Molecular Biology Primer for the Pediatric Pathologist

References

• Genes, I.V., 1st ed, B. Lewin. Oxford University Press, Oxford 1990
   Google Scholar
• Drapkin R., Merino A., Reinberg D. Regulation of RNA polymerase II transcription. Curr Opin Cell Biol 1993; 3: 469–76
   Google Scholar
• Thompson C. C., McKnight S. L. Anatomy of an enhancer. Trends Biochem Sci 1992; 8: 232–6
   Google Scholar
• McKeown M. The role of small nuclear RNAs in RNA splicing. Curr Opin Cell Biol 1993; 5: 448–54
   Google Scholar
• Early P., Rogers J., Davis M., et al. Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell 1980; 20: 313–9
   PubMed Web of Science ®Google Scholar
• Rogers J., Early P., Carter C., et al. Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell 1980; 20: 303–12
   PubMed Web of Science ®Google Scholar
• Williams L. T., Escobedo J. A., Ueno H., . Signal transduction by the platelet-derived growth factor and fibroblast growth factor receptors. Origins of Human Cancer: A Comprehensive Review. 1st ed., J. Brugge, T. Curran, E. Harlow, et al. Cold Spring Harbor Laboratory Press, Plainview, NY 1991; Vol. 1: 237–45
   Google Scholar
• Lord J. M., Bunce C. M., Brown G. The role of protein phosphorylation in the control of cell growth and differentiation. Br J Cancer 1988; 58: 549–55
   PubMed Web of Science ®Google Scholar
• Meek D. W., Street A. J. Nuclear protein phosphorylation and growth control. Biochem J 1992; 287(1 Oct, Pt 1)1–15
   Google Scholar
• DeBond H. L., Rosenblatt J., Jancarik J., et al. Crystal structure of cyclin-dependent kinase 2. Nature 1993; 363: 595–602
   Google Scholar
• Charbonneau H., Tonks N. K. 1002 protein phosphatases. Annu Rev Cell Biol 1992; 8: 463–93
   PubMedGoogle Scholar
• Sprague GF J. Kinase cascade conserved. Curr Biol 1992; 2: 587–9
   Google Scholar
• Iyengar R. Molecular and functional diversity of mammalian Gs-stimulated adenylyl cyclases. FASEB J 1993; 7: 768–75
   PubMedGoogle Scholar
• Hepler J. R., Gilman A. G. G proteins. Trends Biochem Sci 1992; 17: 383–7
   PubMed Web of Science ®Google Scholar
• Taylor S. S. cAMP-dependent protein kinase: Model for an enzyme family. J Biol Chem 1989; 264: 8443–6
   PubMed Web of Science ®Google Scholar
• Karin M. Complexities of gene regulation by cAMP. Trends Genet 1989; 5: 65–7
   PubMedGoogle Scholar
• Rink T. J., Merritt J. E. Calcium signalling. Curr Opin Cell Biol 1990; 2: 198–205
   Google Scholar
• Lohnes D., Dierich A., Ghyselinck N., et al. Retinoid receptors and binding proteins. J Cell Sci Suppl 1992; 16: 69–76
   Google Scholar
• Leid M., Kastner P., Chambon P. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem Sci 1992; 17: 427–33
   PubMed Web of Science ®Google Scholar
• Satoh T., Nakafuku M., Kaziro Y. Function of ras as a molecular switch in signal transduction. J Biol Chem 1992; 267: 24149–52
   PubMed Web of Science ®Google Scholar
• Marx J. Forging a path to the nucleus. Science 1993; 260: 1588–90
   PubMedGoogle Scholar
• Feig L. A. The many roads that lead to Ras. Science 1993; 260: 767–8
   PubMed Web of Science ®Google Scholar
• Moodie S. A., Willumsen B. M., Weber M. J., et al. Complexes of Ras-GTP with Raf-1 and mitogen-activated protein kinase kinase. Science 1993; 260: 1658–61
   PubMed Web of Science ®Google Scholar
• Nishida E., Gotoh Y. The MAP kinase cascade is essential for diverse signal transduction pathways. Trends Biochem Sci 1993; 18: 128–31
   PubMed Web of Science ®Google Scholar
• Ruderman J. V. MAP kinase and the activation of quiescent cells. Curr Biol 1993; 5: 207–13
   Google Scholar
• Egan S. E., Giddings B. W., Brooks M. W., et al. Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation. Nature 1993; 363: 45–51
   PubMed Web of Science ®Google Scholar
• Darnell J., Lodish H., Baltimore D. Growing and manipulating cells and viruses. Molecular Cell Biology. 2nd ed., J. Darnell, H. Lodish, D. Baltimore. Scientific American Books, New York 1990; 151–9
