825
Views
34
CrossRef citations to date
0
Altmetric
Research Article

Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia/reperfusion injury in diabetic and normal mice

, , , , , , & show all
Pages 428-436 | Received 19 Dec 2012, Accepted 20 Dec 2012, Published online: 23 Jan 2013

References

  • Aleshin A, Ananthakrishnan R, Li Q, Rosario R, Lu Y, Qu W, et al. 2008. RAGE modulates myocardial injury consequent to LAD infarction via impact on JNK and STAT signaling in a murine model. Am J Physiol Heart Circ Physiol. 294:H1823–832.
  • Ananthakrishnan R, Kaneko M, Hwang YC, Quadri N, Gomez T, Li Q, et al. 2009. Aldose reductase mediates myocardial ischemia- reperfusion injury in part by opening mitochondrial permeability transition pore. Am J Physiol Heart Circ Physiol. 296:H333–341.
  • Bilban M, Haschemi A, Wegiel B, Chin BY, Wagner O, Otterbein LE. 2008. Heme oxygenase and carbon monoxide initiate homeostatic signaling. J Mol Med (Berl). 86:267–279.
  • Bobofchak KM, Mito T, Texel SJ, Bellelli A, Nemoto M, Traystman RJ, et al. 2003. A recombinant polymeric hemoglobin with conformational, functional, and physiological characteristics of an in vivo O2 transporter. Am J Physiol Heart Circ Physiol. 285:H549–561.
  • Cabrales P, Tsai AG, Intaglietta M. 2007. Deferoxamine lowers tissue damage after 80% exchange transfusion with polymerized hemoglobin. Antioxid Redox Signal. 9:375–384.
  • Capellini VK, Celotto AC, Baldo CF, Olivon VC, Viaro F, Rodrigues AJ, Evora PR. 2010. Diabetes and vascular disease: basic concepts of nitric oxide physiology, endothelial dysfunction, oxidative stress and therapeutic possibilities. Curr Vasc Pharmacol. 8:526–544.
  • Cheng X, Siow RC, Mann GE. 2011. Impaired redox signaling and antioxidant gene expression in endothelial cells in diabetes: a role for mitochondria and the nuclear factor-E2-related factor 2-Kelch-like ECH-associated protein 1 defense pathway. Antioxid Redox Signal. 14:469–487.
  • Chin BY, Jiang G, Wegiel B, Wang HJ, Macdonald T, Zhang XC, et al. 2007. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci USA. 104:5109–5114.
  • Clark JE, Naughton P, Shurey S, Green CJ, Johnson TR, Mann BE, et al. 2003. Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule. Circ Res. 93:e2–8.
  • Cole DJ, Drummond JC, Patel PM, Reynolds LR. 1997. Hypervolemic-hemodilution during cerebral ischemia in rats: effect of diaspirin cross-linked hemoglobin (DCLHb) on neurologic outcome and infarct volume. J Neurosurg Anesthesiol. 9:44–50.
  • Conover CD, Lejeune L, Shum K, Gilbert C, Shorr RG. 1997. Physiological effect of polyethylene glycol conjugation on stroma-free bovine hemoglobin in the conscious dog after partial exchange transfusion. Artif Organs. 21:369–378.
  • Conover CD, Malatesta P, Lejeune L, Chang CL, Shorr RG. 1996. The effects of hemodilution with polyethylene glycol bovine hemoglobin (PEG-Hb) in a conscious porcine model. J Investig Med. 44:238–246.
  • Dawn B, Bolli R. 2005. HO-1 induction by HIF-1: a new mechanism for delayed cardioprotection?Am J Physiol Heart Circ Physiol. 289:H522–524.
  • Dong DL, Zhang Y, Lin DH, Chen J, Patschan S, Goligorsky MS, et al. 2007. Carbon monoxide stimulates the Ca2(+)-activated big conductance k channels in cultured human endothelial cells. Hypertension. 50:643–651.
  • Dunne JR, Malone D, Tracy JK, Gannon C, Napolitano LM. 2002. Perioperative anemia: an independent risk factor for infection, mortality, and resource utilization in surgery. J Surg Res. 102:237–244.
  • Dunne JR, Malone DL, Tracy JK, Napolitano LM. 2004. Allogenic blood transfusion in the first 24 hours after trauma is associated with increased systemic inflammatory response syndrome (SIRS) and death. Surg Infect (Larchmt). 5:395–404.
  • Francia P, Cosentino F, Schiavoni M, Huang Y, Perna E, Camici GG, et al. 2009. p66(Shc) protein, oxidative stress, and cardiovascular complications of diabetes: the missing link. J Mol Med (Berl). 87:885–891.
  • Hwang YC, Kaneko M, Bakr S, Liao H, Lu Y, Lewis ER, et al. 2004. Central role for aldose reductase pathway in myocardial ischemic injury. FASEB J. 18:1192–1199.
