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Pharmacological Aspects

Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia

Más allá del receptor de dopamina: nuevos blancos terapéuticos para tratar la esquizofrenia

Au-delà du récepteur dopaminergique: de nouvelles cibles thérapeutiques pour traiter la schizophrénie.

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Pages 359-382 | Published online: 01 Apr 2022

REFERENCE

  • DelayJDenickerPNeuroleptic effects of chlorpromazine in therapeutics of neuropsychiatry. J Clin Exp Psychopathol. 1955161041 1214392209
  • JanssenPAAwoutersFHIs it possible to predict the clinical effects of neuroleptics from animal data? Part V: From haloperidol and pipamperone to risperidone. Arzneimittelforschung. 1994442692777514873
  • CarlssonADoes dopamine play a role in schizophrenia? Psychol Med. 1977758359722890
  • CreeseIBurtDRSnyderSHDopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs. Science. 19761924814833854
  • SeemanPLeeTChau-WongMWongKAntipsychotic drug doses and neuroleptic/dopamine receptors. Nature. 1976 261717719945467
  • MeltzerHYIlluminating the molecular basis for some antipsychotic drug-induced metabolic burden. Proc Natl Acad Sci U S A. 20071043019302017360600
  • LehmanAFCordrayDSPrevalence of alcohol, drug and mental disorders among the homeless: one more time. Contemporary Drug Problems. 199320355384
  • HartvigPKjelsbergEPenrose's law revisited: the relationship between mental institution beds, prison population and crime rate. Nord J Psychiatry. 200963515618985517
  • WuEQBirnbaumHGShiLEt al.The economic burden of schizophrenia in the United States in 2002. J Clin Psychiatry. 2005661122112916187769
  • DavisJMChenNGlickIDA meta-analysis of the efficacy of secondgeneration antipsychotics. Arch Gen Psychiatry. 20036055356412796218
  • LiebermanJAStroupTSMcEvoyJPet al.Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) investigators: Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med. 20053531209122316172203
  • JonesPBBarnesTRDaviesLet al.Randomized controlled trial of the effect on quality of life of second- vs first-generation antipsychotic drugs in schizophrenia: Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS 1). Arch Gen Psychiatry. 2006631079108717015810
  • LiebermanJAComparative effectiveness of antipsychotic drugs: a commentary on: Cost Utility Of The Latest Antipsychotic Drugs In c Schizophrenia Study (CUtLASS 1) and Clinical Antipsychotic Trials Of Intervention Effectiveness (CATIE). Arch Gen Psychiatry. 2006631069107217015808
  • dAmatoTRochetTDaleryJet al.Relationship between symptoms rated with the Positive and Negative Syndrome Scale and brain measures in schizophrenia. Psychiatry Res. 19924455621461947
  • ArangoCBuchananRWKirkpatrickBCarpenterWTThe deficit syndrome in schizophrenia: implications for the treatment of negative symptoms Eur Psychiatry. 200419212614969777
  • Mesholam-GatelyRIGiulianoAJGoffKPFaraoneSVSeidmanLJNeurocognition in first-episode schizophrenia: a meta-analytic review. Neuropsychology. 20092331 5336
  • HeinrichsRWZakzanisKKNeurocognitive deficit in schizophrenia: a quantitative review of the evidence. Neuropsychology. 1998124264459673998
  • VelakoulisDWoodSJWongMTet al.Hippocampal and amygdala volumes according to psychosis stage and diagnosis: a magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultrahigh-risk individuals. Arch Gen Psychiatry. 20066313914916461856
  • SalisburyDFKurokiNKasaiKShentonMEMcCarleyRWProgressive and interrelated functional and structural evidence of post-onset brain reduction in schizophrenia. Arch Gen Psychiatry. 20076452152917485604
  • PearlsonGDCalhounVDConvergent approaches for defining functional imaging endophenotypes in schizophrenia. Front Hum Neurosci. 200933719956400
  • KyriakopoulosMFrangouSRecent diffusion tensor imaging findings in early stages of schizophrenia. Curr Opin Psychiatry. 20092216817619553871
  • CamchongJMacDonaldAW 3rdBellCMuellerBALimKOAltered functional and anatomical connectivity in schizophrenia. Schizophr Bull. 2009Nov17 [Epub ahead of print]
  • JavittDCSensory processing in schizophrenia: neither simple nor intact. Schizophr Bull. 2009351059106419833806
  • ItilTKeskinerAKiremitciNHoldenJMEffect of phencyclidine in chronic schizophrenics. Can Psychiatr Assoc J . 1967122092126040448
  • LubyEDCohenBDRosenbaumGGottliebJSKelleyRStudy of a new schizophrenomimetic drug; sernyl. AMA Arch Neurol Psychiatry 195981363369
  • JavittDCZukinSRRecent advances in the phencyclidine model of schizophrenia. Am J Psychiatry. 1991148130113081654746
  • AnisNABerrySCBurtonNRLodgeDThe dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate. Br J Pharmacol. 1983795655756317114
  • KrystalJHKarperLPSeibylJPet al.Subanesthetic effects of the noncompetitive NMDA antagonist, ketamine, in humans: Psychotomimetic, perceptual, cognitive, and neuroendocrine responses. Arch Gen Psychiatry 1994511992148122957
  • NewcomerJWFarberNBJevtovic-TodorovicVet al.Ketamineinduced NMDA receptor hypofunction as a model of memory impairment and psychosis. Neuropsychopharmacology. 1999201061189885791
  • UmbrichtDSchmidLKollerRVollenweiderFXHellDJavittDCKetamine-induced deficits in auditory and visual context-dependent processing in healthy volunteers: implications for models of cognitive deficits in schizophrenia. Arch Gen Psychiatry. 2000571139114711115327
