Impairment of thymocyte function via induction of apoptosis by areca nut extract

References

• Ashwell, J., Lu, F., and Vacchio, M. 2000. Glucocorticoids in T-cell development and function. Annu. Rev. Immunol. 18:309–345
   PubMed Web of Science ®Google Scholar
• Chang, M. C., Chiang, C. P., Lin, C. L., et al. 2005. Cell-mediated immunity and head and neck cancer with special emphasis on betel quid chewing habit. Oral Oncol. 41:757–775
   PubMed Web of Science ®Google Scholar
• Changrani, J., and Gany, F. 2005. Paan and Gutka in the United States: An emerging threat. J. Immigr. Health 7:103–108
   PubMedGoogle Scholar
• Chue, A. L., Carrara, V. I., Paw, M. K., et al. 2012. Is areca innocent? The effect of areca (betel) nut chewing in a population of pregnant women on the Thai-Myanmar border. Int. Health 172:204–209
   Google Scholar
• Ciofani, M., and Zuniga-Pflucker, J. C. 2007. The thymus as an inductive site for T-lymphopoiesis. Annu. Rev. Cell Dev. Biol. 23:463–493
   PubMed Web of Science ®Google Scholar
• Cohen, J. J., Duke, R. C., Fadok, V. A., and Sellins, K. S. 1992. Apoptosis and programmed cell death in immunity. Annu. Rev. Immunol. 10:267–293
   PubMed Web of Science ®Google Scholar
• Comment, C., Blaylock, B., Germolec, D., et al. 1992. Thymocyte injury after in vitro chemical exposure: Potential mechanisms for thymic atrophy. J. Pharmacol. Exp. Ther. 262:1267–1273
   PubMed Web of Science ®Google Scholar
• Coppola, M., and Mondola, R. 2012. Potential action of betel alkaloids on positive and negative symptoms of schizophrenia: A review. Nord. J. Psychiatry 66:73–78
   PubMed Web of Science ®Google Scholar
• Dietert, R., and Dewitt, J., (Eds.). 2010. Developmental immunotoxicity (DIT): The why, when, and how of DIT testing. In: Methods in Molecular Biology. Clifton, NJ: Humana Press, pp. 598:17–25
   Google Scholar
• Doherty, P. C. 1993. Immune exhaustion: Driving virus-specific CD8+ T-cells to death. Trends Microbiol. 1:207–209
   PubMedGoogle Scholar
• Drela, N. 2006. Xenobiotic-induced alterations in thymocyte development. APMIS 114:399–419
   PubMed Web of Science ®Google Scholar
• Farrand, P., Rowe, R. M., Johnston, A., and Murdoch, H. 2001. Prevalence, age of onset and demographic relationships of different areca nut habits amongst children in Tower Hamlets, London. Br. Dent. J. 190:150–154
   PubMed Web of Science ®Google Scholar
• Fine, J. S., Silverstone, A. E., and Gasiewicz, T. A. 1990. Impairment of prothymocyte activity by 2,3,7,8-tetrachlorodibenzo-p-dioxin. J. Immunol. 144:1169–1176
   PubMed Web of Science ®Google Scholar
• Frawley, R., White, K. Jr, Brown, R., et al. 2011. Gene expression alterations in immune system pathways in the thymus after exposure to immunosuppressive chemicals. Environ. Health Perspect. 119:371–376
   PubMed Web of Science ®Google Scholar
• Gupta, P. C., and Warnakulasuriya, S. 2002. Global epidemiology of areca nut usage. Addict. Biol. 7:77–83
   PubMed Web of Science ®Google Scholar
• Haque, M. F., Meghji, S., Khitab, U., and Harris, M. 2000. Oral submucous fibrosis patients have altered levels of cytokine production. J. Oral Pathol. Med. 29:123–128
   PubMed Web of Science ®Google Scholar
• Haynes, B. F., Markert, M. L., Sempowski, G. D., et al. 2000. The role of thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18:529–560
