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Miscellany

Symposium on Intensive Therapy in Pseudomonas Infections Lyngby, October 23–24, 1980

Pages 1-103 | Published online: 02 Jan 2015

References

  • Atik, M., Liu, P. V., Hanson, B. A., Amini, S. & Rosenberg, C. F.: Pseudomonas exotoxin shock. A preliminary report of studies in dogs. JAMA 205: 134, 1968
  • Berk, R. S.: Production and characterization of Pseudomonas aeruginosa hemolysin. J Bacteriol 84: 1041, 1962
  • Bjorn, M. J., Pavlovskis, O. R., Thompson, M. R. & Iglewski, B. H.: Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. Infect Immun 24: 837, 1979
  • Brown, M. R. W., Foster, J. H. S. & Clamp, J. R.: Composition of Pseudomonas aeruginosa slime. Biochem J 112: 521, 1969
  • Carlson, D. M. & Matthews, L. W.: Polyuronic acids produced by Pseudomonas aeruginosa. Biochemistry 5: 2817, 1966
  • Costerton, J. W., Brown, M. R. W. & Sturgess, J. M.: The cell envelope: Its role in infection. In: Psudomonas aeruginosa. Clinical manifestations of infection and current therapy (ed. Doggett, R. G.), p. 41. Academic Press, New York, 1979
  • Czegledy-Nagy, E. & Sturgess, J. M.: Cystic fibrosis: Effect of serum factors on mucus secretion. Lab Invest 35: 588, 1976
  • Esselmann, M. & Liu, P. V.: Lecithinase production by Gram-negative bacteria. J Bacteriol 81: 939, 1961
  • Fuller, R. & Brooke, B. E.: Lactobacilli which attach to the crop epithelium of the fowl. Am J Clin Nutr 27: 1305, 1974
  • Gerke, J. R. & Magliocco, M. V.: Experimental Pseudomonas aeruginosa infection of the mouse cornea. Infect Immun 3: 209, 1971
  • Gibbons, R. J. & van Houten, J.: Bacterial adherence in oral microbial ecology. Annu Rev Microbiol 29: 19, 1975
  • Govan J. R. W. & Fyfe, J. A. M.: Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin, and tobramycin and the isolation of mucoid variants in vitro. J Antimicrob Chemother 4: 233, 1978
  • Gray, L. D. & Kreger, A. S.: Rabbit corneal damage produced by Pseudomonas aeruginosa infection. Infect Immun 12: 419, 1975
  • Hirao, Y. & Homma, J. Y.: Thereapeutic effect of immunization with OEP, protease toxoid and elastase toxoid on corneal ulcers in mice due to Pseudomonas aeruginosa infection. Jpn J Exp Med 48: 41, 1978
  • Høiby, N.: Immunity-humoral response. In: Pseudomonas aeruginosa. Clinical mainfestations of infection and current therapy, (ed Doggett, R. G.) p. 157. Academic Press, New York, 1979
  • Homma, J. Y., Abe, C., Tanamoto, K., Hirato, Y., Morihara, K., Tsuzuki, H., Yanagawa, R., Honda, E., Aoi, Y., Fujimoto, Y., Goryo, M., Imazeki, N., Noda, H., Goda, A. Takeuchi, S. & Ishihara, T.: Effectiveness or immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa. Jpn J Exp Med 48: 111, 1978
  • Iglewski, B. H., Liu, P. V. & Kabat, D.: Mechanism of action of Pseudomonas aeruginosa exotoxin A: adenosine diphosphateribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun 15: 138, 1977
  • Jessen, O: Pseudomonas aeruginosa and other fluorescent pseudomonads. A taxonomic study. Munksgaard, Copenhagen 1965
  • Johnson, G. G., Morris, J. M. & Berk, R. S.: The extracellular protease from Pseudomonas aeruginosa exhibiting elastase activity. Can J Microbiol 13: 711, 1967
  • Karns, J. S., Phibbs, P. V. & Macrina, F. L.: Abstr Ann Meet Amer Soc Microbiol K-235, 1977
  • Kawaharajo, K. & Homma J. Y.: Effects of elastase, protease and common antigen (PEP) from Pseudomonas aeruginosa on protection against burns in mice. Jpn J Exp Med 47: 495, 1977
  • Kawaharajo, K., Homma, J. Y., Aoyama, Y. & Morihara, K.: Corneal ulcers caused by protease and elastase from Pseudomonas aeruginosa. Jpn J Exp Med 45: 435, 1975
  • Kobayashi, F.: Experimental infection with Pseudomonas aeruginosa in mice. I. The virulence of Pseudomonas aeruginosa for mice. Microbiol Immunol 15: 295, 1971
  • Kreger, A. S. & Griffin, R. H.: Physicochemical fractionation of extracellular cornea-damaging proteases of Pseudomonas aeruginosa. Infect Immun 9: 828, 1974
  • Kubota, Y. & Liu, P. V.: An enterotoxin of Pseudomonas aeruginosa. J Infect Dis 123: 97, 1971
  • Kusama, H. & Suss, R. H.: Vascular Permeability factor of Pseudomonas aeruginosa. Infect Immun 5: 363, 1972
  • Liu, P. V.: Survey of hemolysin production among species of Pseudomonas. J Bacteriol 74: 718, 1957
  • Liu, P. V.: Identification of pathogenic pseudomonads by extracellular antigens. J Bacteriol 81: 28, 1961
  • Liu, P. V.: The roles of various fractions of Pseudomonas aeruginosa in its pathogenesis. II. Effects of lecithinase and protease. J Infect Dis 116: 112, 1966
  • Liu, P. V.: Toxins Pseudomonas aeruginosa. In Pseudomonas aeruginosa. Clinical manifestations of infection and current therapy (ed. Doggett, R. G.), p. 63, Academic Press, New York 1979
  • Liu, P. V. & Hsieh, J.: Exotoxins of Pseudomonas aeruginosa. III. Characterization of antitoxin A. J Infect Dis 128: 520, 1973
  • Meincke, G., Barum, J., Rosenberg, B. & Berk, R.: In vivo studies with the partially purified protease (elastase) from Pseudomonas aeruginosa. Infect Immun 2: 583, 1970
  • Morihara, K.: Pseudomonas aeruginosa protease. Purification and general properties. Biochim Biophys Acta 73: 113, 1963
  • Morihara, K., Tsuzuki, H., Oka, T., Inoue, H. & Ebata, M.: Pseudomonas aeruginosa elastase. Isolation, crystallization and preliminary characterization. J Biol Chem 240: 3295, 1965
  • Moorhouse, R., Winter, W. T., Arnott, S. & Bayer, M. E.: Conformation and molecular organization in fibers of the capsular polysaccharide from Escherichia coli M41 mutant. J Mol Biol 109: 373, 1977
  • Mull, J. D. & Callahan, W. S.: The role of the elastase of Pseudomonas aeruginosa in experimental infection. Exp Mol Pathol 4: 567, 1965
  • Muszynski, A. & Kedzia, W. B.: Production of extracellular substances by different virulent strains of Pseudomonas aeruginosa. J Hyg Epidemiol Microbiol Immunol 18: 313, 1974
  • Oakley, C. L. & Banerjee, N. G.: Bacterial elastases. J Pathol 85: 489, 1963
  • Pollack, M. & Anderson, S. E.: Toxicity of Pseudomonas aeruginosa exotoxin A for human macrophages. Infect Immun 19: 1092, 1978
  • Rossman, C., Dolovich, J., Dolovich, M., Wilson, W. & Newhouse, M.: Cystic fibrosis-related inhibition of mucociliary clearance in vivo in man. J Pediatr 90: 579, 1977
  • Scharmann, W.: Formation and isolation of leucocidin from Pseudomonas aeruginosa. J Gen Microbiol 93: 283, 1976
  • Scharmann, W.: Purification and characterization of leucocidin from Pseudomonas aeruginosa. J Gen Microbiol 93: 292, 1936
  • Sensakovic, J. W. & Bartell, P. F.: The slime of Pseudomonas aeruginosa: biological characterization and possible role in experimental infection. J Infect Dis 129: 101, 1974
  • Sezen, I. Y., Scharmann, W. & Blobel, H.: Effects of an anti-serum prepared against purified protease of Pseudomonas aeruginosa. Zentralbl Bakteriol [Orig A] 231: 126, 1975
  • Sierra, G.: Hemolytic effect of a glycolipid produced by Pseudomonas aeruginosa. Antonie van Leeuwenhoek 26: 189, 1960
  • Spock, A. Heick, H. M., Cress, H. & Logan, W. S.: Abnormal serum factor in patients with cystic fibrosis of the pancreas. Pediatr Res 1: 173, 1967
  • Vasil, M. L. & Iglewski, B. H.: Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors. J Gen Microbiol 108: 333, 1978
  • Wretlind, B. & Kronevi, T.: Experimental infections with protease-deficient mutants of Pseudomonas aeruginosa in mice. J Med Microbiol 11: 145, 1978
  • Wretlind, B. & Pavlovskis, O. R.: The role of protease and exotoxin A in the pathogenicity of Pseudomonas aeruginosa infections. Scand J Infect Dis. Suppl. 29: 13, 1981
  • Wretlind, B. & Wadström, T.: Purification and properties of a protease with elastase activity from Pseudomonas aeruginosa. J Gen Microbiol 103: 319, 1977