  • RadantADBowdleTACowleyDSKharaschEDRoy-ByrnePPDoes ketamine-mediated N-methyl-D-aspartate receptor antagonism cause schizophrenia-like oculomotor abnormalities? Neuropsychopharmacology 1998194344449778665
  • KegelesLSAbi-DarghamAZea-PonceYet al.Modulation of amphetamine-induced striatal dopamine release by ketamine in humans: implications for schizophrenia. Biol Psychiatry. 20004862764011032974
  • LahtiACWeilerMATamaraMichaelidisBAParwaniATammingaCAEffects of ketamine in normal and schizophrenic volunteers. Neuropsychopharmacology. 20012545546711557159
  • SpokesEGAn analysis of factors influencing measurements of dopamine, noradrenaline, glutamate decarboxylase and choline acetylase in human post-mortem brain tissue. Brain. 1979102333346455043
  • LewisDAHashimotoTVolkDWCortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. 2005631232415803162
  • BenesFMEvidence for altered trisynaptic circuitry in schizophrenic hippocampus. Biol Psychiatry. 19994658959910472413
  • HashimotoTBazmiHHMirnicsKWuQSampsonARLewisDAConserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 200816547948918281411
  • VolkDWPierriJNFritschyJMAuhSSampsonARLewisDAReciprocal alterations in pre- and post-synaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb Cortex. 2002121063107012217970
  • GlantzLALewisDADecreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia. Arch Gen Psychiatry. 200057657310632234
  • SweetRAHenteleffRAZhangWSampsonARLewisDAReduced dendritic spine density in auditory cortex of subjects with schizophrenia. Neuropsychopharmacology. 20093437438918463626
  • BehrensMMAliSSDaoDNLuceroJShekhtmanGQuickKLDuganLLKetamine-induced loss of phenotype of fast-spiking interneurons is mediated by NADPH-oxidase. Science. 20073181645164718063801
  • ZhangYBehrensMMLismanJEProlonged exposure to NMDAR antagonist suppresses inhibitory synaptic transmission in prefrontal cortex. J Neurophysiol. 200810095996518525022
  • LismanJECoyleJTGreenRWet al.Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 20083123424218395805
  • UltanirSKKimJEHallBJDeerinckTEllismanMGhoshARegulation of spine morphology and spine density by NMDA receptor signaling in vivo. Proc Natl Acad Sci U S A. 2007104195531955818048342
  • BasuACTsaiGEMaCLet al.Targeted disruption of serine racemase affects glutamatergic neurotransmission and behavior. Mol Psychiatry. 20091471972719065142
  • BaluDBasuACCoyleJTAltered cortical dendritic morphology in serine racemase knockout mice, a genetic model of NMDA receptor hypofunction. Soc Neurosci. 2009Abs. No. 443.16
  • AllenNCBagadeSMcQueenMBet al.Systematic meta-analyses and field synopsis of genetic association studies in schizophrenia: the SzGene database. Nat Genet. 20084082783418583979
  • HahnCGWangHYChoDSet al.Altered neuregulin 1-erbB4 signaling contributes to NMDA receptor hypofunction in schizophrenia. Nat Med. 20061282482816767099
  • JentschJDTrantham-DavidsonHJairlCTinsleyMCannonTDLavinADysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice. Neuropsychopharmacology. 2009342601260819641486
  • Whitfield-GabrieliSThermenosHWMilanovicSet al.Hyperactivity and hyperconnectivity of the default network in schizophrenia and in firstdegree relatives of persons with schizophrenia. Proc Natl Acad Sci U S A. 20091061279128419164577
  • GraceAADopamine system dysregulation by the ventral subiculum as the common pathophysiological basis for schizophrenia psychosis, psychostimulant abuse, and stress. Neurotox Res. 2010 (Epub ahead of print)
  • KomuroHRakicPModulation of neuronal migration by NMDA receptors. Science. 199326095978096653
  • AkbarianSBunneyWE JrPotkinSGWigalSBHagmanJOSandmanCAJonesEGAltered distribution of nicotinamide-adenine dinucleotide phosphate-diaphorase cells in frontal lobe of schizophrenics implies disturbances of cortical development. Arch Gen Psychiatry. 1993501691777679891
  • MargolisRLRossCANeuronal signaling pathways: genetic insights into the pathophysiology of major mental illness. Neuropsychopharmacology. 20103535035120010716
  • RietkerkTBoksMPSommerIEde JongSKahnRSOphoffRANetwork analysis of positional candidate genes of schizophrenia highlights myelin-related pathways. Mol Psychiatry. 20091435335519308022
  • BradleyJCarterSRRaoVRWangJFinkbeinerSSplice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J Neurosci. 2006261065107616436592
  • LynchDRGuttmannRPNMDA receptor pharmacology: Perspectives from molecular biology. Curr. Drug Targets. 20012215231
  • BergerAJDieudonneSAscherPGlycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J Neurophysiol. 199880333633409862928
  • RansomRWStecNLCooperative modulation of [3H]MK-801 binding to the N-methyl-D-aspartate receptor-ion channel complex by L-glutamate, glycine, and polyamines. J Neurochem 1988518308362457653
  • FosterACWongEHThe novel anticonvulsant MK-801 binds to the activated state of the N-methyl-D-aspartate receptor in rat brain. Br J Pharmacol. 1987914034092886170
  • WongEHKempJAPriestleyTKnightARWoodruffGNIversenLLThe anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist. Proc Natl Acad Sci U S A. 198683710471083529096
  • HongSJLiHBeckerKGDawsonVLDawsonTMIdentification and analysis of plasticity-induced late-response genes. Proc Natl Acad Sci U S A. 20041002145215014766980
