2,651
Views
12
CrossRef citations to date
0
Altmetric
Original

Acid Transport through Gastric Mucus

Pages 1-24 | Received 14 Oct 2003, Accepted 05 Nov 2003, Published online: 12 Jul 2009

REFERENCES

  • Bernard, C.: Leçons de Physiologie experimentale appliquee à la medicine. Paris, Balliere, 1856.
  • LaMont, J.T.: Unlocking the secrets of a porcelain vase. Gastroenterology, 119: 1397–1401,2000.
  • Helander, H.F.: Physiology and pharmacology of the parietal cell. Baillier's Clin Gastroenterol 2: 539–554,1988.
  • Kopin, A.S., Lee, Y., McBride, E.W., Miller, L.J., Lu, M., Lin, H.Y., Kolakowski, L.F. Jr & Bein-born, M.: Expression Cloning and Characterization of the Canine Parietal Cell Gastrin Receptor. Proc. Natl. Acad. Sci. USA. April 15; 89 (8): 3605–3609,1992.
  • Niv, Y. & Fraser, G.M.: The alkaline tide phenomenon. J Clin Gastroenterol 35:5-8,2002.
  • Rune, S.J.: The metabolic alkalosis following aspiration of gastric acid secretion. Scand J Clin Lab Invest 17: 305–310,1965.
  • Holm, L., Agren, J. & Persson, A.E.: Stimulation of acid secretion increases the gastric gland luminal pressure in the rat. Gastroenterology 103: 1797–1803,1992.
  • Ross, IN., Bahari, H.M.M. & Turnberg, L.A.: The pH gradient across mucus adherent to rat fundic mucosa in vivo and the effect of potential damaging agents. Gastroenterology 81: 713–718, 1981.
  • Schade, C., Flemström, G. & Holm, L.: Hydrogen ion concentration in the mucus layer on top of acid-stimulated and -inhibited rat gastric mucosa. Gastroenterology 107: 180–188,1994.
  • Williams, S.E. & Turnberg, L.A.: Retardation of acid diffusion by pig gastric mucus: A potential role in mucosal protection. Gastroenterology 79: 299–304,1980.
  • Allen, A.: Gastrointestinal mucus. In: Handbook of Physiology: The gastrointestinal system. (ed. J.G. Forte), pp. 359–382. Baltimore: Waverly Press Inc, 1989.
  • Atuma, C., Strugala, V., Allen, A. & Holm, L.: The adherent gastrointestinal mucus gel layer: Thickness and physical state in vivo. Am J Physiol Gastrointestinal Liver Physiol 280: G922—G929,2001.
  • Allen, A., Flemström, G., Garner, A. & Kivilaakso, E.: Gastroduodenal mucosal protection. Phys-iol Rev 73: 823–857,1993.
  • Brown, J.F., Hanson, P.J. & Whittle, B.J.: Nitric oxide donors increase mucus gel thickness in rat stomach. Eur J Pharmacol 223: 103–104,1992.
  • Teorell, T:. The acid-base balance of the secreting isolated gastric mucosa. J. Physiol. 114: 267–276,1951.
  • Forssell, H., Stenquist, B. & Olbe, L.: Vagal stimulation of human gastric bicarbonate secretion. Gastroenterology 89: 581–586,1985.
  • Flemström, G.: Gastric and duodenal mucosal secretion of bicarbonate. Physiology of the gas-trointestinal tract. (ed. L.R. Johnson), pp. 1285–1309. Raven, New York, 1994.
  • Forssell, H., Lind, T. & Olbe, L.: Comparative potency of carbachol, sham feeding, fundic disten- sion and 16,16-dimethyl prostaglandin E2 as stimulants of human gastric bicarbonate secretion. Acta Physiol Scand 134: 75–78, 1988.
  • Garner, A. & Heylings, J.R.: Stimulation of alkaline secretion in amphibian-isolated gastric mucosa by 16,16-dimethyl PGE2 and PGF2 alpha. A proposed explanation for some of the cyto-protective actions of prostaglandins. Gastroenterology 76: 497–503, 1979.
