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Research Article

Chitosan–pDNA nanoparticle characteristics determine the transfection efficacy of gene delivery to human mesenchymal stem cells

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Pages 376-384 | Received 14 Jul 2013, Accepted 05 Aug 2013, Published online: 03 Sep 2013

References

  • ASTM Standard. 1985. Zeta potential of colloids in water and waste water. Am Soc Testing Mater. 4187–4182.
  • Chae SY, Son S, Lee M, Jang MK, Nah JW. 2005. Deoxycholic acid- conjugated chitosan oligosaccharide nanoparticles for efficient gene carrier. J Control Release. 109:330–344.
  • Cook SE, Park IK, Kim EM, Jeong HJ, Park TG, Choi YJ, et al. 2005. Galactosylated polyethylenimine-graft-poly(vinyl pyrorolidone) as a hepatocyte-targeting gene carrier. J Control Release. 105: 151–163.
  • Corsi K, Chellat F, Yahia LH, Fernandes JC. 2003. Mesenchymal stem cells, MG63 and HEK293 transfection using chitosan-DNA nanoparticles. Biomaterials. 24:1255–1264.
  • Chen XA., Zhang LJ., He ZJ., Wang WW., Xu B, Zhong Q, et al. 2011. Plasmid-encapsulated polyethylene glycol-grafted polyethylenimine nanoparticles for gene delivery into ratmesenchymal stem cells. Int J Nanomedicine. 6:843–853.
  • Deshpande D, Blezinger P, Pillai R, Duguid J, Freimark B, Rolland A. 1998. Target specific optimization of cationic lipid-based systems for pulmonary gene therapy. Pharm Res. 15:1340–1347.
  • Dongwon L, Richard L, Shyam M. 2006. Folate receptor-mediated cancer cell specific gene delivery using folic acid-conjugated oligochitosan. J Nanosci Nanotechnol. 6:2860–2866.
  • Duceppe N, Tabrizian M. 2009. Factors influencing the transfection efficiency of ultra low molecular weight chitosan/hyaluronic acid nanoparticles. Biomaterials. 13:2625–2631.
  • Duceppe N, Tabrizian M. 2010. Advances in using chitosan based nanoparticles for in vitro and in vivo drug and gene delivery. Expert Opin Drug Deliv. 7:1191–1207.
  • Gao Y, Zhang Z, Chen L, Gu W, Li Y. 2009. Chitosan N-betainates/ DNA self-assembly nanoparticles for gene delivery: in vitro uptake and transfection efficiency. Int J Pharm. 371:156–162.
  • Germershaus O, Mao S, Sitterberg J, Bakowsky U, Kissel T. 2008. Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structureeactivity relationships in vitro. J Control Release. 125: 145–154.
  • Hashimoto M, Morimoto M, Saimoto H, Shigemasa Y, Yanagie H, Eriguchi M, Sato T. 2006. Gene transfer by DNA/mannosylated chitosan complexes into mouse peritoneal macrophages. Biotechnol Lett. 28:815–821.
  • Hejazi R, Amiji M. 2003. Chitosan-based gastrointestinal delivery systems. J Control Release. 89:151–165.
  • Heller J, Liu LS, Duncan R, Richardson S. 1996. Alginate:chitosan microporous microspheres for the controlled release of proteins and antigens. Proc Int Symp Control Release Bioact Mater. 23:269–270.
  • Hoggard MK, Varum KM, Issa M, Danielsen S, Christensen BE, Stokke BT, Artursson P. 2004. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther. 11:1441–1145.
  • Hu FQ, Zhao MD, Yuan H, You J, Du YZ, Zeng S. 2006. A novel chitosan oligosaccharide-stearic acid micelles for gene delivery: properties and in vitro transfection studies. Int J Pharm. 315:158–166.
  • Huang M, Khor E, Lim LY. 2004. Uptake and cytotoxicity of chitosan molecules and nanoparticles: effects of molecular weight and degree of deacetylation. Pharm Res. 21:344–353.
  • Ishii T, Okahata Y, Sato T 2001Mechanism of cell transfection with plasmid/chitosan complexes. Biochim Biophys Acta. 1514:51–64.
  • Jeon SY, Park JS, Yang HN, Woo DG, Park KH. 2012. Co-delivery of SOX9 genes and anti-Cbfa-1 siRNA coated onto PLGA nanoparticles for chondrogenesis of human MSCs. Biomaterials. 33:4413–4423.
  • Kean T, Roth S, Thanou M. 2005. Trimethylated chitosans as non- viral gene delivery vectors: cytotoxicity and transfection efficiency. J Control Release. 103:643–653.
  • Kiang T, Wen J, Lim HW, Leong KW. 2004. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials. 25:5293–5301.
  • Kim JH, Park JS, Yang HN, Woo DG, Jeon SY, Do HJ, et al. 2011. The use of biodegradable PLGA nanoparticles to mediate SOX9 gene delivery in human mesenchymal stem cells (hMSCs) and induce chondrogenesis. Biomaterials. 32:268–78.
  • Kim TH, Jiang HL, Nah JW, Cho MH, Akaike T, Cho CS. 2007. Receptor-mediated gene delivery using chemically modified chitosan. Biomed Mater. 2:S95–S100.
