Biomedical nanoparticles modulate specific CD4⁺ T cell stimulation by inhibition of antigen processing in dendritic cells

References

• Aggarwal P, Hall JB, McLeland CB, Dobrovolskaia MA & McNeil SE. 2009. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 61:428–437.
   PubMed Web of Science ®Google Scholar
• Balenga NA, Zahedifard F, Weiss R, Sarbolouki MN, Thalhamer J & Rafati S. 2006. Protective efficiency of dendrosomes as novel nano-sized adjuvants for DNA vaccination against birch pollen allergy. J Biotechnol 124:602–614.
   PubMed Web of Science ®Google Scholar
• Baumgartner CE. 1987. Spectrophotometric determination of polyvinyl-alcohol in cadmium hydroxide pastes. Analytical Chemistry 59:2716–2718.
   Google Scholar
• Bee A, Massart R & Neveu S. 1995. Synthesis of very fine maghemite particles. J Magn Magn Mater 149:6–9.
   Web of Science ®Google Scholar
• Boyer C, Whittaker M R, Bulmus V, Liu J & Davis TP. 2010. The design and utility of polymer-stabilized iron-oxide nanoparticles for nanomedicine application. NPG Asia Mater 2:23–30.
   Web of Science ®Google Scholar
• Broos S, Lundberg K, Akagi T, Kadowaki K, Akashi M, Greiff L, 2010. Immunomodulatory nanoparticles as adjuvants and allergen-delivery system to human dendritic cells: implications for specific immunotherapy. Vaccine 28:5075–5085.
   PubMed Web of Science ®Google Scholar
• Butoescu N, Jordan O, Burdet P, Stadelmann P, Petri-Fink A, Hofmann H, 2009. Dexamethasone-containing biodegradable superparamagnetic microparticles for intra-articular administration: physicochemical and magnetic properties, in vitro and in vivo drug release. Eur J Pharm Biopharm 72:529–538.
   PubMed Web of Science ®Google Scholar
• Butoescu N, Jordan O, Petri-Fink A, Hofmann H & Doelker E. 2008. Co-encapsulation of dexamethasone 21-acetate and SPIONs into biodegradable polymeric microparticles designed for intra-articular delivery. J Microencapsul 25:339–350.
   PubMed Web of Science ®Google Scholar
• Cengelli F, Maysinger D, Tschudi-Monnet F, Montet X, Corot C, Petri-Fink A, 2006. Interaction of functionalized superparamagnetic iron oxide nanoparticles with brain structures. J Pharmacol Exp Ther 318:108–116.
   PubMed Web of Science ®Google Scholar
• Chastellain M, Petri A & Hofmann H. 2004. Particle size investigations of a multistep synthesis of PVA coated superparamagnetic nanoparticles. J Colloid Interface Sci 278:353–360.
   PubMed Web of Science ®Google Scholar
• Chen BX, Wilson SR, Das M, Coughlin DJ & Erlanger BF. 1998. Antigenicity of fullerenes: antibodies specific for fullerenes and their characteristics. Proc Natl Acad Sci USA 95:10809–10813.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia MA, Aggarwal P, Hall JB & McNeil SE. 2008. Preclinical studies to understand nanoparticle interaction with the immune system and its potential effects on nanoparticle biodistribution. Mol Pharm 5:487–495.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia MA, Germolec DR & Weaver JL. 2009. Evaluation of nanoparticle immunotoxicity. Nat Nanotechnol 4:411–414.
   PubMed Web of Science ®Google Scholar
• Dobrovolskaia MA & McNeil SE. 2007. Immunological properties of engineered nanomaterials. Nat Nanotechnol 2:469–478.
   PubMed Web of Science ®Google Scholar
• Donaldson K, Stone V, Borm PJ, Jimenez LA, Gilmour PS, Schins RP, 2003. Oxidative stress and calcium signaling in the adverse effects of environmental particles (PM10). Free Radic Biol Med 34:1369–1382.
   PubMed Web of Science ®Google Scholar
• Donaldson K, Tran L, Jimenez LA, Duffin R, Newby DE, Mills N, 2005. Combustion-derived nanoparticles: a review of their toxicology following inhalation exposure. Part Fibre Toxicol 2:10.
   PubMed Web of Science ®Google Scholar
• EMEA 2006. Reflection paper on nanotechnology-based medicinal products for human use. European Medicines Agency.
   Google Scholar
• FDA 2007. Nanotechnology Task Force Report 2007. FDA.
   Google Scholar
• Foged C, Brodin B, Frokjaer S & Sundblad A. 2005. Particle size and surface charge affect particle uptake by human dendritic cells in an in vitro model. Int J Pharm 298:315–322.
   PubMed Web of Science ®Google Scholar
• Gomez S, Gamazo C, Roman BS, Ferrer M, Sanz ML & Irache JM. 2007. Gantrez AN nanoparticles as an adjuvant for oral immunotherapy with allergens. Vaccine 25:5263–5271.
   PubMed Web of Science ®Google Scholar
• Gomez S, Gamazo C, San Roman B, Ferrer M, Sanz ML, Espuelas S, 2008. Allergen immunotherapy with nanoparticles containing lipopolysaccharide from Brucella ovis. Eur J Pharm Biopharm 70:711–717.
