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Translational Research

Animal models and high field imaging and spectroscopy

Modelos animales y espectroscopía e imaginología de alto campo

Modèles animaux et imagerie et spectroscopie à champ élevé

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Pages 263-278 | Published online: 01 Apr 2022

REFERENCES

  • UgurbilK.AdrianyG.AndersenP.et alUltrahigh field magnetic resonance imaging and spectroscopy.Magn Reson Imaging.2003211263128114725934
  • UgurbilK.The road to functional imaging and ultrahigh fields.Neuroimage.20126272673522333670
  • GruetterR.WeisdorfSA.RajanayaganV.et alResolution improvements in in vivo 1H NMR spectra with increased magnetic field strength.J Magn Reson.19981352602649799704
  • LeeSP.SilvaAC.UgurbilK.KimSG.Diffusion-weighted spin-echo fMRI at 9.4 T: microvascular/tissue contribution to BOLD signal changes.Magn Reson Med.19994291992810542351
  • PfeufferJ.TkacI.ChoiIY.et alLocalized in vivo 1H NMR detection of neurotransmitter labeling in rat brain during infusion of [1-13C] D-glucose.Magn Reson Med.1999411077108310371437
  • DuongTQ.KimDS.UgurbilK.KimSG.Spatiotemporal dynamics of the BOLD fMRI signals: toward mapping submillimeter cortical columns using the early negative response.Magn Reson Med.20004423124210918322
  • UgurbilK.Development of functional imaging in the human brain (fMRI); the University of Minnesota experience.Neuroimage.20126261361922342875
  • OgawaS.TankDW.MenonR.et alIntrinsic signal changes accompanying sensory stimulation: functional brain mapping with magnetic resonance imaging.Proc Natl Acad Sci USA.199289595159551631079
  • KwongKK.BelliveauJW.CheslerDA.et alDynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.Proc Natl Acad Sci USA.199289567556791608978
  • BandettiniPA.WongEC.HinksRS.TikofskyRS.HydeJS.Time course EPI of human brain function during task activation.Magn Reson Med.1992253903971614324
  • OgawaS.MenonRS.TankDW.et alFunctional brain mapping by blood oxygenation level-dependent contrast magnetic resonance imaging. A comparison of signal characteristics with a biophysical model.Biophys J.93648038128386018
  • FujitaN.Extravascular contribution of blood oxygenation level-dependent signal changes: a numerical analysis based on a vascular network model.Magn Reson Med.20014672373411590649
  • BoxermanJL.HambergLM.RosenBR.WeisskoffRM.MR contrast due to intravascular magnetic susceptiblity perturbations.Magn Reson Med.1995345555568524024
  • KennanRP.ZhongJ.GoreJC.Intravascular susceptibility contrast mechanisms in tissue.Magn Reson Med.1994319318121277
  • UludagK.Muller-BierlB.UgurbilK.An integrative model for neuronal activity-induced signal changes for gradient and spin echo functional imaging.Neuroimage.20094815016519481163
  • UgurbilK.TothL.KimDS.How accurate is magnetic resonance imaging of brain function?Trends Neurosci.20032610811412536134
  • UgurbilK.AdrianyG.AndersenP.et alMagnetic resonance studies of brain function and neurochemistry.Annu Rev Biorned Eng.20002633660
  • KimSG.UgurbilK.High-resolution functional magnetic resonance imaging of the animal brain.Methods.200330284112695101
  • YacoubE.DuongTQ.Van De MoortelePF.et alSpin-echo fMRI in humans using high spatial resolutions and high magnetic fields.Magn Reson Med.20034965566412652536
  • YacoubE.Van De MoortelePF.ShmuelA.UgurbilK.Signal and noise characteristics of Hahn SE and GE BOLD fMRI at 7T in humans.Neuroimage.20052473875015652309
  • VaughanJT.GarwoodM.CollinsCM.et al7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images.Magn Reson Med.200146243011443707
  • DuongTQ.KimDS.UgurbilK.KimSG.Localized cerebral blood flow response at submillimeter columnar resolution.Proc Natl Acad Sci USA.200198109041090911526212