  • Kim SW, Lee DW, Yu LH, Zhang HZ, Kim CE, Kim JM, et al. 2012. Mesenchymal stem cells overexpressing GCP-2 improve heart function through enhanced angiogenic properties in a myocardial infarction model. Cardiovasc Res. 95:495–506.
  • Kurisawa M, Yokoyama M, Okano T. 2000. Transfection efficiency increases by incorporating hydrophobic monomer units into polymeric gene carriers. J Control Release. 68:1–8.
  • Lee M, Nah JW, Kwon Y, Koh JJ, Ko KS, Kim SW. 2001. Water-soluble and low molecular weight chitosan-based plasmid DNA delivery. Pharm Res. 18:427–431.
  • Lee D, Zhang W, Shirley SA, Kong X, Hellermann GR, Lockey RF, Mohapatra SS. 2007. Thiolated chitosan/DNA nanocomplexes exhibit enhanced and sustained gene delivery. Pharm Res. 24: 157–167.
  • Leong KW, Mao HQ, Truong-Le VL, Roy K, Walsh SM, August JT. 1998. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release. 53:183–193.
  • Liu WG, Yao KD, Liu QG. 2001. Formation of a DNA/N-dodecylated chitosan complex and salt-induced gene delivery. J Appl Polym Sci. 82:3391–3395.
  • Liu Z, Zhang Z, Zhou C, Jiao Y. 2010. Hydrophobic modifications of cationic polymers for gene delivery. Prog Polym Sci. 35:1144–1162.
  • Lou J, Xu F, Merkel K, Manske P. 1999. Gene therapy: adenovirus- mediated human bone morphogenetic protein-2 gene transfer induces mesenchymal progenitor cell proliferation and differentiation in vitro and bone formation in vivo. J Orthop Res. 17:43–50.
  • MacLaughlin F, Mumper R, Wang J, Tagliaferri J, Gill I, Hinchcliffe M, Rolland A. 1998. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release. 56:259–272.
  • Mansouri S, Lavigne P, Corsi K, Benderdour M, Beaumont E, Fernandes JC. 2004. Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy. Eur J Pharm Biopharm. 57:1–8.
  • Mao HQ, Roy K, Troung-Le VL, Janes KA, Lin KY, Wang Y, et al. 2001.Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release. 70:399–421.
  • Mao S, Sun W, Kissel T. 2010. Chitosan-based formulations for delivery of DNA and siRNA. Adv Drug Deliv Rev62:12–27.
  • McMahon JM, Conroy S, Lyons M, Greiser U, O'shea C, Strappe P, et al. 2006. Gene transfer into rat mesenchymal stem cells: a comparative study of viral and nonviral vectors. Stem Cells Dev. 15:87–96.
  • Morimoto K, Nishikawa M, Kawakami S, Nakano T, Hattori Y, Fumoto S, et al. 2003Molecular weight-dependent gene transfection activity of unmodified and galactosylated polyethyleneimine on hepatoma cells and mouse liver. Mol Ther. 7:254–261.
  • Oligino TJ, Yao Q, Ghivizzani SC, Robbins P. 2000. Vector systems for gene transfer to joints. Clin Orthop Relat Res. 379: S17–S30.
  • Park IK, Kim TH, Park YH, Shin BA, Choi ES, Chowdhury EH, et al. 2001. Galactosylated chitosan-graft poly(ethylene glycol) as hepatocyte-targeting DNA carrier. J Control Release. 76: 349–362.
  • Park JS, Na K, Woo DG, Yang HN, Kim JM, Kim JH, et al. 2010. Non-viral gene delivery of DNA polyplexed with nanoparticles transfected into human mesenchymal stem cells. Biomaterials. 31: 124–132.
  • Pimpha N, Sunintaboon P, Inphonlek S, Tabata Y. 2010. Gene delivery efficacy of polyethyleneimine-introduced chitosan shell/poly(methyl Methacrylate) core nanoparticles for rat mesenchymal stem cells. J Biomaterials Sci. 21:205–223.
  • Quong D, Neufeld RJ. 1998. DNA protection from extracapsular nucleases, within chitosan- or poly-L-lysine-coated alginate beads. Biotechnol Bioeng. 60:124–134.
  • Sato T, Ishii T, Okahata Y 2000. In vitro gene delivery mediated by chitosan. Effect of pH, serum,and molecular mass of chitosan on the transfection efficiency. Biomaterials. 22:2075–2080.
  • Smith AE. 1995. Viral vectors in gene therapy. Annu Rev Microbiol49:807–838.
  • Vinogradov SV, Bronich TK, Kabanov AV. 2002.Nanosized cationic hydrogels for drug delivery: preparation, properties and interactions with cells. Adv Drug Deliv Rev. 54:135–147.
  • Wong K, Sun G, Zhang X, Dai H, Liu Y, He C, Leong KW. 2006. PEIg-chitosan, a novel gene delivery system with transfection efficiency comparable to polyethylenimine in vitro and after liver administration in vivo. Bioconjugate Chem. 17:152–158.
  • Yomota C, Miyazaki T, Okada S. 1993. Determination of the viscometric constants for chitosan and the application of universal calibration procedure in its gel permeation chromatography. Colloid Polym Sci. 271:76–82.
  • Zhang H, Mardyani S, Chan WCW, Kumacheva E. 2006. Design of biocompatible chitosan microgels for targeted pH-mediated intracellular release of cancer therapeutics. Biomacromolecules. 7:1568–1572.

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