  • LiuLWongTPPozzaMFet al.Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 20043041021102415143284
  • CoyleJTGlutamate and schizophrenia: beyond the dopamine hypothesis. Cell Mol Neurobiol. 20062636538416773445
  • JohnsonJWAscherPGlycine potentiates the NMDA response in cultured mouse brain neurons. Nature. 19873255295312433595
  • KlecknerNWDingledineRRequirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science. 19882418358372841759
  • ThomsonAMWalkerVEFlynnDMGlycine enhances NMDA-receptor mediated synaptic potentials in neocortical slices. Nature. 19893384224242538754
  • BergeronRMeyerTMCoyleJTGreeneRWModulation of N-methylD-aspartate receptor function by glycine transport. Proc Natl Acad Sci U S A. 1 998951 57301 5734
  • HashimotoKFukushimaTShimizuEet al.Decreased serum levels of D-serine in patients with schizophrenia: evidence in support of the Nmethyl-D-aspartate receptor hypofunction hypothesis of schizophrenia. Arch Gen Psychiatry. 20036057257612796220
  • BendikovINadriCAmarSPanizzuttiRDe MirandaJWoloskerHAgamGA CSF and postmortem brain study of D-serine metabolic parameters in schizophrenia. Schizophr Res. 200790415117156977
  • SchwarczRRassoulpourAWuHQMedoffDTammingaCARobertsRCIncreased cortical kynurenate content in schizophrenia. Biol Psychiatry. 20015052153011600105
  • NilssonLKLinderholmKREngbergGet al.Elevated levels of kynurenic acid in the cerebrospinal fluid of male patients with schizophrenia. Schizophr Res. 200515;8031 5322
  • MatsuiTSekiguchiMHashimotoATomitaUNishikawaTWadaKFunctional comparison of D-serine and glycine in rodents: the effect on cloned NMDA receptors and the extracellular concentration. J Neurochem. 1995654544587790891
  • WatsonGBBolanowskiMABaganoffMPDeppelerCLLanthornTHD-cycloserine acts as a partial agonist at the glycine modulatory site of the NMDA receptor expressed in Xenopus oocytes. Brain Res. 199026;510158160
  • TsaiGELinPYStrategies to enhance N-methyl-D-aspartate receptormediated neurotransmission in schizophrenia, a critical review and metaanalysis. Curr Ph arm Des. 201016522537
  • BuchananRWJavittDCMarderSRet al.The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments. Am J Psychiatry. 20071641593160217898352
  • Heresco-LevyUJavittD CErmilovMordelCSilipoGLichtensteinMEfficacy of high-dose glycine in the treatment of enduring negative symptoms of schizophrenia. Arch Gen Psychiatry. 19995629369892253
  • JavittDCSilipoGCienfuegosAShelleyAMBarkNParkMet al.Adjunctive high-dose glycine in the treatment of schizophrenia. Int J Neuropsychopharmacol. 20014385391 11806864
  • GoffDCTsaiGManoachDSCoyleJTDose-finding trial of D-cycloserine added to neuroleptics for negative symptoms in schizophrenia. Am J Psychiatry. 1995152121312157625475
  • QuartermainDMowerJRaffertyMFHertingRLLanthornTHAcute but not chronic activation of the NMDA-coupled glycine receptor with Dcycloserine facilitates learning and retention. Eur J Pharmacol. 1994257712
  • BakerJDAzorlosaJLThe NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning. Behav Neurosci. 1 9961106186208889007
  • WalkerDLResslerKJLuKTDavisMFacilitation of conditioned fear extinction by systemic administration or intra-amygdala infusions of Dcycloserine as assessed with fear-potentiated startle in rats. J Neurosci. 2002222343235111896173
  • MyersKMCarlezonWA JrD-cycloserine facilitates extinction of naloxone-induced conditioned place aversion in morphine-dependent rats. Biol Psychiatry. 201067858719782965
  • ResslerKJRothbaumBOTannenbaumLet al.Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobic individuals to facilitate extinction of fear. Arch Gen Psychiatry. 2004611 1361 144
  • NorbergMMKrystalJHTolinDFA meta-analysis of D-cycloserine and the facilitation of fear extinction and exposure therapyBiol Psychiatry. 2008631118112618313643
  • OldendorfWHUptake of radiolabeled essential amino acids by brain following arterial injection. Proc Soc Exp Biol Med. 19711363853865544467
  • HashimotoAChibaSEffect of systemic administration of D-serine on the levels of D- and L-serine in several brain areas and periphery of rat. Eur J Pharmacol. 200449515315815249164
  • NinanIJardemarkKEWangRYDifferential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pryramidal cells of the rat medial prefrontal cortexSynapse. 200348667912619040
  • JavittDCDuncanLBallaASershenHInhibition of system A-mediated glycine transport in cortical synaptosomes by therapeutic concentrations of clozapine: implications for mechanisms of action. Mol Psychiatry. 20051027528715278098
  • NagataYInvolvement of D-amino acid oxidase in elimination of Dserine in mouse brainExperientia. 1992487537551355447
  • HoriikeKTojoHAraiRYamanoTNozakiMMaedaTLocalization of D-amino acid oxidase in Bergmann glial cells and astrocytes of rat cerebellum. Brain Res Bull. 1987195875962891417
  • VerrallLBurnetPWBettsJFHarrisonPJThe neurobiology of Damino acid oxidase and its involvement in schizophrenia. Mol Psychiatry. 20101512213719786963
  • Detera-WadleighSDMcMahonFJG72/G30 in schizophrenia and bipolar disorder: review and meta-analysis. Biol Psychiatry. 20066010611416581030
  • ShiJBadnerJAGershonESLiuCAllelic association of G72/ G30 with schizophrenia and bipolar disorder: a comprehensive meta-analysis. Schizophr Res. 200898899718023149