  • UgurbilK.Two decades of functional imaging: from nuclear spins to cortical columns.Cognitive Critique.20124121186
  • UgurbilK.Imaging of brain function using deoxyhemoglobin and magnetic fields. In: Choi l-Y, Gruetter R, eds.Neural Metabolism in Vivo. New York, NY: Springer US;2012501545
  • EngelSA.GloverGH.WandellBA.Retinotopic organization in human visual cortex and the spatial precision of functional MRI.Cereb Cortex.199771811929087826
  • RonenI.OlmanC.KimSG.UgurbilK.TothLJ.Spatial relationship between neuronal activity and BOLD functional MRI.Neuroimage.20042187688515006654
  • ParkJC.RonenI.KimD-S.UgurbilK.Spatial specificity of high resolution GE BOLD and CBF fMRI in the cat visual cortex.Proc Intl Soc Mag Reson Med.2004121014
  • ParkJC.RonenI.KimD-S.UgurbilK.Spatial specificity of high resolution GE BOLD and Spin Ech (SE) BOLD fMRI in the cat visual cortex at 9.4 Tesla. Procintl Soc Mag Reson Med.20051331
  • OlmanCA.HarelN.FeinbergDA.et alLayer-specific fMRI reflects different neuronal computations at different depths in human V1.PLoS One.20127e3253622448223
  • ZimmermannJ.GoebelR.De MartinoF.et alMapping the organization of axis of motion selective features in human area MT using high-field fMRI.PLoS One.20116e2871622163328
  • PolimeniJR.FischlB.GreveDN.WaldLL.Laminar analysis of 7T BOLD using an imposed spatial activation pattern in human V1.Neuroimage.2010521334134620460157
  • KoopmansPJ.EarthM.OrzadaS.NorrisDG.Multi-echo fMRI of the cortical laminae in humans at 7 T.Neuroimage.2011561276128521338697
  • YacoubE.ShmuelA.LogothetisN.UgurbilK.Robust detection of ocular dominance columns in humans using Hahn Spin Echo BOLD functional MRI at 7 Tesla.Neuroimage.2007371161117717702606
  • YacoubE.HarelN.UgurbilK.High-field fMRI unveils orientation columns in humans.Proc Natl Acad Sci U S A.2008105106071061218641121
  • MenonRS.OgawaS.StruppJP.UgurbilK.Ocular dominance in human V1 demonstrated by functional magnetic resonance imaging.J Neurophysiol.199777278027879163392
  • ChengK.WaggonerRA.TanakaK.Human ocular dominance columns as revealed by high-field functional magnetic resonance imaging.Neuron.20013235937411684004
  • GoodyearBG.MenonRS.Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI.Hum Brain Mapp.20011421021711668652
  • FukudaM.MoonCH.WangP.KimSG.Mapping iso-orientation columns by contrast agent-enhanced functional magnetic resonance imaging: reproducibility, specificity, and evaluation by optical imaging of intrinsic signal.J Neurosci.200626118211183217108155
  • SunP.UenoK.WaggonerRA.GardnerJL.TanakaK.ChengK.A temporal frequency-dependent functional architecture in human V1 revealed by high-resolution fMRI.Nat Neurosci.2007101404140617934459
  • ZhaoF.WangP.HendrichK.UgurbilK.KimSG.Cortical layer-dependent BOLD and CBV responses measured by spin-echo and gradient-echo fMRI: insights into hemodynamic regulation.Neuroimage.2006301149116016414284
  • ZhaoF.WangP.KimSG.Cortical depth-dependent gradient-echo and spin-echo BOLD fMRI at 9.4T.Magn Reson Med.20045151852415004793
  • KimSG.DuongTQ.Mapping cortical columnar structures using fMRI.Physiol Behav.20027764164412527012
  • DuongTQ.SilvaAC.LeeSP.KimSG.Functional MRI of calcium-dependent synaptic activity: cross correlation with CBF and BOLD measurements.Magn Reson Med.20004338339210725881
  • HarelN.LinJ.MoellerS.UgurbilK.YacoubE.Combined imaging-histological study of cortical laminar specificity of fMRI signals.Neuroimage.20062987988716194614
  • GoenseJB.LogothetisNK.Laminar specificity in monkey V1 using highresolution SE-fMRI.Magn Reson Imaging.20062438139216677944
  • YuX.GlenD.WangS.et alDirect imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV-V of the rat whisker-barrel cortex.Neuroimage.2012591451146021851857