References

  • Atik, M., Liu, P. V., Hanson, B. A., Amini, S. & Rosenberg, C. F.: Pseudomonas exotoxin shock. A preliminary report of studies in dogs. JAMA 205: 134, 1968
  • Balke, E. & Scharmann, W.: Untersuchungen an einer Protease (Elastase) aus Pseudomonas aeruginosa. II. Charcterisierung des Enzyms. Hoppe-Seyler's Z Physiol Chem 355: 958, 1974
  • Bjorn, M. J., Pavlovskis, O. R., Thompson, M. R. & Iglewski, B. H.: Production of exoenzyme S during Pseudomonas aeruginosa infections of burned mice. Infect Immun 24: 837, 1979
  • Bjorn, M. J., Sokol, P. A. & Iglewski, B. H.: Influence of iron on yields of extracellular products in Pseudomonas aeruginosa culture. J Bacteriol 138: 193, 1979
  • Bjorn, M. J., Vasil, M. L., Sadoff, J. C. & Iglewski, B. H.: Incidence of exotoxin production by Pseudomonas species. Infect Immun 16: 362, 1977
  • Brown, S. I., Bloomfield, S. E. & Tam, W. I.: The cornea-destroying enzyme of Pseudomonas aeruginosa. Invest Ophthalmol 13: 174, 1974
  • Callahan, L. T., III: Purification and characterization of Pseudomonas aeruginosa exotoxin. Infect Immun 9: 113, 1974
  • Callahan, L. T., III: Pseudomonas aeruginosa exotoxin: purification by preparative polyacrylamide gel electrophoresis and the development of a highly specific antitoxin serum. Infect Immun 14: 55, 1976
  • Cicmanec, J. F. & Holder, I. A.: Growth of Pseudomonas aeruginosa in normal and burned skin extract: role of extracellular proteases. Infect Immun 25: 477, 1979
  • Cryz, S. J. & Iglewski, B. H.: Production of alkaline protease by Pseudomonas aeruginosa. J Clin Microbiol 12: 131, 1980
  • DeBell, R. M.: Production of exotoxin A by Pseudomonas aeruginosa in a chemically defined medium. Infect Immun 24: 132, 1979
  • Gray, L. D. & Kreger, A. S.: Rabbit corneal damage produced by Pseudomonas aeruginosa infection. Infect Immun 12: 419, 1975
  • Gray, L. & Kreger, A.: Microscopic characterization of rabbit lung damage produced by Pseudomonas aeruginosa proteases. Infect Immun 23: 150, 1979
  • Greer, G. G. & Milazzo, F. H.: Pseudomonas aeruginosa lipopolysaccharide: factors influencing toxicity for isolated mitochondria and endotoxin properties. Can J Microbiol 22: 800, 1976
  • Hirao, Y & Homma, J. Y.: Therapeutic effect of immunization with OEP, protease toxoid and elastase toxoid on corneal ulcers in mice due to Pseudomonas aeruginosa infection. Jpn J Exp Med 48: 41, 1978
  • Holder, I. A. & Haidaris, C. G.: Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: extracellular protease and elastase as in vivo virulence factors. Can J Microbiol 25: 593, 1979
  • Homma, J. Y., Abe, C., Tanamoto, K., Hirao, Y., Morihara, K., Tsuzuki, H., Yanagawa, R., Honda, E., Aoi, Y., Fujimoto, Y., Goryo, M., Imazeki, N., Noda, H., Goda, A., Taeuchi, S. & Ishihara, T.: Effectiveness of immunization with single and multi-component vaccines prepared from a common antigen (OEP), protease and elastase toxoids of Pseudomonas aeruginosa on protection against hemorrhagic pneumonia in mink due to P. aeruginosa. Jpn J Exp Med 48: 111, 1978
  • Homma, J. Y., Tomiyama, T., Sano, H., Hirao, Y. & Saku, K.: Passive hemagglutination using formalinized sheep erythrocytes treated with tannic acid and coated with protease or elastase of Pseudomonas aeruginosa. Jpn J Exp Med 45: 361, 1975
  • Iglewski, B. H., Burns, R. P. & Gipson, I. K.: Pathogenesis of corneal damage from Pseudomonas aeruginosa exotoxin A. Invest Ophthalmol Vis Sci 16: 73, 1977
  • Iglewski, B. H. & Kabat, D.: NAD-dependent inhibition of protein synthesis by Pseudomonas aeruginosa toxin. Proc Natl Acad Sci USA 72: 2284, 1975
  • Iglewski, B. H., Liu, P. V. & Kabat, D.: Mechanism of action of Pseudomonas aeruginosa exotoxin A: adenosine diphosphate-ribosylation of mammalian elongation factor 2 in vitro and in vivo. Infect Immun 15: 138, 1977
  • Iglewski, B. H. & Sadoff, J. C.: Toxin inhibitors of protein synthesis: Production, purification, and assay of Pseudomonas aeruginosa toxin A. Methods Enzymol 60: 780, 1979
  • Jensen, S. E., Fecycz, I. T., Stemke, G. W. & Campbell, J. N.: Demonstration of a cell-associated, inactive precursor of an exocellular protease produced by Pseudomonas aeruginosa. Can J Microbiol 26: 87, 1980
  • Jensen, S. E., Phillippe, L., Teng Tseng, J., Stemke, G. W. & Campbell, J. N.: Purification and characterization of exocellular proteases produced by a clinical isolate and a laboratory strain of Pseudomonas aeruginosa. Can J Microbiol 26: 77, 1980
  • Kawaharajo, K., Abe, C., Homma, J. Y., Kawano, M., Gotoh, E., Tanaka, N. & Morihara, K.: Corneal ulcers caused by protease and elastase from Pseudomonas aeruginosa. Jpn J Exp Med 44: 435, 1974
  • Kawaharajo, K., Homma, J. Y., Aoyama, Y., Okada, K. & Morihara, K.: Effects of protease and elastase from Pseudomonas aeruginosa on skin. Jpn J Exp Med 45: 79, 1975
  • Kawaharajo, K. & Homma, J. Y.: Pathogenesis of the mouse keratitis produced with Pseudomonas aeruginosa. Jpn J. Exp Med 45: 515, 1975
  • Kawaharajo, K. & Homma, J. Y.: Synergistic effect of immune γ-globulin fraction on protection by antibiotic against corneal ulcers in experimental mice infected with Pseudomonas aeruginosa. Jpn J Exp Med 46: 155, 1976
  • Kawaharajo, K. & Homma, J. Y.: Effects of elastase, protease and common antigen (OEP) from Pseudomonas aeruginosa on protection against burns in mice. Jpn J Exp Med 47: 495, 1977
  • Kawaharajo, K., Homma, J. Y.: Aoyama, Y. & Morihara, K.: In vivo studies on protease and elastase from Pseudomonas aeruginosa. Jpn J Exp Med 45: 89, 1975
  • Kessler, E., Kennah, H. E. & Brown, S. I.: Pseudomonas protease. Purification, partial characterization, and its effect on collagen, proteoglycan, and rabbit corneas. Invest Ophthalmol Vis Sci 16: 488, 1977
  • Kessler, E., Mondino, B. J. & Brown, S. I.: The corneal response to Pseudomonas aeruginosa: histopathological and enzymatic characterization. Invest Ophthalmol Vis Sci 16: 116, 1977
  • Klinger, J. D., Straus, D. C., Hilton, C. B. & Bass, J. A.: Antibodies to proteases and exotoxin A of Pseudomonas aeruginosa in patients with cystic fibrosis: demonstration by radioimmunoassay. J Infect Dis 138: 49, 1978
  • Kobayashi, F.: Experimental infection with Pseudomonas aeruginosa in mice. I. The virulence of Pseudomonas aeruginosa for mice. Jpn J Microbiol 15: 295, 1971
  • Kreger, A. S. & Gray, L. D.: Purification of Pseudomonas aeruginosa proteases and microscopic characterization of pseudomonadal protease-induced rabbit corneal damage. Infect Immun 19: 630, 1978
  • Kreger, A. S. & Griffin, O. K.: Physicochemical fractionation of extracellular cornea-damaging proteases of Pseudomonas aeruginosa. Infect Immun 9: 828, 1974
  • Leake, E. S., Wright, M. J. & Kreger, A. S.: In vitro effect of purified proteases of Pseudomonas aeruginosa on rabbit lung macrophages. Exp Mol Pathol 29: 241, 1978
  • Leppla, S. H.: Large scale purification and characterization of the exotoxin of Pseudomonas aeruginosa. Infect Immun 14: 1077, 1976
  • Leppla, S. H., Martin, O. C. & Muehl, L. A.: The exotoxin of Pseudomonas aeruginosa: a proenzyme having an unusual mode of activation. Biochem Biophys Res Commun 81: 532, 1978
  • Leppla, S. H., Martin, O. C. & Pavlovskis, O. R.: Development of an efficacious glutaraldehyde toxoid of Pseudomonas aeruginosa exotoxin A. Abstr Annu Meet Am Soc Microbiol, B96, p. 29, 1978
  • Liu, P. V.: The roles of various fractions of Pseudomonas aeruginosa in its pathogenesis. III. Identity of the lethal toxins produced in vitro and in vivo. J Infect Dis 116: 481, 1966
  • Liu, P. V.: Exotoxins of Pseudomonas aeruginosa. I. Factors that influence production of exotoxin A. J Infect Dis 128: 506, 1973
  • Liu, P. V.: Extracellular toxins of Pseudomonas aeruginosa. J Infect Dis 130: S94, 1974
  • Liu, P. V. & Hsieh, H.-C.: Inhibition of protease production of various bacteria by ammonium salts: Its effect on toxin production and virulence. J Bacteriol 99: 406, 1969
  • Liu, P. V. & Hsieh, H.: Exotoxins of Pseudomonas aeruginosa. III. Characteristics of antitoxin A. J Infect Dis 128: 520, 1973
  • Liu, P. V., Yoshii, S. & Hsieh, H.: Exotoxins of Pseuodomonas aeruginosa. II. Concentration, purification and characterization of exotoxin A. J Infect Dis 128: 514, 1973
  • Morihara, K.: Production of elastase and proteinase by Pseudomonas aeruginosa. J Baceriol 88: 745, 1964
  • Morihara, K.: Pseudomonas aeruginosa proteinase. I. Purification and general properties. Biochim Biophys Acta 73: 113, 1963
  • Morihara, K.: Comparative specificty of microbial proteinases. Adv Enzymol 41: 179, 1974
  • Morihara, K. & Tsuzuki, Pseudomonas aeruginosa elastase: affinity chromatography and some properties as a metallo-neutral proteinase. Agr Biol Chem 39: 1123, 1975
  • Morihara, K. & Tsuzuki, H.: Production of protease and elastase by Pseudomonas aeruginosa strains isolated from patients. Infect Immun 15: 679, 1977
  • Morihara, K., Tsuzuki, H. & Oda, K.: Protease and elastase of Pseudomonas aeruginosa: inactivation of human plasma α1-proteinase inhibitor. Infect Immun 24: 188, 1979
  • Morihara, K., Tsuzuki, H., Oka, T., Inoue, H. & Ebata, M.: Pseudomonas aeruginosa elastase. Isolation, crystallization, and preliminary characterization. J Biol Chem 240: 3295, 1965
  • Mull, J. D. & Callahan, W. S.: The role of the elastase of Pseudomonas aeruginosa in experimental infection. Exp Mol Pathol 4: 567, 1965
  • Muszynski, Z. & Kedzia, W. B.: Production of extracellular substances by different virulent strains of Pseudomonas aeruginosa. J Hyg Epidemiol Microbiol Immunol 18: 313, 1974
  • Nishino, N. & Powers, J. C.: Pseudomonas aeruginosa elastase. Development of a new substrate, inhibitors, and an affinity ligand. J Biol Chem 255: 3482, 1980
  • Nordstoga, K.: Pseudomonas infections in mink with special reference to pseudomonas vasculitis in pulmonary lesions. Acta Vet Scand 9: 33, 1968
  • Pavlovskis, O. R., Iglewski, B. H. & Pollack, M.: Mechanism of action of Pseudomonas aeruginosa exotoxin A in experimental mouse infections: adenosine diphosphate ribosylation of elongation factor 2. Infect Immun 19: 29, 1978
  • Pavlovskis, O. R., Pollack, M., Callahan, L. T., III & Iglewski, B. H.: Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infection. Infect Immun 18: 596, 1977
  • Pavlovskis, O. R., & Shackelford, A. H.: Pseudomonas aeruginosa exotoxin in mice: localization and effects on protein synthesis. Infect Immun 9: 540, 1974
  • Pavlovskis, O. R., Voelker, F. A. & Shackelford, A. H.: Pseudomonas aeruginosa exotoxin in mice: histopathology and serum enzyme changes. J Infect Dis 133: 253, 1976
  • Pavlovskis, O. R. & Wretlind, B.: Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection. Infect Immun 24: 181, 1979
  • Pollack, M., Callahan, L. T., III & Taylor, N. S.: Neutralizing antibody to Pseudomonas aeruginosa exotoxin in human sera: evidence for in vivo toxin production during infections. Infect Immun 14: 942, 1976
  • Pollack, M. & Taylor, N. S.: Serum antibody to Pseudomonas aeruginosa exotoxin measured by passive hemagglutination assay. J Clin Microbiol 6: 58, 1977
  • Pollack, M. & Young, L. S.: Protective activity of antibodies to exotoxin A and lipoplysaccharide at the onset of Pseudomonas aeruginosa septicemia in man. J Clin Invest 63: 276, 1979
  • Saelinger, C. B., Snell, K. & Holder, I. A.: Experimental studies on pathogenesis of infections due to Pseudomonas aeruginosa: direct evidence for toxin production during pseudomonas infections of burned skin tissues. J Infect Dis 136: 555, 1977
  • Scharmann, W. & Balke, E.: Untersuchungen über eine Protease (Elastase) von Pseudomonas aeruginosa, I. Bildung und Reinigung der Protease. Hoppe Seylers Z Physiol Chem 355: 443, 1974
  • Schultz, D. R. & Miller, K. D.: Elastase of Pseudomonas aeruginosa: inactivation of complement components and complement-derived chemotactic and phagocytic factors. Infect Immun 10: 128, 1974
  • Sensakovic, J. W. & Bartell, P. F.: Biological activity of fragments derived from the extracellular slime glycolipoprotein of Pseudomonas aeruginosa. Infect Immun 12: 808, 1975
  • Sezen, I. Y., Scharmann, W. & Blobel, H.: Effects of an antiserum prepared against purified protease of Pseudomonas aeruginosa. Zentralbl Bakteriol [Orig A] 231: 126, 1975
  • Shimizu, T., Homma, J. Y., Aoyama, T., Onodera, T. & Noda, H.: Virulence of Pseudomonas aeruginosa and spontaneous spread of pseudomonas pneumonia in a mink ranch. Infect Immun 10: 16, 1974
  • Snell, K., Holder, I. A., Leppla, S. A. & Saelinger, C. B.: Role of exotoxin and protease as possible virulence vactors in experimental infections with Pseudomonas aeruginosa. Infect Immun 19: 839, 1978
  • Stieritz, D. D. & Holder, I. A.: Experimental studies of the pathogenesis of infections due to Pseudomonas aeruginosa: description of burned mouse model. J Infect Dis 131: 688, 1975
  • Stieritz, D. D. & Holder, I. A.: Experimental studies of the pathogenesis of Pseudomonas aeruginosa infection: evidence for the in vivo production of a lethal toxin, J Med Microbiol 11: 101, 1978
  • Takeshi, K. & Homma, J. Y.: Passive hemagglutination reaction using formalinized sheep erythrocytes treated with tannic acid and coated with exotoxin of Pseudomonas aeruginosa. Jpn J Exp Med 48: 497, 1978
  • Taylor, N. S. & Pollack, M.: Purification of Pseudomonas aeruginosa exotoxin by affinity chromatography. Infect Immun 19: 66, 1978
  • Tillotson, J. R. & Lerner, A. M.: Characteristics of nonbacteremic pseudomonas pneumonia. Ann Intern Med 68: 295, 1968
  • Van Horn, D. L., Davis, S. D., Hyndiuk, R. A. & Alpren, T. V. P.: Pathogenesis of experimental Pseudomonas keratitis in the guinea pig: bacteriologic, clinical and microscopic observations. Invest Ophthalmol Vis Sci 17: 1076, 1978
  • Vasil, M. L. & Iglewski, B. H.: Comparative toxicities of diphtherial toxin and Pseudomonas aeruginosa exotoxin A: evidence for different cell receptors. J Gen Microbiol 108: 333, 1978
  • Wretlind, B. & Kronevi, T.: Experimental infections with protease-deficient mutants of Pseudomonas aeruginosa in mice. J Med Microbiol 11: 145, 1978
  • Wretlind, B., Sjöberg, L. & Wadström, T.: Protease-deficient mutants of Pseudomonas aeruginosa: pleiotropic changes in activity of other extracellular enzymes. J Gen Microbiol 103: 329, 1977
  • Wretlind, B. & Wadström, T.: Purification and properties of a protease with elastase activity from Pseudomonas aeruginosa. J Gen Microbiol 103: 319, 1977

