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Original Article

Long-term exposure of A549 cells to titanium dioxide nanoparticles induces DNA damage and sensitizes cells towards genotoxic agents

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Pages 913-923 | Received 20 Apr 2015, Accepted 07 Jan 2016, Published online: 22 Feb 2016

References

  • Aberg C, Kim JA, Salvati A, Dawson KA. 2013. Theoretical framework for nanoparticle uptake and accumulation kinetics in dividing cell populations. EPL 101:number 3. doi: 10.1209/0295-5075/101/38007
  • Armand L, Biola-Clier M, Bobyk L, Collin-Faure V, Diemer H, Strub J-M, et al. 2015. Molecular responses of alveaolar epithelial A549 cells to chronic exposure to titanium dioxide nanoparticles: a proteomic view. J Proteomics. [Epub ahead of print]. doi: 10.1016/j.jprot.2015.08.006
  • Baan RA. 2007. Carcinogenic hazards from inhaled carbon black, titanium dioxide, and talc not containing asbestos or asbestiform fibers: recent evaluations by an IARC Monographs working group. Inhal Toxicol 19:213–28
  • Barberet P, Incerti S, Andersson F, Delalee F, Serani L, Moretto P. 2009. Technical description of the CENBG nanobeam line. Nucl Instrum Methods Phys Res B 267:2003–7
  • Barillet S, Jugan ML, Laye M, Leconte Y, Herlin-Boime N, Reynaud C, Carriere M. 2010. In vitro evaluation of SiC nanoparticles impact on A549 pulmonary cells: cyto-, genotoxicity and oxidative stress. Toxicol Lett 198:324–30
  • Bekker-Jensen S, Mailand N. 2010. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair 9:1219–28
  • Beranek DT. 1990. Distribution of methyl and ethyl adducts following alkylation with monofunctional alkylating-agents. Mutation Res 231:11–30
  • Brun E, Barreau F, Veronesi G, Fayard B, Sorieul S, Chaneac C, et al. 2014. Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Part Fibre Toxicol 11:13
  • Campbell JL, Boyd NI, Grassi N, Bonnick P, Maxwell JA. 2010. The Guelph PIXE software package IV. Nucl Instrum Methods Phys Res B 268:3356–63
  • Carriere M, Gouget B, Gallien JP, Avoscan L, Gobin R, Verbavatz JM, Khodja H. 2005. Cellular distribution of uranium after acute exposure of renal epithelial cells: SEM, TEM and nuclear microscopy analysis. Nucl Instrum Methods Phys Res B 231:268–73
  • Carriere M, Pigeot-Remy S, Casanova A, Dhawan A, Lazzaroni J-C, Guillard C, Herlin-Boime N. 2014. Impact of titanium dioxide nanoparticle dispersion state and dispersion method on their toxicity towards A549 lung cells and Escherichia coli bacteria. J Transl Toxicol 1:10–20
  • Chen T, Yan J, Li Y. 2014. Genotoxicity of titanium dioxide nanoparticles. J Food Drug Anal 22:95–104
  • Collins AR. 2009. Investigating oxidative DNA damage and its repair using the comet assay. Mutat Res Rev Mutat Res 681:24–32
  • Fenech M. 2000. The in vitro micronucleus technique. Mutat Res-Fund Mol Mechan Mutagen 455:81–95
  • Gerloff K, Albrecht C, Boots AW, Forster I, Schins RP. 2009. Cytotoxicity and oxidative DNA damage by nanoparticles in human intestinal Caco-2 cells. Nanotoxicology 3:355–64
  • Guadagnini R, Halamoda Kenzaoui B, Walker L, Pojana G, Magdolenova Z, Bilanicova D, et al. 2015. Toxicity screenings of nanomaterials: challenges due to interference with assay processes and components of classic in vitro tests. Nanotoxicology 1:13–24
  • Gurr JR, Wang ASS, Chen CH, Jan KY. 2005. Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells. Toxicology 213:66–73
  • Hackenberg S, Scherzed A, Technau A, Froelich K, Hagen R, Kleinsasser N. 2013. Functional responses of human adipose tissue-derived mesenchymal stem cells to metal oxide nanoparticles in vitro. J Biomed Nanotechnol 9:86–95
  • Huang S, Chueh PJ, Lin Y-W, Shih T-S, Chuang S-M. 2009. Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure. Toxicol Appl Pharmacol 241:182–94
