β2-microglobulin is required for the full expression of xenobiotic-induced systemic autoimmunity

References

• Abréu Vélez A. M., Warfvinge, G., Herrera, W. L., Abréu Vélez C. E., Montoya M, F., Hardy, D. M., Bollag, W. B., and Hashimoto, K. 2003. Detection of mercury and other undetermined materials in skin biopsies of endemic pemphigus foliaceus. Am J Dermatopathol 25:384–391.
   PubMed Web of Science ®Google Scholar
• Ahouse, J. J., Hagerman, C. L., Mittal, P., Gilbert, D. J., Copeland, N. G., Jenkins, N. A. and Simister, N. E. 1993. Mouse MHC class I-like Fc receptor encoded outside the MHC. J Immunol 151:6076–6088.
   PubMed Web of Science ®Google Scholar
• Baccala, R., Hoebe, K., Kono, D. H., Beutler, B. and Theofilopoulos, A. N. 2007. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat Med 13:543–551.
   PubMed Web of Science ®Google Scholar
• Bell, S. A., Hobbs, M. V. and Rubin, R. L. 1992. Isotype-restricted hyperimmunity in a murine model of the toxic oil syndrome. J Immunol 148:3369–3376.
   PubMed Web of Science ®Google Scholar
• Bendelac, A., Killeen, N., Littman, D. R. and Schwartz, R. H. 1994. A subset of CD4+ thymocytes selected by MHC class I molecules. Science 263:1774–1778.
   PubMed Web of Science ®Google Scholar
• Björkman, L., Reich, C. F. and Pisetsky, D. S. 2003. The use of fluorometric assays to assess the immune response to DNA in murine systemic lupus erythematosus. Scand J Immunol 57:525–533.
   PubMed Web of Science ®Google Scholar
• Boehm, U., Klamp, T., Groot, M. and Howard, J. C. 1997. Cellular responses to interferon-γ. Annu Rev Immunol 15:749–795.
   PubMed Web of Science ®Google Scholar
• Burlingame, R. W. and Rubin, R. L. 1990. Subnucleosome structures as substrates in enzyme-linked immunosorbent assays. J Immunol Methods 134:187–199.
   PubMed Web of Science ®Google Scholar
• Bustin, S. A. 2000. Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays. J Mol Endocrinol 25:169–193.
   PubMed Web of Science ®Google Scholar
• Cauvi, D. M., Cauvi, G. and Pollard, K. M. 2007. Reduced expression of decay-accelerating factor 1 on CD4+ T cells in murine systemic autoimmune disease. Arthritis Rheum 56:1934–1944.
   PubMedGoogle Scholar
• Chan, O. T., Paliwal, V., McNiff, J. M., Park, S. H., Bendelac, A. and Shlomchik, M. J. 2001. Deficiency in β(2)-microglobulin, but not CD1, accelerates spontaneous lupus skin disease while inhibiting nephritis in MRL-Fas(lpr) nice: An example of disease regulation at the organ level. J Immunol 167:2985–2990.
   PubMedGoogle Scholar
• Chen, J. A., Meister, S., Urbonaviciute, V., Rödel, F., Wilhelm, S., Kalden, J. R., Manger, K. and Voll, R. E. 2007. Sensitive detection of plasma/serum DNA in patients with systemic lupus erythematosus. Autoimmunity 40:307–310.
   PubMed Web of Science ®Google Scholar
• Chen, S. Y., Takeoka, Y., Pike-Nobile, L., Ansari, A. A., Boyd, R. and Gershwin, M. E. 1997. Autoantibody production and cytokine profiles of MHC class I (β2-microglobulin) gene deleted New Zealand black (NZB) mice. Clin Immunol Immunopathol 84:318–327.
   Google Scholar
• Christianson, G. J., Blankenburg, R. L., Duffy, T. M., Panka, D., Roths, J. B., Marshak-Rothstein, A. and Roopenian, D. C. 1996. β2-microglobulin dependence of the lupus-like autoimmune syndrome of MRL-lpr mice. J Immunol 156:4932–4939.
