Gene expression of glutamate transporters SLC1A1, SLC1A3 and SLC1A6 in the cerebellar subregions of elderly schizophrenia patients and effects of antipsychotic treatment

References

• Andreasen N, Pierson R. 2008. The role of the cerebellum in schizophrenia. Biol Psychiatry 64(2):81–88.
   Google Scholar
• Andreasen NC, Nopoulos P, O’Leary DS, Miller DD, Wassink T, Flaum M. 1999. Defining the phenotype of schizophrenia: cognitive dysmetria and its neural mechanisms. Biol Psychiatry 46(7):908–920.
   Google Scholar
• Aparicio-Legarza MI, Cutts AJ, Davis B, Reynolds GP. 1997. Deficits of [3H]D-aspartate binding to glutamate uptake sites in striatal and accumbens tissue in patients with schizophrenia. Neurosci Lett 232(1):13–16.
   Google Scholar
• Baldacara L, Borgio JG, Lacerda AL, Jackowski AP. 2008. Cerebellum and psychiatric disorders. Rev Bras Psiquiatr 30(3): 81–289.
   Google Scholar
• Bauer D, Gupta D, Harotunian V, Meador-Woodruff JH, McCullumsmith RE. 2008. Abnormal expression of glutamate transporter and transporter interacting molecules in prefrontal cortex in elderly patients with schizophrenia. Schizophr Res 104:108–120.
   Google Scholar
• Bauer D, Haroutunian V, Meador-Woodruff JH, McCullumsmith RE. 2010. Abnormal glycosylation of EAAT1 and EAAT2 in prefrontal cortex of elderly patients with schizophrenia. Schizophr Res 117(1):92–98.
   Google Scholar
• Braak H, Braak E. 1991. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 82(4):239–259.
   PubMed Web of Science ®Google Scholar
• Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K. 2006. Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112(4):389–404.
   Google Scholar
• Buard I, Steinmetz CC, Claudepierre T, Pfrieger FW. 2010. Glial cells promote dendrite formation and the reception of synaptic input in Purkinje cells from postnatal mice. Glia 58(5): 538–545.
   Google Scholar
• Chaudhry FA, Lehre KP, Campage ML, Ottersen OP, Danbolt NC, Storm-Mathisen J. 1995. Glutamate transporters in glial plasma membrane: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry Neuron 15:711–720.
   Google Scholar
• Danbolt NC. 2001. Glutamate uptake. Prog Neurobiol 65(1): 1–105.
   Google Scholar
• Deakin JF, Slater P, Simpson MD, Gilchrist AC, Skan WJ, Royston MC, et al 1989. Frontal cortical and left temporal glutamatergic dysfunction in schizophrenia. J Neurochem 52(6):1781–786.
   Google Scholar
• Eastwood SL, Cotter D, Harrison PJ. 2001. Cerebellar synaptic protein expression in schizophrenia. Neuroscience 105(1): 219–229.
   Google Scholar
• Ghez C, Fahn S. 1985. The cerebellum. In: Kandel ER, Schwartz JH, editors. Principles of neural science. 2nd ed. New York: Elsevier. p 502–522.
   Google Scholar
• Gruber O, von Cramon DY. 2003. The functional neuroanatomy of human working memory revisited. Evidence from 3-T fMRI studies using classical domain-specific interference tasks. Neuroimage 19:797–809.
   PubMed Web of Science ®Google Scholar
• Harrison PJ, Weinberger DR. 2005. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10:40–68.
   PubMed Web of Science ®Google Scholar
• Hubrich-Ungureanu P, Kaemmerer N, Henn FA, Braus DF. 2002. Lateralized organization of the cerebellum in a silent verbal fluency task: a functional magnetic resonance imaging study in healthy volunteers. Neurosci Lett 319(2): 91–94.
   Google Scholar
• Ichimiya T, Okubo Y, Suhara T, Sudo Y. 2001. Reduced volume of the cerebellar vermis in neuroleptic-naive schizophrenia. Biol Psychiatry 49(1):20–27.
   Google Scholar
• Jentsch JD, Roth RH. 1999. The neuropsychopharmacology of phencyclidine: from NMDA receptor hypofunction to the dopamine hypothesis of schizophrenia. Neuropsychopharmacology 20(3):201–225.
   Google Scholar
• Lauriat TL, Dracheva S, Chin B, Schmeidler J, McInnes LA, Haroutunian V. 2006. Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain. Neuroscience 137(3): 843–851.
   Google Scholar
• Matute C, Melone M, Vallejo-Illarramendi A, Conti F. 2005. Increased expression of the astrocytic glutamate transporter GLT-1 in the prefrontal cortex of schizophrenics. Glia 49(3): 451–455.
   Google Scholar
• McCullumsmith RE, Meador-Woodruff JH. 2002. Striatal excitatory amino acid transporter transcript expression in schizophrenia, bipolar disorder, and major depressive disorder. Neuropsychopharmacology 26(3):368–375.
   Google Scholar
• Monyer H, Burnashev N, Laurie DJ, Sakmann B, Seeburg PH.1994. Developmental and regional expression in the rat brain and functional properties of four NMDA receptors. Neuron 12:529–540.