  • MandevilleJB.MarotaJJ.KosofskyBE.et alDynamic functional imaging of relative cerebral blood volume during rat forepaw stimulation.Magn Reson Med.1998396156249543424
  • SmirnakisSM.SchmidMC.WeberB.ToliasAS.AugathM.LogothetisNK.Spatial specificity of BOLD versus cerebral blood volume fMRI for mapping cortical organization.J Cereb Blood Flow Metab.2007271248126117213863
  • LeiteFP.TsaoD.VanduffelW.et alRepeated fMRI using iron oxide contrast agent in awake, behaving macaques at 3 Tesla.Neuroimage.20021628329412030817
  • LogothetisNK.PaulsJ.AugathM.TrinathT.OeltermannA.Neurophysiological investigation of the basis of the fMRI signal.Nature.200141215015711449264
  • LogothetisNK.What we can do and what we cannot do with fMRI.Nature.200845386987818548064
  • KimDS.RonenI.OlmanC.KimSG.UgurbilK.TothLJ.Spatial relationship between neuronal activity and BOLD functional MRI.Neuroimage.20042187688515006654
  • LeopoldDA.MaierA.Ongoing physiological processes in the cerebral cortex.Neuroimage.2012622190220022040739
  • ScholvinckML.MaierA.YeFQ.DuynJH.LeopoldDA.Neural basis of global resting-state fMRI activity.Proc Natl Acad Sci U S A.12010107102381024320439733
  • ShmuelA.LeopoldDA.Neuronal correlates of spontaneous fluctuations in fMRI signals in monkey visual cortex: Implications for functional connectivity at rest.Hum Brain Mapp.082975176118465799
  • LiuX.ZhuXH.ZhangY.ChenW.Neural origin of spontaneous hemodynamic fluctuations in rats under burst-suppression anesthesia condition.Cerebral Cortex.20112137438420530220
  • BiswalB.YetkinFZ.HaughtonVM.HydeJS.Functional connectivity in the motor cortex of resting human brain using echo-planar MRI.Magn Res Med.199534537541
  • FoxMD.RaichleME.Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging.Nat Rev Neurosci.2007870071117704812
  • VincentJL.PatelGH.FoxMD.et alIntrinsic functional architecture in the anaesthetized monkey brain.Nature.2007447838617476267
  • BeckmannCF.DeLucaM.DevlinJT.SmithSM.Investigations into resting-state connectivity using independent component analysis.Philos Trans R Soc Lond B Biol Sci.20053601001101316087444
  • SmithSM.MillerKL.Salimi-KhorshidiG.et alNetwork modelling methods for FMRI.Neuroimage.20115487589120817103
  • SmithSM.BeckmannCF.AnderssonJ.et alResting-state fMRI in the Human Connectome Project.Neuroimage.20138014416823702415
  • KimS-G.HuX.UgurbilK.Accurate T1 determination from inversion recovery images: application to human brain at 4 Tesla.Magn Reson Med.1994314454498208121
  • JezzardP.DuewellS.BalabanRS.MR relaxation times in human brain: measurement at 4 T.Radiology.19961997737798638004
  • BarthaR.MichaeliS.MerkleH.et alIn vivo HO T(dagger) measurement in the human occipital lobe at 4T and 7T by Carr-Purcell MRI: detection of microscopic susceptibility contrast.Magn Reson Med.024774275011948736
  • MichaeliS.GarwoodM.ZhuXH.et alProton T relaxation study of water, N-acetylaspartate, and creatine in human brain using Hahn and Carr-Purcell spin echoes at 4T and 7T.Magn Reson Med.20024762963311948722
  • NorrisDG.High field human imaging.J Magn Reson Imaging.20031851952914579394
  • RooneyW.JohnsonG.LiX.et alMagnetic field and tissue dependencies of human brain longitudinal 1 H2O relaxation in vivo.Magn Reson Med.20075730831817260370
  • DobreMC.MarjanskaM.UgurbilK.Blood T1 measurement at high magnetic field strength.Proc Intl Soc Mag Reson Med.2005131162
  • BolanPJ.YacoubE.GarwoodM.UgurbilK.HarelN.In vivo micro-MRI of intracortical neurovasculature.Neuroimage.200632626916675271
  • DuynJH.van GelderenP.LiTQ.de ZwartJA.KoretskyAP.FukunagaM.High-field MRI of brain cortical substructure based on signal phase.Proc Natl Acad Sci USA.2007104117961180117586684
  • MarquesJP.MaddageR.MlynarikV.GruetterR.On the origin of the MR image phase contrast: an in vivo MR microscopy study of the rat brain at 14.1T.Neuroimage.20094634535219254768