References

  • Basker, M. J., Edmondson, R. A. E. & Sutherland, R.: Comparative antibacterial activity of azlocillin, mezlocillin, carbenicillin and ticarcillin and relative stability to beta-lactamases of Pseudomonas aeruginosa and Klebsiella aerogenes. Infection 7: 67, 1979
  • Bennett, P. M. & Richmond, M. H.: Translocation of a discrete piece of deoxyribonucleic acid carrying an amp gene between replicons in Escherichia coli. J Bacteriol 126: 1, 1976
  • Bidwell, J. L. & Reeves, D. S.: Isoelectric focusing of β-lactamases. J Antimicrob Chemother 6: 793, 1980
  • Bidwell, J. L., Reeves, D. S. & Bullock, D. W.: Diversity of R-plasmids in epidemic Serratia marcescens from the South West of England. Proc. Symp. Fondazione Giovanni Lorenzini, “New trends in Antibiotics: Research and Therapy”. Elsevier/North-Holland (in press).
  • Boman, H. G., Nordström, K. & Normark, S.: Penicillin resistance in Escherichia coli K12; synergism between penicillinases and a barrier in the outer part of the envelope. Ann NY Acad Sci 235: 569, 1974
  • Brown, M. R. W.: Resistance of Pseudomonas aeruginosa. John Wiley, London and New York, 1975
  • Cohen, S. N.: Transposable genetic elements and plasmid evolution. Nature 263: 731, 1976
  • Costerton, J. W., Ingram, J. M. & Chen, K. J.: Structure and function of the cell envelope of Gram-negative bacteria. Bacteriol Rev 38: 87, 1974
  • Dale, J. W.: Purification of β-lactamases. In: Beta-lactamases, p. 73 (ed. J. M. T. Hamilton-Miller & J. T. Smith). Academic Press, London 1979
  • Dale, J. W. & Smith, J. T.: R-factor-mediated β-lactamases that hydrolyse oxacillin: Evidence for two distinct groups. J Bacteriol 119: 351, 1974
  • Datta, N. & Kontomichalou, P.: Penicillinase synthesis controlled by infectious R-factors in Enterobacteriaceae. Nature 208: 239, 1965
  • Egawa, R., Sawai, T. & Mitsuhashi, S.: Drug resistance of enteric bacteria. XII. Unique substrate specificity of penicillinase produced by R-factor. Jpn J Microbiol 11: 173, 1967
  • Fu, K. P. & Neu, H. C.: Beta-lactamase stability of HR756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin. Antimicrob Agents Chemother 14: 322, 1978
  • Fu, K. P. & Neu, H. C.: Azlocillin and mezlocillin: New ureidopenicillins. Antimicrob Agents Chemother 13: 930, 1978
  • Fuchs, P. C., Gavan, T. L., Gerlach, E. H., Jones, R. N., Barry, A. L. & Thornsberry, C.: Ticarcillin: A collaborative in vitro comparison with carbenicillin against over 9000 clinical bacterial isolates. Am J Med Sci 274: 255, 1977
  • Furth, A.: Purification and properties of constitutive β-lactamase from Pseudomonas aeruginosa strain Dalgleish. Biochim Biophys Acta 377: 431, 1975
  • Furth, A.: The β-lactamases of Pseudomonas aeruginosa. In: Beta-lactamases, p. 403 (ed. J. M. T. Hamilton-Miller & J. T. Smith). Academic Press, London 1979
  • Hamilton-Miller, J. M. T.: The effect of EDTA upon bacterial permeability to benzyl penicillin. Biochem Biophys Res Commun 20: 688, 1965
  • Hedges, R. W., Datta, N., Kontomichalou, P. & Smith, J. T.: Molecular specificites of R-factor-determined β-lactamases: Correlation with plasmid compatibility. J Bacteriol 117: 56, 1974
  • Hedges, R. W. & Jacob, A. E.: Transposition of ampicillin resistance from RP4 to other replicons. MGG 132: 31, 1974
  • Hedges, R. W. & Matthew, M.: Acquisition by Escherichia coli of plasmid-borne β-lactamases normally confined to Pseudomonas spp. Plasmid 2: 169, 1979
  • Heffron, F., Rubens, C. & Falcow, S.: Translocation of a plasmid DNA sequence which mediates ampicillin resistance: Molecular nature and specificity of insertion. Proc Natl Acad Sci USA 72: 3623, 1975
  • Hirai, K., Iyobe, S., Inoue, M. & Mitsuhashi, S.: Purification and properties of a new β-lactamase from Pseudomonas cepacia. Antimicrob Agents Chemother 17: 355, 1980
  • King, J. D., Farmer, T., Reading, C. & Sutherland, R.: Sensitivity to carbenicillin and ticarcillin, and the β-lactamases of Pseudomonas aeruginosa in the U. K. in 1978–79. J Clin Pathol 33: 297, 1980
  • Kleckner, N.: Transposition. Cell 11: 11, 1977
  • Matthew, M.: Properties of the β-lactamase specified by the Pseudomonas plasmid R151. FEMS Microbiology Letters 4: 241, 1978
  • Matthew, M.: Plasmid-mediated β-lactamases of Gram-negative bacteria: Properties and distribution. J Antimicrob Chemother 5: 349, 1979
  • Matthew, M. & Harris, A. M.: Identification of β-lactamases by analytical isoelectric focusing: Correlation with bacterial taxonomy. J Gen Microbiol 94: 55, 1976
  • Matthew, M., Harris, A. M., Marshall, M. J. & Ross, G. W.: The use of analytical isoelectric focusing for detection and identification of β-lactamases. J Gen Microbiol 88: 169, 1975
  • Matthew, M. & Sykes, R. B.: Properties of the beta-lactamase specified by the pseudomonas plasmid RPL11. J Bacteriol 132: 341, 1977
  • Mehta, R. J., Fox, M. K., Newman, D. J. & Nash, C. H.: An HPLC assay for cephalosporinase activity. J Antibiot 30: 1132, 1977
  • Neu, H. C.: Effect of beta-lactamase location in Escherichia coli on penicillin synergy. Appl Environ Microbiol 17: 783, 1969
  • Neu, H. C. & Fu, K. P.: Cefuroxime, a beta-lactamase-resistant cephalosporin with a broad spectrum of Gram-positive and -negative activity. Antimicrob Agents Chemother 13: 657, 1978
  • Newson, S. W. B., Sykes, R. B. & Richmond, M. H.: Detection of a β-lactamase markedly active against carbenicillin in a strain of Pseudomonas aeruginosa. J Bacteriol 101: 1079, 1970
  • Nordström, K. & Sykes, R. B.: Induction kinetics of β-lactamase biosynthesis in Pseudomonas aeruginosa. Antimicrob Agents Chemother 6: 734, 1974
  • Nordström, K. & Sykes, R. B.: Effects of sub-lethal concentrations of benzylpenicillin on Pseudomonas aeruginosa. Antimicrob Agents Chemother 6: 741, 1974
  • O'Callaghan, C. H., Muggleton, P. W. & Ross, G. W.: Effects of β-lactamase from Gram-negative organisms on cephalosporins and penicillins. Antimicrob Agents Chemother, p. 57 (ed. G. L. Hobby). American Society for Microbiology, Bethesda 1968
  • Reeves, D. S., Bywater, M. J., Holt, H. A. & Broughall, J. M.: Azlocillin and mezlocillin: Laboratory studies of their properties, including comparison with the antibacterial activity of other antibiotics. Arzneim Forsch 29: 1920, 1979
  • Richmond, M. H. & Curtis, N. A. C.: The interplay of beta-lactamases and intrinsic factors in the resistance of Gram-negative bacteria to penicillins and cephalosporins. Ann N Y Acad Sci 235: 553, 1974
  • Richmond, M. H. & Sykes, R. B.: The β-lactamases of Gram-negative bacteria and their possible physiological role. Adv Microb Physiol 9: 31, 1973
  • Ross, G. W. & Boulton, M. G.: Purification of β-lactamases on QAE-Sephadex. Biochim Biophys Acta 309: 430, 1973
  • Russell, A. D.: Ethylenediaminetetra-acetic acid. In: Inhibition and destruction of the microbial cell, p. 209. Academic Press, London 1971
  • Sabath, L. D. & Abraham, E. P.: Synergistic action of penicillins and cephalosporins against Pseudomonas pyocyanea. Nature 204: 1066, 1964
  • Sabath, L. D., Jago, M. & Abraham, E. P.: Cephalosporinase and penicillinase activities of a β-lactamase from Pseudomonas pyocyanea. Biochem J 96: 739, 1965
  • Sawada, Y., Yaginuma, S., Tai, M., Iyobe, S. & Mitsuhashi, S.: Resistance to β-lactam antibiotics in Pseudomonas aeruginosa. In: Microbial drug resistance, p. 391 (ed. S. Mitsuhashi & H. Hashimoto). University of Tokyo Press, Tokyo 1974
  • Stewart, D. & Bodey, G. P.: Azlocillin: In vitro studies of a new semisynthetic penicillin. Antimicrob Agents Chemother 11: 865, 1977
  • Sykes, R. B. & Matthew, M.: The β-lactamases of Gram-negative bacteria and their role in resistance to β-lactam antibiotics. J Antimicrob Chemother 2: 115, 1976
  • Sykes, R. B. & Matthew, M.: Detection, assay and immunology of β-lactamases. In: Beta-lactamases, p. 17 (ed. J. M. T. Hamilton-Miller & J. T. Smith). Academic Press, London 1979
  • Sykes, R. B. & Morris, A.: Resistance of Pseudomonas aeruginosa to antimicrobial drugs. In: Progress in medicinal chemistry, p. 333. North-Holland, Amsterdam 1975
  • Sykes, R. B. & Nordström, K.: Microiodometric determination of β-lactamase activity. Antimicrob Agents Chemother 1: 94, 1972
  • Sykes, R. B. & Richmond, M. H.: R-factors, β-lactamase and carbenicillin-resistant Pseudomonas aeruginosa. Lancet ii: 342, 1971
  • White, L. O. & Bidwell, J. L. Unpublished.
  • Wilkinson, S. G.: Sensitivity to ethylenediaminetetraacetic acid. In: Resistance of Pseudomonas aeruginosa, p. 145 (ed. M. R. W. Brown). John Wiley, London and New York 1975
  • Yaginuma, S., Terakado, N. & Mitsuhashi, S.: Biochemical properties of a penicillin β-lactamase mediated by R-factor from Bordetella bronchiseptica. Antimicrob Agents Chemother 8: 238, 1975