  • KapoorRLimKSChengAGarrickTKapoorVPreliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1). Brain Res. 2006110620521016828464
  • MadeiraCFreitasMEVargas-LopesCWoloskerHPanizzuttiRIncreased brain D-amino acid oxidase (DAAO) activity in schizophrenia. Schizophr Res. 2008101768318378121
  • BurnetPWEastwoodSLBristowGCGodlewskaBRSikkaPWalkerMHarrisonPJD-amino acid oxidase activity and expression are increased in schizophrenia. Mol Psychiatry. 2008365866018560437
  • ChumakovIBlumenfeldMGuerassimenkoOCavarecLPalicioMAbderrahimHet al.Genetic and physiological data implicating the new human gene G72 and the gene for Damino acid oxidase in schizophrenia. Proc Natl Acad Sci U S A. 200299136751368012364586
  • AdageTTrillatACQuattropaniAet al.In vitro and in vivo pharmacological profile of AS057278, a selective d-amino acid oxidase inhibitor with potential anti-psychotic properties. Eur Neuropsychopharmacol. 20081820021417681761
  • HashimotoKFujitaYHorioMet al.Co-administration of a D-amino acid oxidase inhibitor potentiates the efficacy of D-serine in attenuating prepulse inhibition deficits after administration of dizocilpine. Biol Psychiatry. 2009651103110619217074
  • SmithSMUslanerJMYaoLet al.The behavioral and neurochemical effects of a novel D-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and D-serine. J Pharmacol Exp Ther. 200932892193019088300
  • GoltsovAYLosevaJGAndreevaTVealPolymorphism in the 5'-promoter region of serine racemase gene in schizophrenia. Mol Psychiatry. 20061132532616446740
  • MoritaYUjikeHTanakaYOtaniKet al.A genetic variant of the serine racemase gene is associated with schizophrenia. Biol Psychiatry. 2007611200120317067558
  • LabrieVFukumuraRRastogiAet al.Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009183227324319483194
  • WoloskerHBlackshawSSnyderSHSerine racemase: A glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Proc Natl Acad Sci U S A. 199996134091341410557334
  • KartvelishvilyEShleperMBalanLDuminEWoloskerHNeuronderived D-serine release provides a novel means to activate N-methyl-Daspartate receptors. J Biol Chem. 2006281141511416216551623
  • MiyaKInoueRTakataYet al.Serine racemase is predominantly localized in neurons in mouse brain. J Comp Neurol. 200820;510641654
  • LabrieVFukumuraRRastogiAFickLJWangWBoutrosPCKennedyJLSemeralulMOLeeFHBakerGBBelshamDDBargerSWGondoYWongAHRoderJCSerine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Hum Mol Genet. 2009183227324319483194
  • RutterARFradleyRLGarrettEMet al.Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur J Neurosci. 2007251757176617432963
  • HelboeLEgebjergJMøllerMThomsenCDistribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. Eur J Neurosci. 2003182227223814622183
  • MatsuoHKanaiYTokunagaMet al.High affinity D- and L-serine transporter Asc-1: cloning and dendritic localization in the rat cerebral and cerebellar cortices. Neurosci Lett. 200435812312615026164
  • YangCRSvenssonKAAllosteric modulation of NMDA receptor via elevation of brain glycine and D-serine: the therapeutic potentials for schizophrenia. Pharmacol Ther. 200812031733218805436
  • XieXDumasTTangLet al.Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 2005105221222116026768
  • GuastellaJBrechaNWeigmannCLesterHADavidsonNCloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc Natl Acad Sci U S A. 199289718971931353889
  • ZafraFGomezaJOlivaresLAragónCGiménezCRegional distribution and developmental variation of the glycine transporters GLYT1 and GLYT2 in the rat CNS. Eur J Neurosci. 19957134213527582108
  • ChenLMuhlhauserMYangCRGlycine tranporter-1 blockade potentiates NMDA-mediated responses in rat prefrontal cortical neurons in vitro and in vivo. J Neurophysiol 20038969170312574447
  • KinneyGGSurCBurnoMet al.The glycine transporter type 1 inhibitor N-[3-(4_-fluorophenyl)-3-(4_- phenylphenoxy)propyl]sarcosine potentiates NMDA receptor-mediated responses in vivo and produces an antipsychotic profile in rodent behavior. J Neurosci. 20032375867591 12930797
  • LindsleyCWWolkenbergSEKinneyGGProgress in the preparation and testing of glycine transporter type-1 (GlyT1) inhibitors. Curr Top Med Chem. 200661883189617017963
  • SwansonCBuresMJohnsonMLindenAMonnJSchoeppDMetabotropic glutamate receptors as novel targets for anxiety and stress disorders. Nat Rev Drug Discov. 2005413114415665858
  • PaluchaAPilcAMetabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs. Pharm Ther. 2007115116147
  • KalivasPWThe glutamate homeostasis hypothesis of addiction. Nat Rev Neurosci. 20091056157219571793
  • ConnPJLindsleyCWJonesCKActivation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci. 2009302531 19058862
  • ConnPJPinJPharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol. 1997372052379131252
  • ScanzianiMSalinPAVogtKEMalenkaRCNicollRAUse-dependent increases in glutamate concentration activate presynaptic metabotropic glutamate receptors. Nature. 19973856306349024660
  • MarekGJWrightRASchoeppDDMonnJAAghajanianGKPhysiological antagonism between 5-hydroxytryptamine 2A and group II metabotropic glutamate receptors in prefrontal corotexJ Pharmacol Exp Ther. 2000292768710604933