  • Rees, W.D.W., Gibbons, L.C. & Turnberg, L.A.: Alkali secretion by isolated rabbit gastric mucosa: effects of non-steroidal anti-inflammatory drugs and prostaglandins. Scand J Gastroen-terol 19: 63–68, 1984.
  • Takeuchi, K., Yagi, K., Kato, S. & Ukawa, H.: Roles of prostaglandin E-receptor subtypes in gas-tric and duodenal bicarbonate secretion in rats. Gastroenterology 113: 1553–1559, 1997.
  • Flemström, G.: Cl- dependence of HCO transport in frog gastric mucosa. Upsala J Med Sci 85: 303–309, 1980.
  • Kiviluoto, T., Ahonen, M., Back, N., Happöld, O., Mustonen, H., Paimela, H. & Kivilaakso, E.: Preepithelial mucus-HCO layer protects against intracellular acidosis in acid-exposed gastric mucosa. Am J Physiol Gastrointestinal Liver Physiol. 264: G57-G63, 1993.
  • Ashley, S.W., Soybel, DI., Moore, C.D. & Cheung, L.Y.: Intracellular pH (pHi) in gastric surface epithelium is more susceptible to serosal than mucosal acidification Surgery 102: 371–379, 1987.
  • Kivilaakso, E. & Kiviluoto, T.: Intracellular pH in isolated Necturus antral mucosa in simulated ulcerogenic conditions. Gastroenterology 95: 1198–1205, 1988.
  • Hirst, B.H.: The gastric mucosal barrier. In: Forte JG, ed. Handbook of physiology: The gastroin-testinal system vol 3, section 6. Am Physiol Soc, Baltimore: Waverly Press Inc:279-308, 1989.
  • Shull, G.E., Miller, M.L. & Schultheis, P.J.: Lessons from genetically engineered animal mod-els.VIII. Absorption and secretion of ions in the gastrointestinal tract. Am J Physiol Gastrointesti-nal Liver Physiol 278: G185—G190, 2000.
  • Gannon, B., Browning, J. & O'Brien, P.: The microvascular architecture of the glandular mucosa of rat stomach. J Anat 135: 667–683, 1982.
  • Li, D.S., Raybould, HE., Quintero, E. & Guth, P.H.: Calcitonin gene-related peptide mediates the gastric hyperemic response to acid back-diffusion. Gastroenterology 102: 1124–1128, 1992.
  • Holzer, P.: Neural emergency system in the stomach. Gastroenterology 114:823–839, 1998.
  • Wallace, J.L. & Miller, M.J.S.: Nitric oxide in mucosal defense: A little goes a long way. Gas-troenterology 119: 512–520, 2000.
  • Knowles, R.G. & Moncada, S.: Nitric oxide synthases in mammals. Biochem J 298: 249–258, 1994.
  • Price, K.J., Hanson, P.J. & Whittle, B.J.R.: Localization of constitutive isoforms of nitric oxide synthase in the gastric glandular mucosa of the rat. Cell Tissue Res 285: 157–163, 1996.
  • Holm-Rutili, L. & ()brink, K.J.: Rat gastric mucosal microcirculation in vivo. Am J Physiol Gas-trointestinal Liver Physiol .248: G741—G746, 1985.
  • Nylander, O., Kvietys, P.R. & Granger, D.N.: Effects of hydrochloric acid on duodenal and jeju-nal mucosal permeability in the rat. Am. J. Physiol Gastrointestinal Liver Physiol. 257: G653—G660, 1989.
  • Bjarnason, I., Smethurst, P., Levi, A.J. & Peters, T.J.: Intestinal permeability to 51Cr-EDTA in rats with experimental induced enteropathy. Gut 26: 579–585, 1985.
  • Crissinger, K.D., Kvietys, P.R. & Granger, D.N.: Pathophysiology of gastrointestinal mucosal permeability. J. Int. Med. 228 Suppl 1: 145–154, 1990.
  • Hall, E.J., Batt, R.M. & Brown, A.: Assessment of canine intestinal permeability using 51Cr-labelled ethylenediaminetetraacetate. Am. J. Vet. Res. 50: 2069–2074, 1989.