   PubMed Web of Science ®Google Scholar
• Hellstern D, Schulze K, Schopf B, Petri-Fink A, Steitz B, Kamau S, 2006. Systemic distribution and elimination of plain and with Cy3.5 functionalized poly(vinyl alcohol) coated superparamagnetic maghemite nanoparticles after intraarticular injection in sheep in vivo. J Nanosci Nanotechnol 6:3261–3268.
   Google Scholar
• Holt PG & Stumbles PA. 2000. Characterization of dendritic cell populations in the respiratory tract. J Aerosol Med 13:361–367.
   PubMedGoogle Scholar
• ISO 2008. Nanotechnologies – terminology and definitions for nano-objects – nanoparticle, nanofibre and nanoplate. ISO/TS 27687.
   Google Scholar
• Klippstein R & Pozo D. 2010. Nanotechnology-based manipulation of dendritic cells for enhanced immunotherapy strategies. Nanomedicine.
   Google Scholar
• Lafuse WP, Brown D, Castle L & Zwilling BS. 1995. IFN-gamma increases cathepsin H mRNA levels in mouse macrophages. J Leukoc Biol 57:663–669.
   PubMedGoogle Scholar
• Lah TT, Hawley M, Rock KL & Goldberg AL. 1995. Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett 363:85–89.
   PubMed Web of Science ®Google Scholar
• Landmark KJ, Dimaggio S, Ward J, Kelly C, Vogt S, Hong S, 2008. Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic Acid-conjugated dendrimers. ACS Nano 2:773–783.
   PubMed Web of Science ®Google Scholar
• Laurent S, Forge D, Port M, Roch A, Robic C, Vander Elst L, 2008. Magnetic iron oxide nanoparticles: synthesis, stabilization, vectorization, physicochemical characterizations, and biological applications. Chem Rev 108:2064–2110.
   PubMed Web of Science ®Google Scholar
• Lehmann AD, Parak WJ, Zhang F, Ali Z, Rocker C, Nienhaus GU, 2010. Fluorescent-magnetic hybrid nanoparticles induce a dose-dependent increase in proinflammatory response in lung cells in vitro correlated with intracellular localization. Small 6:753–762.
   PubMed Web of Science ®Google Scholar
• Mach B, Steimle V, Martinez-Soria E & Reith W. 1996. Regulation of MHC class II genes: lessons from a disease. Annu Rev Immunol 14:301–331.
   PubMed Web of Science ®Google Scholar
• Manolova V, Flace A, Bauer M, Schwarz K, Saudan P & Bachmann MF. 2008. Nanoparticles target distinct dendritic cell populations according to their size. Eur J Immunol 38:1404–1413.
   PubMed Web of Science ®Google Scholar
• Maynard AD, Aitken RJ, Butz T, Colvin V, Donaldson K, Oberdorster G, 2006. Safe handling of nanotechnology. Nature 444:267–269.
   PubMed Web of Science ®Google Scholar
• Montet-Abou K, Daire JL, Hyacinthe JN, Jorge-Costa M, Grosdemange K, Mach F, 2009. In vivo labelling of resting monocytes in the reticuloendothelial system with fluorescent iron oxide nanoparticles prior to injury reveals that they are mobilized to infarcted myocardium. Eur Heart J.
   Google Scholar
• Moss OR & Wong VA. 2006. When nanoparticles get in the way: impact of projected area on in vivo and in vitro macrophage function. Inhal Toxicol 18:711–716.
   PubMed Web of Science ®Google Scholar
• Oberdorster G, Oberdorster E & Oberdorster J. 2005. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113:823–839.
   PubMed Web of Science ®Google Scholar
• Petri-Fink A, Chastellain M, Juillerat-Jeanneret L, Ferrari A & Hofmann H. 2005. Development of functionalized superparamagnetic iron oxide nanoparticles for interaction with human cancer cells. Biomaterials 26:2685–2694.
   PubMed Web of Science ®Google Scholar
• Petri-Fink A & Hofmann H. 2007. Superparamagnetic iron oxide nanoparticles (SPIONs): from synthesis to in vivo studies – a summary of the synthesis, characterization, in vitro, and in vivo investigations of SPIONs with particular focus on surface and colloidal properties. IEEE Trans Nanobioscience 6:289–297.
   PubMed Web of Science ®Google Scholar
• Petri-Fink A, Steitz B, Finka A, Salaklang J & Hofmann H. 2008. Effect of cell media on polymer coated superparamagnetic iron oxide nanoparticles (SPIONs): colloidal stability, cytotoxicity, and cellular uptake studies. Eur J Pharm Biopharm 68:129–137.
   PubMed Web of Science ®Google Scholar
• Powers M. 2006. Nanomedicine and nano device pipeline surges 68%. NanoBiotech News 1–69.
   Google Scholar
• Regamey N, Obregon C, Ferrari-Lacraz S, Van Leer C, Chanson M, Nicod LP, 2007. Airway Epithelial IL-15 transforms monocytes into dendritic cells. Am J Respir Cell Mol Biol 37:75–84.