  • DietrichDKralTClusmannHFriedlMSchrammJPresynaptic group II metabotropic glutamate receptors reduce stimulated and spontaneous transmitter release in human dentate gyrus. Neuropharmacology. 20024229730511897108
  • MoghaddamBAdamsBReversal of phencyclidine effects by a group II metabotropic glutamate receptor agonist in rats. Science. 1998281134913529721099
  • MoghaddamBAdamsBVermaADalyDActivation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex. J Neurosci. 199717292129279092613
  • LewisDAHashimotoTVolkDWCortical inhibitory neurons and schizophrenia. Nat Rev Neurosci. 2005631232415803162
  • LewisDAMoghaddamBCognitive dysfunction in schizophrenia: convergence of gamma-aminobutyric acid and glutamate alterations. Arch Neurol. 2006631372137617030651
  • LismanJECoyleJTGreenRWet al.Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci. 20083123424218395805
  • SchoeppDDJaneDEMonnJAPharmacological agents acting at subtypes of metabotropic glutamate receptors. Neuropharmacology. 1999381431147610530808
  • CartmellJMonnJASchoeppDDThe metabotropic glutamate 2/3 receptor agonists LY354740 and LY379268 selectively attenuate phencyclidine versus d-amphetamine motor behaviors in rats. J Pharmacol Exp Ther. 199929116117010490900
  • CartmellJSchoeppDDRegulation of neurotransmitter release by metabotropic glutamate receptors. J Neurochem. 20007588990710936169
  • GaliciREchemendiaNGRodriguezALConnPJA selective allosteric potentiator of metabotropic glutamate (mGlu) 2 receptors has effects similar to an orthosteric mGlu2/3 receptor agonist in mouse models predictive of antipsychotic activity. J Pharmacol Exp Ther. 200531 51 1811 187
  • GaliciRJonesCKHemstapatKNongYEchemendiaNGWilliamsLCde PaulisTConnPJBiphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther. 200631817318516608916
  • Rorick-KehnLMHartJCMcKinzieDLPharmacological characterization of stress-induced hyperthermia in DBA/2 mice using metabotropic and ionotropic glutamate receptor ligands. Psychopharmacology (Berl). 200518322624016175401
  • GrecoBInvernizziRWCarliMPhencyclidine-induced impairment in attention and response control depends on the background genotype of mice: reversal by the mGLU(2/3) receptor agonist LY379268. Psychopharmacology (Berl). 2005179687615678361
  • AdamsBMoghaddamBCorticolimbic dopamine neurotransmission is temporally dissociated from the cognitive and locomotor effects of phencyclidine. J Neurosci. 199815;1855455554
  • BenneyworthMAXiangZSmithRLGarciaEEConnPJSanders-BushEA selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis. Mol Pharmacol. 20077247748417526600
  • PatilSTZhangLMartenyiFet al.Activation of mGlu2/3 receptors as a new approach to treat schizophrenia: a randomized Phase 2 clinical trial. Nat Med. 2007131102110717767166
  • KrystalJHAbi-SaabWPerryEet al.Preliminary evidence of attenuation of the disruptive effects of the NMDA glutamate receptor antagonist, ketamine, on working memory by pretreatment with the group II metabotropic glutamate receptor agonist, LY354740, in healthy human subjects. Psychopharmacology (Berl). 200517930330915309376
  • HomayounHJacksonMEMoghaddamBActivation of metabotropic glutamate 2/3 receptors reverses the effects of NMDA receptor hypofunction on prefrontal cortex unit activity in awake rats. J Neurophysiol. 2005931989200115590730
  • higemotoRKinoshitaAWadaEet al.Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci. 199717750375229295396
  • TamaruYNomuraSMizunoNShigemotoRDistribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sitesNeuroscience. 200110648150311591452
  • CortiCBattagliaGMolinaroGet al.The use of knock-out mice unravels distinct roles for mGlu2 and mGlu3 metabotropic glutamate receptors in mechanisms of neurodegeneration/neuroprotection. J Neurosci. 20071;2782978308
  • poorenWPGaspariniFvan derPutten HKollerMNakanishiSKuhnRLack of effect of LY314582 (a group 2 metabotropic glutamate receptor agonist) on phencyclidine-induced locomotor activity in metabotropic glutamate receptor 2 knockout mice. Eur J Pharmacol. 2000397R1R210844118
  • 147 ConnPJLindsleyCWJonesCKActivation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci. 2009302531 19058862
  • ConnPJChristopoulosALindsleyCWAllosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders. Nat Rev Drug Discov. 20098415419116626
  • SchaffhauserHRoweBAMoralesSet al.Pharmacological characterization and identification of amino acids involved in the positive modulation of metabotropic glutamate receptor subtype 2. Mol Pharmacol. 20036479881014500736
  • JohnsonMPBaezMJagdmannGEet al.Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2- trifluoroethylsulfonyl)pyrid-3-ylmethylamine. J Med Chem. 2003463189319212852748
  • JohnsonMPBardaDBrittonTCet al.Metabotropic glutamate 2 receptor potentiators: receptor modulation, frequency-dependent synaptic activity, and efficacy in preclinical anxiety and psychosis model(s). Psychopharmacology. 20051 7927128315717213
  • BakerDAMcFarlandKLakeRWShenHTodaSKalivasPWN-acetyl cysteine-induced blockade of cocaine-induced reinstatement. Ann N Y Acad Sci. 2003100334935114684458
  • McBeanGJCerebral cystine uptake: a tale of two transportersTrends Pharmacol Sci. 20022329930212119142
  • MoranMMMcFarlandKMelendezRlKalivasPWSeamansJKCystine/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci. 2005256389639316000629