   Google Scholar
• Minshull J. Cyclin synthesis: Who needs it?. Bioessays 1993; 15: 149–55
   PubMedGoogle Scholar
• Pines J. Cyclins and cyclin-dependent kinases: Take your partners. Trends Biochem Sci 1993; 18: 195–7
   PubMed Web of Science ®Google Scholar
• Murray A. W. Turning on mitosis. Curr Biol 1993; 3: 291–3
   Google Scholar
• Nigg E. A. Targets of cyclin-dependent protein kinases. Curr Opin Cell Biol 1993; 5: 187–93
   PubMed Web of Science ®Google Scholar
• Williams G. T., Smith C. A., McCarthy N. J., et al. Apoptosis final control point in cell biology. Trends Cell Biol 1992; 2: 263–7
   PubMedGoogle Scholar
• Wyllie A. H. Apoptosis (The 1992 Frank Rose Memorial Lecture). Br J Cancer 1993; 67: 205–8
   PubMed Web of Science ®Google Scholar
• Maden M., Holder N. Retinoic acid and the development of the central nervous system. Bioessays 1992; 14: 431–8
   PubMed Web of Science ®Google Scholar
• Gillard E. F., Solomon E. Retinoic acid-induced remission. Curr Biol 1993; 3: 185–7
   Google Scholar
• Rous P. A sarcoma of the fowl transmissible by an agent separable from the tumour cells. J Exp Med 1911; 13: 397
   PubMedGoogle Scholar
• Bishop J. M. The molecular biology of RNA tumor viruses: A physician's guide. N Engl J Med 1980; 303: 675–82
   PubMed Web of Science ®Google Scholar
• Bishop J. M. Viral oncogenes. Cell 1985; 42: 23–8
   PubMed Web of Science ®Google Scholar
• Spector D. H., Varmus H. E., Bishop J. M. Nucleotide sequences related to the transforming gene of avian sarcoma virus are present in DNA of uninfected vertebrates. Proc Natl Acad Sci USA 1978; 75: 4102–6
   PubMed Web of Science ®Google Scholar
• Bishop J. M. Cellular oncogenes and retroviruses. Annu Rev Biochem 1983; 52: 301–54
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. A molecular basis of cancer. Sci Am 1983; 249(5)126–43
   Google Scholar
• Bos J. L., Fearon E. R., Hamilton S. R., et al. Prevalence of ras gene mutations in human colrectal cancer. Nature 1987; 327: 293–7
   PubMed Web of Science ®Google Scholar
• Pitot H. C. The molecular biology of carcinogenesis. Cancer 1993; 72: 962–70
   PubMed Web of Science ®Google Scholar
• Hayward W. S., Neel B. G., Astrin S. M. Activation of a cellular oncogene by promoter insertion in ALV-induced lymphoid leukosis. Nature 1981; 290: 475–9
   PubMed Web of Science ®Google Scholar
• Dalla-Favera R., Bregni M., Erikson J., et al. Human c-myconcogene is located in the region of chromosome 8 that is translocated in Burkitt lymphoma cells. Proc Natl Acad Sci USA 1982; 79: 7824–7
   PubMed Web of Science ®Google Scholar
• Taub R., Kirsch I., Morton C., et al. Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells. Proc Natl Acad Sci USA 1982; 79: 7837–41
   PubMed Web of Science ®Google Scholar
• Cline M. Biology of human disease. Molecular diagnosis of human cancer. Lab Invest 1989; 61: 368–80
   PubMed Web of Science ®Google Scholar
• Bacon T., Wickstrom E. Walking along the human c-myc mRNA: Maximum efficacy at the 5′ cap region. Oncogene Res 1991; 6: 13–9
   PubMedGoogle Scholar
• Brison O. Gene amplification and tumour progression. Biochim Biophys Acta 1993; 1155: 25–41
   PubMedGoogle Scholar
• De Klein A., Van Kessel A., Grosveld D., et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukemia. Nature 1982; 300: 765–7
   PubMed Web of Science ®Google Scholar
• Korsmeyer S. J. BCL2: An antidote to programmed cell death. Cancer Surv 1992; 15: 105–18
   PubMedGoogle Scholar
• Korsmeyer S. J. Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood 1992; 80: 879–86
   PubMed Web of Science ®Google Scholar
• Land H., Parada L. F., Weinberg R. A. Tumorigenic transformation of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1982; 304: 596–601
   Google Scholar
