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Original Article

No effect of immunosuppression with cyclosporin: A detected on bone ingrowth into cancellous alio- and xenografts in the rat

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Pages 491-496 | Published online: 08 Jul 2009

References

  • Aspenberg P, Wang J S. A new bone chamber used for measuring osteoconduction in rats. Eur J Exp Musculoskel Res 1993; 2: 69–74
  • Aspenberg P, Wang J S. The bone conduction chamber, materials and growth factors. Cells & Material 1995; 5: 337–44
  • Berrey B H, Lord C F, Gebhart M C, Mankin H J. Fractures in allografts. J Bone Joint Surg (Am) 1990; 72: 825–33
  • Bertolini D R, Nedwin G E, Bringman T S, Smith D D, Mundy G R. Stimulation of bone resorption and inhibition of bone formation in vitro by human tumour necro sis factors. Nature 1986; 319: 516–8
  • Bobyn J D, Pilliar R M, Cameron H V, Weatherly G C. The optimum pore size for the fixation of porous surfaces. Clin Orthop 1980; 150: 263–70
  • Borel J F, Bauman G, Chapman I, et al. In vivo pharmacological effects of cyclosporin and some analogues. Adv Pharmacol 1996; 35: 115–246
  • Bos G D, Goldberg V M, Zika J M, Heiple K G, Powell A E. Immune responses of rats to frozen bone grafts. J Bone Joint Surg (Am) 1983; 65: 239–46
  • Bunjes D, Hardt C, Röllinghoff M, Wagner H. Cyclosporin A mediates immunosuppression of primary cytotoxic T-cell responses by impairing the release of interleukin-1 and interleukin-2. Eur J Immunol 1981; 11: 657–61
  • Burchart H, Glowczewskie F P, Enneking W F. Allogeneic segmental fibular transplants in azathioprine-immuno-suppressed dogs. J Bone Joint Surg (Am) 1977; 59: 881–94
  • Ekelund A, Nilsson O. Effects of cyclosporin A on experimental new bone formation in rats. Clin Orthop 1992; 284: 288–98
  • Ekelund A, Ahmed M, Bjurholm A, Nilsson O. Neuropeptides in heterotopic bone induced by bone matrix in im-munosuppressed rats. Clin Orthop 1997; 345: 229–38
  • Enneking W F, Mindell E R. Observations on massive retrieved allografts. J Bone Joint Surg (Am) 1991; 73: 1123–42
  • Evans D B, Bunning R A D, Russel R G G. The effects of recombinant human interleukin-IB on cellular proliferation and production of prostaglandin E2, plasminogen activator, osteocalcin and alkaline phosphatase by osteo-blast-like cells derived from human bone. Biochem Bio-phys Res Comm 1990; 166: 208–16
  • Frost A, Jonsson K B, Nilsson O, Ljunggren Ö. Inflammatory cytokines regulate proliferation of cultured human osteoblasts. Acta Orthop Scand 1997; 68: 91–6
  • Fukunaga T, Masumi S, Yano H, Ikebe S, Shimizu K. Osteogenesis in xenogeneic bone transplantation, using an immunosuppressant. Acta Orthop Scand 1995; 66: 557–60
  • Goldberg V M, Bos G D, Heiple K G, Zika J M, Powell A. Improved acceptance of frozen bone allografts in genetically mismatched dogs by immunosuppression. J Bone Joint Surg (Am) 1984; 66: 937–50
  • Goldberg V M, Powell A, Shaffer J W, Zika J, Bos G D, Heiple K G. Bone grafting: role of histocompatibility in transplantation. J Orthop Res 1985; 3: 389–404
  • Gowen M, Chapman K, Littlewood A, Hughes D, Evans D, Russel G. Production of tumour necrosis factor by human osteoblasts is modulated by other cytokines, but not by osteotropic hormones. Endocrinology 1990; 126: 1250–5
  • Hallen I G. Heterologous transplantation with Kiel bone. Acta Orthop Scand 1966; 37: 1–19
  • Holt D W, Marsden J T, Johnston A, Bewick M, Taube D H. Blood cyclosporin concentrations and renal allograft dysfunction. BMJ 1986; 293: 1057–9
  • Hooten J P, Engh C A, Heekin R D, Vinh T N. Structural bulk allografts in acetabular reconstruction. J Bone Joint Surg (Br) 1996; 78: 270–5
  • Horowitz M C, Friedlander G E. Induction of specific T-cell responsiveness to allogeneic bone. J Bone Joint Surg (Am) 1991; 73: 1157–68
  • Hukkanen M, Konttinen Y T, Santavirta S, Paavolainen P, Gu X H, Terenghi G, Polak J M. Rapid proliferation of calcitonin gene-related peptide-immunoactive nerves during healing of rat tibial fracture suggests neural involvement in bone growth and remodeling. Neuro-science 1993; 54: 969–79
  • Irschik E, Tilg H, Niederwieser D, Gastl G A, Huber C H, Margreiter R. Cyclosporin blood levels do correlate with clinical complications. Lancet 1984; II: 692–3
  • Kirkeby O J, Larsen T B, Lereim P. Bone grafts in T-cell-deficient rats. Acta Orthop Scand 1991; 62: 459–62
  • Kirkeby O J, Nordsletten L, Skjeldal S. Healing of cortical bone grafts in athymic rats. Acta Orthop Scand 1992; 63: 318–22
  • Madsen J E, Wang J S, Hukkanen M, Nordsletten L, Konttinen Y T, Santavirta S, Polak J M, Aspenberg P. Sensory nerve ingrowth during graft incorporation in the rat. Acta Orthop Scand 1996; 67: 217–20
  • Mankin H J. Complications in allograft surgery. Osteochondral allografts, G E Friedlander, H J Mankin, K W Sell. Little Brown, Boston 1983; 259–74
  • Mankin H J, Doppelt S, Tomford W. Clinical experience with allograft implantation. Clin Orthop 1983; 174: 69–86
  • Martens M, Ducheyne P, De Meester P, Mulier J C. Skeletal fixation of implants by bone ingrowth into surface pores. Arch Orthop Traum Surg 1980; 97: 111–6
  • Russel G, Graveley R, Seid J, Al-Humidan A K, Skjodt H. Mechanisms of action of cyclosporine and effects on connective tissues. Semin Arthritis Rheum 1992; 21: 16–22
  • Salama R. Xenogeneic bone grafting in humans. Clin Orthop 1983; 174: 113–21
  • Stevenson S, Li X Q, Davy D T, Klein L, Goldberg V M. Critical biological determinants of incorporation of non-vascularized cortical bone grafts. J Bone Joint Surg (Am) 1997; 79: 1–16
  • Szturm K, Jeffrey J R, Rush D N, McKenna R M. Cyclosporin A and G inhibition of cytokine production. Transpl Proc 1989; 21: 857
  • Thoren K, Aspenberg P, Thorngren K G. Lipid extraction decreases the specific immunologic response to bone allografts in rabbits. Acta Orthop Scand 1993; 64: 44–6
  • Urist M R. Bone: Formation by autoinduction. Science 1965; 150: 893–9

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