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Research Article

Ocular toxicology of marijuana: an update

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Pages 309-334 | Published online: 27 Sep 2008

References

  • Green K. Marihuana and the eye—a review. J. Toxicol.—Cut. Ocular Toxicol. 1982; 1: 3
  • The Cannabinoids: Chemical, Pharmacologic and Therapeutic Aspects, S. Agurell, W. L. Dewey, R. E. Willette. Academic Press, New York 1984
  • Marihuana in Science and Medicine, G. G. Nahas. Raven Press, New York 1984
  • Adverse Health and Behavioral Consequences of Cannabis Use, K. O. Fehr, H. Kalant. Addictive Research Foundation, TorontoCanada 1983
  • Pharmacol. Rev. 1986; 38: 21–178
  • Wood G. B., Bache F. The Dispensatory of the United States of America. J. B. Lippincott, Philadelphia 1868
  • Nahas G. G. Marihuana—Deceptive Weed. Raven Press, New York 1973
  • Snyder S. The Uses of Marihuana. Oxford University Press, London 1971
  • Waller C. W., Nair R. S., McAllister A. F., Urbanek B., Turner C. E. Marihuana: An Annotated Bibliography, Volume II. MacMillan, New York 1982
  • Hollister L. E. Health aspects of cannabis. Pharmacol. Rev. 1986; 38: 1
  • Allen T. Tetrahydrocannabinol and chemotherapy. N. Engl. J. Med. 1976; 294: 168
  • Agurell S., Halldin M., Lindgren J.-E., Ohlsson A., Widman M., Gillespie H., Hollister L. Pharmacokinetics and metabolism of Δ1-tetrahydrocannabinol and other cannabinoids with emphasis on man. Pharmacol. Rev. 1986; 38: 21
  • Nahas G. G. Toxicology and pharmacology. Marihuana in Science and Medicine, G. G. Nahas. Raven Press, New York 1984
  • Nahas G. G. The medical use of cannabis. Marihuana in Science and Medicine, G. G. Nahas. Raven Press, New York 1984
  • Lemberger L., Crabtree R. E., Rowe H. M. 11-hydroxy-Δ9-tetrahydrocannabinol: Pharmacology, disposition, and metabolism of a major metabolite of marihuana in man. Science 1972; 177: 62
  • Dewey W. L. Cannabinoid pharmacology. Pharmacol. Rev. 1986; 38: 15
  • Klonoff H. Acute psychological effects of marihuana in man, including acute cognitive, psychomotor, and perceptual effects in driving. Adverse Health and Behavioral Consequences of Cannabis Use, K. O. Fehr, H. Kalant. Addictive Research Foundation, Toronto 1983
  • Munson A. E., Fehr K. O. Immunological effects of cannabis. Adverse Health and Behavioral Consequences of Cannabis Use, K. O. Fehr, H. Kalant. Addictive Research Foundation, Toronto 1983
  • Bloch E. Effects of marihuana and cannabinoids in reproduction, endocrine function, development, and chromosomes. Adverse Health and Behavioral Consequences of Cannabis Use, K. O. Fehr, H. Kalant. Addictive Research Foundation, Toronto 1983
  • Rosenkrantz H. Cannabis, marihuana, and cannabinoid toxicological manifestations in man and animals. Adverse Health and Behavioral Consequences of Cannabis Use, K. O. Fehr, H. Kalant. Addictive Research Foundation, Toronto 1983
  • Martin B. R. Cellular effects of cannabinoids. Pharmacol. Rev. 1986; 38: 45
  • McLane N. J., Carroll D. M. Ocular manifestations of drug abuse. Surv. Ophthalmol. 1986; 30: 298
  • Dawson W. W., Jiminez-Antillon C. F., Perez J. M., Zeskind J. A. Marihuana and vision after ten years' use in Costa Rica. Invest. Ophthalmol. 1977; 16: 689
  • Merritt J. C., Cook C. E., Davis K. H. Orthostatic hypotension after Δ9-tetrahydrocannabinol marihuana inhalation. Ophthal. Res. 1982; 14: 124