  • SatiP.van GelderenP.SilvaAC.et alMicro-compartment specific T2* relaxation in the brain.Neuroimage.20137726827823528924
  • LeeJ.ShmueliK.KangBT.et alThe contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain.Neuroimage.2012593967397522056461
  • FukunagaM.LiTQ.van GelderenP.et alLayer-specific variation of iron content in cerebral cortex as a source of MRI contrast.Proc Natl Acad Sci USA.20101073834383920133720
  • LiTQ.YaoB.van GelderenP.et alCharacterization of T* heterogeneity in human brain white matter.Magn Reson Med.2009621652165719859939
  • LodygenskyGA.MarquesJP.MaddageR.et alIn vivo assessment of myelination by phase imaging at high magnetic field.Neuroimage.2012591979198721985911
  • JackCR.Jr.GarwoodM.WengenackTM.et alIn vivo visualization of Alzheimer's amyloid plaques by magnetic resonance imaging in transgenic mice without a contrast agent.Magn Reson Med.2004521263127115562496
  • JackCR.Jr Wengenack TM, Reyes DA, et al. In vivo magnetic resonance microimaging of individual amyloid plaques in Alzheimer's transgenic mice.J Neurosci.200525100411004816251453
  • JenkinsBG.KraftE.Magnetic resonance spectroscopy in toxic encephalopathy and neurodegeneration.Curr Opin Neurol.19991275376010676760
  • ChoiIY.LeeSP.GuilfoyleDN.HelpernJA.In vivo NMR studies of neurodegenerative diseases in transgenic and rodent models.Neurochem Res.200328987100112737523
  • MichaelisT.BoretiusS.FrahmJ.Localized proton MRS of animal brain in vivo: models of human disorders.Prog NMR Spect.200955134
  • DuarteJM.LeiH.MlynarikV.GruetterR.The neurochemical profile quantified by in vivo 1H NMR spectroscopy.Neuroimage.20126134236222227137
  • DautryC.VaufreyF.BrouilletE.et alEarly N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3- nitropropionic acid.J Cereb Blood Flow Metab.20002078979910826529
  • JenkinsBG.KlivenyiP.KustermannE.et alNonlinear decrease over time in N-acetyl aspartate levels in the absence of neuronal loss and increases in glutamine and glucose in transgenic Huntington's disease mice.J Neurochem.2000742108211910800956
  • BossuetC.VaufreyF.CondeF.et alUp-regulation of glutamate concentration in the putamen and in the prefrontal cortex of asymptomatic SIVmac251-infected macaques without major brain involvement.J Neurochem.20048892893814756814
  • DedeogluA.ChoiJK.CormierK.KowallNW.JenkinsBG.Magnetic resonance spectroscopic analysis of Alzheimer's disease mouse brain that express mutant human APP shows altered neurochemical profile.Brain Res.20041012606515158161
  • EmirUE.AuerbachEJ.MoortelePF.et alRegional neurochemical profiles in the human brain measured by H MRS at 7 T using local B shimming.NMR Biorned.201225152160
  • TkacI.OzG.AdrianyG.UgurbilK.GruetterR.In vivo 1H NMR spectroscopy of the human brain at high magnetic fields: metabolite quantification at 4T vs. 7T.Magn Reson Med.20096286887919591201
  • PfeufferJ.TkacI.ProvencherSW.GruetterR.Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time H NMR spectra of the rat brain.J Magn Reson.199914110412010527748
  • TkacI.HenryPG.AndersenP.KeeneCD.LowWC.GruetterR.Highly resolved in vivo 1H NMR spectroscopy of the mouse brain at 9.4 T.Magn Reson Med.20045247848415334565
  • SchwarczA.NattO.WatanabeT.BoretiusS.FrahmJ.MichaelisT.Localized proton MRS of cerebral metabolite profiles in different mouse strains.Magn Reson Med.20034982282712704764
  • HolmayMJ.TerpstraM.ColesLD.et alN-acetylcysteine boosts brain and blood glutathione in gaucher and Parkinson diseases.Clin Neuropharrnacol.201336103106
  • TkacI.OzG.In vivo proton MR spectroscopy: animal and human applications at high fields. In: Garrido L, Beckmann N, eds.New Applications of NMR in Drug Discovery and Development. London, UK: Royal Society of Chemistry;2013237258
