Genetics of serum BDNF: Meta-analysis of the Val66Met and genome-wide association study

References

• Alzheimer Research Forum. 2011. http://www.alzforum.org/res/com/gen/alzgene/meta.asp?geneID = 109&polyID = 334.
   Google Scholar
• Athanasiu L, Mattingsdal M, Melle I, Inderhaug E, Lien T, Agartz I, et al. 2011. Intron 12 in NTRK3 is associated with bipolar disorder. Psychiatry Res 185:358–362.
   Google Scholar
• Bhang S, Ahn JH, Choi SW. 2011. Brain-derived neurotrophic factor and serotonin transporter gene-linked promoter region genes alter serum levels of brain-derived neurotrophic factor in humans. J Affect Disord 128:299–304.
   PubMed Web of Science ®Google Scholar
• Bocchio-Chiavetto L, Bagnardi V, Zanardini R, Molteni R, Nielsen GM, Placentino A, et al. 2010. Serum and plasma BDNF levels in major depression: A replication study and meta-analyses. World J Biol Psychiatry 11:763–773.
   PubMed Web of Science ®Google Scholar
• Brandys MK, Kas MJ, van Elburg AA, Campbell IC, Adan RA. 2011. A meta-analysis of circulating BDNF concentrations in anorexia nervosa. World J Biol Psychiatry 12:444 454.
   Google Scholar
• Bremer T, Diamond C, McKinney R, Shehktman T, Barrett TB, Herold C. et al. 2007. The pharmacogenetics of lithium response depends upon clinical co-morbidity. Mol Diagn Ther 11:161–170.
   PubMed Web of Science ®Google Scholar
• Brunoni AR, Lopes M, Fregni F. 2008. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: implications for the role of neuroplasticity in depression. Int J Neuropsychopharmacology 11:1169–1180.
   PubMed Web of Science ®Google Scholar
• Bus BA, Tendolkar I, Franke B, de Graaf J, Heijer MD, Buitelaar JK, et al. 2011. Serum brain-derived neurotrophic factor: Determinants and relationship with depressive symptoms in a community population of middle-aged and elderly people. World J Biol Psychiatry doi:10.3109/15622975.15622010.15545187.
   Web of Science ®Google Scholar
• Cattaneo A, Bocchio-Chiavetto L, Zanardini R, Marchina E, Bellotti D, Milanesi E, et al. 2010. BDNF Val66Met polymorphism and protein levels in amniotic fluid. BMC Neurosci 11:16.
   PubMed Web of Science ®Google Scholar
• Cavalli-Sforza LL, Menozzi P, Piazza A. 1994. The history and geography of human genes. Princeton, NJ: Princeton University Press.
   Google Scholar
• Chen WM, Abecasis GR. 2007. Family-based association tests for genomewide association scans. Am J Hum Genet 81: 913–926.
   PubMed Web of Science ®Google Scholar
• de Moor MH, Costa PT., Terracciano A, Krueger RF, de Geus EJ, Toshiko T, et al. 2012. Meta-analysis of genome-wide association studies for personality. Mol Psychiatry doi:10.1038/mp.2010.1128.
   PubMed Web of Science ®Google Scholar
• Diniz BS, Teixeira AL, Talib LL, Mendonca VA, Gattaz WF, Forlenza OV. 2010. Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression. World J Biol Psychiatry 11:550–555.
   PubMed Web of Science ®Google Scholar
• Duman RS, Monteggia LM. 2006. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 59:1116–1127.
   PubMed Web of Science ®Google Scholar
• Duncan LE, Hutchison KE, Carey G, Craighead WE. 2009. Variation in brain-derived neurotrophic factor (BDNF) gene is associated with symptoms of depression. J Affect Disord 115: 215–219.
   PubMed Web of Science ®Google Scholar
• Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, et al. 2003. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112:257–269.
   PubMed Web of Science ®Google Scholar
• Elzinga, BM, Molendijk ML, Oude Voshaar RC, Bus BA, Prickaerts J, Spinhoven P, et al. 2011. The impact of childhood abuse and recent stress on serum brain-derived neurotrophic factor and the moderating role of BDNF Val66Met. Psycho pharmacology (Berlin) 214:319–328.
