References
- Miller J. A., Miller E. C. A survey of molecular aspects of chemical carcinogenesis. Lab. Invest. 1966; 15: 217
- Burdette W. J. The significance of mutation in relation to the origin of tumors: a review. Cancer Res. 1955; 15: 201
- Miller E. C., Miller J. A. The Mutagenicity of Chemical Carcinogens: Correlation, Problems, and Interpretations. Chemical Mutagens: Principles and Methods for Their Detection, A. Hollaender. Plenum, New York, London 1971; 83
- Ames B. N. The Detection of Chemical Mutagens with Enteric Bacteria. Chemical Mutagens: Principles and Methods for Their Detection, E. A. Hollaender. Plenum, New York, London 1971; Vol. 1: 267
- Ames B. N. A Bacterial System for Detecting Mutagens and Carcinogens. Mutagenic Effects of Environmental Contaminants, M. E. Sutton, M. I. Harris. Academic, New York 1972; 57
- Ames B. N., Lee F. D., Durston W. E. An improved bacterial test system for the detection and classification of mutagens and carcinogens. Proc. Natl. Acad. Sci., U. S. 1973; 70: 782
- Ames B. N., Durston W. E., Yamasaki E., Lee F. D. Carcinogens are mutagens: A simple test system combining liver homogenates for activation and bacteria for detection. Proc. Natl. Acad. Sci., U. S. 1973; 70: 2281
- Isono K., Yourno J. Chemical carcinogens as frameshift mutagens: Salmonella DNA sequence sensitive to mutagenesis by polycyclic carcinogens. Proc. Natl. Acad. Sci., U. S. 1974; 71: 1612
- Kier L. D., Yamasaki E., Ames B. N. Detection of mutagenic activity in cigarette smoke condensates. Proc. Natl. Acad. Sci., U. S. 1974; 71: 4159
- McCann J., Spingarn N. E., Kobori J., Ames B. N. The detection of carcinogens as mutagens: Bacterial tester strains with R factor plasmids. Proc. Natl. Acad. Sci., U. S. 1975; 72: 979
- Kao F., Puck T. T. Genetics of somatic mammalian cells XII: Mutagenesis by carcinogenic nitroso compounds. J. Cell. Physiol. 1971; 78: 139
- Malling H. V. Dimethylnitrosamine: Formation of mutagenic compounds by interaction with mouse liver microsomes. Mutation Res. 1971; 13: 425
- Stolz D. R., Poirier L. A., Irving C. C., Stich H. E., Weisburger J. H., Grice H. C. Evaluation of short-term tests for carcinogenicity. Toxicol. Appl. Pharmacol. 1974; 29: 157
- Slater E. E., Anderson M. D., Rosenkranz H. S. Rapid detection of mutagens and carcinogens. Cancer Res. 1971; 31: 970
- Yahagi T., Nagao M., Hara K., Matsushima T., Sugimura T., Bryan G. T. Relationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide, a food additive. Cancer Res. 1974; 34: 2266
- Teranishi K., Hamada K., Watanabe H. Quantitative relationship between carcinogenicity and mutagenicity of polyaromatic hydrocarbons in Salmonella typhimurium mutants. Mutation Res. 1975; 31: 97
- Magee P. N., Swann P. F. Nitroso compounds. Brit. Med. Bull. 1969; 26: 240
- Parke D. V., Williams R. T. Metabolism of toxic substances. Brit. Med. Bull. 1969; 25: 256
- Conney A. H., Burns J. J. Metabolic interactions among environmental chemicals and drugs. Science 1972; 178: 576
- Gutmann H. R., Malejka-Giganti D., Barry E. J., Rydell R. E. On the correlation between the hepatocarcinogenicity of the carcinogen, N-2-fluorenylacetamide, and its metabolic activation by the rat. Cancer Res. 1972; 32: 1554
- Gabridge M. G., Legator M. S. A host-mediated assay for the detection of mutagenic compounds. Proc. Soc. Exptl. Biol. Med. 1969; 130: 831
