Nitric oxide synthase in diabetic rat testicular tissue and the effects of pentoxifylline therapy

References

• Abou-Seif, M.A. and Youssef, A.A. (2004) Evaluation of some biochemical changes in diabetic patients. Clin Chim Acta 346:161–170
   PubMed Web of Science ®Google Scholar
• Agbaje, I.M., Rogers, D.A., McVicar, C.M., McClure, N., Atkinson, A.B., Mallidis, C., et al. (2007) Insulin dependant diabetes mellitus: Implications for male reproductive function. Hum Reprod 22:1871–1877
   PubMed Web of Science ®Google Scholar
• Alves, M.G., Martins, A.D., Rato, L., Moreira, P.I., Socorro, S. and Oliveira, P.F. (2013) Molecular mechanisms beyond glucose transport in diabetes-related male infertility. Biochim Biophys Acta 1832:626–635
   PubMed Web of Science ®Google Scholar
• Amaral, S., Oliveira, P.J. and Ramalho-Santos, J. (2008) Diabetes and the impairment of reproductive function: Possible role of mitochondria and reactive oxygen species. Curr Diabetes Rev 4:46–54
   PubMedGoogle Scholar
• Armagan, A., Uz, E., Yilmaz, H.R., Soyupek, S., Oksay, T. and Ozcelik, N. (2006) Effects of melatonin on lipid peroxidation and antioxidant enzymes in streptozotocin-induced diabetic rat testis. Asian J Androl 8:595–600
   PubMed Web of Science ®Google Scholar
• Bayatli, F., Akkus, D., Kilic, E., Saraymen, R. and Sonmez, M.F. (2013) The protective effects of grape seed extract on MDA, AOPP, apoptosis and eNOS expression in testicular torsion: An experimental study. World J Urol 31:615–622
   PubMed Web of Science ®Google Scholar
• Chen, Y.M., Chien, C.T., Hu-Tsai, M.I., Wu, K.D., Tsai, C.C., Wu, M.S., et al. (1999) Pentoxifylline attenuates experimental mesangial proliferative glomerulonephritis. Kidney Int 56:932–943
   PubMed Web of Science ®Google Scholar
• Davila-Esqueda, M.E. and Martinez-Morales, F. (2004) Pentoxifylline diminishes the oxidative damage to renal tissue induced by streptozotocin in the rat. Exp Diabesity Res 5:245–251
   PubMedGoogle Scholar
• Delfino, M., Imbrogno, N., Elia, J., Capogreco, F. and Mazzilli, F. (2007) Prevalence of diabetes mellitus in male partners of infertile couples. Minerva Urol Nefrol 59:131–135
   PubMedGoogle Scholar
• Dellamea, B.S., Leitao, C.B., Friedman, R. and Canani, L.H. (2014) Nitric oxide system and diabetic nephropathy. Diabetol Metab Syndr 6:17
   PubMed Web of Science ®Google Scholar
• Garcia, F.A., Pinto, S.F., Cavalcante, A.F., Lucetti, L.T., Menezes, S.M., Felipe, C.F., et al. (2014) Pentoxifylline decreases glycemia levels and TNF-alpha, iNOS and COX-2 expressions in diabetic rat pancreas. Springerplus 3:283
   PubMed Web of Science ®Google Scholar
• Guerrero-Romero, F., Rodriguez-Moran, M., Paniagua-Sierra, J.R., Garcia-Bulnes, G., Salas-Ramirez, M. and Amato, D. (1995) Pentoxifylline reduces proteinuria in insulin-dependent and non insulin-dependent diabetic patients. Clin Nephrol 43:116–121
   PubMed Web of Science ®Google Scholar
• Guneli, E., Tugyan, K., Ozturk, H., Gumustekin, M., Cilaker, S. and Uysal, N. (2008) Effect of melatonin on testicular damage in streptozotocin-induced diabetes rats. Eur Surg Res 40:354–360
   PubMed Web of Science ®Google Scholar
• Hink, U., Li, H., Mollnau, H., Oelze, M., Matheis, E., Hartmann, M., et al. (2001) Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 88:E14–22
   PubMed Web of Science ®Google Scholar
• Horvath, B., Marton, Z., Halmosi, R., Alexy, T., Szapary, L., Vekasi, J., et al. (2002) In vitro antioxidant properties of pentoxifylline, piracetam, and vinpocetine. Clin Neuropharmacol 25:37–42
   PubMed Web of Science ®Google Scholar
• Jo, H., Otani, H., Jo, F., Shimazu, T., Okazaki, T., Yoshioka, K., et al. (2011) Inhibition of nitric oxide synthase uncoupling by sepiapterin improves left ventricular function in streptozotocin-induced diabetic mice. Clin Exp Pharmacol Physiol 38:485–493
   PubMed Web of Science ®Google Scholar
• Johnsen, S.G. (1970) Testicular biopsy score count–a method for registration of spermatogenesis in human testes: Normal values and results in 335 hypogonadal males. Hormones 1:2–25
   PubMedGoogle Scholar
• Khanna, S., Singh, G.B. and Khullar, M. (2014) Nitric oxide synthases and diabetic cardiomyopathy. Nitric Oxide 43:29–34
   PubMed Web of Science ®Google Scholar
• La Vignera, S., Condorelli, R., Vicari, E., D'Agata, R. and Calogero, A.E. (2012) Diabetes mellitus and sperm parameters. J Androl 33:145–153
   PubMed Web of Science ®Google Scholar
• Liu, Z.M., Zheng, X.M., Yang, Z.W. and Li, S.W. (2006) Protective effect of pentoxifylline on spermatogenesis following testicular torsion/detorsion in rats. Zhonghua Nan Ke Xue 12:323–325, 329
   PubMedGoogle Scholar