   PubMed Web of Science ®Google Scholar
• Feng Y, Vetro A, Kiss E, Kapornai K, Daroczi G, Mayer L, et al. 2008. Association of the neurotrophic tyrosine kinase receptor 3 (NTRK3) gene and childhood-onset mood disorders. Am J Psychiatry 165:610–616.
   PubMed Web of Science ®Google Scholar
• Forlenza OV, Diniz BS, Teixeira AL, Ojopi EB, Talib LL, Mendonca VA, et al. 2010. Effect of brain-derived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World J Biol Psychiatry 11:774–780.
   PubMed Web of Science ®Google Scholar
• Gottesman II, Gould TD. 2003. The endophenotype concept in psychiatry: Etymology and strategic intentions. Am J Psychiatry 160:636–645.
   PubMed Web of Science ®Google Scholar
• Jiang H, Wang R, Liu Y, Zhang Y, Chen ZY. 2009. BDNF Val66Met polymorphism is associated with unstable angina. Clin Chim Acta 400:3–7.
   PubMed Web of Science ®Google Scholar
• Lamballe F, Klein R, Barbacid, M. 1991. trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66:967–979.
   PubMed Web of Science ®Google Scholar
• Lang UE, Hellweg R, Gallinat J. 2004. BDNF serum concentrations in healthy volunteers are associated with depression- related personality traits. Neuropsychopharmacology 29: 795–798.
   PubMed Web of Science ®Google Scholar
• Lang UE, Hellweg R, Sander T, Gallinat J. 2009. The Met allele of the BDNF Val66Met polymorphism is associated with increased BDNF serum concentrations [letter]. Mol Psychiatry 14:120–122.
   PubMed Web of Science ®Google Scholar
• Mattson MP, Maudsley S, Martin B. 2004. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends Neurosci 27:589–594.
   PubMed Web of Science ®Google Scholar
• Minelli A, Zanardini R, Bonvicini C, Sartori R, Pedrini L, Gennarelli M, et al. 2011. BDNF serum levels, but not BDNF Val66Met genotype, are correlated with personality traits in healthy subjects. Eur Arch Psychiatry Clin Neurosci 261:323 329.
   Google Scholar
• Molendijk ML, Bus BA, Spinhoven P, Penninx BW, Kenis G, Prickaerts J, et al. 2011. Serum levels of brain-derived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment. Mol Psychiatry doi:10.1038/mp.2010.1098.
   PubMed Web of Science ®Google Scholar
• Mossner R, Mikova O, Koutsilieri E, Saoud M, Ehlis AC, Muller N, et al. 2007. Consensus paper of the WFSBP Task Force on Biological Markers: biological markers in depression. World J Biol Psychiatry 8:141–174.
   PubMed Web of Science ®Google Scholar
• Muinos-Gimeno M, Guidi M, Kagerbauer B, Martin-Santos R, Navines R, Alonso P, et al. 2009. Allele variants in functional MicroRNA target sites of the neurotrophin-3 receptor gene (NTRK3) as susceptibility factors for anxiety disorders. Hum Mutat 30:1062–1071.
   PubMed Web of Science ®Google Scholar
• Ozan E, Okur H, Eker C, Eker OD, Gonul AS, Akarsu N. 2010. The effect of depression, BDNF gene val66met polymorphism and gender on serum BDNF levels. Brain Res Bull 81:61–65.
   PubMed Web of Science ®Google Scholar
• Pilia G, Chen WM, Scuteri A, Orrú M, Albai G, Dei M, et al. 2006. Heritability of cardiovascular and personality traits in 6,148 Sardinians. PloS Genetics 2:e132.
   PubMed Web of Science ®Google Scholar
• Roth TL, Lubin FD, Funk AJ, Sweatt JD. 2009. Lasting epigenetic influence of early-life adversity on the BDNF gene. Biol Psychiatry 65:760–769.
   PubMed Web of Science ®Google Scholar
• Sanchez-Mora C, Ribases M, Ramos-Quiroga JA, Casas M, Bosch R, Boreatti-Hummer A, et al. 2010. Meta-analysis of brain-derived neurotrophic factor p.Val66Met in adult ADHD in four European populations. Am J Med Genet B Neuropsychiatr Genet 153B:512–523.
   PubMed Web of Science ®Google Scholar
• Sanna S, Jackson AU, Nagaraja R, Willer CJ, Chen WM, Bonnycastle LL, et al. 2008. Common variants in the GDF5-UQCC region are associated with variation in human height. Nat Genet 40:198–203.