  • BarthaR.DrostDJ.MenonRS.WilliamsonPC.Comparison of the quantification precision of human short echo time H spectroscopy at 1.5 and 4.0 Tesla.Magn Reson Med.20004418519210918316
  • OtazoR.MuellerB.UgurbilK.WaldL.PosseS.Signal-to-noise ratio and spectral linewidth improvements between 1.5 and 7 Tesla in proton echoplanar spectroscopic imaging.Magn Reson Med.2006561200121017094090
  • MekleR.MlynarikV.GambarotaG.HergtM.KruegerG.GruetterR.MR spectroscopy of the human brain with enhanced signal intensity at ultrashort echo times on a clinical platform at 3T and 7T.Magn Reson Med.2009611279128519319893
  • ClarkJB.N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction.Dev Neurosci.1998202712769778562
  • DemougeotC.GamierP.MossiatC.et alN-Acetylaspartate, a marker of both cellular dysfunction and neuronal loss: its relevance to studies of acute brain injury.J Neurochem.20017740841511299303
  • PetroffOA.PlebanLA.SpencerDD.Symbiosis between in vivo and in vitro NMR spectroscopy: the creatine, N-acetylaspartate, glutamate, and GABA content of the epileptic human brain.Magn Reson Imaging.199513119712118750337
  • Storm-MathisenJ.DanboltNC.RotheF.et alUltrastructural immuno-cytochemical observations on the localization, metabolism and transport of glutamate in normal and ischemic brain tissue.Prog Brain Res.1992942252411363142
  • OzG.TkacI.CharnasLR.et alAssessment of adrenoleukodystrophy lesions by high field MRS in non-sedated pediatric patients.Neurology.20056443444115699371
  • MarjanskaM.CurranGL.WengenackTM.et alMonitoring disease progression in transgenic mouse models of Alzheimer's disease with proton magnetic resonance spectroscopy. ProcNatl Acad Sci U S A.20051021190611910
  • AndreassenOA.JenkinsBG.DedeogluA.et alIncreases in cortical glutamate concentrations in transgenic amyotrophic lateral sclerosis mice are attenuated by creatine supplementation.J Neurochem.20017738339011299300
  • OttersenOP.Storm-MathisenJ.Glutamate- and GABA-containing neurons in the mouse and rat brain, as demonstrated with a new immuno-cytochemical technique.J Comp Neurol.19842293743926150049
  • PalmiM.BrookeS.SmithAD.BolarnJP.GABA-like immunoreactivity in different cellular populations of cerebellar cortex of rats before and after treatment with amino-oxyacetic acid.Brain Res.19915432772862059835
  • BrandA.Richter-LandsbergC.LeibfritzD.Multinuclear NMR studies on the energy metabolism of glial and neuronal cells.Dev Neurosci.1993152892987805581
  • SchuhmannMU.StillerD.SkardellyM.et alMetabolic changes in the vicinity of brain contusions: a proton magnetic resonance spectroscopy and histology study.J Neurotrauma.20032072574312965052
  • PouwelsPJ.KruseB.KorenkeGC.MaoX.HanefeldFA.FrahmJ.Quantitative proton magnetic resonance spectroscopy of childhood adrenoleukodystrophy.Neuropediatrics.1998292542649810561
  • KantarciK.PetersenRC.BoeveBF.et al1H MR spectroscopy in common dementias.Neurology.2004631393139815505154
  • VrenkenH.BarkhofF.UitdehaagBM.CastelijnsJA.PolmanCH.PouwelsPJ.MR spectroscopic evidence for glial increase but not for neuro-axonal damage in MS normal-appearing white matter.Magn Reson Med.20055325626615678547
  • FisherSK.NovakJE.AgranoffBW.Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance.J Neurochem.20028273675412358779
  • KimJP.LentzMR.WestmorelandSV.et alRelationships between astrogliosis and 1H MR spectroscopic measures of brain choline/creatine and myo-inositol/creatine in a primate model.Am J Neuroradiol.20052675275915814917
  • UrenjakJ.WilliamsSR.GadianDG.NobleM.Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types.J Neurosci.1993139819898441018
  • BitschA.BruhnH.VougioukasV.et alInflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy.Am J Neuroradiol.1999201619162710543631
