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Review Article

Adenosine in fibrosis

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Pages 114-122 | Received 24 Aug 2009, Accepted 26 Oct 2009, Published online: 02 Jan 2014

References

  • Drury AN, Szent-Gyorgi A. The physiological activity of adenine compounds with special reference to their action upon the mammalian heart. J Physiol. 1929;68:213–37.
  • Sattin A, Rall TW. The effect of adenosine and adenine nucle-otides on the cyclic adenosine-3',5'-phosphate content of guinea pig cerebral cortex slices. Mol Pharmacol. 1970;6:13–23.
  • Olah ME, Stiles GL. Adenosine receptor subtypes: character-ization and therapeutic regulation. Ann Rev Pharmacol Toxicol. 1995;35:581–606.
  • Fredholm BB, Arslan G, Halldner L, Kull B, Schulte G, Wass-erman W. Structure and function of adenosine receptors and their genes. Naunyn Schmiedebergs Arch Pharmacol. 2000;362(4-5):364–74.
  • Montesinos MC, Cronstein BN. Role of P1 receptors in inflam-mation. In: Abbracchio MP, Williams M, editors. Handbook of experimental pharmacology, vol 151/II: Purinergic and pyrimid-inergic signaling II. Cardiovascular respiratory, immune, meta-bolic and gastrointestinal tract function. Berlin: Springer; 2001. p. 303–21.
  • Chan ESL, Fernandez P, Cronstein BN. Adenosine in inflam-matory joint diseases. Purinergic Signal. 2007;3:145–52.
  • Salmon JE, Cronstein BN. Fcgamma receptor-mediated functions in neutrophils are modulated by adenosine receptor occupancy: Al receptors are stimulatory and A2 receptors are inhibitory. J Immunol. 1990;145:2235–40.
  • Londos C, Cooper DM, Wolff J. Subclasses of external adenosine receptors. Proc Natl Acad Sci USA. 1980;77(5):2551–4.
  • Montesinos MC, Gadangi P, Longaker M, Sung J, Levine J, Nilsen D, et al. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors. J Exp Med. 1997;186(9):1615–20.
  • Montesinos MC, Desai A, Chen JF, Yee H, Schwarzschild MA, Fink JS, et al. Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am J Pathol. 2002;160(6):2009–18.
  • Victor-Vega C, Desai A, Montesinos MC, Cronstein BN. Aden-osine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Beca-plermin gel). Inflammation. 2002;26(1):19–24.
  • Cronstein BN, Kramer SB, Weissmann G, Hirschhorn R. Aden-osine: a physiological modulator of superoxide anion generation by human neutrophils. J Exp Med. 1983;158(4):1160–77.
  • Cronstein BN, Rosenstein ED, Kramer SB, Weissmann G, Hirsch-horn R. Adenosine; a physiologic modulator of superoxide anion generation by human neutrophils. Adenosine acts via an A2 receptor on human neutrophils. J Immunol. 1985;135(2):1366–71.
  • Sullivan GW, Linden J, Buster BL, Scheld WM. Neutrophil A2A adenosine receptor inhibits inflammation in a rat model of men-ingitis: synergy with the type IV phosphodiesterase inhibitor, rofipram. J Infect Dis. 1999;180(5):1550–60.
  • Cronstein BN, Levin RI, Belanoff J, Weissmann G, Hirschhorn R. Adenosine: an endogenous inhibitor of neutrophil-mediated injury to endothelial cells. J Clin Invest. 1986;78:760–70.
  • Rosengren S, Arfors KE, Proctor KG. Potentiation of leukotriene B4-mediated inflammatory response by the adenosine antagonist, 8-phenyl theophylline. Int J. Microcirc Clin Exp. 1991;10: 345–57.
  • Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature. 2001;414(6866):916–20.
  • Okusa MD, Linden J, Macdonald T, Huang L. Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney. Am J Physiol. 1999;277(3 Pt 2):F404–12.
  • Okusa MD, Linden J, Huang L, Rieger JM, Macdonald TL, Huynh LP. A(2A) adenosine receptor-mediated inhibition of renal injury and neutrophil adhesion. Am J Physiol Renal Physiol. 2000;279(5):F809–18.
  • Ross SD, Tribble CG, Linden J, Gangemi JJ, Lanpher BC, Wang AY, et al. Selective adenosine-A2A activation reduces lung reperfusion injury following transplantation. J Heart Lung Transplant. 1999;18(10):994–1002.