- Legator M. S., Mailing H. V. The Host-Mediated Assay, a Practical Procedure for Evaluating Potential Mutagenic Agents in Mammals. Chemical Mutagens: Principles and Methods for Their Detection, A. Hollaender. Plenum, New York, London 1971
- Propping P., Buselmaier W. The influence of metabolism on mutagenic activity in the host-mediated assay. Arch. Toxikol. 1971; 28: 129
- Zeiger E., Legator M. Mutagenicity of N-nitrosomorpholine in the host-mediated assay. Mutation Res. 1971; 12: 469
- Martone W. J., Mukai F. H. Bacteriophage T4 as an indicator organism for the host-mediated assay. Proc. Am. Assoc. Cancer Res. 1972; 13: 113
- Ames B. N., Sims P., Grover P. L. Epoxides of polycyclic hydrocarbons are frameshift mutagens. Science 1972; 176: 47
- Ames B. N., Gurney F. G., Miller J. A., Bartsch H. Carcinogens as frameshift mutagens: Metabolites and derivatives of acetylaminofluorene and other aromatic amine carcinogens. Proc. Natl. Acad. Sci., U. S. 1972; 69: 3128
- Belman S., Troll W., Teebor G., Mukai F. The carcinogenic and mutagenic properties of N-hydroxyaminonaphthalenes. Cancer Res. 1968; 28: 535
- Mukai F., Troll W. The mutagenicity and initiating activity of some aromatic amine metabolites. Ann. N. Y. Acad. Sci. 1969; 163: 828
- Huberman E., Aspiras L., Heideberger C., Grover P. L., Sims P. Mutagenicity to mammalian cells of epoxides and other derivatives of polycyclic hydrocarbons. Proc. Natl. Acad. Sci., U. S. 1971; 68: 3195
- Huberman E., Donovan P. J., DiPaolo J. A. Mutation and transformation of cultured mammalian cells by N-acetoxy-N-2-fluorenylacetamide. J. Natl. Cancer Inst. 1972; 48: 837
- Malling H. V. Mutagenic activation of dimethylnitrosamine and diethylnitrosamine in the host-mediated assay and the microsomal system. Mutation Res. 1974; 26: 465
- Weekes U., Brusick D. J. In vitro activation of chemical mutagens. II. The relationships among mutagen formation, metabolism and carcinogenicity for dimethyl- and diethylnitrosamine in the liver, kidneys and lungs of GALB/cJ, C57BL/6J and RF/J mice. Mutation Res. 1975; 31: 175
- Nakajima T., Iwahara S. Mutagenicity of dimethylnitrosamine in metabolic processes by rat liver microsomes. Mutation Res. 1973; 18: 121
- Kada T., Tutikawa K., Sadaie Y. In vitro and host-mediated “rec-assay” procedures for screening chemical mutagens: and phloxine, a mutagenic red dye detected. Mutation Res. 1972; 16: 165
- Brusick D. J., Andrews H. Comparison of the genetic activity of dimethylnitrosamine, ethylmethane sulfonate, 2-acetyl-aminofluorene and ICR-170 in Saccharomyces cerevisiae strains D3, D4 and D5 using in vitro genetic assays with and without metabolic activation. Mutation Res. 1974; 26: 491
- Neumann H.-G. Ultimate electrophilic carcinogens and cellular nucleophilic reactants. Arch. Toxicol. 1974; 32: 27
- Reeves A. L., Puro H. E., Smith R. G. Inhalation carcinogenesis from various forms of asbestos. Environmental Res. 1974; 8: 178
- Prehn R. T. Function of depressed immunologic reactivity during carcinogenesis. J. Natl. Cancer Inst. 1963; 31: 791
- Todaro G. J., Huebner R. J. The viral oncogene hypothesis: New evidence. Proc. Natl. Acad. Sci., U. S. 1972; 69: 1009
- Temin H. M. On the origin of the genes for neoplasia: G. H. A. Clowes Memorial Lecture. Cancer Res. 1974; 34: 2835
- Benveriate R. E., Todaro G. J. Evolution of C-type viral genes: Inheritance of exogenously acquired viral genes. Nature 1974; 252: 456