   PubMed Web of Science ®Google Scholar
• Schizophrenia Research Forum. 2011. http://www.szgene.org/meta.asp?geneID = 2&polyID = 28.
   Google Scholar
• Schmidt HD, Duman RS. 2010. Peripheral BDNF produces antidepressant-like effects in cellular and behavioral models. Neuropsychopharmacology 35:2378–2391.
   PubMed Web of Science ®Google Scholar
• Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, et al. 2005. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry 58:307–314.
   PubMed Web of Science ®Google Scholar
• Sutin AR, Scuteri A, Lakatta EG, Tarasov KV, Ferrucci L, , Costa PT Jret al. 2010. Trait antagonism and the progression of arterial thickening: women with antagonistic traits have similar carotid arterial thickness as men. Hypertension 56: 617–622.
   PubMed Web of Science ®Google Scholar
• Swardfager W, Herrmann N, Marzolini S, Saleem M, Shammi P, Oh PI, et al. 2011. Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease. Brain Behav Immun 25:1264–1271.
   PubMed Web of Science ®Google Scholar
• Terracciano A, Martin B, Ansari D, Tanaka T, Ferrucci L, Maudsley S, et al. 2010a. Plasma BDNF concentration, Val66Met genetic variant and depression-related personality traits. Genes Brain Behav 9:512–518.
   PubMed Web of Science ®Google Scholar
• Terracciano A, Sanna S, Uda M, Deiana B, Usala G, Busonero F, et al. 2010b. Genome-wide association scan for five major dimensions of personality. Mol Psychiatry 15:647–656.
   PubMed Web of Science ®Google Scholar
• Terracciano A, Tanaka T, Sutin AR, Deiana B, Balaci L, Sanna S, et al. 2010c. BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology 35:1083–1089.
   PubMed Web of Science ®Google Scholar
• Terracciano A, Tanaka T, Sutin AR, Sanna S, Deiana B, Lai S, et al. 2010d. Genome-wide association scan of trait depression. Biol Psychiatry 68:811–817.
   PubMed Web of Science ®Google Scholar
• Terracciano A, Lobina M, Piras MG, Mulas A, Cannas A, Meirelles O, et al. 2011. Lower serum BDNF associated with higher neuroticism and depressive symptoms. Psychosom Med 73:638 642.
   Google Scholar
• Trajkovska V, Marcussen AB, Vinberg M, Hartvig P, Aznar S, Knudsen GM. 2007. Measurements of brain-derived neurotrophic factor: methodological aspects and demographical data. Brain Res Bull 73:143–149.
   PubMed Web of Science ®Google Scholar
• Verma R, Holmans P, Knowles JA, Grover D, Evgrafov OV, Crowe RR, et al. 2008. Linkage disequilibrium mapping of a chromosome 15q25-26 major depression linkage region and sequencing of NTRK3. Biol Psychiatry 63:1185–1189.
   PubMed Web of Science ®Google Scholar
• Vinberg M, Trajkovska V, Bennike B, Knorr U, Knudsen GM, Kessing LV. 2009. The BDNF Val66Met polymorphism: relation to familiar risk of affective disorder, BDNF levels and salivary cortisol. Psychoneuroendocrinology 34:1380–1389.
   PubMed Web of Science ®Google Scholar
• Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, et al. 2009. Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry 33:1508–1512.
   PubMed Web of Science ®Google Scholar
• Yoshimura R, Kishi T, Suzuki A, Umene-Nakano W, Ikenouchi-Sugita A, Hori H, et al. 2011. The brain-derived neurotrophic factor (BDNF) polymorphism Val66Met is associated with neither serum BDNF level nor response to selective serotonin reuptake inhibitors in depressed Japanese patients. Prog Neuropsychopharmacol Biol Psychiatry 35:1022–1025.
   PubMed Web of Science ®Google Scholar
• Yu H, Zhang Z, Shi Y, Bai F, Xie C, Qian Y, et al. 2008. Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry 69:1104–1111.
   PubMed Web of Science ®Google Scholar
• Zhang XY, Zhou DF, Wu GY, Cao LY, Tan YL, Haile CN, et al. 2008. BDNF levels and genotype are associated with antipsychotic-induced weight gain in patients with chronic schizophrenia. Neuropsychopharmacology 33:2200–2205.
   PubMed Web of Science ®Google Scholar