  • McPherson JA, Baninghaus KG, Bishop GG, Sanders JM, Rieger JM, Hesselbacher SE, et al. Adenosine A(2A) receptor stimula-tion reduces inflammation and neointimal growth in a murine carotid ligation model. Arterioscler Thromb Vase Biol. 2001;21(5): 791–6.
  • Cronstein BN, Levin RI, Philips MR, Hirschhorn R, Abramson SB, Weissmann G. Neutrophil adherence to endothelium is enhanced via adenosine Al receptors and inhibited via adenosine A2 receptors. J Immunol. 1992;148:2201–6.
  • Huang S, Apasov S, Koshiba M, Sitkovsky M. Role of A2a extracellular adenosine receptor-mediated signaling in adenosine-mediated inhibition of T-cell activation and expansion. Blood. 1997;90(4):1600–10.
  • Marone G, Plaut M, Lichtenstein LM. Characterization of a specific adenosine receptor on human lymphocytes. J Immunol. 1978;121:2153–9.
  • Schultz LA, Kammer GM, Rudolph SA. Characterization of the human T lymphocyte adenosine receptor: comparison of normal and systemic lupus erythematosus cells. FASEB J. 1988;2:244–50.
  • Kammer GM, Birch RE, Polmar SH. Impaired immunoregulation in systemic lupus erythematosus: defective adenosine-induced suppressor T lymphocyte generation. J Immunol. 1983;130: 1706–12.
  • Mandler R, Birch RE, Polmar SH, Kammer GM, Rudolph SA. Abnormal adenosine-induced immunosuppression and cAMP metabolism in T lymphocytes of patients with systemic lupus erythematosus. Proc Natl Acad Sci USA. 1982;79:7542–6.
  • Apasov SG, Koshiba M, Chused TM, Sitkovsky MV. Effects of extracellular ATP and adenosine on different thymocyte subsets. Possible role of ATP-gated channels and G protein-coupled pu-rinergic receptor. J Immunol. 1997;158:5095–105.
  • Resta R, Hooker SW, Laurent AB, Jamshedur Rahman SM, Franklin M, Knudsen TB, et al. Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73). J Clin Invest. 1997;99(4):676–83.
  • Williams BA, Blay J, Hoskin DW. 2-Chloroadenosine stimulates granule exocytosis from mouse natural killer cells: evidence for signal transduction through a novel extracellular receptor. Exp Cell Res. 1997;233(1):187–97.
  • Hoskin DW, Reynolds T, Blay J. 2-Chloroadenosine inhibits the MHC-unrestricted cytolytic activity of anti-CD3-activated killer cells: evidence for the involvement of a non- Al/A2 cell-surface adenosine receptor. Cell Immunol. 1994;159(1):85–93.
  • Koshiba M, Rosin DL, Hayashi N, Linden J, Sitkovsky MV. Patterns of A2A extracellular adenosine receptor expression in different functional subsets of human peripheral T cells. Flow cytometry studies with anti-A2A receptor monoclonal antibodies [In Process Citation]. Mol Pharmacol. 1999;55(3):614–24.
  • Sitkovsky MV. Extracellular purines and their receptors in immunoregulation. Review of recent advances. Nippon &a Dai-gaku Zasshi. 1998;65(5):351–7.
  • Koshiba M, Kojima H, Huang S, Apasov S, Sitkovsky MV. Memory of extracellular adenosine A2A purinergic receptor-mediated sig-naling in murine T cells. J Biol Chem. 1997;272(41):25881–9.
  • Reinstein LJ, Lichtman SN, Currin RT, Wang J, Thurman RG, Lemasters JJ, et al. Suppression of lipopolysaccharide-stimulated release of tumor necrosis factor by adenosine: evidence for A2 receptors on rat Kupffer cells. Hepatology. 1994;19(6):1445–52.
  • Hasko G, Szabo C, Nemeth ZH, Kvetan V, Pastores SM, Vizi ES. Adenosine receptor agonists differentially regulate IL-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages and in endotoxemic mice. J Immunol. 1996;157(10):4634–40.
  • Sajjadi FG, Takabayashi K, Foster AC, Domingo RC, Firestein GS. Inhibition of TNF-alpha expression by adenosine: role of A3 adenosine receptors. J Immunol. 1996;156(9):3435–42.