  • Tiedeman J. S., Shields M. B., Weber P. A., Crow J. N., Corletto D. M., Harris W. A., Howes J. P. Effect of synthetic cannabinoids on elevated intraocular pressure. Ophthalmology 1981; 88: 270
  • Green K. Marijuana effects on intraocular pressure. Glaucoma: Applied Pharmacology in Medical Treatment, S. M. Drance, A. H. Neufeld. Grune & Stratton, Orlando 1984
  • Crawford W. J., Merritt J. C. Effects of tetrahydrocannabinol on arterial and intraocular hypertension. Int. J. Clin. Pharmacol. Biopharm. 1979; 17: 191
  • Cooler P., Gregg J. M. The effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans. Therapeutic Potential of Marihuana, S. Cohen, R. C. Stillman. Plenum Press, New York
  • Merritt J. C., McKinnon S. M., Armstrong J. R., Katern G., Reid L. A. Oral Δ9-tetrahydrocannabinol in hypertensive glaucomas. Ann. Ophthalmol. 1980; 12: 947
  • Perez-Reyes M., Wagner D., Wall M. E., Davis K. H. Intravenous administration of cannabinoids on intraocular pressure. The Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven Press, New York 1976
  • Hepler R. S., Frank I. M., Petrus R. Ocular effects of marijuana smoking. The Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven Press, New York 1976
  • Hepler R. S., Petrus R. Experiences with administration of marihuana to glaucoma patients. The Therapeutic Potential of Marihuana, S. Cohen, R. C. Stillman. Plenum Press, New York 1976
  • Green K., Bowman K. A. Effect of marihuana derivatives on intraocular pressure. The Pharmacology of Marihuana, M. C. Braude, S. Szara. Raven Press, New York 1976
  • El-Sohly M. A., Harland E., Murphy J. C., Wirth P., Waller C. W. Cannabinoids in glaucoma: A primary screening procedure. J. Clin. Pharmacol. 1981; 21: 472S
  • Green K., Symonds C. M., Oliver N. W., Elijah R. D. Intraocular pressure following systemic administration of cannabinoids. Curr. Eye Res. 1982; 2: 247–83
  • El-Sohly M. A., Harland E. C., Benigni D. A., Waller C. W. Cannabinoids in glaucoma II; The effect of different cannabinoids on intraocular pressure of the rabbit. Curr. Eye Res. 1984; 3: 841
  • Waller C. W., Benigni D. A., Harland E. C., Bedford J. A., Murphy J. C., El-Sohly M. A. Cannabinoid in glaucoma III: The effects of different cannabinoids on intraocular pressure in the monkey. The Cannabinoids: Chemical, Pharmacologic and Therapeutic Aspects, S. Agurell, W. L. Dewey, R. E. Willette. Academic Press, New York 1984
  • Howes J. F. Antiglaucoma effects of topically and orally administered cannabinoids. The Cannabinoids: Chemical, Pharmacologic and Therapeutic Aspects, S. Agurell, W. L. Dewey, R. E. Willette. Academic Press, New York 1984
  • Green K., Sobel R. E., Fineberg E., Wynn H. R., Bowman K. A. Subchronic ocular and systemic toxicity of topically applied Δ9-tetrahydrocannabinol. Ann. Ophthalmol. 1981; 13: 1219
  • Merritt J. C., Whitaker R., Page C. J., Peace J. H., Grinson R. C., Olsen J. C., Peiffer R. L., Davanzo R. Topical Δ8-tetrahydrocannabinol as a potential glaucoma agent. Glaucoma 1982; 4: 253
  • Merritt J. C., Peiffer R. L., McKinnon S. M., Stapleton S. S., Goodwin T., Risco J. M. Topical Δ9-tetrahydrocannabinol on intraocular pressure in dogs. Glaucoma 1981; 3: 13
  • Mechoulam R., Lander H., Srebnik M., Zamir I., Breuer A., Shalita B., Dikstein S., Carlini E. A., Leite J. R., Edery H., Porath G. Recent advances in the use of cannabinoids as therapeutic agents. The Cannabinoids: Chemical, Pharmacologic and Therapeutic Aspects, S. Agurell, W. L. Dewey, R. E. Willette. Academic Press, New York 1984