   PubMedGoogle Scholar
• Christianson, G. J., Brooks, W., Vekasi, S., Manolfi, E. A., Niles, J., Roopenian, S. L., Roths, J. B., Rothlein, R. and Roopenian, D. C. 1997. β 2-microglobulin-deficient mice are protected from hypergammaglobulinemia and have defective antibody responses because of increased IgG catabolism. J Immunol 159:4781–4792.
   PubMedGoogle Scholar
• Cooper, G. S., Parks, C. G., Treadwell, E. L., St Clair, E. W., Gilkeson, G. S. and Dooley, M. A. 2004. Occupational risk factors for the development of systemic lupus erythematosus. J Rheumatol 31:1928–1933.
   PubMed Web of Science ®Google Scholar
• Gardner, R. M., Nyland, J. F., Silva, I. A., Ventura, A. M., de Souza, J. M. and Silbergeld, E. K. 2010. Mercury exposure, serum antinuclear/antinucleolar antibodies and serum cytokine levels in mining populations in Amazonian Brazil: A cross-sectional study. Environ Res 110:345–354.
   PubMed Web of Science ®Google Scholar
• Ghetie, V., Hubbard, J. G., Kim, J. K., Tsen, M. F., Lee, Y. and Ward, E. S. 1996. Abnormally short serum half-lives of IgG in β2-microglobulin-deficient mice. Eur J Immunol 26:690–696.
   PubMed Web of Science ®Google Scholar
• Giese, T. and Davidson, W. F. 1995. In CD8+ T cell-deficient lpr/lpr mice, CD4+B220+ and CD4+B220- T cells replace B220+ double-negative T cells as the predominant populations in enlarged lymph nodes. J Immunol 154:4986–4995.
   Google Scholar
• Giulietti, A., Overbergh, L., Valckx, D., Decallonne, B., Bouillon, R. and Mathieu, C. 2001. An overview of real-time quantitative PCR: Applications to quantify cytokine gene expression. Methods 25:386–401.
   PubMed Web of Science ®Google Scholar
• Haymann, J. P., Levraud, J. P., Bouet, S., Kappes, V., Hagège, J., Nguyen, G., Xu, Y., Rondeau, E. and Sraer, J. D. 2000. Characterization and localization of the neonatal Fc receptor in adult human kidney. J Am Soc Nephrol 11:632–639.
   PubMed Web of Science ®Google Scholar
• Hultman, P., Bell, L. J., Eneström, S. and Pollard, K. M. 1992. Murine susceptibility to mercury. I. Autoantibody profiles and systemic immune deposits in inbred, congenic and intra-H-2 recombinant strains. Clin Immunol Immunopathol 65:98–109.
   PubMedGoogle Scholar
• Hultman, P., Johansson, U. and Dagnaes-Hansen, F. 1995. Murine mercury-induced autoimmunity: The role of T-helper cells. J Autoimmun 8:809–823.
   PubMed Web of Science ®Google Scholar
• Israel, E. J., Patel, V. K., Taylor, S. F., Marshak-Rothstein, A. and Simister, N. E. 1995. Requirement for a β2-microglobulin-associated Fc receptor for acquisition of maternal IgG by fetal and neonatal mice. J Immunol 154:6246–6251.
   PubMed Web of Science ®Google Scholar
• Israel, E. J., Wilsker, D. F., Hayes, K. C., Schoenfeld, D. and Simister, N. E. 1996. Increased clearance of IgG in mice that lack β2-microglobulin: Possible protective role of FcRn. Immunology 89:573–578.
   PubMed Web of Science ®Google Scholar
• Jiang, Y. and Möller, G. 1995. In vitro effects of HgCl2 on murine lymphocytes. I. Preferable activation of CD4+ T cells in a responder strain. J Immunol 154:3138–3146.
   PubMed Web of Science ®Google Scholar
• Khare, S. D., Hansen, J., Luthra, H. S. and David, C. S. 1996. HLA-B27 heavy chains contribute to spontaneous inflammatory disease in B27/human β2-microglobulin (β2m) double transgenic mice with disrupted mouse β2m. J Clin Invest 98:2746–2755.