  • Szabo C, Scott GS, Virag L, Egnaczyk G, Salzman AL, Shanley TP, et al. Suppression of macrophage inflammatory protein (MIP)-lalpha production and collagen-induced arthritis by adenosine receptor agonists. Br J Pharmacol. 1998;125(2):379–87.
  • Hasko G, Kuhel DG, Chen JF, Schwarzschild MA, Deitch EA, Mabley JG, et al. Adenosine inhibits IL-12 and TNF-alpha pro-duction via adenosine A2a receptor-dependent and independent mechanisms [In Process Citation]. FASEB J. 2000;14(13):2065–74.
  • Khoa ND, Montesinos MC, Reiss AB, Delano D, Awadallah N, Cronstein BN. Inflammatory cytokines regulate function and expression of adenosine A(2A) receptors in human monocytic THP-1 cells. J Immunol. 2001;167(7):4026–32.
  • Lukashev D, Ohta A, Apasov S, Chen JF, Sitkovsky M. Cutting edge: physiologic attenuation of proinflammatory transcription by the Gs protein-coupled A2A adenosine receptor in vivo. J Immunol. 2004;173(1):21–4.
  • Majumdar S, Aggarwal BB. Methotrexate suppresses nf-kappab activation through inhibition of ikappabalpha phosphorylation and degradation. J Immunol. 2001;167(5):2911–20.
  • Boyle DL, Sajjadi FG, Firestein GS. Inhibition of synoviocyte collagenase gene expression by adenosine receptor stimulation. Arthritis Rheum. 1996;39:923–30.
  • Bong GW, Rosengren S, Firestein GS. Spinal cord adenosine receptor stimulation in rats inhibits peripheral neutrophil accu-mulation. The role of N-methyl-D-aspartate receptors. J Clin Invest. 1996;98:2779–85.
  • Sun CX, Young HW, Molina JG, Volmer JB, Schnermann J, Blackburn MR. A protective role for the Al adenosine receptor in adenosine-dependent pulmonary injury. J Clin Invest. 2005; 115(1):35–43.
  • Panther E, Corinti S, Idzko M, Herouy Y, Napp M, la Sala A, et al. Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimula-tory capacity of human dendritic cells. Blood. 2003;101(10): 3985–90.
  • Link AA, Kino T, Worth JA, McGuire JL, Crane ML, Chrousos GP, et al. Ligand-activation of the adenosine A2a receptors inhibits IL-12 production by human monocytes. J Immunol. 2000;164(1):436–42.
  • Erdmann AA, Gao ZG, Jung U, Foley J, Borenstein T, Jacobson KA, et al. Activation of Th 1 and Tc 1 cell adenosine A2A receptors directly inhibits IL-2 secretion in vitro and IL-2-driven expansion in vivo. Blood. 2005;105(12):4707–14.
  • Bryce PJ, Dascombe MJ, Hutchinson IV. Immunomodulatory effects of pharmacological elevation of cyclic AMP in T lym-phocytes proceed via a protein kinase A independent mechanism. Immunopharmacology. 1999;41(2):139–46.
  • Merrill JT, Shen C, Schreibman D, Coffey D, Zakharenko O, Fisher R, et al. Adenosine A1 receptor promotion of multinu-cleated giant cell formation by human monocytes: a mechanism for methotrexate-induced nodulosis in rheumatoid arthritis. Arthritis Rheum. 1997;40:1308–15.
  • Driver AG, Kukoly CA, Ali S, Mustafa SJ. Adenosine in bron-choalveolar lavage fluid in asthma. Am Rev Respir Dis. 1993; 148(1):91–7.
  • Huszar E, Vass G, Vizi E, Csoma Z, Barat E, Molnar Vilagos G, et al. Adenosine in exhaled breath condensate in healthy volunteers and in patients with asthma. Eur Respir J. 2002;20(6):1393–8.
  • Blackburn MR, Lee CG, Young HW, Thu Z, Chunn JL, Kang MJ, et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest. 2003;112(3):332–44.
  • Ma B, Blackburn MR, Lee CG, Homer RJ, Liu W, Flavell RA, et al. Adenosine metabolism and murine strain-specific IL-4-induced inflammation, emphysema, and fibrosis. J Clin Invest. 2006;116(5):1274–83.