  • IARC. 2010. Carbon black, titanium dioxide, and talc. IARC Monogr Eval Carcinog Risks Hum 93:1–413
  • Johnston HJ, Hutchison GR, Christensen FM, Peters S, Hankin S, Stone V. 2009. Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics. Part Fibre Toxicol 6:33–8977
  • Jugan M-L, Barillet S, Simon-Deckers A, Herlin-Boime N, Sauvaigo S, Douki T, Carriere M. 2012. Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in A549 cells. Nanotoxicology 6:501–13
  • Kim JA, Aberg C, Salvati A, Dawson KA. 2011. Role of cell cycle on the cellular uptake and dilution of nanoparticles in a cell population. Nat Nanotechnol 7:62–8
  • Kocbek P, Teskac K, Kreft ME, Kristl J. 2010. Toxicological aspects of long-term treatment of keratinocytes with ZnO and TiO2 nanoparticles. Small 6:1908–17
  • Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. 1976. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 17:62–70
  • Loomis D, Grosse Y, Lauby-Secretan B, El Ghissassi F, Bouvard V, Benbrahim-Tallaa L, et al. 2013. The carcinogenicity of outdoor air pollution. Lancet Oncol 14:1262–3
  • Magdolenova Z, Bilanicova D, Pojana G, Fjellsbo LM, Hudecova A, Hasplova K, et al. 2012a. Impact of agglomeration and different dispersions of titanium dioxide nanoparticles on the human related in vitro cytotoxicity and genotoxicity. J Environ Monit 14:455–64
  • Magdolenova Z, Lorenzo Y, Collins A, Dusinska M. 2012b. Can standard genotoxicity tests be applied to nanoparticles? J Toxicol Environ Health Part A 75:800–6
  • Mayer M. 2002. Ion beam analysis of rough thin films. Nucl Instrum Methods Phys Res B 194:177–86
  • Moller P, Jensen DM, Christophersen DV, Kermanizadeh A, Jacobsen NR, Hemmingsen JG, et al. 2015. Measurement of oxidative damage to DNA in nanomaterial exposed cells and animals. Environ Mol Mutagen 56:97–110
  • Monopoli MP, Aberg C, Salvati A, Dawson KA. 2012. Biomolecular coronas provide the biological identity of nanosized materials. Nat Nanotechnol 7:779–86
  • Paur H-R, Cassee FR, Teeguarden J, Fissan H, Diabate S, Aufderheide M, et al. 2011. In-vitro cell exposure studies for the assessment of nanoparticle toxicity in the lung-A dialog between aerosol science and biology. J Aerosol Sci 42:668–92
  • Pogozelski WK, Tullius TD. 1998. Oxidative strand scission of nucleic acids: routes initiated by hydrogen abstraction from the sugar moiety. Chem Rev 98:1089–108
  • Robichaud CO, Uyar AE, Darby MR, Zucker LG, Wiesner MR. 2009. Estimates of upper bounds and trends in nano-TiO2 production as a basis for exposure assessment. Environ Sci Technol 43:4227–33
  • Shi H, Magaye R, Castranova V, Zhao J. 2013. Titanium dioxide nanoparticles: a review of current toxicological data. Part Fibre Toxicol 10:15
  • Simon-Deckers A, Gouget B, Mayne-L'Hermite M, Herlin-Boime N, Reynaud C, Carriere M. 2008. In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes. Toxicology 253:137–46
  • Singh NP, McCoy MT, Tice RR, Schneider EL. 1988. A simple technique for quantitation of low-levels of DNA damage in individual cells. Exp Cell Res 175:184–91
  • Vales G, Rubio L, Marcos R. 2014. Long-term exposures to low doses of titanium dioxide nanoparticles induce cell transformation, but not genotoxic damage in BEAS-2B cells. Nanotoxicology 19:1–11
  • Wang S, Hunter LA, Arslan Z, Wilkerson MG, Wickliffe JK. 2011. Chronic exposure to nanosized, anatase titanium dioxide is not cyto- or genotoxic to Chinese Hamster ovary cells. Environ Mol Mutagen 52:614–22
  • Weir A, Westerhoff P, Fabricius L, Hristovski K, von Goetz N. 2012. Titanium dioxide nanoparticles in food and personal care products. Environ Sci Technol 46:2242–50
  • Wu J, Sun J, Xue Y. 2010. Involvement of JNK and P53 activation in G2/M cell cycle arrest and apoptosis induced by titanium dioxide nanoparticles in neuron cells. Toxicol Lett 199:269–76

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