References

  • Bodey, G. P. & Le Blanc, B.: Piperacillin: In vitro evaluation. Antimicrob Agents Chemother 14: 78, 1978
  • Bryan, L. E.: Resistance to antimicrobial agents: The general nature of the problem and the basis of resistance. In: Pseudomonas aeruginosa, clinical manifestations of infection and current therapy, p. 219 (ed. R. G. Doggett). Academic Press, New York 1979
  • Daikos, G. K., Giamarellou, H., Hadjipolydorou, K. & Kanellakopoulou, K.: Pseudomonas infections of the lung treated with azlocillin, microbiology, pharmacokinetics, clinic. Arzneim Forsch 29: 1976, 1979
  • Diem, K.: Documenta Geigy Scientific Tables, p. 105. J. R. Geigy S. A., Basle 1962
  • Ellis, C. J., Geddes, A. M., Davey, P. G., Wise, R., Andrews, J. M. & Grimley, R. P.: Mezlocillin and azlocillin: An evaluation of two new β-lactam antibiotics. J Antimicrob Chemother 5: 517, 1979
  • Fu, K. P. & Neu, H. C.: Azlocillin and mezlocillin: New ureido penicillins. Antimicrob Agents Chemother 13: 930, 1978
  • Høiby, N.: Prevalence of mucoid strains of Pseudomonas aeruginosa in bacteriological specimens from patients with cystic fibrosis and patients with other diseases. Acta Pathol Microbiol Scand [B] 83: 549, 1975
  • Jones, R. N., Thornsberry, C., Barry, A. L., Fuchs, P. C., Gavan, T. L. & Gerlach, E. M.: Piperacillin (T-1220), a new semisynthetic penicillin: In vitro antimicrobial activity comparison with carbenicillin, ticarcillin, ampicillin, cephalothin, cefamandole and cefoxitin. J Antibiot 30: 1107, 1977
  • Lowbury, E. J. L. & Jones, R. J.: Treatment and prophylaxis for Pseudomonas infections. In: Resistance of Pseudomonas aeruginosa, p. 237 (ed. M. R. W. Brown). Wiley, London 1975
  • Michalsen, H. & Bergan, T.: Azlocillin in respiratory tract infections with Pseudomonas aeruginosa in children with cystic fibrosis. Chemotherapy 26: 135, 1980
  • Milne, S. E. & Waterworth, P. M.: Piperacillin, a new penicillin with high anti-pseudomonal activity. J Antimicrob Chemother 4: 247, 1978
  • Møller, N. E.: Side-effects of carbenicillin treatment in patients with cystic fibrosis with chronic infections with Pseudomonas aeruginosa. Ugeskr Læger 141: 1746, 1979
  • Møller, N. E. & Høiby, N.: Antibiotic treatment of chronic Pseudomonas aeruginosa infection in cystic fibrosis patients. Scand J Infect Dis, Suppl. 000000
  • Reyn, A., Bentzon, M. W. & Ericsson, H.: Comparative investigations of the sensitivity of N. gonorrhoeae to penicillin. Acta Pathol Microbiol Scand 57: 235, 1963
  • Roy, I., Abernathy, W. M., Bach, V. T. & Thadepalli, H.: In vitro activity of piperacillin against aerobic bacteria. Curr Ther Res 23: 200, 1978
  • Thadepalli, H. & Rao, B.: Clinical evaluation of mezlocillin. Antimicrob Agents Chemother 16: 605, 1979
  • Wise, R., Gillett, A. P., Andrews, J. M. & Bedford, K. A.: Activity of azlocillin and mezlocillin against gram-negative organisms: Comparison with other penicillins. Antimicrob Agents Chemother 13: 559, 1978