  • MountfordCE.StanwellP.LinA.RamadanS.RossB.Neurospectroscopy: the past, present and future.Chem Rev.20101103060308620387805
  • ZacharoffL.TkacI.SongQ.et alCortical metabolites as blomarkers in the R6/2 model of Huntington's disease.J Cereb Blood Flow Metab.20123250251422044866
  • TkacI.HenryPG.ZacharoffL.et alHomeostatic adaptations in brain energy metabolism in mouse models of Huntington disease.J Cereb Blood FlowMetab.20123219771988
  • TerpstraM.MarjanskaM.HenryPG.TkacI.GruetterR.Detection of an antioxidant profile in the human brain in vivo via double editing with MEGA-PRESS.Magn Reson Med.2006561192119917089366
  • TkacI.RaoR.GeorgieffMK.GruetterR.Developmental and regional changes in the neurochemical profile of the rat brain determined by in vivo 1H NMR spectroscopy.Magn Reson Med.200350243212815675
  • ValetteJ.GulllermlerM.BesretL.HantrayeP.BlochG.LebonV.Isoflurane strongly affects the diffusion of intracellular metabolites, as shown by 1H nuclear magnetic resonance spectroscopy of the monkey brain.J Cereb Blood Flow Metab.20072758859616788716
  • LeiH.DuarteJM.MlynarikV.PythonA.GruetterR.Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex.J Neurosci Res.20108841341919746430
  • BakerM.In biomarkers we trust?Nat Biotechnol.052329730415765081
  • MlynarikV.CacquevelM.Sun-ReimerL.et alProton and phosphorus magnetic resonance spectroscopy of a mouse model of Alzheimer's disease.J Alzheimers Dis.201231(suppl 3)S87S9922451319
  • ChassainC.BielickiG.KellerC.RenouJP.DurifF.Metabolic changes detected in vivo by 1H MRS in the MPTP-intoxicated mouse.NMR Biomed.102354755320661872
  • EmirUE.TuitePJ.OzG.Elevated pontine and putamenal GABA levels in mild-moderate Parkinson disease detected by 7 tesla proton MRS.PLoS One.20127e3091822295119
  • HeikkinenT.LehtimakiK.VartiainenN.et alCharacterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington's disease.PLoS One.20127e5071723284644
  • TkacI.ZacharoffL.DubinskyJM.Longitudinal changes in neurochemical profiles of Huntington's disease mouse models. Paper presented at: 20th Scientific Meeting of the ISMRM; May 5-11, 2012; Melbourne, Australia.
  • UnschuldPG.EddenRA.CarassA.et alBrain metabolite alterations and cognitive dysfunction in early Huntington's disease.Mov Disord.20122789590222649062
  • van den BogaardSJ.DumasEM.TeeuwisseWM.et alExploratory 7Tesla magnetic resonance spectroscopy in Huntington's disease provides in vivo evidence for impaired energy metabolism.J Neurol.20112582230225921614431
  • DeKoskyST.MarekK.Looking backward to move forward: early detection of neurodegenerative disorders.Science.200330283083414593169
  • BurrightEN.ClarkHB.ServadioA.et alSCA1 transgenic mice: a model for neurodegeneration caused by an expanded CAG trinucleotide repeat.Cell.1995829379487553854
  • OzG.NelsonCD.KoskiDM.et alNoninvasive detection of presymptomatic and progressive neurodegeneration in a mouse model of spinocerebellar ataxia type 1.J Neurosci.2010303831383820220018
  • OzG.HutterD.TkacI.et alNeurochemical alterations in spinocerebellar ataxia type 1 and their correlations with clinical status.Mov Disord.2010251253126120310029
  • ChoiJK.JenkinsBG.CarrerasI.et alAnti-inflammatory treatment in AD mice protects against neuronal pathology.Exp Neurol.201022337738419679126
  • OzG.VollmersML.NelsonCD.et alIn vivo monitoring of recovery from neurodegeneration in conditional transgenic SCA1 mice.Exp Neurol.201123229029821963649
  • litisI.KoskiDM.EberlyLE.et alNeurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized H MRS study.NMR Biomed.20092273774419338025
  • de GraafRA.PatelAB.RothmanDL.BeharKL.Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex.Neurochem Int.20064850851416517019