- Ledinko N., Evans M. Enhancement of adenovirus transformation of hamster cells by N-methyl-N-nitro-N-nitrosoguanidine, caffeine and hydroxylamine. Cancer Res. 1973; 33: 2936
- Diamond L., Knorr R., Shimizu Y. Enhancement of simian virus 40-induced transformation of Chinese hamster embryo cells by 4-nitroquinoline 1-oxide. Cancer Res. 1974; 34: 2599
- Casto B. C., Pieczynski W. J., DiPaolo J. A. Enhancement of adenovirus transformation by treatment of hamster embryo cells with diverse chemical carcinogens. Cancer Res. 1974; 34: 72
- Klein G., Klein E. Antigenic properties of other experimental tumors. Symposia Quant. Biol. 1962; 27: 463
- Klein G., Sjogren H. O., Klein E., Hellstrom K. E. Demonstration of resistance against methylcolanthrene-induced sarcomas in the primary autochthonous host. Cancer Res. 1960; 20: 1561
- Old L. J., Boyse E. A., Clarke D. A., Carswell E. A. Antigenic properties of chemically-induced tumors. Ann. N. Y. Acad. Sci. 1962; 101: 80
- Sjogren H. O., Hellstrom I., Klein G. Transplantation of polyoma virus-induced tumors in mice. Cancer Res. 1961; 21: 329
- Remmer H. Induction of drug metabolizing enzymes in the liver. Europ. J. Clin. Pharmacol. 1972; 5: 115
- Campbell T. C., Hayes J. R. Role of nutrition in the drugmetabolizing enzyme system. Pharmacol. Rev. 1974; 26: 171
- Jagannath D. R. In vitro biotransformation of chemical carcinogens to mutagenic intermediates by kidney microsomal fractions of male and female mice. Howard University, Washington, D. C. 1975, Ph. D. Thesis
- Gyorgy P. G., Siefter J., Tomarelli R. M., Goldblatt H. G. Influence of dietary factors and sex on the toxicity of carbon tetrachloride in rats. J. Exptl. Med. 1946; 83: 449
- DeLucia P., Cairns J. Isolation of an E. coli strain with a mutation affecting DNA polymerase. Nature 1969; 224: 1164
- Bridges B. A. Simple bacterial systems for detecting mutagenic agents. Lab. Pract. 1972; 21: 413
- Kondo S. Environmental mutagen testing in Escherichia coli and phage lambda. Mutation Res. 1974; 26: 235
- Mohm G., Ellenberger J. Mammalian blood-mediated mutagenicity tests using a multipurpose strain of Escherichia coli K12. Mutation. 1973; 19: 257
- Zimmermann F. K. Procedures used in the induction of mitotic recombination and mutation in the yeast. Saccharomyces cerevisiae, Mutation Res. 1975; 31: 71
- Zimmermann F. K. Genetic aspects of carcinogenesis. Biochem. Pharmacol. 1971; 20: 985
- Zimmermann F. K., Schwaier R., Laer U. V. Mitotic recombination induced in Saccharomyces cerevisiae with nitrous acid, diethylsulfate and carcinogenic alkylating nitrosamides. Z. Vererbungsl. 1966; 98: 230
- Brusick D. J., Mayer V. W. New developments in mutagenicity screening techniques using yeast. Environ. Health Perspectives 1973; 6: 83
- DeSerres F. J., Mailing H. V. Measurement of Recessive Lethal Damage over the Entire Genome and at Two Specific Loci in the ad-3 Region of a Two-Component Heterokaryon of Neurospora crassa. Chemical Mutagens, Principles and Methods for Their Detection, A. Hollaender. Plenum, New York 1971; Vol. 2: 311
- Sobels F. H. The advantages of Drosophila for mutation studies. Mutation Res. 1974; 26: 277
- Clive D., Spector J. F. S. Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutation Res. 1975; 31: 17
- Schmid W. The micronucleus test. Mutation Res. 1975; 31: 9