References

  • Adam, D. & Bauer, W.: Pharmakokinetische Untersuchungen mit der Kombination Mezlocillin-Oxacillin. Arzneim Forsch 29: 1971, 1979
  • Adam, D. & Roth, H.: Zur Diffusionsfähigkeit von Mezlocillin in das Prostatagewebe. Therapiewoche 30: 6990, 1980
  • Aronoff, G. R., Sloan, R. S., Luft, F. C., Nelson, R. L., Maxwell, D. R. & Kleit, S. A.: Mezlocillin pharmacokinetics in renal impairment. Clin Pharmacol Ther 28: 523, 1980
  • Baier, R., Puppel, H., Zelder, O. & Zehner, R.: Piperacillin-Konzentrationen in der Galle. In: Antimikrobielle Chemotherapie. Piperacillin Symposion (ed. W. Siegenthaler & K. Benkert), pp. 163–168. Lederle Arzneimittel, Wolfratshausen 1980
  • Batra, V. K., Morrison, J. A., Lasseter, K. C. & Joy, V. A.: Piperacillin kinetics. Clin Pharmacol Ther 26: 41, 1979
  • Bergan, T.: Pharmacokinetics of mezlocillin in healthy volunteers. Antimicrob Agents Chemother 14: 801, 1978
  • Bergan, T.: Penicillins. Antibiotics and Chemotherapy 25: 1, 1978
  • Bergan, T. Brodwall, E. K. & Wiik-Larsen, E.: Mezlocillin pharmacokinetics in patients with normal and impaired renal functions. Antimicrob Agents Chemother 16: 651, 1979
  • Bergan, T. & Michalsen, H.: Pharmacokinetics of azlocillin in children with cystic fibrosis. Arzneim Forsch 29: 1955, 1979
  • Bergan, T., Thorsteinsson, S. & Steingrimsson, O.: Dose dependent pharmacokinetics of azlocillin compared to mezlocillin. Submitted.
  • Bergan, T. & Williams, J. D.: Pharmacokinetics of piperacillin. Submitted.
  • Bergogne-Berezin, E., Even, P., Pierre, J. & Raynaud, P.: Penetration of mezlocillin into bronchial secretions. In: International Symposium Acylureido-Penicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 87–92. Excerpta Medica, Amsterdam 1980
  • Coppens, L. & Klastersky, J.: Comparative study of anti-Pseudomonas activity of azlocillin, mezlocillin, and ticarcillin. Antimicrob Agents Chemother 15: 396, 1979
  • Düben, W., Helwing, E., Tettenborn, D., Förster, D. & Püttner, J.: Die biliäre Exkretion von Azlocillin. Fortschr Med 97: 419, 1979
  • Evans, M. A. L., Wilson, P., Leung, T. & Williams, J. D.: Pharmacokinetics of piperacillin following intravenous administration. J Antimicrob Chemother 4: 255, 1978
  • Fiegel, P. & Becker, K.: Pharmacokinetics of azlocillin in persons with normal and impaired renal functions. Antimicrob Agents Chemother 14: 288, 1978
  • Francke, E. L., Appel, G. B. & Neu, H.: Pharmacokinetics of intraveonus piperacillin in patients undergoing chronic hemodialysis. Antimicrob Agents Chemother 16: 788, 1979
  • Francke, E., Mehta, S., Neu, H. & Appel, G. B.: Kinetics of intravenous mezlocillin in chronic hemodialysis patients. Clin Pharmacol Ther 26: 288, 1979
  • Friedrich, H., Pelz, K., Hänsel-Friedrich, G. & Isele, E.: Liquorspiegeluntersuchung von Mezlocillin bei Patienten mit und ohne Meningitis. Inn Med 6: 165, 1979
  • Frimodt-Møller, N., Maigaard, S., Toothaker, R. D., Bundtzen, R. W., Brodey, M. V., Craig, W. A., Welling, P. G. & Madsen, P. O.: Mezlocillin pharmacokinetics after single intravenous doses to patients with varying degree of renal function. Antimicrob Agents Chemother 17: 599, 1980
  • Gau, W. & Horster, F. A.: Hochdruckflüssigkeits-chromatographische Analyse von Azlocillin und seinem Penicilloat im Urin. Arzneim Forsch 29: 1941, 1979
  • Graber, H., Arr, M. & Csiba, A.: Biotransformation of azlocillin and mezlocillin. In: International Symposium Acylureido-Penicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 76–78. Excerpta Medica, Amsterdam 1980
  • Gundert-Remy, J., Förster, D. & Schacht, P.: Pharmakokinetische Untersuchungen von Mezlocillin unter besonderer Berücksichtigung der Galleausscheidung. In: Berichte über das Internationale Symposium Acylureido-Penicilline, Stuttgart 1978 (ed. K. H. Spitzy), pp. 137–143. Verlag für angewandte Wissenschaften, München 1978
  • Heimann, G., Heereman von, B. & Gladtke, E.: Pharmakokinetik von Azlocillin bei Früh- und Neugeborenen. Arzneim Forsch 29: 1949, 1979
  • Heimann, G.: Pharmacokinetics of azlocillin and mezlocillin in prematures and neonates. In: International Symposium Acylureido-Penicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 57–64. Excerpta Medica, Amsterdam 1980
  • Hoffmann, H.-G., Förster, D. & Schoen, I.: Mezlocillinkonzentrationen im Liquor bei Virusmeningitis. Infection 8: 162, 1989
  • Ishiyama, S., Nakayama, I., Iwamoto, H., Iwai, S., Takatori, M., Kawabe, T., Murata, I., Ohashi, M. & Mizuashi, H.: Antibacterial spectrum, absorption, excretion, distribution metabolism of mezlocillin and its clinical application to surgical field. Chemotherapy (Tokyo) 27 ( Suppl. 1): 325, 1979
  • Issell, B. F., Bodey, G. P. & Weaver, S.: Clinical pharmacology of mezlocillin. Antimicrob Agents Chemother 13: 180, 1978
  • Kalmar, P., Krebber, H. J., Müller-Schwefe, C., Malerczyk, V. & Wolf, W.: Mezlocillin-Konzentrationen in Gewebe und Serum während Herzoperationen. Herz 5: 314, 1980
  • Kampf, D., Schurig, R. Weihermüller, K. & Schacht, P.: Pharmacokinetics of azlocillin and mezlocillin in patients with chronic renal failure and haemodialysis or peritoneal dialysis. In: International Symposium Acylureido-Penicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 53–56. Excerpta Medica, Amsterdam 1980
  • Kobyletzki von, D. & Berkenberg, W.: Untersuchungen bei Anwendung von Mezlocillin in der Frauenheilkunde. Klinikarzt 8: 878, 1979
  • Kobyletzki von, D., Sas, W., Berkenberg, B. W., Pal, A., Förster, D. & Schacht, P.: Pharmakokinetische Untersuchungen bei Anwendung von Mezlocillin in der Frauenheilkunde. In: Bericht über das Internationale Symposium Acylureido-Penicilline, Stuttgart 1978 (ed. K. H. Spitzy), pp. 192–196. Verlag für angewandte Wissenschaften, München 1978
  • Kosmidis, J., Stathakis, Ch., Doundoulaki, P., Zerefos, N. & Daikos, G. K.: Mezlocillin: In vitro activity, therapeutic efficacy and pharmacokinetics in normal and impaired renal function. In: Proc. I. Mediterranean Congress of Chemotherapy, Madrid 1978, pp. 569–573.
  • Kosmidis, J., Doundoulaki, P., Stathakis, Ch., Zerefos, N., Bounia, A. & Daikos, G. K.: Elimination kinetics of mezlocillin in normal and impaired renal function including the effects of dialysis. Arzneim Forsch 29: 1960, 1979
  • Leroy, A., Humbert, G., Godin, M. & Fillastre, J. P.: Pharmacokinetics of azlocillin in subjects with normal and impaired renal function. Antimicrob Agents Chemother 17: 344, 1980
  • Lode, H., Tomas, W., Koeppe, P. & Wagner, J.: Clinical pharmacology of a new ureidopenicillin: Bay k 4999. Chemotherapy 26: 81, 1980
  • Lode, H., Niestrath, U., Koeppe, P. & Langmaack, H.: Azlocillin and mezlocillin. Zwei neue semisynthetische Acylureidopenicilline. Infection 5: 163, 1977
  • Mester, U., Hartwig, H., Krasemann, Ch. & Stein, H. J.: Tierexperimentelle Untersuchungen zur Pharmakokinetik von Azlocillin und Mezlocillin am Auge. In: Berichte über das Internationale Symposium Acylureido-Penicilline, Stuttgart 1978 (ed. K. H. Spitzy), pp. 199–205. Verlag für angewandte Wissenschaften, München 1978
  • Meyers, B. R. Hirschman, S. Z., Strougo, L. & Srulevitch, E.: Comparative study of piperacillin, ticarcillin, and carbenicillin pharmacokinetics. Antimicrob Agents Chemother 17: 608, 1980
  • Modai, J., Pierre, J., Bergogne-Berezin, E. & Avril, M. F.: Cerebrospinal fluid penetration of mezlocillin. Arzneim Forsch 29: 1967, 1979
  • Morikawa, Y., Haruta, T. & Kobayashi, Y.: Penicillin, carbenicillin, and ticarcillin. Passage in semisynthetic penicillins into the cerebrospinal fluid in experimental staphylococcal meningitis in rabbits. Proceedings 10th Int. Congr. Chemother, Vol. I, Zürich 1977, pp. 582–583. American Society for Microbiology, Washington 1978.
  • Münzel, M. & Schassan, H. H.: Concentrations of mezlocillin in tonsillar tissue. In: International Symposium Acylureido-penicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 93–94. Excerpta Medica, Amsterdam 1980
  • Ohlsson, H. & Bergan, T.: Comparison between the pharmacokinetic properties of mezlocillin when given intravenously as a bolus injection or as an infusion. Arzneim Forsch 29: 1958, 1979
  • Oishi, M., Nishizuka, K., Motoyama, M. & Ogawa, T.: Ophthalmic use of mezlocillin. Chemotherapy (Tokyo) 27 ( Suppl. 1): 389, 1979
  • Pancoast, S. J. & Neu, H. C.: Kinetics of mezlocillin and carbenicillin. Clin Pharmacol Ther 24: 108, 1978
  • Rosenkranz, H. & Förster, D.: Comparative study of the binding of acylureidopenicillins and carbenicillin to human serum proteins. Infection 7: 102, 1979
  • Scheld, W. M., Kely, W. J. & Sande, M. A.: Comparison of mezlocillin, azlocillin, piperacillin, and cefsulodin with tobramycin, ticarcillin, and carbenicillin, alone or in combination, in the therapy of experimental Pseudomonas meningitis. In: Current chemotherapy and infectious disease (ed. J. D. Nelson & Grassi). Proc. 11th Int. Congr. Chemother, and 19th Interschi. Conf. Antimicrob. Agents Chemother, Boston, October 1979, vol. 2. American Society for Microbiology, Washington, D.C., 1980
  • Schurig, R., Kampf, D., Becker, H. & Förster, D.: Pharmakokinetik von Azlocillin bei Niereninsuffizienz und Hämodialyse. Arzneim Forsch 29: 1944, 1979
  • Simon, C.: Piperacillin in Hautblasenflüssigkeit. In: Antimikrobielle Chemotherapie. Piperacillin Symposion (ed. W. Siegenthaler & K. Benkert), pp. 137–141. Lederle Arzneimittel, Wulfretshausen 1980
  • Sitka, U., Weingärther, L., Patsch, R. & Richter, R. & I.: Pharmacokinetics of azlocillin in neonates. Chemotherapy 26: 153, 1980
  • Thorsteinsson, S. B., Steingrimsson, O., Asmundsson, P. & Bergan, T.: Pharmacokinetics of mezlocillin during haemodialysis. Scand J Infect Dis, Suppl. 29: 59, 1981
  • Tjandramaga, T. B., Mullie, A., Verbesselt, R., De Schepper, P. J. & Verbist, L.: Piperacillin: Human pharmacokinetics after intravenous and intramuscular administration. Antimicrob Agents Chemother 14: 829, 1978
  • Tunn, U. W. & Adam, D.: Konzentrationen von piperacillin im menschlichen Prostatagewebe. In: Antimikrobielle Chemotherapie. Piperacillin Symposion (ed. W. Siegenthaler & K. Benkert), pp. 153–158. Lederle Arzneimittel, Wolfratshausen 1980
  • Ullmann, V. & Wurst, W.: Antibacterial active components in human urine after administration of penicillins. Infection 7: 187, 1979
  • Verbist, L.: Comparison of the activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and Bay k 4999 against Gram-negative organisms. Antimicrob Agents Chemother 16: 115, 1979
  • Verbist, L., Tjandramaga, T. B., Verbesselt, R. & De Schepper, P. J.: Mezlocillin pharmacokinetics. Comparison with ampicillin and influence of probenecid. Arzneim Forsch 29: 1962, 1979
  • Vent, J.: Azlocillin-Konzentration im menschlichen Knochen. In: Berichte über das Internationale Symposium Acylureido-Penicilline, Stuttgart 1978 (ed. K. H. Spitzy), pp. 197–198. Verlag für angewandte Wissenschaften, München 1978
  • Vent, J.: Mezlocillin-Konzentrationen im menschlichen Knochen. Arzneim Forsch 29: 1969, 1979
  • Weingärtner, L., Sitka, U., Patsch, R., Richter, I. & Thiemann, H. H.: Zur Frage der Ausscheidung von Azlocillin in das Bronchialsekret im Kindesalter. Arzneim Forsch 29: 1952, 1979
  • Wewalka, G., Endler, M. & Kraft, A.: Concentration of mezlocillin in wound secretion. In: International Symposium Acylureidopenicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 81–85. Excerpta Medica, Amsterdam 1980
  • White, G. W., Malow, J. B., Zimelis, V. M., Pahlavanzadeh, H., Panwalker, A. P. & Jackson, G. G.: Comparative in vitro activity of azlocillin, ampicillin, mezlocillin, piperacillin, and ticarcillin, alone and in combination with an aminoglycoside. Antimicrob Agents Chemother 15: 140, 1979
  • Wirth, K., Schomerus, M. & Hengstmann, J. H.: Zur Pharmakokinetik von Azlocillin, einem neuen halbsynthetischen Breitspektrumantibiotikum. Infection 4: 25, 1976
  • Wise, R., Cadge, B., Gillett, A. P., Bhamjee, A., Livingston, R., Welling, P. G. & Thornhill, D. P.: Pharmacokinetics of Bay k 4999, a new broad-spectrum penicillin. Antimicrob Agents Chemother 15: 670, 1979
  • Wise, R., Gillett, A. P., Cadge, B., Durham, S. R. & Baker, S.: The influence of protein binding upon tissue fluid levels of six β-lactam antibiotics. J Infect Dis 142: 77, 1980
  • Wittmann, D. H. & Schassan, H.-H.: Piperacillin-Konzentrationen im Serum, Knochen, Peritonealexsudat und in der interstitiellen Flüssigkeit bei hospitalisierten Patienten. In: Antimikrobielle Chemotherapie. Piperacillin Symposium (ed. W. Siegenthaler & K. Benkert), pp. 142–152. Lederle Arzneimittel, Wolfratshausen 1980
  • Wittmann, D. H., Welter, J. & Schassan, H. H.: Untersuchungen über die Penetration von β-lactam-Antibiotika in das Peritonealexsudat als Grundlage der systematischen Peritonitistherapie. In: Peritonitis (ed. R. Häring). TM-Verlag, Bad Oeynhausen, West-Germany, 1979).
  • Wittman, D. H., Schassan, H. H. & Schreiner, P.: Pharmacokinetic investigations into the penetration of azlocillin and mezlocillin into bone and wound tisse fluid. In: International Symposium Acylureidopenicillins, Vienna 1979 (ed. W. Siegenthaler), pp. 85–86. Excerpta Medica, Amsterdam 1980

References

  • Bergan, T.: Pharmacokinetics of mezlocillin in healthy volunteers. Antimicrob Agents Chemother 14: 801, 1978
  • Bergan, T., Brodwall, E. K. & Wiik-Larsen, E.: Mezlocillin pharmacokinetics in patients with normal and impaired renal functions. Antimicrob Agents Chemother 16: 651, 1979
  • Bergan, T., Thorsteinsson, S. B. & Steingrimsson, O.: Dose-dependent pharmacokinetics of azlocillin compared to mezlocillin. Submitted.
  • Bergan, T., Williams, J. D. : Pharmacokinetics of Piperacillin. In preparation.
  • Bonsnes, R. W. & Tausky, H. H.: On the colorimetric determination of creatinine by the Jaffe reaction. J Biol Chem 158: 581, 1945
  • Chabbert, Y. A. & Boulingre, A.: Modifications pratiques concernant le dosage des antibiotiques en clinique. Rev Fr Etud Clin Biol 2: 636, 1957
  • Coppens, L. & Klastersky, J.: Comparative study of anti-Pseudomonas activity of azlocillin, mezlocillin and ticarcillin. Antimicrob Agents Chemother 15: 396, 1979
  • Düben, W., Helwing, E., Tettenborn, D., Förster, D. & Pütter, J.: Die biliäre Exkretion von Azlocillin. Fortschr Med 97: 419, 1979
  • Fiegel, P. & Becker, K.: Pharmacokinetics of azlocillin in persons with normal and impaired renal functions. Antimicrob Agents Chemother 14: 288, 1978
  • Fu, K. P. & Neu, H. C.: Azlocillin and mezlocillin: New ureidopenicillins. Antimicrob Agents Chemother 13: 930, 1978
  • Gau, W. Horster, F. A.: Hochdrucksflüssigkeits-chromatographische Analyse von Azlocillin und seinem Penicilloat im Urin. Arzneim Forsch 29: 1941, 1979
  • Grove, D. C. & Randall, W. A.: Assay methods of antibiotics: a laboratory manual. Antibiot Monography No. 2 Medical Encylopedia, New York, 1955, pp. 34–36.
  • Gundert-Remy, J., Förster, D. & Schacht, P.: Pharmakokinetische Untersuchungen von Mezlocillin unter besonderer Berüchsichtigung der Galleausscheidung. In: Berichte über das Internationale Symposium Acylureido-Penicilline. Stuttgart 1978 (ed. K. H. Spitzy), pp. 137–143. Verlag für angewandte Wissenschaften, München 1978
  • Hoffman, T. A., Cestero, R. & Bullock, W. E.: Pharmacodynamics of carbenicillin in hepatic and renal failure. Ann Intern Med 73: 173, 1970
  • Höffler, D., Stegemann, I. & Scheler, F.: Ampicillin Spiegel in Serum und Harn bei eingeschränkter Nierenfunktion. Dtsch Med Wschr 91: 206, 1966
  • König, B., Metzger, K., Mürmann, P., Offe, H. & Schröck, W.: Azlocillin: Ein neues Penicillin gegen Pseudomas aeruginosa und andere Gram-negative Bakterien. Infection 5: 60, 1977
  • Leroy, A., Humbert, G., Godin, M. & Fillastre, J. P.: Pharmacokinetics of azlocillin in subjects with normal and impaired renal function. Antimicrob Agents Chemother 17: 344, 1980
  • Levy, G. & Gibaldi, M.: Pharmacokinetics. In: Handbook of experimental pharmacology. New Series: concepts in biochemical pharmacology, vol. 28, part 3 (ed J. R. Gillette & J. R. Mitchell), 6–18–20. Springer-Verlag, Berlin 1975
  • Lode, H., Niestrath, U., Koeppe, P. & Langmaack, H.: Azlocillin und Mezlocillin: Zwei neue semisynthetische Acylureidopenicilline. Infection 5: 163, 1977
  • Stewart, D. & Bodey, G. P.: Azlocillin: In vitro studies of a new semisynthetic penicillin. Antimicrob Agents Chemother 11: 865, 1977
  • Werner, H., Krasemann, C., Ungerechts, J. & Schmitz, H. J.: Die in vitro Aktivität von Mezlocillin, Azlocillin and Carbenicillin gegen Bacteroidaceae unter besonderer Berücksichtigung der fragilis-Gruppe. Infection 5: 17, 1977
  • Wirth, K., Schomerus, M. & Hengstmann, J. H.: Zur Pharmacokinetik von Azlocillin, einem neuen halbsynthetischen Breitspektrumantibiotikum. Infection 4: 25, 1976
  • Wise, R., Gillett, A. P., Andrews, J. M. & Bedford, K. A.: Activity of azlocillin and mezlocillin against Gram-negative organisms: Comparison with other penicillins. Antimicrob Agents Chemother 13: 559, 1978
  • Youden, W. J.: Statistical methods for chemists, pp. 42–43. Wiley, New York 1959