  • ZhouWKalivasPWN-acetylcysteine reduces extinction respondi d induces enduring reductions in cue- and heroin-induced drug-seekin Biol Psychiatry. 20086333834017719565
  • PetersJKalivasPWThe group II metabotropic glutamate recept onist, LY379268, inhibits both cocaine- and food-seeking behavior in rats. Psychopharmacology (Berl). 200618614314916703399
  • BakerDAMadayagAKristiansenLVMeador-WoodruffJHHaroutunianVRajuIContribution of cystine-glutamate antiporters e psychotomimetic effects of phencyclidine. Neuropsychopharmacology. 08331760167217728701
  • BerkMCopolovDDeanOet al.N-acetyl cysteine as a glutathione precursor for schizophrenia-a double-blind, randomized, placebo-controlled trial. Biol Psychiatry. 20086436136818436195
  • KôhrGEckardtSLûddensHMonyerHSeeburgPHNMDA receptor channels: subunit-specific potentiation by reducing agents. Neuron. 199412103110407514425
  • BehrensMMSejnowksiTJDoes schizophrenia arise from oxidative dysregulation of parvalbumin-interneurons in the developing cortex? Neuropharmacology. 20095719320019523965
  • TuJCXiaoBNaisbittSet al.Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron. 19992358359210433269
  • DohertyAJPalmerMJHenleyJMCollingridgeGLJaneDE(RS)-2chloro-5-hydroxyphenylglycine (CHPG) activates mGlu5, but not mGlul, receptors expressed in CHO cells and potentiates NMDA responses in the hippocampus. Neuropharmacology. 1997362652679144665
  • PisaniAGubelliniPBonsiPet al.Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. Neuroscience. 200110657958711591458
  • AwadHHubertGWSmithYLeveyAlConnPJActivation of metabotropic glutamate receptor 5 has direct excitatory effects and potentiates NMDA receptor currents in neurons of the subthalamic nucleus. J Neurosci. 2000207871787911050106
  • HenrySALehmann-MastenVGaspariniFGeyerMAMarkouAThe mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology. 2002431 199120912213254
  • KinneyGGBurnoMCampbellUCet al.Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. J Pharmacol Exp Ther. 200330611612312660307
  • HomayounHStefaniMRAdamsBWTamaganGDMoghaddamBFunctional interaction Between NMDA and mGlu5 receptors: effects on working memory, instrumental learning, motor behaviors, and dopamine release. Neuropsychopharmacology. 2004291259126915010696
  • CampbellUCLalwaniKHernandezLKinneyGGConnPJBristowLJThe mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. Psychopharmacology (Berl). 200417531031815024550
  • HomayounHMoghaddamBBursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors. Cereb Cortex. 2006169310515843630
  • LiuFGrauerSKelleyCNavarraRet al.ADX47273 [S-(4-fluorophenyl)-{3-[3-(4-fluoro-phenyl)-[1,2,4]-oxadiazol-5-yl]-piperidin-1-yl}methanone]: a novel metabotropic glutamate receptor 5-selective positive allosteric modulator with preclinical antipsychotic-like and procognitive activities. J Pharmacol Exp Ther. 200832782783918753411
  • SchlumbergerCPietraszekMGraviusAet al.Comparison of the mGlu receptor positive allosteric modulator ADX47273 and the mGlu(2/3) receptor agonist LY354740 in tests for antipsychotic-like activity. Eur J Pharmacol. 2009623738319765575
  • HashimotoTBazmiHHMimicsKWuQSampsonARLewisDAConserved regional patterns of GABA-related transcript expression in the neocortex of subjects with schizophrenia. Am J Psychiatry. 200816547948918281411
  • BehrensMMAliSSDuganLLlnterleukin-6 mediates the increase in NADPH-oxidase in the ketamine model of schizophrenia. J Neurosci. 200828139571396619091984
  • WhittingtonMATraubRDInterneuron diversity series: inhibitory interneurons and network oscillations in vitro. Trends Neurosci. 20032667668214624852
  • MohlerHRole of GABAA receptors in cognitionBiochem Soc Trans. 2009371328133319909270
  • CruzDAWeaverCLLovalloEMMelchitzkyDSLewisDASelective alterations in postsynaptic markers of chandelier cell inputs to cortical pyramidal neurons in subjects with schizophrenia. Neuropsychopharmacology. 2009342112212419322171
  • YeeBKKeistRvon BoehmerLet al.A schizophrenia-related sensorimotor deficit links alpha 3-containing GABAA receptors to a dopamine hyperfunction. Proc Natl Acad Sci U S A. 2005102171541715916284244
  • RudolphUMohlerHGABA-based therapeutic approaches: GABAA receptor subtype functionsCurr Opin Pharmacol. 20066182316376150
  • LewisDAChoRYCarterCSet al.Subu nit-selective modulation of GABA type A receptor neurotransmission and cognition in schizophrenia. Am J Psychiatry. 20081651585159318923067
  • 0kadaHMatsushitaNKobayashiKKobayashiK10. Identification of GABAA receptor subunit variants in midbrain dopaminergic neurons. J Neurochem. 20048971415030384
  • LangmeadCJWatsonJReavillCMuscarinic acetylcholine receptors as CNS drug targets. Pharmacol Ther. 20081 1723224318082893
  • CaulfieldMPBirdsallNJInternational Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998502792909647869
  • GrossbergGTEffect of rivastigmine in the treatment of behavioral disturbances associated with dementia: review of neuropsychiatrie impairment in Alzheimer's disease. Curr Med Res Opin. 2005211631163916238903
  • FigielGSadowskyCA systematic review of the effectiveness of rivastigmine for the treatment of behavioral disturbances in dementia and other neurological disorders. Curr Med Res Opin. 20082415716618036286