   PubMed Web of Science ®Google Scholar
• Rothen-Rutishauser B, Muhlfeld C, Blank F, Musso C & Gehr P. 2007. Translocation of particles and inflammatory responses after exposure to fine particles and nanoparticles in an epithelial airway model. Part Fibre Toxicol 4:9.
   PubMedGoogle Scholar
• Sallusto F & Lanzavecchia A. 1994. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med 179:1109–1118.
   PubMed Web of Science ®Google Scholar
• Scholl I, Weissenbock A, Forster-Waldl E, Untersmayr E, Walter F, Willheim M, 2004. Allergen-loaded biodegradable poly(D,L-lactic-co-glycolic) acid nanoparticles down-regulate an ongoing Th2 response in the BALB/c mouse model. Clin Exp Allergy 34:315–321.
   PubMed Web of Science ®Google Scholar
• Schroder K, Hertzog PJ, Ravasi T & Hume DA. 2004. Interferon-gamma: an overview of signals, mechanisms and functions. J Leukoc Biol 75:163–189.
   PubMed Web of Science ®Google Scholar
• Steitz B, Salaklang J, Finka A, O'Neil C, Hofmann H & Petri-Fink A. 2007. Fixed bed reactor for solid-phase surface derivatization of superparamagnetic nanoparticles. Bioconjug Chem 18:1684–1690.
   PubMedGoogle Scholar
• Thiele L, Rothen-Rutishauser B, Jilek S, Wunderli-Allenspach H, Merkle HP & Walter E. 2001. Evaluation of particle uptake in human blood monocyte-derived cells in vitro. Does phagocytosis activity of dendritic cells measure up with macrophages? J Control Release 76:59–71.
   Google Scholar
• Trombetta ES, Ebersold M, Garrett W, Pypaert M & Mellman I. 2003. Activation of lysosomal function during dendritic cell maturation. Science 299:1400–1403.
   PubMed Web of Science ®Google Scholar
• Trombetta ES & Mellman I. 2005. Cell biology of antigen processing in vitro and in vivo. Annu Rev Immunol 23:975–1028.
   PubMed Web of Science ®Google Scholar
• Tsoli M, Kuhn H, Brandau W, Esche H & Schmid G. 2005. Cellular uptake and toxicity of Au55 clusters. Small 1:841–844.
   PubMed Web of Science ®Google Scholar
• Von Garnier C, Filgueira L, Wikstrom M, Smith M, Thomas JA, Strickland DH, 2005. Anatomical location determines the distribution and function of dendritic cells and other APCs in the respiratory tract. J Immunol 175:1609–1618.
   PubMed Web of Science ®Google Scholar
• Von Garnier C & Nicod LP. 2009. Immunology taught by lung dendritic cells. Swiss Med Wkly 139:186–192.
   PubMed Web of Science ®Google Scholar
• Von Garnier C, Wikstrom ME, Zosky G, Turner DJ, Sly PD, Smith M, 2007. Allergic airways disease develops after an increase in allergen capture and processing in the airway mucosa. J Immunol 179:5748–5759.
   PubMed Web of Science ®Google Scholar
• Von Zur C, Von Elverfeldt D, Bassler N, Neudorfer I, Steitz B, Petri-FInk A, 2007. Superparamagnetic iron oxide binding and uptake as imaged by magnetic resonance is mediated by the integrin receptor Mac-1 (CD11b/CD18): implications on imaging of atherosclerotic plaques. Atherosclerosis 193:102–111.
   PubMedGoogle Scholar
• Warheit DB, Webb TR, Colvin VL, Reed KL & Sayes CM. 2007. Pulmonary bioassay studies with nanoscale and fine-quartz particles in rats: toxicity is not dependent upon particle size but on surface characteristics. Toxicol Sci 95:270–280.
   PubMed Web of Science ®Google Scholar
• Wegmann KW, Wagner CR, Whitham RH & Hinrichs DJ. 2008. Synthetic Peptide dendrimers block the development and expression of experimental allergic encephalomyelitis. J Immunol 181:3301–3309.
   PubMedGoogle Scholar
• Wikstrom ME, Batanero E, Smith M, Thomas JA, Von Garnier C, Holt PG, 2006. Influence of mucosal adjuvants on antigen passage and CD4+ T cell activation during the primary response to airborne allergen. J Immunol 177:913–924.
   PubMed Web of Science ®Google Scholar
• Wolf PR & Ploegh HL. 1995. How MHC class II molecules acquire peptide cargo: biosynthesis and trafficking through the endocytic pathway. Annu Rev Cell Dev Biol 11:267–306.
   PubMed Web of Science ®Google Scholar
• Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, 2006. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano Lett 6:1794–1807.
   PubMed Web of Science ®Google Scholar
• Yang D, Zhao Y, Guo H, Li Y, Tewary P, Xing G, 2010. [Gd@C(82)(OH)(22)](n) nanoparticles induce dendritic cell maturation and activate Th1 immune responses. ACS Nano 4:1178–1186.
   PubMed Web of Science ®Google Scholar