References

  • Aletta, J. M., Francke, E. F. & Neu, C.: Intravenous azlocillin kinetics in patients on long-term hemodialysis. Clin Pharmacol Ther 27: 563, 1980
  • Düben, W., Helwing, E., Tettenborn, D., Förster, D. & Pütter, J.: Die biliäre Exkretion von Azlocillin. Fortschr Med 97: 419, 1979
  • Fiegel, P. & Becker, K.: Pharmacokinetics of azlocillin in persons with normal and impaired renal functions. Antimicrob Agents Chemother 14: 288, 1978
  • Jørstad, S., Smeby, L. C., Widerøe, T. E. & Berg, K. J.: Removal of uremic toxins and regeneration of hemofiltrate by a selective dual hemofiltration artificial kidney (SEDUFARK) system. Clin Nephrol 13: 85, 1980
  • Leroy, A., Humbert, G., Godin, M. & Fillastre, J. P.: Pharmacokinetics of azlocillin in subjects with normal and impaired renal function. Antimicrob Agents Chemother 17: 344, 1980
  • Man, N. K., Granger, A., Rondon-Nucete, M., Zingraff, J., Junger, S. P., Sausse, A. & Funck-Brentano, J. L.: One year follow-up of short dialysis with membrane highly permeable to middle molecule. Proc Europ Dialysis and Transpl Ass 10: 236, 1973
  • Ramsey, J. C. & Gehring, P. J.: Application of pharmacokinetic principles in practice. Federation Proceedings 39: 60, 1980
  • Schurig, P., Kampf, D., Weihermüller, K. & Schacht, P.: Effect of hemodialysis and peritoenal dialysis on the pharmacokinetics of azlocillin and mezlocillin. In: Current chemotherapy and infectious diseases (ed. J. D. Nelson & C. Grassi), p. 576. The American Society for Microbiology, Washington, DC, 1980
  • Stewart, D. & Bodey, G. P.: Azlocillin—in vitro studies of a new semisynthetic penicillin. Antimicrob Agent Chemother 11: 865, 1977
  • Wirth, K., Schomerus, M. & Hengstmann, J. H.: Zur Pharmakokinetik von Azlocillin, einem neuen halbsynthetischen Breitspektrumantibiotikum. Infection 4: 25, 1976

References

  • Bergan, T.: Pharmacokinetics of mezlocillin in healthy volunteers. Antimicrob Agents Chemother 14: 801, 1978
  • Bergan, T.: Overview of acylureidopenicillin pharmacokinetics. Scand J Infect Dis, Suppl. 29: 33, 1981
  • Bergan, T., Brodwall, E. K. & Wiik-Larsen, E.: Mezlocillin pharmacokinetics in patients with normal and impaired renal functions. Antimicrob Agents Chemother 16: 651, 1979
  • Bergan, T., Brodwall, E. K. & Ørjavik, O.: Pharmacokinetics of cefazolin in patients with normal and impaired renal function. J Antimicrob Chemother 3: 435, 1977
  • Francke, E., Mehta, S., Neu, H. & Appel, G. B.: Kinetics of intravenous mezlocillin in chronic hemodialysis patients. Clin Pharmacol Ther 26: 228, 1979
  • Frimodt-Møller, N., Maigaard, S., Toothaker, R. D., Bundtzen, R. W., Brodey, M. V., Craig, W. A., Welling, P. G. & Madsen, P. O.: Mezlocillin pharmacokinetics after single intravenous doses to patients with varying degrees of renal function. Antimicrob Agents Chemother 17: 599, 1980
  • Hoffman, T. A., Cestero, R. & Bullock, W. E.: Pharmacodynamics of carbenicillin in patients with hepatic and renal failure. Ann Intern Med 73: 173, 1980
  • Kosmidis, J., Stathakis, Ch., Doundoulaki, P., Zerefos, N. & Daikos, G. K. Mezlocillin: in vitro activity, therapeutic efficacy and pharmacokinetics in normal and impaired renal function. In: Proc. I Mediterranean Congress of Chemotherapy, Madrid 1978, pp. 569–573.
  • Lode, N. Niestrath, U., Koepe, P. & Langmack, H.: Azlocillin und Mezlocillin. Zwei neue semisynthetische Acylureidopenicilline. Infection 5: 163, 1977
  • Neu, H. C. & Garvey, G. J.: Comparative in vitro activity and clinical pharmacology of ticarcillin and carbenicillin. Antimicrob Agents Chemother 8: 457, 1975
  • Parry, M. F. & Neu, H. C.: Ticarcillin for treatment of serious gram-negative infections with gram-negative bacteria. J Infect Dis 134: 476, 1976
  • Verbist, L.: Comparison of the activities of the new ureidopenicillins piperacillin, mezlocillin, azlocillin, and Bay k 4999 against Gram-negative organisms. Antimicrob Agents Chemother 16: 115, 1979
  • White, G. W., Malow, J. B., Zimelis, V. M., Pahlavanzadeh, H., Panwalker, A. P. & Jackson, G. G.: Comparative in vitro activity of azlocillin, ampicillin, mezlocillin, piperacillin, and ticarcillin, alone and in combination with an aminoglycoside. Antimicrob Agents Chemother 15: 140, 1979
  • Wagner, J. G.: Fundamentals of pharmacokinetics. Drug Intelligence Publications, Hamilton, Ill., 1975
  • Weber, E.: Grundriss der biologischen Statistik. Gustav Fischer Verlag, Stuttgart 1972

References

  • Bergan, T. & Michalsen, H.: Pharmacokinetics of azlocillin in children with cystic fibrosis. Arzneim Forsch 29: 1955, 1979
  • Daikos, G. K., Giamarellou, M., Hadjipolydorou, A. & Kanellakopoulou, K. J.: In vitro and in vivo activity of azlocillin against Pseudomonas aeruginosa. Proc 10th Int Congr Chemotherapy Curr Chemother 1: 626, 1977
  • Daikos, G. K., Giamarellou, H., Hadjipolydorou, K. & Kanellakopoulou, K. J.: Pseudomonas infections of the lung treated with azlocillin: Microbiology, pharmacokinetics, clinic. Arzneim Forsch 29: 1976, 1979
  • Ericsson, H. M. & Sherris, J. C.: Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand (B), Suppl. 217, 1971
  • Friis, B.: Chemotherapy of chronic infections with mucoid Pseudomonas aeruginosa in lower airways of patients with cystic fibrosis. Scand J Infect Dis 11: 211, 1979
  • Fu, K. P., Sainz, L. & Neu, H. C.: Synergy studies of azlocillin and mezlocillin combined with gentamicin, netilmicin and amikacin. 16th Interscience Conference on Antimicrobial Agents and Chemotherapy, Chicago 1976, Abstract 1.
  • Hawley, H. B., Lewis, R. M., Swartz, D. R. & Gump, D. W.: Tobramycin therapy of pulmonary infections in patients with cystic fibrosis. Curr Therap Res 16: 414, 1974
  • Helm, E. B., Ristou, W., Shah, R. M., Schacht, P. & Stille, W.: Behandlung von Pseudomonas-Infektionen mit dem neuen Ureidopenicillin Azlocillin. Dtsch Med Wschr 102: 1211, 1977
  • Huang, N. N. & Doggett, R. G.: Antibiotic therapy of Pseudomonas infection in patients with cystic fibrosis. In: Pseudomonas aeruginosa. Clinical manifestations of infection and current therapy (ed. R. G. Doggett), p. 409. Academic Press, 1979
  • Høiby, N., Flensborg, E. W., Beck, B., Jacobsen, S. V. & Jacobsen, L.: Pseudomonas aeruginosa infection in cystic fibrosis: Diagnostic and prognostic significans of Pseudomonas aeruginosa precipitins determinated by means of crossed immunoelectrophoresis. Scand J Respir Dis 58: 65, 1977
  • Knothe, H.: Die antibakterielle Aktivität von Mezlocillin and Azlocillin. Arzneim Forsch 29: 1916, 1979
  • König, B., Metzger, K., Mürmann, P., Offe, H. & Schröck, W.: Azlocillin: Ein neues Penicillin gegen Pseudomonas aeruginosa und andere gramnegative Bakterien. Infection 5: 60, 1977
  • Lode, H., Niestrath, U., Koeppe, P. & Langmaack, H.: Azlocillin und Mezlocillin: Zwei neue semisynthetische Acylureido-Penicilline. Infection 5: 163, 1977
  • Marks, M. I., Prentice, R., Swarson, R., Cotton, E. K. & Eickhoff, T. C.: Carbenicillin and gentamicin: Pharmacologic studies in patients with cystic fibrosis and pseudomonas pulmonary infections. J Pediatr 79: 822, 1971
  • McCrae, W. M., Raeburn, J. A. & Hanson, E. J.: Tobramycin therapy of infections due to Pseudomonas aeruginosa in patients with cystic fibrosis: Effect of dosage and concentration of antibiotic in sputum. J Infect Dis 134 ( Suppl): 191, 1976
  • Michalsen, H. & Bergan, T.: Azlocillin in respiratory tract infections with Pseudomonas aeruginosa in children with cystic fibrosis. Chemotherapy 26: 135, 1980
  • Parry, M. F., Neu, H. C., Merlino, M., Gaerlan, P. F., Ores, C. N. & Denning, C. R.: Treatment of pulmonary infections in patients with cystic fibrosis: A comparative study of ticarcillin and gentamicin. J Pediatr 90: 144, 1977
  • Shibl, A. M. & Al-Sowaygh, J. A.: Inhibition of Pseudomonas aeruginosa slime production by staphylococcal extracellular product. J Clin Microbiol 11: 123, 1980
  • Shwachman, H. & Kulczycki, L. L.: Long-term study of one hundred five patients with cystic fibrosis. Am J Dis Child 96: 6, 1958
  • Stewart, D. & Bodey, G. P.: Azlocillin: In vitro studies of a new semisynthetic penicillin. Antimicrob Agents Chemother 11: 865, 1977
  • Yuce, K. & van Rooyen, C. E.: Carbenicillin and gentamicin in the treatment of Pseudomonas aeruginosa infection. CMA Journal 105: 919, 1971