  • Intaglietta M. 1999. Microcirculatory basis for the design of artificial blood. Microcirculation. 6:247–258.
  • Klaus JA, Kibler KK, Abuchowski A, Koehler RC. 2010. Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion. Artif Cells Blood Substit Immobil Biotechnol. 38:223–229.
  • Matheson B, Kwansa HE, Bucci E, Rebel A, Koehler RC. 2002. Vascular response to infusions of a nonextravasating hemoglobin polymer. J Appl Physiol. 93:1479–1486.
  • Mito T, Nemoto M, Kwansa H, Sampei K, Habeeb M, Murphy SJ, et al. 2009. Decreased damage from transient focal cerebral ischemia by transfusion of zero-link hemoglobin polymers in mouse. Stroke. 40:278–284.
  • Motterlini R, Clark JE, Foresti R, Sarathchandra P, Mann BE, Green CJ. 2002. Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities. Circ Res. 90:E17–24.
  • Natanson C, Kern SJ, Lurie P, Banks SM, Wolfe SM. 2008. Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis. JAMA. 299:2304–2312.
  • Natarajan R, Salloum FN, Fisher BJ, Kukreja RC, Fowler AA III. 2006. Hypoxia inducible factor-1 activation by prolyl 4-hydroxylase-2 gene silencing attenuates myocardial ischemia reperfusion injury. Circ Res. 98:133–140.
  • Nemoto M, Mito T, Brinigar WS, Fronticelli C, Koehler RC. 2006. Salvage of focal cerebral ischemic damage by transfusion of high O2-affinity recombinant hemoglobin polymers in mouse. J Appl Physiol. 100:1688–1691.
  • Nho K, Glower D, Bredehoeft S, Shankar H, Shorr R, Abuchowski A. 1992. PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model. Biomater Artif Cells Immobilization Biotechnol. 20:511–524.
  • Nucci ML, Shorr RGL, Abuchowski A. 1996. PEG-hemoglobin oxygen carrying blood substitute. Drugs Future. 21:29–32.
  • Ockaili R, Natarajan R, Salloum F, Fisher BJ, Jones D, Fowler AA III, Kukreja RC. 2005. HIF-1 activation attenuates postischemic myocardial injury: role for heme oxygenase-1 in modulating microvascular chemokine generation. Am J Physiol Heart Circ |Physiol. 289:H542–548.
  • Sammut IA, Foresti R, Clark JE, Exon DJ, Vesely MJ, Sarathchandra P, et al. 1998. Carbon monoxide is a major contributor to the regulation of vascular tone in aortas expressing high levels of haeme oxygenase-1. Br J Pharmacol. 125:1437–1444.
  • Saxena R, Wijnhoud AD, Carton H, Hacke W, Kaste M, Przybelski RJ, et al. 1999. Controlled safety study of a hemoglobin-based oxygen carrier, DCLHb, in acute ischemic stroke. Stroke. 30:993–996.
  • Silverman TA, Weiskopf RB. 2009. Hemoglobin-based oxygen carriers: current status and future directions. Transfusion. 49:2495–2515.
  • Small EM, Thatcher JE, Sutherland LB, Kinoshita H, Gerard RD, Richardson JA, et al. 2010. Myocardin-related transcription factor-a controls myofibroblast activation and fibrosis in response to myocardial infarction. Circ Res. 107:294–304.
  • Stein AB, Guo Y, Tan W, Wu WJ, Zhu X, Li Q, et al. 2005. Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction. J Mol Cell Cardiol. 38:127–134.
  • Tsai AG, Acero C, Nance PR, Cabrales P, Frangos JA, Buerk DG, Intaglietta M. 2005. Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion. Am J Physiol Heart Circ Physiol. 288:H1730–1739.
  • Tsai AG, Cabrales P, Manjula BN, Acharya SA, Winslow RM, Intaglietta M. 2006. Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers. Blood. 108:3603–3610.
  • Van den Oever IA, Raterman HG, Nurmohamed MT, Simsek S. 2010. Endothelial dysfunction, inflammation, and apoptosis in diabetes mellitus. Mediators Inflamm. 2010:792393.
  • Vandegriff KD, Young MA, Lohman J, Bellelli A, Samaja M, Malavalli A, Winslow RM. 2008. CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats. Br J Pharmacol. 154:1649–1661.
  • Wettstein R, Tsai AG, Erni D, Winslow RM, Intaglietta M. 2003. Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters. Crit Care Med. 31:1824–1830.
  • Yellon DM, Downey JM. 2003. Preconditioning the myocardium: from cellular physiology to clinical cardiology. Physiol Rev. 83: 1113–1151.
  • Young MA, Malavalli A, Winslow N, Vandegriff KD, Winslow RM. 2007. Toxicity and hemodynamic effects after single dose administration of MalPEG-hemoglobin (MP4) in rhesus monkeys. Transl Res. 149:333–342.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.