176
Views
8
CrossRef citations to date
0
Altmetric
Research Article

Kinetics of fomepizole in pregnant rats

, &
Pages 743-748 | Received 11 May 2012, Accepted 24 Jul 2012, Published online: 14 Aug 2012

References

  • Pietruszko R. Human liver alcohol dehydrogenase – inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole. Biochem Pharmacol 1975; 24:1603–1607.
  • Brent J, McMartin KE, Phillips S, Burkhart KK, Donovan JW, Wells M, . Fomepizole for the treatment of ethylene glycol poisoning. N Engl J Med 1999; 340:832–838.
  • Brent J, McMartin KE, Phillips S, Aaron C, Kulig K. Fomepizole for the treatment of methanol poisoning. New Engl J Med 2001; 444: 424–429.
  • Hovda KE, Jacobsen D. Expert opinion: Fomepizole may ameliorate the need for hemodialysis in methanol poisoning. Human Exp Toxicol 2008; 28:539–546.
  • McMartin KE. Antidotes for alcohol and glycol toxicity – translating mechanisms to treatments. Clin Pharmacol Therap 2010; 88: 400–404.
  • Lepik KL, Levy AR, Sobolev BG, Purssell RA, DeWitt CR, Erhardt GD, . Adverse drug events associated with antidotes for methanol and ethylene glycol poisoning: A comparison of ethanol and fomepizole. Ann Emerg Med 2009; 53:439–450.
  • Corley RA, McMartin KE. Incorporation of therapeutic interventions in physiologically based pharmacokinetic modeling of human clinical case reports of accidental or intentional overdosing with ethylene glycol. Toxicol Sci 2005; 85:491–501.
  • Hantson P, Lambermont J, Mahieu P. Methanol poisoning during late pregnancy. Clin Toxicol 1997; 35:187–191.
  • Sulik KK. Genesis of alcohol-induced craniofacial dysmorphism. Exp Biol Med 2005; 230:366–375.
  • Bailey B. Are there teratogenic risks associated with antidotes used in the acute management of poisoned pregnant women? Birth Defects Res Clin Mol Teratol 2003; 67:133–140.
  • Jung AL, Roan Y, Temple AR. Neonatal death associated with acute transplacental ethanol intoxication. Am J Dis Child 1980; 134: 419–420.
  • Velez L, Kulstad E, Shepherd G, Roth B. Inhalational methanol toxicity in pregnancy treated twice with fomepizole. Vet Hum Toxicol 2003; 45:28–30.
  • Anseeuw K, Sabbe MB, Legrand A. Methanol poisoning: the duality between ‘fast and cheap’ and ‘slow and expensive’. Eur J Emerg Med 2008; 15:107–109.
  • McMartin KE, Sebastian CS, Dies D, Jacobsen D. Kinetics and metabolism of fomepizole in healthy humans. Clin Toxicol 2012; 50:375–383.
  • Marraffa JM, Forrest A, Grant W, Stork C, McMartin KE, Howland MA. Oral administration of fomepizole produces similar blood levels as identical intravenous dose. Clin Toxicol 2007; 46: 181–186.
  • Mayersohn MI, Owens SM, Anaya AL, Bliss M, Achari R. 4-methylpyrazole disposition in the dog: Evidence for saturable elimination. J Pharmac Sci 1985; 74:895–896.
  • Collins MD, Echkoff C, Chahoud I, Bochert G, Nau H. 4-Methylpyrazole partially ameliorated the teratogenicity of retinol and reduced the metabolic formation of all-trans-retinoic acid in the mouse. Arch Toxicol 1992; 66:652–659.
  • McMartin KE, Collins TD, Hewlett TP. High pressure liquid chromatographic assay of 4-methylpyrazole. Measurements of plasma and urine levels. J Toxicol Clin Toxicol 1984; 22:133–148.
  • Jacobsen D, Barron SK, Sebastian CS, Blomstrand R, McMartin KE. Non-linear kinetics of 4-methylpyrazole in healthy human subjects. Eur J Clin Pharmacol 1989; 37: 599–604.
  • McMartin KE, Collins TD. Distribution of 4-methylpyrazole in the rat: Inhibition of elimination by ethanol. J Toxicol-Clin Toxicol 1988; 26:451–466.
  • Koren G. Changes in drug disposition in pregnancy and their clinical implications. In: Koren G, ed. Matemal-Fetal Toxicology. A Clinician's Guide. 2nd ed. New York: Marcel Dekker; 1994:3–13.
  • Serjeant EP, Dempsey B. Ionization constants of organic acids in aqueous solution. In: IUPAC Chem Data Series No. 23. New York: Pergamon; 1979:989.
  • Lide DR. CRC Handbook of Chemistry and Physics. 75th ed. Boca Raton, FL: CRC Press, 1994–1995:8–45.
  • Pikkarainen PH, Raiha NC. Development of alcohol dehydrogenase activity in the human liver. Pediatr Res 1967; 1:165–168.
  • Tenenbein M. Methanol poisoning during pregnancy—prediction of risk and suggestions for management. Clin Toxicol 1997; 35: 193–194.
  • Cao QN, Tu GC, Weiner H. Presence of cytosolic aldehyde dehydrogenase isozymes in adult and fetal rat liver. Biochem Pharmacol 1989; 38:77–83.
  • Belson M, Morgan BM. Methanol toxicity in a newborn. J Toxicol Clin Toxicol 2004; 42:673–677.
  • Kralova I, Stepanek Z, Dusek J. Ethylene glycol intoxication misdiagnosed as eclampsia. Acta Anaesthesiol Scand 2006; 50: 385–387.
  • McMartin KE, Makar AB, Martin-Amat G, Palese M, Tephly TR. Methanol poisoning I. The role of formic acid in the development of metabolic acidosis in the monkey and the reversal by 4-methylpyrazole. Biochem Med 1975; 13:319–333.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.