References

  • Alexander, J. W., Stinnett, J. D., Ogle, C. K., Ogle, J. D. & Morris, M. J.: A comparison of immunologic profiles and their influence on bacteremia in surgical patients with a high risk of infection. Surgery 86: 94, 1979
  • Anderson, R. J., Schafer, L. A., Olin, D. B. & Eickhoff, T. S.: Infectious risk factors in the immuno-suppressed host. Am J Med 54: 453, 1973
  • Andriole, V. T.: Pseudomonas bacteriemia: can antibiotic therapy improve survival? J Lab Clin Med 94: 196, 1979
  • Arala-Chaves, M. P., Silva, M. B. M., Porto, M. T., Santerem, M. G. & Fudenberg, H. K.: Suppressor substances secreted by Pseudomonas aeruginosa. Abstract No. 17, 1, 04, 4th International Congress of Immunology, Paris, 1980
  • Baltch, A. L. & Griffin, P. E.: Pseudomonas aeruginosa bacteremia: a clinical study of 75 patients. Am J Med Sci 174, 119, 1977
  • Biggar, W. D., Holmes, B. & Good, R. A.: Opsonic defect in patients with cystic fibrosis of the pancreas. Proc Natl Acad Sci 68: 1716, 1971
  • Bjornson, A. B., Altemeier, W. A. & Bjornson, H. S.: Changes in humoral components of host defense following burn trauma. Ann Surg 186: 88, 1977
  • Bodey, G. P., Sathe, Y. S. & Freireich, E. F.: Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64: 328, 1966
  • Braude, A. J., Ziegler, E. J., Douglas, H. & McCutchan, J. A.: Antibody to cell wall glycolipid of gram-negative bacteria. J Infect Dis 136 ( Suppl.): S 167–S 173, 1977
  • Burdon, K. L.: Textbook of microbiology. Macmillan, New York 1949
  • Chandra, R. K.: Interactions of nutrition, infection and immune response. Immunocompetence in nutritional deficiency, methodological considerations and intervention strategies. Acta Pædiatr Scand 68: 137, 1979
  • Colizzi, V., Campa, M., Garzelli, C. & Falcone, G.: Pseudomonas aeruginosa infection depresses contact sensitivity to oxazolone by enhancing suppressor cell activity. Med Microbiol Immunol 167: 181, 1979
  • Dale, D. C., Guerry, D., Wewerka, J. R., Bull, J. M. & Chusid, M. J.: Chronic neutropenia. Medicine (Baltimore) 58: 128, 1979
  • Fearon, D. T., Ruddy, S., Schur, P. H. & McCabe, W. R.: Activation of the properdin pathway of complement in patients with gram-negative bacteremia. N Engl J Med 292: 937, 1975
  • Flick, M. R. & Cluff, L. E.: Pseudomonas bacteremia. Review of 108 cases. Am J Med 60: 501, 1976
  • Füst, G., Petras, G. & Ujhelyi, E.: Activation of the complement system during infections due to gram-negative bacteria. Clin Immunol Immunopathol 5: 293, 1976
  • Gurwith, M. J., Brunton, J. L., Lank, B. A., Ronald, A. R. & Harding, G. K. M.: Granulocytopenia in hospitalized patients. I. Prognostic factors and etiology of fever. Am J Med 64: 121, 1978
  • Hamilton, J. R. & Overall, J. C.: Synergistic infection with a murine cytomegalovirus and Pseudomonas aeruginosa in mice. J Infect Dis 137: 775, 1978
  • Hayward, A. R.: Immunodeficiency. Edward Arnold Ltd., London 1977
  • Hersh, E. M., Gutterman, J. U. & Mavligit, G. M.: Effect of haematological malignancies and their treatment on host defence factors. Clin Haematol 5: 425, 1976
  • Howard, R. J.: Effect of burn injury, mechanical trauma, and operation on immune defenses. Surg Clin North Am 59: 199, 1979
  • Höiby, N., Flensborg, E. W., Beck, B., Friis, B., Jacobsen, S. V. & Jackson, L.: Pseudomonas aeruginosa infection in cystic fibrosis. Diagnostic and prognostic significance of Pseudomonas aeruginosa precipitins determined by means of crossed immunoelectrophoresis. Scand J Respir Dis 58: 65, 1977
  • Jacob, H. S., Craddock, P. R., Hammerschmidt, D. E. & Moldow, C. F.: Complement-induced granulocyte aggregation. An unsuspected mechanism of disease. N Engl J Med 302: 789, 1980
  • Johanson, W. G., Woods, D. E. & Chaudhuri, T.: Association of respiratory tract colonization with adherence of gram-negative bacilli to epithelial cells. J Infect Dis 139: 667, 1979
  • Johnston, R. B. & Stroud, R. M.: Complement and host defense against infection. J Pediatr 90: 169, 1977
  • Kerby, G. P.: Pseudomonas aeruginosa bacteremia: Summary of literature, with report of a case. Am J Dis Child 74: 610, 1947
  • Klebanoff, S. J. & Clark, R. A.: The neutrophil: Function and clinical disorders. North-Holland Publ. Co., Amsterdam, New York, Oxford 1978
  • Kreger, B. E., Craven, D. E. & McCabe, W. R.: Gram-negative bacteremia. IV. Re-evaluation of clinical features and treatment in 612 patients. Am J Med 68: 344, 1980
  • Lazarus, G. M. & Neu, H. C.: Agents responsible for infection in chronic granulomatous disease of childhood. J Pediatr 86: 415, 1975
  • McCall, C., Bartlett, L., Qualliotine-Mann, D., De-Chatelet, L. & Cooper, R.: Isolated IgM deficiency and defective opsonic activity against Pseudomonas. Clin Res 26: 607, 1973
  • McFarlane, H., Holzel, A., Brenchley, P., Allan, J. P., Wallwork, J. C., Singer, B. E. & Worsley, B.: Immune complexes in cystic fibrosis. Br Med J 1: 423, 1975
  • Moss, R. B. & Lewiston, N. J.: Immune complexes and humoral response to Pseudomonas aeruginosa in cystic fibrosis. Am Rev Respir Dis 121: 23, 1980
  • Murphy, J. F., McDonald, F. D., Dawson, M., Reite, A., Turcotte, J. & Fekety, F. R.: Factors affecting the frequency of infection in renal transplant recipients. Arch Intern Med 136: 670, 1976
  • Nauta, E. H. & van Furth, R.: Infection in immunodepressed patients. The approach to diagnosis and treatment. Infection 3: 202, 1975
  • Osler, W. & McCrae, T.: Modern medicine: Its theory and practice. Lea and Febiger, Philadelphia 1913
  • Pavlovskis, O. R., Pollach, M., Callahan, L. T. & Iglewski, B. H.: Passive protection by antitoxin in experimental Pseudomonas aeruginosa burn infection. Infect Immun 18: 596, 1977
  • Pavlovskis, O. R. & Wretlind, B.: Assessment of protease (elastase) as a Pseudomonas aeruginosa virulence factor in experimental mouse burn infection. Infect Immun 24: 181, 1979
  • Pennington, J. E., Reynolds, H. Y. & Carbone, P. P.: Pseudomonas pneumonia. A retrospective study of 36 cases. Am J Med 55: 155, 1973
  • Pollack, M. & Anderson, S. E.: Toxicity of Pseudomonas aeruginosa exotoxin A for human macrophages. Infect Immun 19: 1092, 1978
  • Pruitt, B. A.: Infections caused by Pseudomonas species in patients with burns and in other surgical patients. J Infect Dis 130 ( Suppl.):S 8–S 13, 1974
  • Reinherz, E. L., Morimoto, C., Penta, A. C. & Schlossman, S. F.: Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man. Eur J Immunol 10: 570, 1980
  • Reynolds, H. Y.: Lung host defenses: A status report. Chest 75 ( Suppl.): 239, 1979
  • Reynolds, H. Y., Levine, A. S., Wood, R. E., Zierdt, C. H., Dale, D. C. & Pennington, J. E.: Pseudomonas aeruginosa infections: Persisting problems and current research to find new therapies. Ann Intern Med 82: 819, 1975
  • Saba, T. M. & Jaffe, E.: Plasma fibronectin (opsonic glycoprotein): Its synthesis by vascular endothelial cells and role in cardiopulmonary integrity after trauma as related to reticuloendothelial function. Am J Med 68: 577, 1980
  • Schimpff, S. C., Greene, W. H., Young, V. M. & Wiernik, P. H.: Pseudomonas septicaemia: Incidence, epidemiology, prevention and therapy in patients with advanced cancer. Eur J Cancer 9: 449, 1973
  • Schiötz, P. B., Höiby, N., Juhl, F., Permin, H., Nielson, H. & Svehag, S. E.: Immune complexes in cystic fibrosis. Acta Pathol Microbiol Scand (C) 85: 57, 1977
  • Schultz, D. R. & Miller, K. D.: Elastase of Pseudomonas aeruginosa: Inactivation of complement components and complement-derived chemotactic and phagocytic factors. Infect Immun 10: 128, 1974
  • Schumer, W.: Steroids in the treatment of clinical septic shock. Ann Surg 184: 333, 1976
  • Seager, K., Bashir, H. V. Geczy, A. F., Edmonds, J. & Vere-Tyndall, A. C.: Evidence for a specific B 27-associated cell surface marker on lymphocytes of patients with ankylosing spondylitis. Nature 277: 68, 1979
  • Sensakovic, J. W. & Bartell, P. F.: The slime of Pseudomonas aeruginosa; biological characterization and possible role in experimental infection. J Infect Dis 129: 101, 1974
  • Shigeoka, A. O. & Hill, H. R.: Recurrent Pseudomonas infection associated with neutrophil dysfunction. Scand J Infect Dis 10: 307, 1978
  • Sickles, E. A., Greene, W. H. & Wiernik, P. H.: Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 135: 715, 1975
  • Singer, C., Kaplan, M. H. & Armstrong, D.: Bacteremia and fungemia complicating neoplastic disease. A study of 364 cases. Am J Med 62: 731, 1977
  • Sorensen, R. U., Stern, R. C. & Polmar, S. H.: Lymphocyte responsiveness to Pseudomonas aeruginosa in cystic fibrosis: Relationship to status of pulmonary disease in sibling pairs. J Pediatr 93: 201, 1978
  • Speirs, C. F., Selwyn, S. & Nicholson, D. N.: Hypogammaglobulinemia presenting as Pseudomonas septicaemia. Lancet, ii: 710, 1963
  • Tillotson, J. R. & Lerner, A. M.: Characteristics of non-bacteremic Pseudomonas pneumonia. Ann Intern Med 68: 295, 1968
  • Valdivieso, M., Gil-Extremera, B., Zornoza, J., Rodriguez, V. & Bodey, G. P.: Gram-negative bacillary pneumonia in the compromised host. Medicine 56: 241, 1977
  • Waksman, B. H.: Cellular hypersensitivity and immunity: Conceptual changes in last decade. Cell Immunol 42: 155, 1979
  • White, A. & Crowder, J. G.: Pseudomonas diseases. Adv Intern Med 20: 23, 1975
  • Winston, D. J., Gale, R. P., Meyer, D. V. & Young, L. S.: Infectious complications of human bone marrow transplantation. Medicine 58, 1, 1979
  • Wollman, M. R., Young, L. S., Armstrong, D. & Haghbin, M.: Anti-Pseudomonas heat-stable opsonins in acute lymphoblastic leukemia of childhood. J Pediatr 86: 376, 1975
  • Young, L. S.: Role of antibody in infections due to Pseudomonas aeruginosa. J Infect Dis 130 ( Suppl.): S 111–S 118, 1974

