Suppression of basal and carbon nanotube-induced oxidative stress, inflammation and fibrosis in mouse lungs by Nrf2

References

• Brown DM, Kinloch IA, Bangert U, Windle AH, Walters DM, Walker GS, et al. 2007. An in vitro study of the potential of carbon nanotubes and nanofibres to induce inflammation mediators and frustrated phagocytosis. Carbon 45:1743–56
   Web of Science ®Google Scholar
• Case BW, Abraham JL, Meeker G, Pooley FD, Pinkerton KE. 2011. Applying definitions of “asbestos” to environmental and “low-dose” exposure levels and health effects, particularly malignant mesothelioma. J Toxicol Environ Health B Crit Rev 14:3–39
   PubMed Web of Science ®Google Scholar
• Chan K, Kan YW. 1999. Nrf2 is essential for protection against acute pulmonary injury in mice. Proc Natl Acad Sci U S A 96:12731–6
   PubMed Web of Science ®Google Scholar
• Cho HY, Jedlicka AE, Reddy SP, Kensler TW, Yamamoto M, Zhang LY, et al. 2002. Role of NRF2 in protection against hyperoxic lung injury in mice. Am J Respir Cell Mol Biol 26:175–82
   PubMed Web of Science ®Google Scholar
• Cho HY, Reddy SP, Yamamoto M, Kleeberger SR. 2004. The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 18:1258–60
   PubMed Web of Science ®Google Scholar
• Donaldson K, Murphy FA, Duffin R, Poland CA. 2010. Asbestos, carbon nanotubes and the pleural mesothelium: a review of the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma. Part Fibre Toxicol 7:5
   PubMed Web of Science ®Google Scholar
• Dong J, Ma Q. 2015. Advances in mechanisms and signaling pathways of carbon nanotube toxicity. Nanotoxicology 9:658–76
   PubMed Web of Science ®Google Scholar
• Dong J, Porter DW, Batteli LA, Wolfarth MG, Richardson DL, Ma Q. 2015a. Pathologic and molecular profiling of rapid-onset fibrosis and inflammation induced by multi-walled carbon nanotubes. Arch Toxicol 89:621–33
   PubMed Web of Science ®Google Scholar
• Dong J, Yu X, Porter DW, Battelli LA, Kashon ML, Ma Q. 2015b. Common and distinct mechanisms of induced pulmonary fibrosis by particulate and soluble chemical fibrogenic agents. Arch Toxicol. [Epub ahead of print]. doi: 10.1007/s00204-015-1589-3
   Web of Science ®Google Scholar
• Finkel T. 2005. Radical medicine: treating ageing to cure disease. Nat Rev Mol Cell Biol 6:971–6
   PubMed Web of Science ®Google Scholar
• He X, Chen MG, Lin GX, Ma Q. 2006. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2 x Keap1 x Cul3 complex and recruiting Nrf2 x Maf to the antioxidant response element enhancer. J Biol Chem 281:23620–31
   PubMed Web of Science ®Google Scholar
• He X, Ma Q. 2012. Redox regulation by nuclear factor erythroid 2-related factor 2: gatekeeping for the basal and diabetes-induced expression of thioredoxin-interacting protein. Mol Pharmacol 82:887–97
   PubMed Web of Science ®Google Scholar
• He X, Young SH, Ferback JE, Ma Q. 2012. Single-walled carbon nanotubes induce fibrogenic effect by disturbing mitochondrial oxidative stress and activating NF-kB signaling. J Clinic Toxicol S5:005
   Google Scholar
• He X, Young SH, Schwegler-Berry D, Chisholm WP, Fernback JE, Ma Q. 2011. Multiwalled carbon nanotubes induce a fibrogenic response by stimulating reactive oxygen species production, activating NF-κB signaling, and promoting fibroblast-to-myofibroblast transformation. Chem Res Toxicol 24:2237–48
   PubMed Web of Science ®Google Scholar
• Husain AN, Kumar V. 2005. The lung. In: Kumar V, Abbas AK, Fausto N, eds. Robbins and Cotran Pathologic Basis of Disease. 7th ed. Philadelphia: Elsevier Saunders, 711–72
   Google Scholar
• Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Aschberger K, et al. 2010. A critical review of the biological mechanisms underlying the in vivo and in vitro toxicity of carbon nanotubes: the contribution of physico-chemical characteristics. Nanotoxicology 4:207–46
   PubMed Web of Science ®Google Scholar
• Kensler TW, Wakabayashi N, Biswal S. 2007. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol 47:89–116
   PubMed Web of Science ®Google Scholar
• Lam CW, James JT, McCluskey R, Hunter RL. 2004. Pulmonary toxicity of single-wall carbon nanotubes in mice 7 and 90 days after intratracheal instillation. Toxicol Sci 77:126–34
   PubMed Web of Science ®Google Scholar
• Ma Q. 2010. Transcriptional responses to oxidative stress: pathological and toxicological implications. Pharmacol Ther 125:376–93
   PubMed Web of Science ®Google Scholar
• Ma Q. 2013. Role of Nrf2 in oxidative stress and toxicity. Annu Rev Pharmacol Toxicol 53:401–26
   PubMed Web of Science ®Google Scholar
• Ma Q, Battelli L, Hubbs AF. 2006. Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2. Am J Pathol 168:1960–74
   PubMed Web of Science ®Google Scholar
• Ma Q, He X. 2012. Molecular basis of electrophilic and oxidative defense: promises and perils of Nrf2. Pharmacol Rev 64:1055–81
   PubMed Web of Science ®Google Scholar
• Mercer RR, Hubbs AF, Scabilloni JF, Wang L, Battelli LA, Friend S, et al. 2011. Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes. Part Fibre Toxicol 8:21
   PubMed Web of Science ®Google Scholar
• Mercer RR, Scabilloni JF, Hubbs AF, Battelli LA, McKinney W, Friend S, et al. 2013. Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol 10:33
   PubMed Web of Science ®Google Scholar
• Murphy FA, Poland CA, Duffin R, Al-Jamal KT, Ali-Boucetta H, Nunes A, et al. 2011. Length-dependent retention of carbon nanotubes in the pleural space of mice initiates sustained inflammation and progressive fibrosis on the parietal pleura. Am J Pathol 178:2587–600
   PubMed Web of Science ®Google Scholar
• Pekovic-Vaughan V, Gibbs J, Yoshitane H, Yang N, Pathiranage D, Guo B, et al. 2014. The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis. Genes Dev 28:548–60
   PubMed Web of Science ®Google Scholar
• Porter DW, Hubbs AF, Mercer RR, Wu N, Wolfarth MG, Sriram K, et al. 2010. Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology 269:136–47
   PubMed Web of Science ®Google Scholar
• Reddy NM, Kleeberger SR, Kensler TW, Yamamoto M, Hassoun PM, Reddy SP. 2009. Disruption of Nrf2 impairs the resolution of hyperoxia-induced acute lung injury and inflammation in mice. J Immunol 182:7264–71
   PubMed Web of Science ®Google Scholar
• Rothen-Rutishauser B, Brown DM, Piallier-Boyles M, Kinloch IA, Windle AH, Gehr P, et al. 2010. Relating the physicochemical characteristics and dispersion of multiwalled carbon nanotubes in different suspension media to their oxidative reactivity in vitro and inflammation in vivo. Nanotoxicology 4:331–42
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin E, Murray AR, Johnson VJ, Gorelik O, Arepalli S, et al. 2008. Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis. Am J Physiol Lung Cell Mol Physiol 295:L552–65
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Mercer R, Murray AR, Johnson VJ, Potapovich AI, et al. 2005. Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice. Am J Physiol Lung Cell Mol Physiol 289:L698–708
   PubMed Web of Science ®Google Scholar
• Shvedova AA, Kisin ER, Murray AR, Gorelik O, Arepalli S, Castranova V, et al. 2007. Vitamin E deficiency enhances pulmonary inflammatory response and oxidative stress induced by single-walled carbon nanotubes in C57BL/6 mice. Toxicol Appl Pharmacol 221:339–48
   PubMed Web of Science ®Google Scholar