• Harris H., Miller O. J., Klein G., et al. Suppression of malignancy by cell fusion. Nature 1969; 223: 363
   PubMed Web of Science ®Google Scholar
• Knudson A. G. Mutation and cancer: Statistical study of retinoblastoma. Proc Natl Acad Sci USA 1971; 68: 820–3
   PubMed Web of Science ®Google Scholar
• Weinberg R. A. Tumor suppressor genes. Science 1991; 254: 1138–46
   PubMed Web of Science ®Google Scholar
• Friend S. H., Bernards R., Rogelj S., et al. A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 1986; 323: 643–6
   PubMed Web of Science ®Google Scholar
• Gallie B. L., Squire J. A., Goddard A., et al. Biology of disease. Mechanism of oncogenesis in retinoblastoma. Lab Invest 1990; 62: 394–408
   PubMed Web of Science ®Google Scholar
• Malkin D., Li F. P., Strong L. C., et al. Germ line p53 mutations in familial syndrome of breast cancer sarcomas and other neoplasms. Science 1990; 250: 1233–8
   PubMed Web of Science ®Google Scholar
• Levine A. J., Momand J., Finlay C. The p53 tumour suppressor gene. Nature 1991; 351: 453–5
   PubMed Web of Science ®Google Scholar
• Vogelstein B., Kinzler K. W. p53 function and dysfunction. Cell 1992; 70: 523–6
   PubMed Web of Science ®Google Scholar
• Lane D. P. Worrying about p53. Curr Biol 1992; 2: 581–3
   PubMedGoogle Scholar
• Augenlicht L. H. Gene structure, function, and abnormalities. Cancer 1992; 70: 1671–84
   Google Scholar
• Sambrook J., Fritsch E. F., Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor Laboratory Press, Plainview, NY 1989
   Google Scholar
• Lasko D., Cavenee W., Nordenskjold M. Loss of constitutional heterozygosity in human cancer. Annu Rev Genet 1991; 25: 281–314
   PubMed Web of Science ®Google Scholar
• Trask B. J. Fluorescence in situ hybridization. Trends Genet 1991; 7: 149–54
   PubMed Web of Science ®Google Scholar
• Gray J. W., Pinkel D. Molecular cytogenetics in human cancer diagnosis. Cancer 1992; 69(6 Suppl)1536–42
   Google Scholar
• LeBeau M. M. Detecting genetic changes in human tumour cells: Have scientists gone FISHing?. Blood 1993; 81: 1979–83
   PubMedGoogle Scholar
• Lyons J. The polymerase chain reaction and cancer diagnostics. Cancer 1992; 69(6 Suppl)1527–31
   Google Scholar
• Weinberg R. A. The retinoblastoma gene and gene product. Cancer Surv 1992; 12: 43–57
   PubMedGoogle Scholar
• Sopta M., Gallie B. L., Gill R. M., et al. The retinoblastoma protein and the cell cycle. Semin Cancer Biol 1992; 3(3)107–13
   Google Scholar
• Nevins J. R. E2F: A link between the Rb tumor suppressor protein and viral oncoproteins. Science 1992; 258: 424–9
   PubMed Web of Science ®Google Scholar
• Cobrinik D., Dowdy S. F., Hinds P. W., et al. The retinoblastoma protein and the regulation of cell cycling. Trends Biochem Sci 1992; 17: 312–5
   PubMed Web of Science ®Google Scholar
• Goodrich D. W., Lee W-H. Molecular characterization of the retinoblastoma susceptibility gene. Biochim Biophys Acta 1993; 1155: 43–61
   PubMed Web of Science ®Google Scholar
• Ewen M., Xing U., Lawrence J. B., et al. Molecular cloning, chromosomal mapping, and expression of cDNA for p107, a retinoblastoma gene product-related protein. Cell 1991; 66: 1155–64
   PubMed Web of Science ®Google Scholar
• Hannon G., Demetrick D. J., Beach D. H. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes and Dev 1993; 7: 2378–2391
   PubMed Web of Science ®Google Scholar
• Haber D. A., Buckler A. J. WTI: A novel tumor suppressor gene inactivated in Wilms' tumor. New Biol 1992; 4(2)97–106
   Google Scholar
• Haber D. A., Housman D. E. Role of the WT1 gene in Wilms' tumour. Cancer Surv 1992; 12: 105–17
   PubMedGoogle Scholar
• Koo H. P., Hensle T. W. Molecular biology of Wilm's tumour. Urol Clin North Am 1993; 20: 323–31
   Google Scholar
• Knudson A. G., Strong L. C. Mutation and cancer: A model for Wilms' tumor of the kidney. J Natl Cancer Inst 1972; 48: 313–24
