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ORIGINAL ARTICLE

Deficiency in EBV-induced gene 3 (EBI3) in MRL/lpr mice results in pathological alteration of autoimmune glomerulonephritis and sialadenitis

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Pages 33-41 | Received 21 May 2008, Accepted 17 Jul 2008, Published online: 02 Jan 2014

References

  • Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. Immunity. 2002;16:779–90.
  • Devergne 0, Hummel M, Koeppen H, Le Beau MM, Nathanson EC, Kieff E, et al. A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytes. J Virol. 1996;70: 1143–53.
  • Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, et al. WSX-1 and glycoprotein 130 constitute a signal-transduc-ing receptor for IL-27. J Immunol. 2004;172:2225–31.
  • Artis D, Villarino A, Silverman M, He W, Thornton EM, Mu S, et al. The IL-27 receptor (WSX-1) is an inhibitor of innate and adaptive elements of type 2 immunity. J Immunol. 2004;173:5626–34.
  • Hibbert L, Pflanz S, De Waal Malefyt R, Kastelein RA. IL-27 and IFN-alpha signal via Statl and Stat3 and induce T-Bet and IL-12Rbeta2 in naive T cells. J Interferon Cytokine Res. 2003;23:513–22.
  • Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial 'Thl commitment. J Immunol. 2003;170:4886–90.
  • Chen Q, Ghilardi N, Wang H, Baker T, Xie MH, Gurney A, et al. Development of Thl-type immune responses requires the type I cytokine receptor TCCR. Nature. 2000;407:916–20.
  • Takeda A, Hamano S, Shiraishi H, Yoshimura T, Ogata H, Ishii K, et al. WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation. Int Immunol. 2005;17:889–97.
  • Yoshida H, Hamano S, Senaldi G, Covey T, Faggioni R, Mu S, et al. WSX-1 is required for the initiation of Thl responses and resistance to L. major infection. Immunity. 2001;15:569–78.
  • Lucas S, Ghilardi N, Li J, de Sauvage FJ. IL-27 regulates IL-12 responsiveness of naive CD4± T cells through Statl-dependent and -independent mechanisms. Proc Natl Acad Sci USA. 2003;100: 15047–52.
  • Miyazaki Y, Inoue H, Matsumura M, Matsumoto K, Nakano T, Tsuda M, et al. Exacerbation of experimental allergic asthma by augmented 'Th2 responses in WSX-1-deficient mice. J Immunol. 2005;175:2401–7.
  • Villarino A, Hibbert L, Lieberman L, Wilson E, Mak T, Yoshida H, et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity. 2003;19:645–55.
  • Dixon FJ. The pathogenesis of glomerulonephritis. Am J Med. 1968;44:493–8.
  • Churg J BJ, Glassock RJ. Renal disease: Classification and atlas of glomerular disease. In: Churg J, Bernstein J, Glassock RJ, editors. Tokyo: Igaku-Shoin; 1995. p. 151–6.
  • Masutani K, Akahoshi M, Tsuruya K, Tokumoto M, Ninomiya T, Kohsaka T, et al. Predominance of Thl immune response in diffuse proliferative lupus nephritis. Arthritis Rheum. 2001;44: 2097–106.
  • Akahoshi M, Nakashima H, Tanaka Y, Kohsaka T, Nagano S, Ohgami E, et al. 'Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus. Arthritis Rheum. 1999;42:1644–8.
  • Van Parijs L, Abbas AK. Role of Fas-mediated cell death in the regulation of immune responses. Curr Opin Immunol. 1996;8:355–61.
  • Theofilopoulos AN, Dixon FJ. Murine models of systemic lupus erythematosus. Adv Immunol. 1985;37:269–390.
  • Shimizu S, Sugiyama N, Masutani K, Sadanaga A, Miyazaki Y, Inoue Y, et al. Membranous glomerulonephritis development with Th2-type immune deviations in MRL//pr mice deficient for IL-27 receptor (WSX-1). J Immunol. 2005;175:7185–92.
  • Sugiyama N, Nakashima H, Yoshimura T, Sadanaga A, Shimizu S, Masutani K, et al. Amelioration of human lupus-like pheno-types in MRL//pr mice by overexpression of IL-2712{ alpha} (WSX-1). Ann Rheum Dis. 2007. (Epub ahead of print).
  • Woodrow DF, Shore I, Moss J, Gower P, Phillips M. Immuno-electron microscopic studies of immune complex deposits and basement membrane components in IgA nephropathy. J Pathol. 1989;157:47–57.
  • Cohen PL, Eisenberg RA. Lpr and gld: single-gene models of systemic autoimmunity and lymphoproliferative disease. Annu Rev Immunol. 1991;9:243–69.
