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ArticlesPoison Centres

Cost minimization analysis comparing enteral N-acetylcysteine to intravenous acetylcysteine in the management of acute acetaminophen toxicity

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Pages 79-83 | Received 01 Sep 2009, Accepted 13 Oct 2009, Published online: 22 Jan 2010

References

  • Bronstein AC, Spyker DA, Cantilena LR, Green JL, Rumack BH, Heard SE. 2007 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 25th annual report. Clin Toxicol 2008; 46:927–1057.
  • Culley CM, Krenzelok EP. A clinical and pharmacoeconomic justification for intravenous acetylcysteine: a US perspective. Toxicol Rev 2006; 24:131–143.
  • Lee WM. Acetaminophen and the US Acute Liver Failure Study Group: lowering the risks of hepatic failure. Hepatology 2004; 40(1):6–9.
  • Jones A. Over-the-counter analgesics: a toxicologic perspective. Am J Ther 2002; 9:245–257.
  • Sheen CL, Dillon JF, Bateman DN, Simpson KJ, MacDonald TM. Paracetamol toxicity: epidemiology, prevention, and costs to the healthcare system. Q J Med 2002; 95:609–619.
  • Piperno E, Berssenbruegge DA. Reversal of experimental paracetamol toxicosis with N-acetylcysteine. Lancet 1976; 2:738–739.
  • Alsalim W, Fadel M. Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. oral methionine compared with intravenous N-acetylcysteine for paracetamol overdose. Emerg Med J 2003; 20:366–367.
  • Keays R, Harrison P, Wendon J, Forbes A, Gove C, Alexander GJ, Williams R. Intravenous acetylcysteine in paracetamol-induced fulminant hepatic failure: a prospective controlled trial. BMJ 1991; 303: 1026–1029.
  • Prescott LF, Park J, Ballantyne A, Adriaenssens P, Proudfoot AT. Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine. Lancet 1977; 2:432–434.
  • Buckley NA, Whyte IM, O'Connell DL, Dawson AH. Oral or intravenous N-acetylcysteine: which is the treatment of choice for acetaminophen (paracetamol) poisoning?. Clin Toxicol 1999; 37:759–767.
  • Perry HE, Shannon MW. Efficacy of oral versus intravenous N‐acetylcysteine in acetaminophen overdose: results of an open-label, clinical trial. J Pediatr 1998; 132:149–152.
  • Kanter MZ. Comparison of oral and i.v. acetylcysteine in the treatment of acetaminophen poisoning. Am J Health Syst Pharm 2006; 63:1821–1827.
  • Marzullo L. An update of N-acetylcysteine treatment for acute acetaminophen toxicity in children. Curr Opin Pediatr 2005; 17:239–245.
  • Smilkstein MJ, Knapp GL, Kulig KW, Rumack BH. Efficacy of oral N‐acetylcysteine in the treatment of acetaminophen overdose: analysis of the National Multicenter Study (1976 to 1985). N Engl J Med 1988; 319:1557–1562.
  • Prescott LF, Illingworth RN, Critchley JA, Stewart MJ, Adam RD, Proudfoot AT. Intravenous N-acetylcysteine: the treatment of choice for paracetamol poisoning. Br Med J 1979; 2:1097–1100.
  • Rumack BH, Peterson RC, Koch GG, Amara IA. Acetaminophen overdose: 662 cases with evaluation of oral acetylcysteine treatment. Arch Intern Med 1981; 141:380–384.
  • Yarema MC, Johnson DW, Berlin RJ, Sivilotti ML, Nettel-Aguirre A, Brant RF, Spyker DA, Bailey B, Chalut D, Lee JS, Plint AC, Purssell RA, Rutledge T, Seviour CA, Stiell IG, Thompson M, Tyberg J, Dart RC, Rumack BH. Comparison of the 20-hour intravenous and 72-hour oral acetylcysteine protocols for the treatment of acute acetaminophen poisoning. Ann Emerg Med 2009; 54:606–614.
  • Thomson Healthcare Staff. Red Book: Pharmacy's Fundamental Reference. New Jersey: Thomson Healthcare; 2009.
  • Consumer Price Index. Federal Bureau of Labor Statistics. http://www.bls.gov/. Accessed 22 March 2009.
  • Bond GR, Novak JE. The human and economic cost of paracetamol (acetaminophen) overdose. Pharmacoeconomics 1995; 8:177–181.
  • Cantrell L, Shah N, Anderson PO, Birnbaum K, Kearney TE. Assessing the influence of Acetadote on use of intravenous N-acetylcysteine for acetaminophen poisonings. Hosp Pharm 2009; 44:491–496.
  • Lai MW, Klein-Schwartz W, Rodgers GC, Abrams JY, Haber DA, Bronstein AC, Wruk KM. 2005 annual report of the American Association of Poison Control Centers’ national poison and exposure database. Clin Toxicol 2006; 44:803–932.
  • Bronstein AC, Spyker DA, Cantilena LR, Green J, Rumack BH, Heard SE. 2006 annual report of the American Association of Poison Control Centers’ National Poison Data System (NPDS). Clin Toxicol 2007; 45:815–917.

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