- Gletten F., Weekes U., Brusick D. J. In vitro activation of chemical mutagens. I. Development of an in vitro mutagenicity assay using liver enzymes for activation dimethylnitrosamine. Mutation Res. 1975; 28: 113
- Greenwald P., Barlow J. J., Nasca P. C., Burnett W. S. Vaginal cancer after maternal treatment with synthetic estrogens. New Engl. J. Med. 1971; 285: 390
- Herbst A. L., Ulfelder H., Poskanzer D. C. Adenocarcinoma of the vagina: Association of maternal stilbesterol therapy with tumor appearance in young women. New Engl. J. Med. 1971; 284: 878
- Freese E. Structure and function of the genetic elements on the molecular explanation of spontaneous and induced mutations. Brookhaven Symp. Biol. 1959; 12: 63
- Fischinger P. J., Nomura S., Peebles P. T., Haapala D. K., Bassin R. H. Reversion of murine sarcoma virus transformed mouse cells: Varients without a rescuable sarcoma virus. Science 1972; 176: 1033
- Takayama S., Oota K. Malignant tumors in mice fed with N-nitrosodimethylamine. GANN 1963; 54: 465
- Heath D. F. The decomposition and toxicity of dialkylnitrosamines in rats. Biochem. J. 1962; 85: 72
- Czygan P., Greim H., Garro A. J., Hutlerer F., Schaffner F., Popper H., Rosenthal O., Cooper D. Y. Microsomal metabolism of dimethylmitrosamine and the cytochrome P-450 dependency of its activation to a mutagen. Cancer Res. 1973; 33: 2983
- Takayama S., Oota K. Induction of malignant tumors in various strains of mice by oral administration of N-nitrosodimethyl-amine and N-nitrosodiethylamine. GANN 1965; 56: 189
- Terracini B., Palestro G., Gigliard M. R., Montesano R. Carcinogenicity of dimethylnitrosamine in Swiss mice. Brit. J. Cancer 1966; 20: 871
- Clapp N. K., Tyndall R. L., Otten J. A. Differences in tumor types and organ susceptibility in BALB/c and RF mice following dimethylnitrosamine and diethylnitrosamine. Cancer Res. 1971; 31: 196
- Weekes U. Metabolism of dimethylnitrosamine to mutagenic intermediates by kidney microsomal enzymes and correlation with reported host susceptibility to kidney tumors. J. Natl. Cancer Inst. 1975; 5: 1199
- Toth B., Magee P. N., Shubik P. Carcinogenesis study with dimethylnitrosamine administered orally to adult and subcutaneously to newborn BALB/c mice. Cancer Res. 1964; 24: 1712
- Weisburger J. H., Weisburger E. K. Biochemical formation and pharmacological, toxicological and pathological properties of hydroxylamines and hydroxamic acids. Pharmacol. Rev. 1973; 25: 2
- Miller E. C., Miller J. A., Entomoto M. The comparative carcinogenicities of 2-acetylaminofluorene and its N-hydroxymetabolite in mice, hamsters, and guinea pigs. Cancer Res. 1964; 24: 2018
- O'Hara R. W., Adamson R. H. Spontaneous and Induced Neoplasma in Nonhuman Primates. Pathology of Simian Primates, R. N. T-W-Fiennes. Karger, New York 1972; 190
- McGregor D. The relationship of 2-acetamidofluorene mutagenicity in plate tests with its in vivo liver cell component distribution and its carcinogenic potential. A paper presented at the 14th Annual Meeting of the Society of Toxicology, Williamsburg, Virginia, 1975
- McCann J., Choi E., Yamasaki E., Ames B. Detection of carcinogens as mutagens in the Salmonella/microsome test: Assay of 300 chemicals. Proc. Natl. Acad. Sci. U. S. 1975; 72: 5135
- DeSerres F. J. Report of the Conference on In Vitro Mutagenicity and Carcinogenicity Tests. Mutation Res. 1976, in press
- Rosenkranz H. S., unpublished results