  • Niedbala W, Wei XQ, Cai B, Hueber AJ, Leung BP, McInnes IB, et al. IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of 'Th17 cells. Eur J Immunol. 2007;37:3021–9.
  • Hoffman RW, Alspaugh MA, Waggie KS, Durham JB, Walker SE. Sjögren's syndrome in MRL/1 and MRL/n mice. Arthritis Rheum. 1984;27: 157–65.
  • Jonsson R, Tarkowski A, Backman K, Holmdahl R, Klareskog L. Sialadenitis in the MRL-1 mouse: morphological and immuno-histochemical characterization of resident and infiltrating cells. Immunology. 1987;60: 611–6.
  • Hasegawa H, Inoue A, Kohno M, Muraoka M, Miyazaki T, Te-rada M, et al. Antagonist of interferon-inducible protein 10/ CXCL10 ameliorates the progression of autoimmune sialadenitis in MRL//pr mice. Arthritis Rheum. 2006;54: 1174–83.
  • Yanagi K, Haneji N, Hamano H, Takahashi M, Higashiyama H, Hayashi Y. In vivo role of IL-10 and -12 during development of Sjögren's syndrome in MRL//pr mice. Cell Immunol. 1996;168:243–50.
  • Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren's syndrome. J Immunol. 1994;152:5532–9.
  • Ohyama Y, Nakamura S, Matsuzaki G, Shinohara M, Hiroki A, Fujimura T, et al. Cytokine messenger RNA expression in the labial salivary glands of patients with Sjögren's syndrome. Arthritis Rheum. 1996;39:1376–84.
  • Konttinen YT, Kemppinen P, Koski H, Li TF, Jumppanen M, Hietanen J, et al. T(H)1 cytokines are produced in labial salivary glands in Sjögren's syndrome, but also in healthy individuals. Scand J Rheumatol. 1999;28:106–12.
  • Price EJ, Venables PJ. The etiopathogenesis of Sjögren's syn-drome. Semin Arthritis Rheum. 1995;25:117–33.
  • Ozaki Y, Amakawa R, Ito T, Iwai H, Tajima K, Uehira K, et al. Alteration of peripheral blood dendritic cells in patients with primary Sjögren's syndrome. Arthritis Rheum. 2001;44:419–31.
  • Hamano H, Kawa S, Horiuchi A, Unno H, Furuya N, Akamatsu T, et al. High serum IgG4 concentrations in patients with scle-rosing pancreatitis. N Engl J Med. 2001;344:732–8.
  • Kamisawa T, Funata N, Hayashi Y, Tsuruta K, Okamoto A, Amemiya K, et al. Close relationship between autoimmune pancreatitis and multifocal fibrosclerosis. Gut. 2003;52:683–7.
  • Kamisawa T, Funata N, Hayashi Y, Eishi Y, Koike M, Tsuruta K, et al. A new clinicopathological entity of IgG4-related autoim-mune disease. J Gastroenterol. 2003;38:982–4.
  • Kamisawa T, Chen PY, Tu Y, Nakajima H, Egawa N. Autoim-mune pancreatitis metachronously associated with retroperitoneal fibrosis with IgG4-positive plasma cell infiltration. World J Gastroenterol. 2006;12: 2955–7.
  • Kitagawa S, Zen Y, Harada K, Sasaki M, Sato Y, Minato H, et al. Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner's tumor). Am J Surg Pathol. 2005;29:783–91.
  • Zen Y, Kasahara Y, Horita K, Miyayama S, Miura S, Kitagawa S, et al. Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level: histologic similarity to sclerosing pan-creatitis. Am J Surg Pathol. 2005;29:275–8.
  • Zen Y, Sawazaki A, Miyayama S, Notsumata K, Tanaka N, Nakanuma Y. A case of retroperitoneal and mediastinal fibrosis exhibiting elevated levels of IgG4 in the absence of sclerosing pancreatitis (autoimmune pancreatitis). Hum Pathol. 2006;37: 239–43.
  • Yamamoto M, Harada S, Ohara M, Suzuki C, Naishiro Y, Yamamoto H, et al. Clinical and pathological differences between Mikulicz's disease and Sjogren's syndrome. Rheuma-tology (Oxford). 2005;44:227–34.
  • Morgan WS, Castleman B. A clinicopathologic study of Miku-licz's disease. Am J Pathol. 1953;29:471–503.
  • Zhang K, Mills FC, Saxon A. Switch circles from IL-4-directed epsilon class switching from human B lymphocytes. Evidence for direct, sequential, and multiple step sequential switch from mu to epsilon Ig heavy chain gene. J Immunol. 1994;152: 3427–35.
  • Agresti A, Vercelli D. Analysis of gamma4 germline transcrip-tion in human B cells. Int Arch Allergy Immunol. 1999;118:279–81.
  • Miyake K, Moriyama M, Aizawa K, Nagano S, Inoue Y, Sadanaga A, et al. Peripheral CD4± T cells showing a 'Th2 phenotype in a patient with Mikulicz's disease associated with lymphadenopathy and pleural effusion. Mod Rheumatol. 2008;18:86–90.

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