Advanced search
Publication Cover
Modern Rheumatology Volume 12, 2002 - Issue 1
Journal homepage
15
Views
1
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLE

Anti-Ki antibodies recognize an epitope homologous with SV40 nuclear localization signal: clinical significance and reactivities in various immunoassays

T. YanoDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
,
Y. TakasakiDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, JapanCorrespondence[email protected]
,
K. TakeuchiDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
,
K. HirokawaDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
,
K. YamanakaDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
&
H. HashimotoDepartment of Internal Medicine and Rheumatology, Juntendo University, School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Pages 50-55 | Received 16 Apr 2001, Accepted 10 Aug 2001, Published online: 02 Jan 2014

References

  • Tojo T, Kaburaki J, Hayakawa M, Okamoto T, Tomii M, Homma M. Precipitating antibody to a soluble nuclear antigen "Ki" with specificity for systemic lupus erythematosus. Ryumachi 1981;21: 129–34.
  • Bernstein RM, Morgan SH, Bunn CC, Gainey RC, Hughes GR, Mathews MB. The SL autoantibody-antigen system: clinical and biochemical studies. Ann Rheum Dis 1986;45:353–8.
  • Harmon C, Peebles C, Tan EM. SL-A new precipitating system (abstract). Arthritis Rheum 1981;24:S122.
  • Sakamoto M, Takasaki Y, Yamanaka K, Kodama A, Hashimoto H, Hirose S. Purification and characterization of Ki antigen and detection of anti-Ki antibody by enzyme-linked immunosorbent assay in patients with systemic lupus erythematosus. Arthritis Rheum 1989;32:1554–62.
  • Nikaido T, Shimada K, Shibata M, Hata M, Sakamoto M, Takasaki Y, et al. Cloning and nucleotide sequence of cDNA for Ki antigen, a highly conserved nuclear protein detected in sera from patients with systemic lupus erythematosus. Clin Exp Immunol 1990;79: 209–14.
  • Ahn JY, Tanahashi N, Akiyama K, Hisamatsu H, Noda C, Tanaka K, et al. Primary structures of two homologous subunits of PA28, a y-interferon-inducible protein activator of the 20S proteasome. FEBS Lett 1995;366:37–42.
  • Tanaka K, Kasahara M. The MHC class I ligand-generating sys-tem: roles of immunoproteasomes and the interferon-gamma-inducible proteasome activator PA28. Immunol Rev 1998;163: 161–76.
  • Wojcik C, Tanaka K, Paweletz N, Naab U, Wilk S. Proteasome activator (PA28) subunits, alpha, beta and gamma (Ki antigen) in NT2 neuronal precursor cells and HeLa S3 cells. Eur J Cell Biol 1998;77: 151–60.
  • Deveraux Q, van Nocker S, Mahaffey D, Vierstra R, Rechsteiner M. Inhibition of ubiquitin-mediated proteolysis by the arabidopsis: 26 S protease subunit 55a. J Biol Chem 1995;270:29660–3.
  • Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome: pathway. J Biol Chem 1998;273: 24057–64.
  • Rousseau D, Cannella D, Boulaire J, Fitzgerald P, Fotedar A, Fotedar R. Growth inhibition by CDK-cyclin and PCNA binding domains of p21 occurs by distinct mechanisms and is regulated by ubiquitin-proteasome pathways. Oncogene 1999;18: 4313— 18. 25.
  • Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, et al. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. 19. Genes Dev 1999;13:1181–9.
  • Takasaki Y, Yano T, Hirokawa K, Takeuchi K, Ando S, Takahashi T, et al. An epitope on Ki antigen recognized by autoan-tibodies from lupus patients shows homology with the SV40 large 20. T antigen nuclear localization signal. Arthritis Rheum 1996;39: 855–62.
  • Yamanaka K, Takasaki Y, Nishida Y, Shimada K, Shibata M, Hashimoto H. Detection and quantification of anti-Ki antibodies 21. by enzyme-linked immunosorbent assay using recombinant Ki antigen. Arthritis Rheum 1992;35:667-71.22.
  • Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982;25: 1271— 23. 7.
  • Merrifield RB. Solid-phase peptide synthesis. Adv Enzymol Relat Areas Mol Biol 1969;32:221–96.
  • Lowry OH, Rosebrough AL, Farr AL, Randall RJ. Protein mea- 24. surement with the Folin phenol reagent. J Biol Chem 1951;193: 265–75.
  • Boire G, Lopez LF, Lapointe S, Menard HA. Sera from patients with autoimmune disease recognize conformational determinants on the 60-kd Ro/SS-A protein (see comments). Arthritis Rheum 1991;34:722–30.
  • Tsuzaka K, Fujii T, Akizuki M, Mimori T, Tojo T, Fujii H, et al. Clinical significance of antibodies to native or denatured 60-kd or 52-kd Ro/SS-A proteins in Sjogren's syndrome. Arthritis Rheum 1994;37:88–92.
  • Buyon J, Winchester R, Slade S, Arnett F, Copel J, Friedman D, et al. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Arthritis Rheum 1993;36:1263–73.
  • Tan EM. Autoantibodies in pathology and cell biology. Cell 1991;67:841–2.
  • Tan EM. Antinuclear antibodies: diagnostic markers for autoim-mune diseases and probes for cell biology. Adv Immunol 1989;44: 93–151.
  • Tanahashi N, Yokota K, Alm J, Chung C, Fujiwara T, Takahashi E, et al. Molecular properties of the proteasome activator PA28 family proteins and y-interferon regulation. Genes Cells 1997;2:195–211.
  • Brand SR, Bernsterin RM, Mathews MB. Trimeric structure of human proliferating cell nuclear antigen. J Immunol 1994;153: 3070.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.