• Motawi, T.K., Darwish, H.A. and Abd El Tawab, A.M. (2011) The relative efficacy of aminoguanidine and pentoxifylline in modulating endotoxin-induced cardiac stress. Cell Biochem Funct 29:694–702
   PubMed Web of Science ®Google Scholar
• Ohmasa, F., Saito, M., Tsounapi, P., Dimitriadis, F., Inoue, S., Shomori, K., et al. (2011) Edaravone ameliorates diabetes-induced dysfunction of NO-induced relaxation in corpus cavernosum smooth muscle in the rat. J Sex Med 8:1638–1649
   PubMed Web of Science ®Google Scholar
• Ozan, E., Sonmez, M.F., Ozan, S., Colakoglu, N., Yilmaz, S. and Kuloglu, T. (2007) Effects of melatonin and vitamin C on cigarette smoke-induced damage in the kidney. Toxicol Ind Health 23:479–485
   PubMed Web of Science ®Google Scholar
• Queiroz-Junior, C.M., Bessoni, R.L., Costa, V.V., Souza, D.G., Teixeira, M.M. and Silva, T.A. (2013) Preventive and therapeutic anti-TNF-alpha therapy with pentoxifylline decreases arthritis and the associated periodontal co-morbidity in mice. Life Sci 93:423–428
   PubMed Web of Science ®Google Scholar
• Rathinam, A., Pari, L., Chandramohan, R. and Sheikh, B.A. (2014) Histopathological findings of the pancreas, liver, and carbohydrate metabolizing enzymes in STZ-induced diabetic rats improved by administration of myrtenal. J Physiol Biochem 70:935–946
   PubMed Web of Science ®Google Scholar
• Roessner, C., Paasch, U., Kratzsch, J., Glander, H.J. and Grunewald, S. (2012) Sperm apoptosis signalling in diabetic men. Reprod Biomed Online 25:292–299
   PubMed Web of Science ®Google Scholar
• Rolo, A.P. and Palmeira, C.M. (2006) Diabetes and mitochondrial function: Role of hyperglycemia and oxidative stress. Toxicol Appl Pharmacol 212:167–178
   PubMed Web of Science ®Google Scholar
• Savas, C., Dindar, H., Aras, T. and Yucesan, S. (2002) Pentoxifylline improves blood flow to both testes in testicular torsion. Int Urol Nephrol 33:81–85
   PubMedGoogle Scholar
• Sexton, W.J. and Jarow, J.P. (1997) Effect of diabetes mellitus upon male reproductive function. Urology 49:508–513
   PubMed Web of Science ®Google Scholar
• Sonmez, M.F., Karabulut, D., Kilic, E., Akalin, H., Sakalar, C., Gunduz, Y., et al. (2015) The effects of streptozotocin-induced diabetes on ghrelin expression in rat testis: Biochemical and immunohistochemical study. Folia Histochem Cytobiol 53:26–34
   PubMed Web of Science ®Google Scholar
• Sonmez, M.F., Narin, F., Akkus, D. and Ozdamar, S. (2009a) Effect of melatonin and vitamin C on expression of endothelial NOS in heart of chronic alcoholic rats. Toxicol Ind Health 25:385–393
   PubMed Web of Science ®Google Scholar
• Sonmez, M.F., Narin, F., Akkus, D. and Turkmen, A.B. (2012) Melatonin and vitamin C ameliorate alcohol-induced oxidative stress and eNOS expression in rat kidney. Ren Fail 34:480–486
   PubMed Web of Science ®Google Scholar
• Sonmez, M.F., Narin, F. and Balcioglu, E. (2009b) Melatonin and vitamin C attenuates alcohol-induced oxidative stress in aorta. Basic Clin Pharmacol Toxicol 105:410–415
   PubMed Web of Science ®Google Scholar
• Stosic-Grujicic, S., Maksimovic, D., Badovinac, V., Samardzic, T., Trajkovic, V., Lukic, M., et al. (2001) Antidiabetogenic effect of pentoxifylline is associated with systemic and target tissue modulation of cytokines and nitric oxide production. J Autoimmun 16:47–58
   PubMed Web of Science ®Google Scholar
• Szabo, C. (2009) Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction. Br J Pharmacol 156:713–727
   PubMed Web of Science ®Google Scholar
• Tang, X.Y., Zhang, Q., Dai, D.Z., Ying, H.J., Wang, Q.J. and Dai, Y. (2008) Effects of strontium fructose 1,6-diphosphate on expression of apoptosis-related genes and oxidative stress in testes of diabetic rats. Int J Urol 15:251–256
   PubMed Web of Science ®Google Scholar
• Toda, N., Imamura, T. and Okamura, T. (2010) Alteration of nitric oxide-mediated blood flow regulation in diabetes mellitus. Pharmacol Ther 127:189–209
   PubMed Web of Science ®Google Scholar
• Tousoulis, D., Kampoli, A.M., Tentolouris, C., Papageorgiou, N. and Stefanadis, C. (2012) The role of nitric oxide on endothelial function. Curr Vasc Pharmacol 10:4–18
   PubMed Web of Science ®Google Scholar
• Wang, W., Zolty, E., Falk, S., Basava, V., Reznikov, L. and Schrier, R. (2006) Pentoxifylline protects against endotoxin-induced acute renal failure in mice. Am J Physiol Renal Physiol 291:F1090–1095
   PubMed Web of Science ®Google Scholar
• Yu, T., Robotham, J.L. and Yoon, Y. (2006) Increased production of reactive oxygen species in hyperglycemic conditions requires dynamic change of mitochondrial morphology. Proc Natl Acad Sci U S A 103:2653–2658
   PubMed Web of Science ®Google Scholar