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Journal of Toxicology: Clinical Toxicology Volume 24, 1986 - Issue 4
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Research Article

The Neurotoxicity of Cyclotrimethylenetrinitramine (RDX) in a Child: A Clinical and Pharmacokinetic Evaluation

Robert C. Woody Departments of Pediatrics, Neurology, Pathology and Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205
,
Gregory L. Kearns Departments of Pediatrics, Neurology, Pathology and Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205
,
Marge A. Brewster Departments of Pediatrics, Neurology, Pathology and Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205
,
Charles P. Turley Departments of Pediatrics, Neurology, Pathology and Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205
,
Gregory B. Sharp Departments of Pediatrics, Neurology, Pathology and Pharmaceutics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205
&
Robert S. Lake Scientific Associates, Inc., 6200 South Lindbergh St., Louis, Missouri, 63123
Pages 305-319 | Published online: 25 Sep 2008

References

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  • Schneider N. R., Bradley S. L., Andersen M. E. Toxicology of cycltrimethylenetrinitramine: distribution and metabolism in the rat and the miniature swine. Toxicol. and Appl. Pharmacol. 1977; 39: 531
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  • Stone W. J., Paletta T. L., Heiman E. M., Bruce J. I., Knepshield J. H. Toxic effects following ingestion of C‐4 plastic explosive. Arch. Intern. Med. 1969; 124: 726
  • Ketel W. B., Hughes J. R. Toxic encephalopathy with seizures secondary to ingestion of composition C‐4. Neurology 1972; 22: 871
  • Schneider N. R., Bradley S. L., Andersen M. E. The distribution and metabolism of cyclotrimethylenetrinitramine (RDX) in the rat after subchronic administration. Toxicol. and Appl. Pharmacol. 1978; 46: 163
  • French J. E., Bradley S. L., Schneider N. R., Andersen M. E., Jenkins L. J. Cyclotrimethylenetrinitramine (RDX)‐induced ultrastructural changes in rat liver and kidney. Toxicol. and Appl. Pharmacol. 1976; 37: 122
  • Bradley S. L. The role of the mixed function oxidases in the metabolism of cyclotrimethylenetrinitramine (RDX). M.S. thesis, American University, Washington, D.C. 1977

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