References

  • Cordaro, C. J., Melton, T., Stratis, J. P., Atagün, M., Gladding, C., Hartman, P. E. & Roseman, S.: Fosfomycin resistance: Selection method for internal and extended deletions of the phosphoenolpyruvate: Sugar phosphotransferase genes of Salmonella typhimurium. J Bacteriol 128: 785, 1976
  • Davis, S. D., Ianetta, A. & Wedgwood, R. J.: Activity of colistin against Pseudomonas aeruginosa: Inhibition of calcium. J Infect Dis 124: 610, 1971
  • Gallego, A., Rodrígues, A. & Mata, J.: Fosfomycin: Pharmacological studies. In: Future trends in chemotherapy. Drugs of today, 10 ( Suppl.): 161, 1974
  • Kahan, F. M., Kahan, J. S., Cassidy, P. J. & Kropp, H.: The mechanism of action of fosfomycin (phosphonomycin). Ann NY Acad Sci 235: 264, 1974
  • Kesado, T., Hashizume, T. & Asahi, Y.: Antibacterial activity of a new stabilized thienamycin, N-formimidoyl thienamycin, in comparison with other antibiotics. Antimicrob Agents Chemother 17: 912, 1980
  • Kropp, H., Sundelof, J. G., Kahan, J. S., Kahan, F. M. & Birnbaum, J.: MK0787 (N-formimidoyl thienamycin): Evaluation of in vitro and in vivo activities. Antimicrob Agents Chemother 17: 993, 1980
  • Kuhin, C. M. & Bugg, A.: Binding of polymyxin antibiotics to tissues: The major determinant of distribution and persistance in the body. J Infect Dis 124: 394, 1971
  • Lang, S. D. R., Edwards, D. J. & Durack, D. T.: Comparison of cefoperazone, cefotaxime and moxalactam (LY127935) against aerobic gram-negative bacilli. Antimicrob Agents Chemother 17: 498, 1980
  • Lus, R. G., Calvao, M. C. R. & Sanchéz, E. D.: Susceptibility of 606 strains of Pseudomonas aeruginosa and 64 strains of Serratia marcescens to fosfomycin. In: Future trends in chemotherapy. Drugs of today, 10 ( Suppl.): 161, 1974
  • Miller, G. H., Sabatelli, F. J., Hare, R. S. & Waitz, J. A.: Survey of aminoglycoside resistance patterns. Dev Industr Microbiol 21, 1980
  • Neu, H. C. & Fu, K. P.: In vitro antibacterial activity and β-lactamase stability of SCE-129, a new cephalosporin. Antimicrob Agents Chemother 15: 646, 1976
  • O'Callaghan, C. O., Acred, P., Harper, P. B., Ryan D. M., Kirby, S. M. & Harding, S. M.: GR 20263, a new broad-spectrum cephalosporin with anti-pseudomonal activity. Antimicrob Agents Chemother 17: 876, 1980
  • Shannon, K., King, A., Warren, C. & Phillips, I.: In vitro antibacterial activity and susceptibility of the cephalosporin Ro 13–9904 to beta-lactamases. Antimicrob Agents Chemother 18: 292, 1980
  • Siegenthaler, W., Fuchs, P. & Lüthy, R.: Treatment of Pseudomonas aeruginosa infections. In: Pseudomonas aeruginosa: The organism, diseases it causes, and their treatment (ed. L. D. Sabath), pp. 160–175. Hans Huber Publishers, Bern 1980
  • Simmons, N. A.: Potentiation of inhibitory activity of colistin on Pseudomonas aeruginosa by sulphamethoxazole and sulphamethizole. Br Med J 3: 693, 1969
  • Smith, C. R., Lipsky, J. J., Laskin, O. L., Hellman, D. B., Mellits, E. D., Longstreth, J. & Lietman, P. S.: Double-blind comparison of the nephrotoxicity and auditory toxicity of gentamicin and tobramycin. N Engl J Med 302: 1106, 1980
  • Sykes, R. B. & Matthew, M.: The β-lactamases of gram-negative bacteria and their role in resistance to β-lactam antibiotics. J Antimicrob Chemother 2: 115, 1976
  • Tally, F. P., Jacobus, N. V. & Gorbach, S. L.: In vitro activity of thienamycin, Antimicrob Agents Chemother 14: 436, 1978
  • Trollfors, B., Alestig, K. & Norrby, R.: Quantitative nephrotoxicity of gentamicin in nontoxic doses. J Infect Dis 141: 306, 1980
  • Verbist, L. & Verhaegen, J.: GR-20263: A new aminothiazolyl cephalosporin with high activity against Pseudomonas and Enterobacteriaceae. Antimicrob Agents Chemother 17: 807, 1980
  • Winston, D. J., Murphy, W., Young, L. S. & Hewitt, W. L.: Piperacillin therapy for serious bacterial infections. Am J Med 69: 225, 1980
  • Wise, R., Andrews, J. M. & Bedford, K. A.: Comparison of in vitro activity of GR 20263, a novel cephalosporin derivative, with activities of other beta-lactam compounds. Antimicrob Agents Chemother 17: 884, 1980
  • Young, L. S.: Recent advances in the therapy of Pseudomonas aeruginosa infections. In: Pseudomonas aeruginosa: Clinical manifestations of infection and current therapy (ed. R. G. Goggett), pp. 311–338. Academic Press, New York, 1979
  • Zak, O.: Antibiotics and Pseudomonas aeruginosa. In: Pseudomonas aeruginosa: The organism, disease it causes, and their treatment (ed. L. D. Sabath), pp. 133–160. Hans Huber Publishers, Bern 1980

References

  • Bergan, T. & Michalsen, H.: Azlocillin in respiratory tract infections with Pseudomonas aeruginosa in children with cystic fibrosis. Chemotherpy 26: 135, 1980
  • Dynesen, H. & Flensborg, E. W.: The prognosis in cystic fibrosis in Denmark in 1945–1974. Ugeskr Læger 140: 463, 1978
  • Friis, B.: Chemotherapy of chronic infections with mucoid Pseudomonas aeruginosa in lower airways of patients with cystic fibrosis. Scand J Inf Dis II: 211, 1979
  • Hoogkamp-Korstanje, J. A. A. & Westerdaal, N. A. C.: Activity and synergy of piperacillin and aminoglycosides against Pseudomonas aeruginosa. Antonie van Leeuwenhoek 45: 617, 1979
  • Høiby, N.: Pseudomonas aeruginosa infection in cystic fibrosis. Acta Pathol Microbiol Scand (C) Suppl. 262: 3, 1977
  • Høiby, N. & Rosendal, K.: Epidemiology of Pseudomonas aeruginosa infection in patients treated at a cystic fibrosis centre. Acta Pathol Microbiol Scand (B) 88: 125, 1980
  • Jørgensen, M. & Møller, N. E.: High dosis tobramycin treatment in chronical Pseudomonas aeruginosa infection in CF patients. 8th Europ Work Gr f CF, Bad Gastein, Austria, 1978
  • Limson, B. M., Guanlao, R. F. & Depakakibo, L. Z.: Piperacillin in the treatment of bacteremia and bacterial endocarditis. Curr Chemoth Infect Dis 297, 1980
  • Lutz, F. B. & Mogabgab, W. J.: Therapeutic efficacy of piperacillin in serious infections in adults. 18th Interscience Conf on Antimicrob Agents and Chemotherapy, Atlanta 1978
  • Marks, M. I., Prentice, R., Swarson, R., Cotton, E. K. & Eickhoff, T. C.: Carbenicillin and gentamycin: Pharmacologic studies in patients with cystic fibrosis and pseudomonas pulmonary infections. J Pediatr 79: 822, 1971
  • Møller, N. E.: Carbenicillin-induced haemorrhagic cystitis. Lancet 2: 946, 1978
  • Møller, N. E.: Side-effects of carbenicillin treatment in patients with cystic fibrosis with chronic infections with Pseudomonas aeruginosa. Ugeskr Læger 141: 1646, 1979
  • Møller, N. E., Ahlstedt, S., Stahl, P. S. & Norn, S.: Allergological examination of cystic fibrosis patients with skin reactions during carbenicillin treatment. Allergy 35: 135, 1980
  • Møller, N. E., Eriksen, K. R., Feddersen, C., Flensborg, E. W., Høiby, N., Norn, S., Rosendal, K., Schiøtz, P. O. & Skov, P. S.: Anti-pseudomonas treatment in cystic fibrosis. In press.
  • Prince, A. & Neu, H. C.: Use of piperacillin, a semisynthetic penicillin, in the therapy of acute exacerbations of pulmonary disease in patients with cystic fibrosis. J Pediatr 97: 148, 1980
  • Reyes, M. P., El-Khatib, M. R., Brown, W. J., Smith, F. & Lerner, A. M.: Synergy between carbenicillin and aminoglycoside (gentamycin or tobramycin) against Pseudomonas aeruginosa isolated from patients with endocarditis and sensitivity of isolates of normal human serum. J Inf Dis 140: 192, 1979
  • Sander, S., Bergan, T. & Fossberg, E.: Piperacillin in treatment of urinary tract infections. Chemotherapy 26: 141, 1980

References

  • Batten, J.: Clinical management of the adolescent and adult patient. In: Perspectives in cystic fibrosis, p. 183 (ed. J. M. Sturgess). Proc 8 Intern CF Congress. Toronto 1980
  • Bergan, T. & Høiby, N.: Epidemiological markers for Pseudomonas aeruginosa. 6. Relationship between concomitant non-mucoid and mucoid strains from the respiratory tract in cystic fibrosis. Acta Pathol Microbiol Scand (B) 83: 553, 1975
  • Bergan, T. & Michalsen, H.: Pharmacokinetics of azlocillin in children with cystic fibrosis. Arzneim Forsch 29 ( II): 1955, 1979
  • Bergan, T. & Michalsen, H.: Farmakokinetikk av antibiotika ved cystisk fibrose. Astra Nytt: 2, 4, 1980
  • Corey, M. L.: Longitudinal studies in cystic fibrosis. In: Perspectives in cystic fibrosis, p. 246 (ed. J. M. Sturgess). Proc 8 Intern CF Congress, Toronto 1980
  • Daikos, G. K., Giamarellou, M., Hadjipolydorou, A. & Kanellakopoulou, K. J.: In vitro and in vivo activity of azlocillin against Pseudomonas aeruginosa. Proc 10 Intern Congress Chemotherapy. Curr Chemother 1: 626, 1977
  • Ericsson, H. M. & Sherris, J. C.: Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand (B) Suppl. 217, 1971
  • Helm, E. B., Ristou, W., Shah, P. M., Schacht, P. & Stille, W.: Behandlung von Pseudomonas-Infektionen mit dem neuen Ureidopenicillin Azlocillin. Dtsch Med Wschr 102: 1211, 1977
  • Hodson, M. E. & Batten, J. C.: Features associated with a poor prognosis in adults with cystic fibrosis (CF). In: Perspectives in cystic fibrosis, p. 18a (ed. J. M. Sturgess). Proc 8 Intern CF Congress, Toronto 1980
  • Høiby, N. & Axelsen, N. H.: Identification and quantitation of precipitins against Pseudomonas aeruginosa in patients with cystic fibrosis by means of crossed immunoelectrophoresis with intermediate gel. Acta Pathol Microbiol Scand (B) 81: 298, 1973
  • Høiby, N.: Pseudomonas aeruginosa infection in cystic fibrosis. Thesis. Acta Pathol Microbiol Scand (C) Suppl. 262, 1977
  • König, B., Metzger, K., Mürmann, P., Offe, H. & Schröck, W.: Azlocillin: Ein neues Penicillin gegen Pseudomonas aeruginosa und andere gramnegative Bakterien. Infection 5: 170, 1977
  • Lode, H., Niestrath, U., Koeppe, P. & Langmaack, H.: Azlocillin und Mezlocillin: Zwei neue semisynthetische Acylureidopenicilline. Infection 5: 163, 1977
  • Mearns, M. B.: Natural history of pulmonary infection in cystic fibrosis. In: Perspectives in cystic fibrosis, p. 325 (ed. J. M. Sturgess). Proc 8 Intern CF Congress, Toronto 1980

References

  • Alfthan, O., Renkonen, O. V. & Ohlsson, H.: Treatment with azlocillin in complicated urinary tract infections. Arzneim Forsch 29 ( II): 1979
  • Daikos, G. K., Gimarellou, H., Hadjipolydorou, K. & Kanellakopulou, K.: In vitro and in vivo activity of azlocillin against Pseudomonas aeruginosa. Proc. 10th Internat. Congr. Chemotherapy, Zürich 1977
  • König, B., Metzger, K., Mürmann, P., Offe, H. & Schröck, W.: Azlocillin: Ein neues Penicillin gegen Pseudomonas aeruginosa und andere gramnegative Bakterien. Infection 5: 60, 1977
  • Popa, G., Nuri, M. & Peters, H. J.: Behandlung chronischer Harnwegsinfekte mit Mezlocillin. Med Welt 29: 441, 1978
  • Stewart, D. & Bodey, G. P.: Azlocillin: In vitro studies of a new semisynthetic penicillin. Antimicrob Agents Chemother 11: 865, 1977
  • Wirth, K., Schomerus, M. & Hengstmann, J. H.: Zur Pharmakokinetik von Azlocillin, einem neuen halbsynthetischen Bretispektrumantibiotikum. Infection 4: 25, 1976
  • Wise, R., Gillett, A. P., Andrews, J. M. & Bedford, K. A.: Activity of azlocillin against gram-negative organisms: Comparison with other penicillins. Antimicrob Agents Chemother 13: 559, 1978

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