  • Volmer JB, Thompson LF, Blackburn MR. Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J Immunol. 2006; 176(7):4449–58.
  • Belperio JA, Dy M, Burdick MD, Xue YY, Li K, Elias JA, et al. Interaction of IL-13 and C10 in the pathogenesis of bleomycin-induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2002;27(4):419–27.
  • Zhu Z, Homer RJ, Wang Z, Chen Q, Geba GP, Wang J, et al. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production. J Clin Invest. 1999;103(6):779–88.
  • Hancock A, Armstrong L, Gama R, Millar A. Production of interleukin 13 by alveolar macrophages from normal and fibrotic lung. Am J Respir Cell Mol Biol. 1998;18(1):60–5.
  • Chiaramonte MG, Donaldson DD, Cheever AW, Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response. J Clin Invest. 1999;104(6):777–85.
  • Chunn JL, Molina JG, Mi T, Xia Y, Kellems RE, Blackburn MR. Adenosine-dependent pulmonary fibrosis in adenosine deami-nase-deficient mice. J Immunol. 2005;175(3):1937–46.
  • Fernandez P, Trzaska S, Wilder T, Chiriboga L, Blackburn MR, Cronstein BN, et al. Pharmacological blockade of A2A receptors prevents dermal fibrosis in a model of elevated tissue adenosine. Am J Pathol. 2008;172(6):1675–82.
  • Blackburn MR, Aldrich M, Volmer JB, Chen W, Zhong H, Kelly S, et al. The use of enzyme therapy to regulate the metabolic and phenotypic consequences of adenosine deaminase deficiency in mice. Differential impact on pulmonary and immunologic abnormalities. J Biol Chem. 2000;275(40:32114–21.
  • Chunn JL, Young HW, Baneijee SK, Colasurdo GN, Blackburn MR. Adenosine-dependent airway inflammation and hyperre-sponsiveness in partially adenosine deaminase-deficient mice. J Immunol. 2001;167(8):4676–85.
  • Chunn JL, Mohsenin A, Young HW, Lee CG, Elias JA, Kellems RE, et al. Partially adenosine deaminase-deficient mice develop pulmonary fibrosis in association with adenosine elevations. Am J Physiol Lung Cell Mol Physiol. 2006;290(3):L579–87.
  • Kaczmarek E, Koziak K, Sevigny J, Siegel JB, Anrather J, Beaudoin AR, et al. Identification and characterization of CD39/ vascular ATP diphosphohydrolase. J Biol Chem. 1996;271(51): 33116–22.
  • Picher M, Burch LH, Hirsh AJ, Spychala J, Boucher RC. Ecto 5'-nucleotidase and nonspecific alkaline phosphatase. Two AMP-hydrolyzing ectoenzymes with distinct roles in human airways. J Biol Chem. 2003;278(15):13468–79.
  • Fortuna R, Anderson HC, Carty RP, Sajdera SW. Enzymatic characterization of the matrix vesicle alkaline phosphatase iso-lated from bovine fetal epiphyseal cartilage. Calcif Tissue Int. 1980;30(3):217–25.
  • Thong H, Belardinelli L, Maa T, Zeng D. Synergy between A2B adenosine receptors and hypoxia in activating human lung fibroblasts. Am J Respir Cell Mol Biol. 2005;32(1):2–8.
  • Sun CX, Thong H, Mohsenin A, Morschl E, Chunn JL, Molina JG, et al. Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury. J Clin Invest. 2006;116(8):2173–82.
  • Morschl E, Molina JG, Volmer JB, Mohsenin A, Pero RS, Hong JS, et al. A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol. 2008; 39(6):697–705.
  • Chan ES, Cronstein BN. Molecular action of methotrexate in inflammatory diseases. Arthritis Res. 2002;4(4):266–73.
  • Cronstein BN. Low-dose methotrexate: a mainstay in the treat-ment of rheumatoid arthritis. Pharmacol Rev. 2005;57(2):163–72.
  • Nagy LE, Diamond I, Casso DJ, Franklin C, Gordon AS. Ethanol increases extracellular adenosine by inhibiting adenosine uptake via the nucleoside transporter. J Biol Chem. 1990;265(4): 1946–51.
  • Puig JG, Fox IH. Ethanol-induced activation of adenine nucleo-tide turnover. Evidence for a role of acetate. J Clin Invest. 1984;74(3):936–41.