   PubMed Web of Science ®Google Scholar
• Brodeur G. M., Azar C., Brother M., et al. Neuroblastoma. Effect of genetic factors on prognosis and treatment. Cancer 1992; 70: 1685–94
   PubMedGoogle Scholar
• Meichle A., Philipp A., Eilers M. The functions of Myc proteins. Biochim Biophys Acta 1992; 1114: 129–46
   PubMedGoogle Scholar
• Blackwood E. M., Eisenman R. N. Max: A helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with myc. Science 1991; 251: 1211–7
   PubMed Web of Science ®Google Scholar
• Ayer D. E., Kretzner L., Eisenman R. N. Mad: A heterodimeric protein partner for Max that antagonizes Myc transcriptional activity. Cell 1993; 72: 211–22
   PubMed Web of Science ®Google Scholar
• Cheng J. M., Hiemstra J. L., Schneider S. S., et al. Paternal amplification of the paternal allele of the N-myc gene in human neuroblastomas. Nature Genet 1993; 4: 191–4
   PubMed Web of Science ®Google Scholar
• Nuovo G. J. PCR In Situ Hybridization. Protocols and Applications. 1st ed. Raven Press, New York 1992
   Google Scholar
• Jacobs WR J., Barletta R. G., Udani R., et al. Rapid susceptibility of drug susceptibility of Mycobacterium tuberculosis by luciferase reporter phages. Science 1993; 260: 819–22
   PubMed Web of Science ®Google Scholar
• Sklar J., Longtine J. The clinical significance of antigen receptor gene rearrangements in lymphoid neoplasia. Cancer 1992; 70: 1710–8
   Google Scholar
• Smith B., Selby P., Southgate J., et al. Detection of melanoma cells in peripheral blood by reverse transcriptase and the polymerase chain reaction. Lancet 1991; 338: 1227–9
   PubMed Web of Science ®Google Scholar
• Brack T., Scholz R. B., Milde-Langosch K., et al. Detection of N-myc gene amplification in bone marrow specimens of stage IV neuroblastoma patients. Cancer Detect Prev 1992; 16: 185–92
   Google Scholar
• Oshima K., Kikuchi M., Masada Y., et al. Epstein-Barr genomes in carcinoma metastatic to lymph nodes. Association with nasopharyngeal carcinoma. Acta Pathol Jpn 1991; 41: 437–43
   Google Scholar
• Lammie G. A., Fentl V., Smith R., et al. D11S287 a putative oncogene on chromosome 11q13 is amplified and expressed in squamous cell and mammary carcinomas and linked to BCL-1. Oncogene 1991; 6: 439–44
   PubMedGoogle Scholar
• Keyomarsi K., Pardee A. B. Redundant cyclin overexpression and gene amplification in breast cancer cells. Proc Natl Acad Sci USA 1993; 90: 1112–6
   PubMed Web of Science ®Google Scholar
• Cance W. G., Brennan M. F., Dudas M. E., et al. Altered expression of the retinoblastoma gene product in human sarcomas. N Engl J Med 1990; 323: 1457–61
   PubMed Web of Science ®Google Scholar
• Buckley M. F., Sweeney K. JE, Hamilton J. A., et al. Expression and amplification of cyclin genes in human breast cancer. Oncogene 1993; 8: 2127–33
   PubMed Web of Science ®Google Scholar
• Schwartz G. K., Jiang J., Kelsen D., et al. Protein kinase C: A novel target for inhibiting gastric cancer cell invasion. J Natl Cancer Inst 1993; 85: 402–7
   PubMed Web of Science ®Google Scholar
• Travis J. Novel anticancer agents move closer to reality. Science 1993; 260: 1877–8
   PubMed Web of Science ®Google Scholar
• Arceci R. J. Clinical significance of P-glycoprotein in multidrug resistance malignancies. Blood 1993; 81: 2215–22
   PubMed Web of Science ®Google Scholar
• Chan HS L., Haddad G., Thorner P. S., . Multidrug resistance in childhood malignancies. Accomplishments in Cancer Research: 1991. 1st ed., J. G. Fortner, J. E. Rhoads, et al. J.B. Lippincott, Philadelphia 1992; 184–216
   Google Scholar
• Stein C. A. Anti-sense oligodeoxynucleotides—promises and pitfalls. Leukemia 1992; 6: 967–74
   PubMed Web of Science ®Google Scholar
• Carter G., Lemoine N. R. Antisense technology for cancer therapy; does it make sense?. Br J Cancer 1993; 67: 869–76
   PubMed Web of Science ®Google Scholar