   PubMed Web of Science ®Google Scholar
• Koh, D. R., Ho, A., Rahemtulla, A., Fung-Leung, W. P., Griesser, H. and Mak, T. W. 1995. Murine lupus in MRL/lpr mice lacking CD4 or CD8 T cells. Eur J Immunol 25:2558–2562.
   PubMed Web of Science ®Google Scholar
• Kono, D. H., Balomenos, D., Pearson, D. L., Park, M. S., Hildebrandt, B., Hultman, P. and Pollard, K. M. 1998. The prototypic Th2 autoimmunity induced by mercury is dependent on IFN-γ and not Th1/Th2 imbalance. J Immunol 161:234–240.
   PubMed Web of Science ®Google Scholar
• Kono, D. H., Haraldsson, M. K., Lawson, B. R., Pollard, K. M., Koh, Y. T., Du, X., Arnold, C. N., Baccala, R., Silverman, G. J., Beutler, B. A. and Theofilopoulos, A. N. 2009. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci USA 106:12061–12066.
   PubMed Web of Science ®Google Scholar
• Kotzin, B. L., Lafferty, J. A., Portanova, J. P., Rubin, R. L. and Tan, E. M. 1984. Monoclonal anti-histone autoantibodies derived from murine models of lupus. J Immunol 133:2554–2559.
   PubMed Web of Science ®Google Scholar
• Kramers, C., Hylkema, M. N., van Bruggen, M. C., van de Lagemaat, R., Dijkman, H. B., Assmann, K. J., Smeenk, R. J. and Berden, J. H. 1994. Anti-nucleosome antibodies complexed to nucleosomal antigens show anti-DNA reactivity and bind to rat glomerular basement membrane in vivo. J Clin Invest 94:568–577.
   PubMed Web of Science ®Google Scholar
• Lencer, W. I. and Blumberg, R. S. 2005. A passionate kiss, then run: Exocytosis and recycling of IgG by FcRn. Trends Cell Biol 15:5–9.
   PubMed Web of Science ®Google Scholar
• Li, S. J., Zhang, S. H., Chen, H. P., Zeng, C. H., Zheng, C. X., Li, L. S. and Liu, Z. H. 2010. Mercury-induced membranous nephropathy: Clinical and pathological features. Clin J Am Soc Nephrol 5:439–444.
   PubMed Web of Science ®Google Scholar
• Low, S. C. and Mezo, A. R. 2009. Inhibitors of the FcRn:IgG protein-protein interaction. AAPS J 11:432–434.
   PubMed Web of Science ®Google Scholar
• Maldonado, M. A., Eisenberg, R. A., Roper, E., Cohen, P. L. and Kotzin, B. L. 1995. Greatly reduced lymphoproliferation in lpr mice lacking major histocompatibility complex class I. J Exp Med 181:641–648.
   Google Scholar
• Marshak-Rothstein, A. and Rifkin, I. R. 2007. Immunologically active autoantigens: The role of toll-like receptors in the development of chronic inflammatory disease. Annu Rev Immunol 25:419–441.
   PubMed Web of Science ®Google Scholar
• Mixter, P. F., Russell, J. Q., Durie, F. H. and Budd, R. C. 1995. Decreased CD4-CD8- TCR-α β + cells in lpr/lpr mice lacking β2-microglobulin. J Immunol 154:2063–2074.
   PubMed Web of Science ®Google Scholar
• Mozes, E., Lovchik, J., Zinger, H. and Singer, D. S. 2005. MHC class I expression regulates susceptibility to spontaneous autoimmune disease in (NZBxNZW)F1 mice. Lupus 14:308–314.
   Google Scholar
• Nimmerjahn, F. and Ravetch, J. V. 2008. Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8:34–47.
   PubMed Web of Science ®Google Scholar
• Ochel, M., Vohr, H. W., Pfeiffer, C. and Gleichmann, E. 1991. IL-4 is required for the IgE and IgG1 increase and IgG1 autoantibody formation in mice treated with mercuric chloride. J Immunol 146:3006–3011.