  • ShekharAPotterWZLightfootJet al.Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia. Am J Psychiatry. 20081651033103918593778
  • BymasterFPCarterPAYamadaMet al.Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur J Neurosci. 2003171403141012713643
  • WessJEglenRMGautamDMuscarinic acetylcholine receptors: mutant mice provide new insights for drug development. Wat Rev Drug Discov. 20076721733
  • CrookJMTomaskovic-CrookECopolovDLDeanBLow muscarinic receptor binding in prefrontal cortex from subjects with schizophrenia: a study of Brodmann's areas 8, 9, 10, and 46 and the effects of neuroleptic drug treatment. Am J Psychiatry. 200115891892511384900
  • DeanBMcLeodMKeriakousDMcKenzieJScarrEDecreased muscarinic1 receptors in the dorsolateral prefrontal cortex of subjects with schizophrenia. Mol Psychiatry. 200271083109112476323
  • AnagnostarasSGMurphyGGHamiltonSEet al.Selective cognitive dysfunction in acetylcholine M1 muscarinic receptor mutant mice. Nat Neurosci. 20036515812483218
  • GerberDJSotnikovaTDGainetdinovRRHuangSYCaronMGTonegawaSHyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. Proc Natl Acad Sci U S A. 200198153121531711752469
  • TzavaraETBymasterFPDavisRJet al.M4 muscarinic receptors regulate the dynamics of cholinergic and dopaminergic neurotransmission: relevance to the pathophysiology and treatment of related CNS pathologies. FASEB J. 2004181410141215231726
  • TzavaraETBymasterFPFelderCCet al.Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice. Mol Psychiatry. 2003867367912874603
  • ShinoeTMatsuiMTaketoMMManabeTModulation of synaptic plasticity by physiological activation of M1 muscarinic acetylcholine receptors in the mouse hippocampus. J Neurosci. 200525111941120016319319
  • MarinoMJRouseSTLeveyAIPotterLTConnPJActivation of the genetically defined m1 muscarinic receptor potentiates N-methyl-Daspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci U S A. 19989511465114709736760
  • ConnPJJonesCKLindsleyCWSubtype-selective allosteric modulators of muscarinic receptors for the treatment of CNS disorders. Trends Pharmacol Sci. 20093014815519201489
  • ShireyJKXiangZOrtonDet al.An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission. Nat Chem Biol. 20084425018059262
  • JonesCKBradyAEDavisAAet al.Novel selective allosteric activator of the M1 muscarinic acetylcholine receptor regulates amyloid processing and produces antipsychotic-like activity in rats. J Neurosci. 200828104221043318842902
  • ShireyJKBradyAEJonesPJet al.A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning. J Neurosci. 200929142711427819906975
  • ChanWYMcKinzieDLBoseSet al.Allosteric modulation of the muscarinic M4 receptor as an approach to treating schizophrenia. Proc Natl Acad Sci U S A. 2008105109781098318678919
  • BradyAEJonesCKBridgesTMet al.Centrally active allosteric potentiators of the M4 muscarinic acetylcholine receptor reverse amphetamineinduced hyperlocomotor activity in rats. J Pharmacol Exp Ther. 200832794195318772318
  • HughesJRHatsukamiDKMitchellJEDahlgrenLAPrevalence of smoking among psychiatric outpatients. Am J Psychiatry. 19861439939973487983
  • KellyCMcCreadieRGSmoking habits, current symptoms, and premorbid characteristics of schizophrenic patients in Nithsdale, Scotland. Am J Psychiatry. 19991561751175710553739
  • StrandJENybackHTobacco use in schizophrenia: a study of cotinine concentrations in the saliva of patients and controls. Eur Psychiatry. 200520505415642444
  • AddingtonJel-GuebalyNAddingtonDHodginsDReadiness to stop smoking in schizophrenia. Can J Psychiatry. 19974249529040923
  • AdlerLEOlincyAWaldoMet al.Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 1998241892029613620
  • MukherjeeSMahadikSPKorenovskyALaevHSchnurDBReddyRSerum antibodies to nicotinic acetylcholine receptors in schizophrenic patients. Schizophr Res. 1994121311368043523
  • ForchukCNormanRMallaAet al.Schizophrenia and the motivation for smoking. Perspect Psychiatr Care. 200238414912132630
  • DaniJABertrandDNicotinic acetylcholine receptors and nicotinic cholinergic mechanisms of the central nervous system. Annu Rev Pharmacol Toxicol. 20074769972917009926
  • FrotscherMLeranthCCholinergic innervation of the rat hippocampus as revealed by choline acetyltransferase immunocytochemistry: a combined light and electron microscopic study. J Comp Neurol. 19852392372464044938
  • GrayRRajanASRadcliffeKAYakehiroMDaniJAHippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature. 19963837137168878480
  • KrenzIKalkanDWeversAet al.Parvalbumin-containing interneurons of the human cerebral cortex express nicotinic acetylcholine receptor proteins. J Chem Neuroanat. 20012123924611382535
  • FrazierCJBuhlerAVWeinerJLDunwiddieTVSynaptic potentials mediated via alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal interneurons. J Neurosci. 199818822882359763468
  • KlinkRde Kerchoved'Exaerde AZoliMChangeuxJPMolecular and physiological diversity of nicotinic acetylcholine receptors in the midbrain dopaminergic nuclei. J Neurosci. 2001211452146311222635
  • MansvelderHDKeathJRMcGeheeDSSynaptic mechanisms underlie nicotine-induced excitability of brain reward areas. Neuron. 20023390591911906697
  • SchilstromBFagerquistMVZhangXet al.Putative role of presynaptic alpha7: nicotinic receptors in nicotine stimulated increases of extracellular levels of glutamate and aspartate in the ventral tegmental area. Synapse. 20003837538311044884