  • PetroffOA.HyderF.CollinsT.MattsonRH.RothmanDL.Acute effects of vigabatrin on brain GABA and homocarnosine in patients with complex partial seizures.Epilepsia.19994095896410403220
  • ZhuXH.MerkleH.KwagJH.UgurbilK.ChenW.170 relaxation time and NMR sensitivity of cerebral water and their field dependence.Magn Reson Med.20014554354911283979
  • HoultDl.RichardsRE.The signal-to-noise ratio of the nuclear magnetic resonance phenomenon.J Magn Reson.1976247185
  • ZhuXH.ZhangY.TianRX.et alDevelopment of O NMR approach for fast imaging of cerebral metabolic rate of oxygen in rat brain at high field.Proc Natl Acad Sci USA.200299131941319912242341
  • ZhangN.ZhuXH.LeiH.UgurbilK.ChenW.Simplified methods for calculating cerebral metabolic rate of oxygen based on 170 magnetic resonance spectroscopic imaging measurement during a short 1702 inhalation.J Cereb Blood Flow Metab.20042484084815362714
  • ZhuXH.ZhangN.ZhangY.ZhangX.UgurbilK.ChenW.In vivo O NMR approaches for brain study at high field.NMR Biomed.2005188310315770611
  • ZhuXH.ZhangN.ZhangY.UgurbilK.ChenW.New insights into central roles of cerebral oxygen metabolism in the resting and stimulus-evoked brain.J Cereb Blood Flow Metab.200929101818781163
  • GruetterR.SeaquistER.UgurbilK.A mathematical model of compartmentalized neurotransmitter metabolism in the human brain.Am J Physiol Endocrinol Metab.2001281E10011211404227
  • OzG.BerkichDA.HenryPG.et alNeuroglial metabolism in the awake rat brain: CO2 fixation increases with brain activity.J Neurosci.200424112731127915601933
  • ChoiIY.GruetterR.In vivo 13C NMR assessment of brain glycogen concentration and turnover in the awake rat.Neurochem Int.20034331732212742075
  • ChoiIY.SeaquistER.GruetterR.Effect of hypoglycemia on brain glycogen metabolism in vivo.J Neurosci Res.200372253212645076
  • GruetterR.Glycogen: the forgotten cerebral energy store.J Neurosci Res.20037417918314515346
  • GruetterR.AdrianyG.ChoiIY.HenryPG.LeiH.OzG.Localized in vivo 13C NMR spectroscopy of the brain.NMR Biomed.20031631333814679498
  • OzG.HenryPG.SeaquistER.GruetterR.Direct, noninvasive measurement of brain glycogen metabolism in humans.Neurochem Int.20034332332912742076
  • SeaquistER.DambergGS.TkacI.GruetterR.The effect of insulin on in vivo cerebral glucose concentrations and rates of glucose transport/metabolism in humans.Diabetes.2001502203220911574399
  • ChoiIY.LeeSP.KimSG.GruetterR.In vivo measurements of brain glucose transport using the reversible Michaelis-Menten model and simultaneous measurements of cerebral blood flow changes during hypoglycemia. JCereb Blood Flow Metab.200121653663
  • ChenW.ZhuXH.GruetterR.SeaquistER.AdrianyG.UgurbilK.Study of tricarboxylic acid cycle flux changes in human visual cortex during hemifield visual stimulation using H-{C} MRS and fMRI.Magn Reson Med.20014534935511241689
  • GruetterR.UgurbilK.SeaquistER.Steady-state cerebral glucose concentrations and transport in the human brain.J Neurochem.1998703974089422387
  • LeiH.UgurbilK.ChenW.Measurement of unidirectional Pi to ATP flux in human visual cortex at 7 T by using in vivo 31 P magnetic resonance spectroscopy.Proc Natl Acad Sci U S A.2003100144091441414612566
  • OzG.TesfayeN.KumarA.DeelchandDK.EberlyLE.SeaquistER.Brain glycogen content and metabolism in subjects with type 1 diabetes and hypoglycemia unawareness.J Cereb Blood Flow Metab.20123225626321971353
  • HattingenE.MagerkurthJ.PilatusU.et alPhosphorus and proton magnetic resonance spectroscopy demonstrates mitochondrial dysfunction in early and advanced Parkinson's disease.Brain.2009132(Pt 12)3285329719952056
  • OzG.MR Spectroscopy in health and disease. In: Manto M, Gruol DL, Schmahmann JD, Koibuchi N, Rossi F, eds.Handbook of the Cerebellum and Cerebellar Disorders. Vol 1. New York, NY: Springer Dordrecht;2013713733