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Clinical Toxicology Volume 4, 1971 - Issue 2
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Miscellaneous Article

100-Day LD50 Index of Chronic Toxicity

Eldon M. Boyd Department of Pharmacology, Queen's University Kingston, Ontario, Canada
Pages 205-213 | Published online: 25 Sep 2008

References

  • Boyd C. E., Boyd E. M. “The chronic toxicity of atropine administered intramuscularly to rabbits,”. Toxicol. Appl. Pharamacol. 1962; 4: 457–467
  • Boyd E. M. “Analgesic abuse: maximal tolerated daily doses of acetylsalicylic acid,”. Can. Med. Assoc. J. 1968; 99: 790–798
  • Boyd E. M. “Sterility from phenacetin,”. J. Clin. Pharmacol. 1971; 11: 96–102
  • Boyd E. M., Abel M. M., Knight L. M. “The chronic oral toxicity of sodium chloride at the range of the LD50 (0.1L)'. “Can. J. Physiol. Pharmacol. 1966; 44: 157–172
  • Boyd E. M., Brown T. M. D. “The chronic subcutaneous toxicity of spiramycin adipate,”. Can. Med. Assoc. J. 1958; 78: 671–674
  • Boyd E. M., Ciampi G. C. “The oral 100‐day LD50 index of phenacetin in guinea pigs. “Toxicol. Appl. Pharmacol. 1970; 16: 232–238
  • Boyd E. M., Ciampi G. C., Krijnen C. J. “Intragastric versus dietary administration of phenacetin,”. Pharmacol. Res. Commun. 1969; 1: 259–264
  • Boyd E. M., Dolman M., Knight L. M., Sheppard E. P. “The chronic oral toxicity of caffeine,”. Can. J. Physiol. Pharmacol. 1965; 43: 995–1007
  • Boyd E. M., Hogan S. E. “The chronic oral toxicity of paracetamol at the range of the LD50 (100 days)'. Can. J. Physiol. Pharmacol. 1968; 46: 239–245
  • Boyd E. M., Hottenroth S. M. H. “The toxicity of phenacetin at the range of the oral LD 50 (100 days) in albino rats,”. Toxicol. Appl. Pharmacol. 1968; 12: 80–93
  • Boyd E. M., Jarzylo S. V. “Daily oral doses of pilocarpine tolerated by albino rats,”. Arch. Intern Pharmacodyn 1968; 174: 84–98
  • Boyd E. M., Lin F. M. “Maximal tolerated daily doses of dicophane,”. Acta Pharmacol. Toxicol. 1970; 28: 149–160
  • Boyd E. M., Selby M. J. “The chronic oral toxicity of benzylpenicillin,”. Antibiotic Chemotherap. 1962; 12: 249–262
  • Constantopoulos G., Boyd E. M. “Maximal tolerated amounts of sucrose given by daily intragastric administration to albino rats,”. Food Cosmet. Toxicol. 1969; 6: 711–727
  • Hayes W. J., Jr. “The 90‐dose LD50 and a chronicity factor as measures of toxicity,”. “Toxicol. Appl. Pharmacol. 1967; 11: 327–335
  • Snedecor G. W., Cochran W. G. Statistical Methods6th ed. The Iowa State University Press, Ames, Iowa 1967; 448
  • Weil C. S., Woodside M. D., Bernard J. R., Carpenter C. P. “Relationship between single‐peroral, one‐week, and ninety‐day rat feeding studies,”. Toxicol. Appl. Pharmacol. 1969; 14: 426–431

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