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Original Article

CD44 Variant Isoforms are Essential for the Function of Epidermal Langerhans Cells and Dendritic Cells

, , , , , , , , , & show all
Pages 157-160 | Received 12 Feb 1998, Accepted 09 Apr 1998, Published online: 11 Jul 2009

References

  • Arch R. Participation in normal immune responses of a metastasis-inducing splice variant of CD44. Science 1992; 257: 682–685
  • Austyn J. M. New insights into the mobilization and phagocytic activity of dendritic cells. J. Exp. Med. 1996; 183: 1287–1292
  • Bennett K. L. CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J. Cell. Biol. 1995; 128: 687–698
  • Butcher E. C. Lymphocyte adherence to high endothelial venules: characterization of a modified in vitro assay, and examination of the binding of syngeneic and allogeneic lymphocyte populations. J. Immunol. 1979; 123: 1996–2003
  • Camp R. L. CD44 is necessary for optimal contact allergic responses but is not required for normal leukocyte extravasation. J. Exp. Med. 1993; 178: 497–507
  • Günthert U. A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991; 65: 13–24
  • Inaba K. Immunologic properties of purified epidermal Langerhans cells. Distinct requirements for stimulation of unprimed and sensitized T lymphocytes. J. Exp. Med. 1986; 164: 605–613
  • Kashihara M. A monoclonal antibody specifically reactive to human Langerhans cells. J. Invest. Dermatol. 1986; 87: 602–607
  • Larsen C. P. Migration and maturation of Langerhans cells in skin transplants and explants. J. Exp. Med. 1990; 172: 1483–1493
  • Moll J. Accelerated immune response in transgenic mice expressing rat CD44v4-v7 on T cells. J. Immunol. 1996; 156: 2085–2094
  • Mulder J. W. Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins. Lancet 1994; 344: 1470–1472
  • Negoescu A. F(ab) secondary antibodies: a general method for double immunolabeling with primary antisera from the same species. Efficiency control by chemiluminescence. J. Histochem. Cytochem. 1994; 42: 433–437
  • Picker L. J., Butcher E. C. Physiological and molecular mechanisms of lymphocyte homing. Annu. Rev. Immunol. 1992; 10: 561–591
  • Pope M. Both dendritic cells and memory T lymphocytes emigrate from organ cultures of human skin and form distinctive dendritic-T-cell conjugates. J. Invest. Dermatol. 1995; 104: 11–17
  • Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J. Exp. Med. 1994; 179: 1109–1118
  • Seiter S. Prevention of tumor metastasis formation by anti-variant CD44. J. Exp. Med. 1993; 177: 443–455
  • Simon J. C. Low dose ultraviolet B-irradiated Langerhans cells preferentially activate CD4+ cells of the T helper 2 subset. J. Immunol. 1990; 145: 2087–2091
  • Simon J. C. In vivo evidence that ultraviolet B-induced suppression of allergic contact sensitivity is associated with functional inactivation of Th1 cells. Photodermatol. Photoimmunol. Photomed. 1994; 10: 206–211
  • Stauder R. CD44 variant isoforms in non-Hodgkin's lymphoma: a new independent prognostic factor. Blood 1995; 85: 2885–2899
  • Steinman R. M. The dendritic cell system and its role in immunogenicity. Ann. Rev. Immunol. 1991; 9: 271–296
  • Weiss J. M. Low-dose UVB radiation perturbs the functional expression of B7.1 and B7.2 co-stimulatory molecules on human Langerhans cells. Eur. J. Immunol. 1995; 25: 2858–2862
  • Weiss J. M. An essential role for CD44 variant isoforms in epidermal Langerhans cell and blood dendritic cell function. J. Cell. Biol. 1997; 137: 1137–1147
  • Zahalka M. A. Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent. J. Immunol. 1995; 154: 5345–5355

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