   PubMed Web of Science ®Google Scholar
• Ohteki, T., Iwamoto, M., Izui, S. and MacDonald, H. R. 1995. Reduced development of CD4-8-B220+ T cells but normal autoantibody production in lpr/lpr mice lacking major histocompatibility complex class I molecules. Eur J Immunol 25:37–41.
   PubMedGoogle Scholar
• Piacenza, F., Malavolta, M., Cipriano, C., Costarelli, L., Giacconi, R., Muti, E., Tesei, S., Pierpaoli, S., Basso, A., Bracci, M., Bonacucina, V., Santarelli, L. and Mocchegiani, E. 2009. l-Arginine normalizes NOS activity and zinc-MT homeostasis in the kidney of mice chronically exposed to inorganic mercury. Toxicol Lett 189:200–205.
   Google Scholar
• Pietsch, P., Vohr, H. W., Degitz, K. and Gleichmann, E. 1989. Immunological alterations inducible by mercury compounds. II. HgCl2 and gold sodium thiomalate enhance serum IgE and IgG concentrations in susceptible mouse strains. Int Arch Allergy Appl Immunol 90:47–53.
   Google Scholar
• Pisetsky, D. S. 2004. The immune response to cell death in SLE. Autoimmun Rev 3:500–504.
   Google Scholar
• Pisetsky, D. S. 2007. The role of nuclear macromolecules in innate immunity. Proc Am Thorac Soc 4:258–262.
   Google Scholar
• Pollard, K. M., Arnush, M., Hultman, P. and Kono, D. H. 2004. Costimulation requirements of induced murine systemic autoimmune disease. J Immunol 173:5880–5887.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M. and Hultman, P. 1997. Effects of mercury on the immune system. Met Ions Biol Syst 34:421–440.
   PubMedGoogle Scholar
• Pollard, K. M., Hultman, P. and Kono, D. H. 2003. Using single-gene deletions to identify checkpoints in the progression of systemic autoimmunity. Ann N Y Acad Sci 987:236–239.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M., Hultman, P. and Kono, D. H. 2005. Immunology and genetics of induced systemic autoimmunity. Autoimmun Rev 4:282–288.
   Google Scholar
• Pollard, K. M., Hultman, P. and Kono, D. H. 2010. Toxicology of autoimmune diseases. Chem Res Toxicol 23:455–466.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M. and Landberg, G. P. 2001. The in vitro proliferation of murine lymphocytes to mercuric chloride is restricted to mature T cells and is interleukin 1 dependent. Int Immunopharmacol 1:581–593.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M., Lee, D. K., Casiano, C. A., Bluthner, M., Johnston, M. M. and Tan, E. M. 1997. The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties. J Immunol 158:3521–3528.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M., Pearson, D. L., Blüthner, M. and Tan, E. M. 2000. Proteolytic cleavage of a self-antigen following xenobiotic-induced cell death produces a fragment with novel immunogenic properties. J Immunol 165:2263–2270.
   PubMed Web of Science ®Google Scholar
• Pollard, K. M., Pearson, D. L., Hultman, P., Hildebrandt, B. and Kono, D. H. 1999. Lupus-prone mice as models to study xenobiotic-induced acceleration of systemic autoimmunity. Environ Health Perspect 107 Suppl 5:729–735.
   Google Scholar
• Richards, H. B., Satoh, M., Shaw, M., Libert, C., Poli, V. and Reeves, W. H. 1998. Interleukin 6 dependence of anti-DNA antibody production: Evidence for two pathways of autoantibody formation in pristane-induced lupus. J Exp Med 188:985–990.
   PubMed Web of Science ®Google Scholar
• Roopenian, D. C. and Akilesh, S. 2007. FcRn: The neonatal Fc receptor comes of age. Nat Rev Immunol 7:715–725.
   PubMed Web of Science ®Google Scholar
• Roopenian, D. C., Christianson, G. J., Sproule, T. J., Brown, A. C., Akilesh, S., Jung, N., Petkova, S., Avanessian, L., Choi, E. Y., Shaffer, D. J., Eden, P. A. and Anderson, C. L. 2003. The MHC class I-like IgG receptor controls perinatal IgG transport, IgG homeostasis and fate of IgG-Fc-coupled drugs. J Immunol 170:3528–3533.
