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Clinical Toxicology Volume 18, 1981 - Issue 9
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Research Article

Clonidine and Naloxone for Rapid Opiate Detoxication: Comparison between Treatments

Emanuela Masini Department of Pharmacology and Toxicology, School of Medicine University of Florence, Florence, Italy
,
Patrizio Blandina Department of Pharmacology and Toxicology, School of Medicine University of Florence, Florence, Italy
,
Pier Francesco Mannaioni Department of Pharmacology and Toxicology, School of Medicine University of Florence, Florence, Italy
&
Giulio Luciani Clinical Research Boehringer Ingelheim S.p.A., Florence, Italy
Pages 1021-1026 | Published online: 25 Sep 2008

References

  • Kleber H. D. Detoxification from methadone maintenance: The state of the art. Int. J. Addict. 1977; 12: 807–820
  • Fantozzi R., Masini E., Blandina P., Luciani G., Man-naioni P. F. Clonidine and naloxone-induced opiate withdrawal: A comparison between clonidine and morphine in man. Substance Alcohol Actions/Misuse 1980; 1: 369–371
  • Resnick R. B., Kestenbaum R. S., Washton A., Poole D. Naloxone-precipitated withdrawal: A method for rapid induction into naltrexone. Clin. Pharmacol. Ther. 1977; 21: 409–413
  • Riordan C. E., Kleber H. D. Rapid opiate detoxification with clonidine and naloxone. Lancet 1980; 1: 1079–1080
  • Wang R. I. H., Wiesen R. L., Lamid S., Roh B. L. Rating the presence and severity of opiate dependence. Clin. Pharmacol. Ther. 1974; 16: 653–659
  • Aghajanian G. K. Tolerance of locus cocruleus neurons to morphine and suppression of withdrawal response by clonidine. Nature 1978; 276: 186–188
  • Gold M. S., Richmond D. E., Jr., Kleber H. D. Naloxone-precipitated withdrawal: A method for rapid induction into naltrexone. Clin. Pharmacol. Ther. 1977; 21: 409–413
  • Gold M. S., Pottosh A. L. C., Sweeney D. R., Kleber H. D. Effect of methadone on clonidine detoxification efficacy. Am. J. Psychiatry 1980; 3: 375–376

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