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Research Article

Randomized controlled study on the use of multiple-dose activated charcoal in patients with supratherapeutic phenytoin levels

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Pages 764-769 | Received 11 Apr 2012, Accepted 09 Jul 2012, Published online: 17 Aug 2012

References

  • Johannessen SI, Ben-Menachem E. Management of focal-onset seizures: an update on drug treatment. Drugs 2006; 66(13):1701–1725 (Review).
  • Brodie MJ, Dichter MA. Antiepileptic drugs. N Engl J Med 1996; 334:168–175.
  • Brodie MJ. Established anticonvulsants and treatment of refractory epilepsy. Lancet 1990; 336:350–354.
  • Brandolese R, Scordo MG, Spina E, Gusella M, Padrini R. Severe phenytoin intoxication in a subject homozygous for CYP2C9*3. Clin Pharmacol ther 2001; 70(4):391–394.
  • American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Position statement and practice guidelines on the use of multi-dose activated charcoal in the treatment of acute poisoning. J Toxicol Clin Toxicol. 1999; 37(6): 731–751 (Review).
  • Chyka PA, Seger D, Krenzelok EP, Vale JA. American Academy of Clinical Toxicology; European Association of Poisons Centres and Clinical Toxicologists. Poistion paper: single-dose activated charcoal. Clin Toxicol (phila). 2005; 43(2):61–87 (Review).
  • Arimori K, Nakano M. The intestinal dialysis of intravenously administered phenytoin by oral activated charcoal in rats. J Pharmacobiodyn 1987; 10(4):157–165.
  • Mauro LS, Mauro VF, Brown DL, Somani P. Enhancement of phenytoin elimination by multiple-dose activated charcoal. Ann Emerg Med 1987; 16:1132–1135.
  • Rowden AM, Spoor JE, Bertino JS. The effect of activated charcoal on phenytoin pharmacokinetics. Ann Emer Med 1990; 19: 1144–1147.
  • Griffiths ML, Kaplan H, Monteagudo FSE. Phenytoin overdose. S Afr Med J 1987; 71:471.
  • Howard CE, Roberts RS, Ely DS, Moye RA. Use of multiple-dose activated charcoal in phenytoin toxicity. Ann Pharmacother 1994; 28:201–203.
  • Ros SP, Black LE. Multiple-dose activated charcoal in management of phenytoin overdose. Pediatr Emerg Care 1989; 5:169–170.
  • Weichbrodt GD, Elliott DP. Treatment of phenytoin toxicity with repeated doses of activated charcoal. Ann Emerg Med 1987; 16:1387–1389.
  • Weidle PJ, Skiest DJ, Forrest A. Multiple-dose activated charcoal as adjunct therapy after chronic phenytoin intoxication. Clin Pharm 1991; 10:711–714.
  • Pettrey J, Rose R, Will B, Cumpston K. Activated charcoal does not reduce duration of phenytoin toxicity in hospitalized patients. Clin Toxicol (Phila). 2011; 49(6):536 (Abstract).
  • Eng J. Sample size estimation: how many individuals should be studied?Radiology 2003; 227(2):309–313.
  • Bauer L. Applied Clinical Pharmacokinetics, 2e. New York: McGraw-Hill; 2008.

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