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Modern Rheumatology Volume 23, 2013 - Issue 3
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RAPID COMMUNICATION

The crucial roles of IFN-γ in the development of M3 muscarinic acetylcholine receptor induced Sjögren’s syndrome-like sialadenitis

Mana IizukaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
,
Hiroto TsuboiDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
,
Naomi MatsuoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
,
Yuya KondoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
,
Hiromitsu AsashimaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
,
Minoru MatsuiDepartments of Clinical Research and General Medicine, Tokyo-Nishi Tokushukai Hospital, Tokyo, Japan
,
Isao MatsumotoDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, Japan
&
Takayuki SumidaDepartment of Internal Medicine, Faculty of Medicine, University of Tsukuba, 1-1-1 Tenodai, Tsukuba, Ibaraki 305-8575, JapanCorrespondence[email protected]
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Pages 614-616 | Received 20 Jul 2012, Accepted 10 Oct 2012, Published online: 02 Jan 2014

REFERENCES

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  • Tsuboi H, Matsumoto I, Wakamatsu E, Nakamura Y, Iizuka M, Hayashi T, et al. New epitopes and function of anti-M3muscarinic acetylcholine receptor antibodies in patients with Sjögren's syndrome. Clin Exp Immunol. 2010;162(1):53–61.
  • Dawson LJ, Stanbury J, Venn N, Hasdimir B, Rogers N, SmithM. Antimuscarinic antibodies in primary Sjögren's syndrome reversibly inhibit the mechanism of fluid secretion by human submandibular salivary acinar cells. Arthritis Rheum. 2006;54: 1165–73.
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  • Sakai A, Sugawara Y, Kuroishi T, Sasano T, Sugawara S. Iden-tification of IL-18 and Th17 cells in salivary glands of patients with Sjögren's syndrome, and amplification of IL-17-mediated secretion of inflammatory cytokines from salivary gland cells by IL-18. J Immunol. 2008;181(4):2898–906.
  • Iizuka M, Wakamatsu E, Tsuboi H, Nakamura Y, Hayashi T, Matsui M, et al. Pathogenic role of immune response to M3 muscarinic acetylcholine receptor in Sjögren's syndrome-like sialoadenitis. J Autoimmun. 2010;35(4):383–9.
  • Xu X, Fu XY, Plate J, Chong A. IFN-y induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression. Cancer Res. 1998;58(13):2832–7.
  • Bulosan M, Pauley KM, Yo K, Chan E, Katz J, Peck AB, et al. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset. Immunol Cell Biol. 2009;87(1):81–90.

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