   PubMed Web of Science ®Google Scholar
• Mukaetova-Ladinska EB, Hurt J, Honer WG, Harrington CR, Wischik CM. 2002. Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics. Neurosci Lett 17(3):161–165.
   Google Scholar
• Ohnuma T, Augood SJ, Arai H, McKenna PJ, Emson PC. 1998. Expression of the human excitatory amino acid transporter 2 and metabotropic glutamate receptors 3 and 5 in the prefrontal cortex from normal individuals and patients with schizophrenia. Brain Res Mol Brain Res 56(1–2):207–217.
   Google Scholar
• Okugawa G, Sedvall G, Nordström M, Andreasen N, Pierson R, Magnotta V, Agartz I. 2002. Selective reduction of the posterior superior vermis in men with chronic schizophrenia. Schizophr Res 55(1–2):61–67.
   Google Scholar
• Olney JW, Farber NB. 1995. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry 52:998–1007.
   PubMed Web of Science ®Google Scholar
• Palacin M, Estevez R, Bertran J, Zorzano A. 1998. Molecular biology of mammalian plasma membrane amino acid transporters. Physiol Rev 78:969–1054.
   PubMed Web of Science ®Google Scholar
• Paxinos G Watson. 1986. The rat brain in stereotaxic coordinates. 2nd ed. San Diego, CA: Academic Press.
   Google Scholar
• Schmitt A, Zink M, May B, Petroianu G, Braus DF, Henn FA. 2003. Decreased gene expression of glial and neuronal glutamate transporters after antipsychotic treatment in rat brain. Neurosci Lett 347(2):81–84.
   Google Scholar
• Schmitt A, Parlapani E, Gruber O, Wobrock T, Falkai P. 2008. Impact of neuregulin-1 on the pathophysiology of schizophrenia in human post-mortem studies. Eur Arch Psychiatry Clin Neurosci 258(Suppl 5):35–39.
   Google Scholar
• Schmitt A, Koschel J, Zink M, Bauer M, Sommer C, Frank J, et al. 2010. Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci 260(2):101–111.
   Google Scholar
• Segnitz N, Schmitt A, Gebicke-Härter P, Zink M. 2009. Differential expression of glutamate transporter genes after chronic oral treatment of rats with aripiprazole. Neurochem Int 55: 619–628.
   PubMed Web of Science ®Google Scholar
• Simpson MD, Slater P, Deakin JF, Gottfries CG, Karlsson I, Grenfeldt B, et al 1998. Absence of basal ganglia amino acid neuron deficits in schizophrenia in three collections of brains. Schizophr Res 31(2–3):167–175.
   Google Scholar
• Smith RE, Haroutunian V, Davis KL, Meador-Woodruff JH. 2001. Expression of excitatory amino acid transporter transcripts in the thalamus of subjects with schizophrenia. Am J Psychiatry 158(9):1393–1399.
   Google Scholar
• Stefansson H, Sigurdsson E, Steinthorsdottir V, Bjornsdottir S, Sigmundsson T, Ghosh S, et al 2002. Neuregulin 1 and susceptibility to schizophrenia. Am J Hum Genet 71(4): 877–892.
   Google Scholar
• Takayasu Y, Iino M, Ozawa S. 2004. Roles of glutamate trans porters in shaping excitatory synaptic currents in cerebellar Purkinje cells. Eur J Neurosci 19:1285–1295.
   Google Scholar
• Takayasu Y, Iino M, Kakegawa W, Maeno H, Watase K, Wada K, et al. 2005. Differential roles of glial and neuronal glutamate transporters in Purkinje cell synapses. J Neurosci 25(38): 8788–8793.
   Google Scholar
• Takayasu Y, Iino M, Takatsuru Y, Tanaka K, Ozawa S. 2009. Functions of glutamate transporters in cerebellar Purkinje cell synapses. Acta Physiol 197(1):1–12.
   Google Scholar
• Tanaka J, Ichikawa R, Watanabe M, Tanaka K, Inoue Y. 1997. Extra-junctional localization of glutamate transporter EAAT4 at excitatory Purkinje cell synapses. Neuroreport 8: 2461–2464.
   PubMedGoogle Scholar
• Volz H, Gaser C, Sauer H. 2000. Supporting evidence for the model of cognitive dysmetria in schizophrenia – a structural magnetic resonance imaging study using deformation-based morphometry. Schizophr Res 46(1):45–56.
   Google Scholar
• Wadiche JI, Jahr CE. 2005. Patterned expression of Purkinje cell glutamate transporters controls synaptic plasticity. Nat Neurosci 8(10):1329–1334.
   Google Scholar
• Yeganeh-Doost P, Gruber O, Falkai P, Schmitt A. 2011. The role of the cerebellum in schizophrenia: from cognition to molecular pathways. Clinics 66(S1):71–77.
   Google Scholar
• Zink M, Schmitt A, May B, Müller B, Braus DF, Henn FA. 2004. Differential effects of long-term treatment with clozapine or haloperidol on GABA transporter expression. Pharmacopsychiatry 37(4):171–174.
   Google Scholar