   PubMed Web of Science ®Google Scholar
• Holladay, S. D., and Luster, M. I. 1996. Alterations in fetal thymic and liver hematopoietic cells as indicators of exposure to developmental immunotoxicants. Environ. Health Perspect. 104:809–813
   PubMed Web of Science ®Google Scholar
• Hung, S. L., Lee, Y. Y., Liu, T. Y., et al. 2006. Modulation of phagocytosis, chemotaxis, and adhesion of neutrophils by areca nut extracts. J. Periodontol. 77:579–585
   PubMedGoogle Scholar
• Jamieson, B., Douek, D., Killian, S., et al. 1999. Generation of functional thymocytes in the human adult. Immunity 10:569–575
   PubMed Web of Science ®Google Scholar
• Kamath, A. B., Xu, H., Nagarkatti, P. S., and Nagarkatti, M. 1997. Evidence for the induction of apoptosis in thymocytes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in vivo. Toxicol. Appl. Pharmacol. 142:367–377
   PubMed Web of Science ®Google Scholar
• Kumpawat, K., Deb, S., Ray, S., and Chatterjee, A. 2003. Genotoxic effect of raw betel nut extract in relation to endogenous glutathione levels and its mechanism of action in mammalian cells. Mutat. Res. 538:1–12
   PubMed Web of Science ®Google Scholar
• Lee, C. Y., Wey, S. P., Liao, M. H., et al. 2008. A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells. Int. Immunopharmacol. 8:732–740
   PubMed Web of Science ®Google Scholar
• Liu, T. Y., Chen, C. L., and Chi, C. W. 1996. Oxidative damage to DNA induced by areca nut extract. Mutat. Res. 367:25–31
   PubMed Web of Science ®Google Scholar
• Lundberg, K. 1991. Dexamethasone and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can induce thymic atrophy by different mechanisms in mice. Biochem. Biophys. Res. Commun. 178:16–23
   PubMed Web of Science ®Google Scholar
• Lundberg, K., Gronvik, K. O., Goldschmidt, T. J., et al. 1990. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) alters intrathymic T-cell development in mice. Chem.-Biol. Interact. 74:179–193
   PubMed Web of Science ®Google Scholar
• Lutz, C., Browne, G., and Petzold, C. 1998. Methylcholanthrene causes increased thymocyte apoptosis. Toxicology 128:151–167
   PubMedGoogle Scholar
• Mitra, S., Keswani, T., Dey, M., et al. 2012. Copper-induced immunotoxicity involves cell cycle arrest and cell death in the spleen and thymus. Toxicology 293:78–88
   PubMedGoogle Scholar
• Pagliacci, M. C., Tognellini, R., Grignani, F., and Nicoletti, I. 1991. Inhibition of human breast cancer cell (MCF-7) growth in vitro by the somatostatin analog SMS 201-995: Effects on cell cycle parameters and apoptotic cell death. Endocrinology 129:2555–2562
   PubMedGoogle Scholar
• Palmer, E. 2003. Negative selection - clearing out the bad apples from the T-cell repertoire. Nat. Rev. Immunol. 3:383–391
   PubMed Web of Science ®Google Scholar
• Panigrahi, G., and Rao, A. 1986. Study of the genotoxicity of the total aqueous extract of betel nut and its tannin. Carcinogenesis 7:37–39
   PubMed Web of Science ®Google Scholar
• Pruett, S. B., Ensley, D. K., and Criltenden, P. L. 1993. The role of chemical-induced stress responses in immunosuppression: A review of quantitative associations and cause-effect relationships between chemical-induced stress responses and immunosuppression. J. Toxicol. Environ. Health 39:163–192
   PubMed Web of Science ®Google Scholar
