Weiss SM, Benwell K, Cliffe A, Gillespie RJ, Knight AR, Lerpiniere J, Misra A, Pratt RM, Revell D, Upton R, Dourish CT (2003). Discovery of nonxanthine adenosine A2A receptor antagonists for the treatment of Parkinson’s disease. Neurology. 61: S101–S106.
   PubMedGoogle Scholar