   PubMed Web of Science ®Google Scholar
• Rumbeiha, W. K., Fitzgerald, S. D., Braselton, W. E., Roth, R. A., Pestka, J. J. and Kaneene, J. B. 2000. Augmentation of mercury-induced nephrotoxicity by endotoxin in the mouse. Toxicology 151:103–116.
   Google Scholar
• Santarelli, L. Bracci, M. and Mocchegiani, E. 2006. In vitro and in vivo effects of mercuric chloride on thymic endocrine activity, NK and NKT cell cytotoxicity, cytokine profiles (IL-2, IFN-γ, IL-6): Role of the nitric oxide-L-arginine pathway. Int Immunopharmacol 6:376–389.
   PubMedGoogle Scholar
• Schiraldi, M. and Monestier, M. 2009. How can a chemical element elicit complex immunopathology? Lessons from mercury-induced autoimmunity. Trends Immunol 30:502–509.
   PubMed Web of Science ®Google Scholar
• Silva, I. A., Nyland, J. F., Gorman, A., Perisse, A., Ventura, A. M., Santos, E. C., Souza, J. M., Burek, C. L., Rose, N. R. and Silbergeld, E. K. 2004. Mercury exposure, malaria and serum antinuclear/antinucleolar antibodies in Amazon populations in Brazil: A cross-sectional study. Environ Health 3:11.
   PubMedGoogle Scholar
• Spriggs, M. K., Koller, B. H., Sato, T., Morrissey, P. J., Fanslow, W. C., Smithies, O., Voice, R. F., Widmer, M. B. and Maliszewski, C. R. 1992. β2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proc Natl Acad Sci USA 89:6070–6074.
   PubMedGoogle Scholar
• Sun, J. C. and Lanier, L. L. 2008. Cutting edge: Viral infection breaks NK cell tolerance to “missing self”. J Immunol 181:7453–7457.
   Google Scholar
• van Bruggen, M. C., Walgreen, B., Rijke, T. P., Tamboer, W., Kramers, K., Smeenk, R. J., Monestier, M., Fournie, G. J. and Berden, J. H. 1997. Antigen specificity of anti-nuclear antibodies complexed to nucleosomes determines glomerular basement membrane binding in vivo. Eur J Immunol 27:1564–1569.
   Google Scholar
• Vas, J., Mattner, J., Richardson, S., Ndonye, R., Gaughan, J. P., Howell, A. and Monestier, M. 2008. Regulatory roles for NKT cell ligands in environmentally induced autoimmunity. J Immunol 181:6779–6788.
   Google Scholar
• Vas, J. and Monestier, M. 2008. Immunology of mercury. Ann N Y Acad Sci 1143:240–267.
   PubMed Web of Science ®Google Scholar
• Williams, R. C. Jr, Malone, C. C., Meyers, C., Decker, P. and Muller, S. 2001. Detection of nucleosome particles in serum and plasma from patients with systemic lupus erythematosus using monoclonal antibody 4H7. J Rheumatol 28:81–94.
   PubMed Web of Science ®Google Scholar
• Yang, J. M., Baserga, S. J., Turley, S. J. and Pollard, K. M. 2001. Fibrillarin and other snoRNP proteins are targets of autoantibodies in xenobiotic-induced autoimmunity. Clin Immunol 101:38–50.
   PubMed Web of Science ®Google Scholar
• Zijlstra, M., Bix, M., Simister, N. E., Loring, J. M., Raulet, D. H. and Jaenisch, R. 1990. β2-microglobulin deficient mice lack CD4-8+ cytolytic T cells. Nature 344:742–746.
   PubMed Web of Science ®Google Scholar
• Zijlstra, M., Li, E., Sajjadi, F., Subramani, S. and Jaenisch, R. 1989. Germ-line transmission of a disrupted β2-microglobulin gene produced by homologous recombination in embryonic stem cells. Nature 342:435–438.
   PubMed Web of Science ®Google Scholar