• Ranadive, K. J., Gothoskar, S. V., Rao, A. R., et al. 1976. Experimental studies on betel nut and tobacco carcinogenicity. Int. J. Cancer 17:469–476
   PubMed Web of Science ®Google Scholar
• Selvan, R. S., Venkateswaran, K. S., and Rao, A. R. 1989. Influence of arecoline on immune system: I. Short-term effects on general parameters and on the adrenal and lymphoid organs. Immunopharmacol. Immunotoxicol. 11:347–377
   PubMed Web of Science ®Google Scholar
• Senn, M., Baiwog, F., Winmai, J., et al. 2009. Betel nut chewing during pregnancy, Madang province, Papua New Guinea. Drug Alcohol Depend. 105:126–131
   PubMed Web of Science ®Google Scholar
• Shah, S. M., Merchant, A. T., Luby, S. P., and Chotani, R. A. 2002. Addicted schoolchildren: prevalence and characteristics of areca nut chewers among primary school children in Karachi, Pakistan. J. Paediatr. Child Health 38:507–510
   PubMed Web of Science ®Google Scholar
• Susin, S., Daugas, E., Ravagnan, L., et al. 2000. Two distinct pathways leading to nuclear apoptosis. J. Exp. Med. 192:571–580
   PubMed Web of Science ®Google Scholar
• Taub, D. D., and Longo, D. L. 2005. Insights into thymic aging and regeneration. Immunol. Rev. 205:72–93
   PubMed Web of Science ®Google Scholar
• Tentori, L., Longo, D. L., Zuniga-Pflucker, J. C., et al. 1988. Essential role of the IL 2-IL 2 receptor pathway in thymocyte maturation in vivo. J. Exp. Med. 168:1741–1747
   PubMed Web of Science ®Google Scholar
• Wang, C. C., Chen, T. Y., Wu, H. Y., et al. 2012. Areca nut extracts suppress the differentiation and functionality of human monocyte-derived dendritic cells. J. Periodontal. Res. 47:198–203
   PubMedGoogle Scholar
• Wang, C. C., Huang, P. L., Liu, T. Y., and Jan, T. R. 2009a. Highly oligomeric procyanidins from areca nut induce lymphocyte apoptosis via the depletion of intracellular thiols. Toxicol. In Vitro 23:1234–1241
   PubMedGoogle Scholar
• Wang, C. C., Lin, H. L., Wey, S. P., and Jan, T. R. 2011. Areca-nut extract modulates antigen-specific immunity and augments inflammation in ovalbumin-sensitized mice. Immunopharmacol. Immunotoxicol. 33:315–322
   PubMed Web of Science ®Google Scholar
• Wang, C. C., Liu, T. Y., Cheng, C. H., and Jan, T. R. 2009b. Involvement of the mitochondrion-dependent pathway and oxidative stress in the apoptosis of murine splenocytes induced by areca nut extract. Toxicol. In Vitro 23:840–847
   PubMedGoogle Scholar
• Wang, C. C., Liu, T. Y., Wey, S. P., et al. 2007. Areca nut extract suppresses T-cell activation and IFNγ production via the induction of oxidative stress. Food Chem. Toxicol. 45:1410–1418
   PubMed Web of Science ®Google Scholar
• Wollina, U., Verma, S., Parikh, A., and Parikh, D. 2004. Oral disease caused by the chewing of betel nut and concoctions containing betel nut. J. Eur. Acad. Dermatol. Venereol. 18:233–235
   PubMedGoogle Scholar
• Yang, M. J., Chung, T. C., Hsu, T. Y., and Ko, Y. C. 2001. Betel quid chewing and risk of adverse birth outcomes among aborigines in eastern Taiwan. J. Toxicol. Environ. Health 64:465–472
   PubMed Web of Science ®Google Scholar
• Young, D. A., Voris, B. P., and Nicholson, M. L. 1981. Cellular and biochemical actions of adrenal glucocorticoid hormones on rat thymic lymphocytes. Environ. Health Perspect. 38:89–97
   PubMedGoogle Scholar