  • Colasanti B. K., Powell S. R., Craig C. R. Intraocular pressure, ocular toxicity and neurotoxicity after administration of delta-9-tetrahydrocannabinol or cannabichromene. Exp. Eye Res. 1984; 38: 63
  • Colasanti B. K., Craig C. R., Allara R. D. Intraocular pressure, ocular toxicity and neurotoxicity after administration of cannabinol or cannabigerol. Exp. Eye Res. 1984; 39: 251
  • Colasanti B. K., Brown R. E., Craig C. R. Ocular hypotension, ocular toxicity, and neurotoxicity in response to marihuana extract and cannabidiol. Gen. Pharmacol. 1984; 15: 479
  • Colasanti B. K., Powell S. R. Factors involved in the intraocular pressure lowering effect of Δ9-tetrahydrocannabinol (Δ9-THC) in the cat. Invest. Ophthalmol. Vis. Sci. 1985; 26(suppl.)232
  • Colasanti B. K., Gong H. Cannabinoid effects on aqueous humor dynamics in the cat. Invest. Ophthalmol. Vis. Sci. 1987; 28(suppl.)12
  • Colasanti B. K., Powell S. R. Effect of Δ9-tetrahydrocannabinol on intraocular pressure after removal of autonomic input. J. Ocular Pharmacol. 1985; 1: 47
  • Chiang C.-W. N., Barrett B. G., Brine D. Systemic absorption of Δ9-tetrahydrocannabinol after ophthalmic administration to the rabbit. J. Pharm. Sci. 1983; 72: 136
  • Galanter M., Wyatt R. J., Lemberger L., Weingartner H., Vaughan T. B., Roth W. T. Effects on humans of Δ9-tetrahydrocannabinol administered by smoking. Science 1972; 176: 934
  • Liu J. H. K., Dacus A. C. Central nervous system and peripheral mechanism in ocular hypotensive effect of cannabinoids. Arch. Ophthalmol. 1987; 105: 245
  • Liu J. H. K., Neufeld A. H. Study of central regulation of intraocular pressure using ventriculocisternal perfusion. Invest. Ophthalmol. Vis. Sci. 1985; 26: 136
  • Gawienowski A. M., Chatterjee D., Anderson P. J., Epstein D. L., Grant W. M. Effect of Δ9-tetrahydrocannabinol on monoamine oxidase activity in bovine eye tissues, in vitro. Invest. Ophthal. Vis. Sci. 1982; 22: 482
  • Merritt J. C., Olsen J. L., Armstrong J. R., McKinnon S. M. Topical Δ9-tetrahydrocannabinol in humans. J. Pharm. Pharmacol. 1981; 33: 40
  • Merritt J. C., Perry D. D., Russell D. N., Jones B. F. Topical Δ9-tetrahydrocannabinol and aqueous dynamics in glaucoma. J. Clin. Pharmacol. 1981; 21: 467S
  • Green K., Roth M. Ocular effects of topical administration of Δ9-tetrahydrocannabinol in man. Arch. Ophthalmol. 1982; 100: 265
  • Jay W. M., Green K. Multiple-drop study of topically applied 1% Δ9-tetrahydrocannabinol in human eyes. Arch. Ophthalmol. 1983; 101: 591
  • Deutsch H. M., Green K., Zalkow L. H. Isolation of ocular hypotensive compounds from Cannabis sativa. J. Clin. Pharmacol. 1981; 21: 479S
  • Green K., Zalkow L. H., Deutsch H. M., Yablonski M. E., Oliver N., Symonds C. M., Elijah R. D. Ocular and systemic responses to water-soluble material derived from Cannabis sativa (marihuana). Curr. Eye Res. 1981; 1: 65
  • Green K., Symonds C. M., Elijah R. D., Zalkow L. H., Deutsch H. M., Bowman K. A., Morgan T. R. Water-soluble marihuana-derived material: Pharmacological actions in rabbit and primate. Curr. Eye Res. 1981; 1: 599/82
  • Kind L. S., Nilsson B. The biological activity of a ragweed arabinogalactan. 1. Galactose specificity of in vitro and in vivo effects. Immunology 1967; 13: 477