  • Ahn, H., Lindhagen, J., Nilsson, G.E., Salerud, E.G., Jodal, M. & Lundgren, O.: Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat. Gastroenterology 88: 951–957, 1985.
  • Patronella, C.K., Vanek, I. & Bowen, J.C.: In vivo measurement of gastric mucus pH in canines: Effect of high luminal acidity and prostaglandin E2. Gastroenterology 95: 612–618, 1988.
  • O'Brien, P. & Silen, W.: Influence of secretory state on gastric mucosal tolerance to back diffu-sion of H. Gastroenterology 71: 760–765, 1976.
  • Teyssen, S., Chad, ST., Scheid, J. & Singer, M.V.: Effect of repeated boluses of intravenous omeprazole and primed infusions of ranitidine on 24-hour intragastric pH in healthy human sub-jects. Dig Dis Sci 40: 247–255, 1995.
  • Phillipson, M., Atuma, C., Henriksnds, J. & Holm, L.: The importance of mucus layers and bicar-bonate transport in preservation of gastric juxtamucosal pH. Am J Physiol Gastrointest Liver Physiol 282: G211–G219, 2002.
  • Synnerstad, I., Johansson, M., Nylander, O. & Holm, L.: Intraluminal acid and gastric mucosal integrity: The importance of blood-borne bicarbonate. Am J Physiol Gastrointestinal Liver Physiol 280: G138–G146, 2001.
  • Kivilaakso, E.: High plasma HCO protects gastric mucosa against acute ulceration in the rat. Gastroenterology 81: 921–7, 1981.
  • Ozaki, J., Tanimoto, N., Kuse, H. & Hori, M.: Comparison of arterial blood gases and acid-base balance in young and aged beagle dogs, with regard to postprandial alkaline tide. Toxicol Sci; 25: 205–211, 2000.
  • Curci, S., Debellis, L., Caroppo, R. & Fromter, E.: Model of bicarbonate secretion by resting frog stomach fundus mucosa. I. Transepithelial measurements. Pfliigers Arch 428: 648–654, 1994.
  • Rossmann, H., Bachmann, O., Vieillard-Baron, D., Gregor, M. & Seidler, U.: Na+MC0i-co trans-port and expression of NBC1 and NBC2 in rabbit gastric parietal and mucous cells. Gastroenterol-ogy 116: 1389–1398, 1999.
  • Horie, S., Yano, S. & Watanabe, K.: Effects of drugs acting on C1--HCOi and Na+-H+ exchangers on acid secretion in the rat gastric mucosa sheet preparation. Pfliigers Arch 229: 15–19, 1992.
  • Ota, H., Katsuyama, T., Ishii, K., Nakayama, J., Shiozawa, T. & Tsukahara Y.: A dual staining method for identifying mucins of different gastric epithelial mucous cells. Histochem J 23: 22–28, 1991.
  • Van Klinken, B.J.W., Dekker, J., Buller, H.A., de Bolos, C. & Einerhand, A.W.C.: Biosynthesis of mucins (MUC2-6) along the longitudinal axis of the human gastrointestinal tract. Am J Physiol 273: G296-G302, 1997.
  • Johansson, M. & Holm, L.: Effects of prostaglandins on the two different gastric mucus layers in the anesthetized rat (Abstract). Pfliigers Arch 435 (suppl) 1998.
  • Holm, L. & Flemstrom, G.: Microscopy of acid transport at the gastric surface in vivo. J Intern Med Suppl 732:91–95,1990.
  • Johansson, M., Synnerstad, I. & Holm, L.: Acid transport through channels in the mucous layer of rat stomach.Gastroenterology 119:1297–1304, 2000.
  • Schreiber, S. & Scheid, P.: Gastric mucus of the guinea pig: proton carrier and diffusion barrier. Am J Physiol Gastrointestinal Liver Physiol 272: G63–G70, 1997.
  • Batzri, S., Harmon, J.W., Dubois, A., Moskowitz, D., Weichbrod, R. & Rich, N.M.: A new in vivo method for repeatedly studying gastric acid secretion and other secretory parameters in awake guinea pig. J Surg Res 43:398-406,1986.