  • El Yacoubi M, Ledent C, Parmentier M, Costentin J, Vaugeois JM. Caffeine reduces hypnotic effects of alcohol through aden-osine A2A receptor blockade. Neuropharmacology. 2003;45(7): 977–85.
  • Klatsky AL, Armstrong MA. Alcohol, smoking, coffee, and cir-rhosis. Am J Epidemiol. 1992;136(10):1248–57.
  • Klatsky AL, Armstrong MA, Friedman GD. Coffee, tea, and mortality. Ann Epidemiol. 1993;3(4):375–81.
  • Jiao J, Friedman SL, Aloman C. Hepatic fibrosis. Curr Opin Gastroenterol. 2009;25(3):223–9.
  • Friedman SL. Hepatic fibrosis-overview. Toxicology. 2008;254(3): 120–9.
  • Friedman SL. Mechanisms of hepatic fibrogenesis. Gastroenter-ology. 2008;134(6):1655–69.
  • Friedman SL. Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev. 2008;88(1):125–72.
  • Chan ES, Montesinos MC, Fernandez P, Desai A, Delano DL, Yee H, et al. Adenosine A(2A) receptors play a role in the pathogenesis of hepatic cirrhosis. Br J Pharmacol. 2006;148(8):1144–55.
  • Hashmi AZ, Hakim W, Kruglov EA, Watanabe A, Watkins W, Dranoff JA, et al. Adenosine inhibits cytosolic calcium signals and chemotaxis in hepatic stellate cells. Am J Physiol Gastroin-test Liver Physiol. 2007;292(1):G395–401.
  • Sohail MA, Hashmi AZ, Hakim W, Watanabe A, Zipprich A, Groszmann RJ, et al. Adenosine induces loss of actin stress fibers and inhibits contraction in hepatic stellate cells via Rho inhibi-tion. Hepatology. 2009;49(1):185–94.
  • Hernandez-Munoz R, Diaz-Munoz M, Suarez-Cuenca JA, Trejo-Solis C, Lopez V, Sanchez-Sevilla L, et al. Adenosine reverses a preestablished CC14-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats. Hepatology. 2001;34(4 Pt 1):677–87.
  • Che J, Chan ES, Cronstein BN. Adenosine A2A receptor occu-pancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular sig-nal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Mol Pharmacol. 2007;72(6):1626–36.
  • Chan ES, Fernandez P, Merchant AA, Montesinos MC, Trzaska S, Desai A, et al. Adenosine A2A receptors in diffuse dermal fibrosis: pathogenic role in human dermal fibroblasts and in a murine model of scleroderma. Arthritis Rheum. 2006;54(8): 2632–42.
  • Katebi M, Fernandez P, Chan ES, Cronstein BN. Adenosine A2A receptor blockade or deletion diminishes fibrocyte accumulation in the skin in a murine model of scleroderma, bleomycin-induced fibrosis. Inflammation. 2008;31(5):299–303.
  • Dubey RK, Gillespie DG, Mi Z, Jackson EK. Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors. Circulation. 1997;96(8):2656–66.
  • Dubey RK, Gillespie DG, Shue H, Jackson EK. A(2B) receptors mediate antimitogenesis in vascular smooth muscle cells. Hypertension. 2000;35(1 Pt 2):267–72.
  • Andresen BT, Gillespie DG, Mi Z, Dubey RK, Jackson EK. Role of adenosine A(1) receptors in modulating extracellular adeno-sine levels. J Pharmacol Exp 'Ther. 1999;291(1):76–80.
  • Dubey RK, Gillespie DG, Jackson EK. Adenosine inhibits col-lagen and protein synthesis in cardiac fibroblasts: role of A2B receptors. Hypertension. 1998;31(4):943–8.
  • Wakeno M, Minamino T, Seguchi O, Okazaki H, Tsukamoto O, Okada K, et al. Long-term stimulation of adenosine A2b recep-tors begun after myocardial infarction prevents cardiac remod-eling in rats. Circulation. 2006;114(18):1923–32.
  • Mi T, Abbasi S, Zhang H, Uray K, Chunn JL, Xia LW, et al. Excess adenosine in murine penile erectile tissues contributes to priapism via A2B adenosine receptor signaling. J Clin Invest. 2008;118(4):1491–501.

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