  • GaultJRobinsonMBergerRet al.Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics. 1998521731859782083
  • CourtJSpurdenDLloydSet al.Neuronal nicotinic receptors in dementia with Lewy bodies and schizophrenia: alpha-bungarotoxin and nicotine binding in the thalamus. J Neurochem. 1999731590159710501205
  • FreedmanRHallMAdlerLELeonardSEvidence in postmortem brain tissue for decreased numbers of hippocampal nicotinic receptors in schizophrenia. Biol Psychiatry. 19953822337548469
  • arutleAZhangXCourtJet al.Laminar distribution of nicotinic receptor subtypes in cortical regions in schizophrenia. J Chem Neuroanat. 20012211512611470559
  • Martin-RuizCMHaroutunianVHLongPet al.Dementia rating and nicotinic receptor expression in the prefrontal cortex in schizophrenia. Biol Psychiatry. 2003541222123314643090
  • PerlOIlaniTStrousRDLapidusRFuchsSThe alpha7 nicotinic acetylcholine receptor in schizophrenia: decreased mRNA levels in peripheral blood lymphocytes. FASEB J. 2003171948195012897067
  • YoungJWCrawfordNKellyJSet al.Impaired attention is central to the cognitive deficits observed in alpha 7 deficient mice. Eur Neuropsychopharmacol. 2007171451 5516650968
  • LevinEDBradleyAAddyNSiguraniNHippocampal alpha 7 and alpha 4 beta 2 nicotinic receptors and working memory. Neuroscience. 200210975776511927157
  • LevinEDBettegowdaCBlosserJGordonJAR-R17779, and alpha7 nicotinic agonist, improves learning and memory in rats. Behav Pharmacol. 19991067568010780509
  • KoikeKHashimotoKTakaiNet al.Tropisetron improves deficits in auditory P50 suppression in schizophrenia. Schizophr Res. 200576677215927799
  • RoncaratiRScaliCComeryTAet al.Procognitive and neuroprotective activity of a novel alpha7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J Pharmacol Exp Ther. 200932945946819223665
  • MeyerEMTayETPapkeRLMeyersCHuangGLde FiebreCM3[2,4-Dimethoxybenzylidene]anabaseine (DMXB) selectively activates rat alpha7 receptors and improves memory-related behaviors in a mecamylamine-sensitive manner. Brain Res. 199776849569369300
  • BriggsCAAndersonDJBrioniJDet al.Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol Biochem Behav. 1997572312419164577
  • Woodruff-PakDSMecamylamine reversal by nicotine and by a partial alpha7 nicotinic acetylcholine receptor agonist (GTS-21) in rabbits test th delay eyeblink classical conditioning. Behav Brain Res. 200314315916712900042
  • StevensKEKemWRMahnirVMFreedmanRSelective alpha7-nic nic agonists normalize inhibition of auditory response in DBA mice Psychopharmacology (Berl). 19981363203279600576
  • KitagawaHTakenouchiTAzumaRet al.Safety, pharmacokinetics, and effects on cognitive function of multiple doses of GTS-21 in healthy, male volunteers. Neuropsychopharmacology. 20032854255112629535
  • MartinLFFreedmanRSchizophrenia and the alpha7 nicotinic acetylcholine receptor. Int Rev Neurobiol. 20077822524617349863
  • OlincyAHarrisJGJohnsonLLet al.Proof-of-concept trial of an alpha7 nicotinic agonist in schizophreniaArch Gen Psychiatry. 20066363063816754836
  • FreedmanROlincyABuchananRWet al.Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry. 20081651040104718381905
  • TregellasJROlincyAJohnsonLet al.Functional magnetic resonance imaging of effects of a nicotinic agonist in schizophrenia. Neuropsychopharmacology. 20103593894219956085
  • RezvaniAHKholdebarinEBrucatoFHCallahanPMLoweDALevinEDEffect of R3487/MEM3454, a novel nicotinic alpha7 receptor partial agonist and 5-HT3 antagonist on sustained attention in rats. Prog Neuropsychopharmacol Biol Psychiatry. 20093326927519110025
  • BitonBBergisOEGalliFet al.SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: binding and functional profile. Neuropsychopharmacology. 20073211617019409
  • PichatPBergisOETerranovaJPet al.SSR180711, a novel selective alpha7 nicotinic receptor partial agonist: (II) efficacy in experimental models predictive of activity against cognitive symptoms of schizophrenia. Neuropsychopharmacology. 200732173416936709
  • BarakSAradMDe LevieABlackMDGriebelGWeinerIPro-cognitive and antipsychotic efficacy of the alpha7 nicotinic partial agonist SSR180711 in pharmacological and neurodevelopmental latent inhibition models of schizophrenia. Neuropsychopharmacology. 2009341753176319158670
  • BertrandDGopalakrishnanMAllosteric modulation of nicotinic acetylcholine receptors. Biochem Pharmacol. 2007741155116317707779
  • HurstRSHajosMRaggenbassMet al.A novel positive allosteric modulator of the alpha7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J Neurosci. 2005254396440515858066
  • BroadLMZwartRPearsonKHet al.Identification and pharmacological profile of a new class of selective nicotinic acetylcholine receptor potentiators. J Pharmacol Exp Ther. 200631 81 1081 117
  • YoungGTZwartRWalkerASSherEMillarNSPotentiation of alpha7 nicotinic acetylcholine receptors via an allosteric transmembrane site. Proc Natl Acad Sci U S A. 2008105146861469118791069
  • FreedmanRGoldowitzDStudies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog Neurobiol. 20109026327519853005
  • LiuJPearlsonGWindemuthARuanoGPerrone-BizzozeroNICalhounVCombining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA. Hum Brain Mapp.20093024125518072279