  • Chu, S., Tanaka, S., Kaunitz, J. & Montrose, M.: Dynamic regulation of gastric surface pH by luminal pH. J Clin Invest 103: 605–612, 1999.
  • Bhaskar, K.R., Garik, P., Turner, B.S., Bradley, J.D., Bansil, R., Stanley, H.E. & LaMont, J.T.: Viscous fingering of HC1 through gastric mucin. Nature 360: 458–461, 1992.
  • Bhaskar, K.R., Gong, D.H., Bansil, R., Pajevic, S., Hamilton, J.A., Turner, B.S. & LaMont, J.T.: Profound increase in viscosity and aggregation of pig gastric mucin at low pH. Am J Physiol Gas-trointestinal Liver Physiol 261: G827-G832, 1991.
  • Barret°, J.C., Smith, G.S., Russell, D.H. & Miller, T.A.: Gastric damage caused by acidified ethanol: role of molecular HC1. Am J Physiol Gastrointestinal Liver Physiol. 265: G133–G137, 1993.
  • Lippe, I.T. & Holzer, P.: Participation of endothelium-derived nitric oxide but not prostacyclin in the gastric mucosal hyperaemia due to acid back-diffusion. Br J Pharmacol 105:708–714, 1992.
  • Holm, M., Powell, T., Casselbrant, A., Johansson, B. & Fändriks, L.: Dynamic involvement of the inducible type of nitric oxide synthase in acid-induced duodenal mucosal alkaline secretion in the rat. Dig Dis Sci 46:1765–1771, 2001.
  • Phillipson, M., Henriksnds, J., Holstad, M., Sandler, S. & Holm, L.: Inducible Nitric Oxide Syn-thase is involved in acid induced gastric hyperemia in rats and mice. Am J Physiol Gastrointest Liver Physiol 85: G154–G162, 2003.
  • Konturek, P.C., Brzozowski, T., Sliwowski, Z., Pajdo, R., Stachura, J., Hahn, E.G. & Konturek, S.J.: Involvement of nitric oxide and prostaglandins in gastroprotection induced by bacterial lipopolysaccharide. Scand J Gastroenterol 33: 691–700, 1998.
  • Guo, F.H., De Raeve, H.R., Rice, T.W., Stuehr, D.J., Thunnissen, F.B.J.M. & Erzurum, S.C.: Continuous nitric oxide synthesis by inducible nitric oxide synthase in normal human airway epithelium in vivo. Proc Natl Acad Sci 92: 7809–7813,1995.
  • Lundberg, JON., Farkas-Szallasi, T., Weitzberg, E., Rinder, J., Lidholm, J., Änggfird, A., Hök-fält, T., Lundberg, J.M. & Alving, K.: High nitric oxide production in human paranasal sinuses. Nature Medicine 1: 370–373,1995.
  • Jain, B., Rubinstein, I., Robbins, R.A., Leise, K.L. & Sisson, J.H.: Modulation of airway epithelial cell ciliary beat frequency by nitric oxide. J Biochem Biophys Res Commun 191: 83–88,1993.
  • Schmidt, H.H.H.W. & Walter, U.: NO at work. Cell 78; 919–925,1994.
  • Casselbrant, A., Pettersson, A., Ruth, M., Bove, M., Lundell, L. & Fändriks, L.: Sources of intra-oesophagal nitric oxide production following intraluminal acid exposure. Scand J Gastroenterol 37: 631–637,2002.
  • Hoffman, R.A., Zhang, G., I\Lssler, N.C., Gleixner, S.L., Ford, H.R., Simmons, R.L. & Watkins, S.C.: Constitutive expression of inducible nitric oxide synthase in the mouse ileal mucosa. Am J Physiol Gastrointestinal Liver Physiol. 272: G383—G392,1997.
  • McCafferty, D.M., Miampamba, M., Sihota, E., Sharkey, K.A. & Kubes, P.: Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice. Gut 45: 864–873, 1999.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.