  • Baraldo W. T., Dias da Silva W., Lemos-Fernandez A. D. Inhibition effects of carbohydrates on histamine release and mast cell disruption by dextran. Br. J. Pharmacol. 1962; 19: 405
  • Green K., Cheeks K., Bowman K. A., Hodges L. C., Deutsch H. M., Zalkow L. H. Marihuana-derived material: Distribution and effects after systemic administration. Curr. Eye Res. 1984; 3: 751
  • Krupin T., Oestrich C. J., Bass J., Podos S. M., Becker B. Acidosis, alkalosis, and aqueous humor dynamics in rabbits. Invest. Ophthalmol. Vis. Sci. 1977; 16: 997
  • Marcus D. R., Krupin T., Podos S. M., Becker B. The effect of exercise on intraocular pressure: II. Rabbits. Invest. Ophthalmol. 1970; 9: 753
  • Green K., Cheeks K., Mittag T., Riley M. V., Symonds C. M., Deutsch H. M., Hodges L. C., Zalkow L. H. Marihuana-derived material: Biochemical studies of the ocular responses. Curr. Eye Res. 1985; 4: 631
  • Green K., Cheeks K. E., Watkins L., Bowman K. A., McDonald T. F., Ocasio H., Deutsch H. M., Hodges L. C., Zalkow L. H. Prostaglandin involvement in the responses of the rabbit eye to water-soluble marihuana-derived material. Curr. Eye Res. 1987; 6: 337
  • Lee P., Podos S. M., Severin C. Effect of prostaglandin F2α on aqueous humor dynamics of rabbit, cat, and monkey. Invest. Ophthalmol. Vis. Sci. 1984; 25: 1087
  • Hodges L. C., Deutsch H. M., Green K., Zalkow L. H. Polysaccharides from Cannabis sativa active in lowering intraocular pressure. Carbohydrate Polymers 1985; 5: 141
  • Deutsch H. M., Green K., Zalkow L. H. Water-soluble high molecular weight components from plants with potent intraocular pressure lowering activity. Curr. Eye Res. 1987; 6: 949–950
  • McDonald T. F., Green K. Effects of water-soluble marihuana-derived material (MDM) on the rabbit ciliary body: Light and electron microscopy. Curr. Eye Res. 1986; 5: 457
  • Green K., Slagle T., Forbes E., McDonald T. F., Deutsch H. M., Zalkow L. H., Pharmacological and morphological responses of the rabbit eye to different routes of administration of water-soluble marihuana-derived material (in preparation).
  • McDonald T. F., Cheeks L., Slagle T., Green K., Morphological and pharmacological effects of water-soluble marihuana-derived material in the monkey eye (in preparation).
  • Gregory D., Sears M., Bausher L., Mishima H., Mead A. Intraocular pressure and aqueous flow are decreased by cholera toxin. Invest. Ophthalmol. Vis. Sci. 1981; 20: 371
  • Battels S. P., Roth H. O., Neufeld A. H. Effects of intravitreal cholera toxin on adenosine 3′, 5′-monophosphate, intraocular pressure, and outflow facility in rabbits. Invest. Ophthalmol. Vis. Sci. 1981; 20: 410
  • Drance S. M., Flammer J. Some effects of antiglaucoma drugs on visual function. Glaucoma: Applied Pharmacology in Medical Treatment, S. M. Drance, A. H. Neufeld. Grune & Stratum, Orlando 1984
  • Bito L. Z., Draga A., Blanco J., Camras C. B. Long-term maintenance of reduced intraocular pressure by daily or twice daily topical applications of prostaglandins to cat or rhesus monkey eyes. Invest. Ophthalmol. Vis. Sci. 1983; 24: 312
  • Camras C. B., Bhuyan K. C., Podos S. M., Bhuyan D. K., Master R. W. P. Multiple dosing of prostaglandin F2α or epinephrine on cynomolgus monkey eyes. n. Slit-lamp biomicroscopy, aqueous humor analysis, and fluorescein angiography. Invest. Ophthalmol. Vis. Sci. 1987; 28: 921

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