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Clinical Research

Epigenetic alterations in depression and antidepressant treatment

Alteraciones epigenéticas en la depresión y el tratamiento antidepresivo

Modifications épigénétiques au cours de la dépression et d'un traitement par antidépresseurs

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REFERENCES

  • BelmakerRH.AgamG.Major depressive disorder.N Engl J Med.2008358556818172175
  • TrivediMH.RushAJ.WisniewskiSR.et alEvaluation of outcomes with citaiopram for depression using measurement-based care in STAR*D: implications for clinical practice.Am J Psychiatry.2006163284016390886
  • NestlerEJ.BarrotM.DiLeoneRJ.EischAJ.GoldSJ.MonteggiaLM.Neurobiology of depression.Neuron.200234132511931738
  • SullivanPF.NealeMC.KendlerKS.Genetic epidemiology of major depression: review and meta-analysis.Am J Psychiatry.20001571552156211007705
  • McGuffinP.CohenS.KnightJ.Homing in on depression genes.Am J Psychiatry.200716419519717267777
  • RipkeS.WrayNR.LewisCM.et alA mega-analysis of genomewide association studies for major depressive disorder.Mol Psychiatry.20131849751122472876
  • KellerMC.MillerG.Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?Behav Brain Sci.200629385404;discussion 405-45217094843
  • UherR.The role of genetic variation in the causation of mental illness: an evolution-informed framework.Mol Psychiatry.2009141072108219704409
  • KarlssonJL.Inheritance of Creative Intelligence. Chicago, IL: Nelson-Hall;1978
  • BrancoMR.FiczG.ReikW.Uncovering the role of 5-hydroxymethyl-cytosine in the epigenome.Nat Rev Genet.20111371322083101
  • TsankovaN.RenthalW.KumarA.NestlerEJ.Epigenetic regulation in psychiatric disorders.Nat Rev Neurosci.2007835536717453016
  • PowerRA.KyagaS.UherR.et alFecundity of patients with schizophrenia, autism, bipolar disorder, depression, anorexia nervosa, or substance abuse vs their unaffected siblings.JAMA Psychiatry.201370223023147713
  • KlengelT.PapeJ.BinderEB.MehtaD.The role of DNA methylation in stress-related psychiatric disorders.Neuropharmacology.20148011513224452011
  • DaltonVS.KolshusE.McLoughlinDM.Epigenetics and depression: return of the repressed.J Affect Disord.201415511224238955
  • AveryOT.MacleodCM.McCartyM.Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III.J Exp Med.19447913715819871359
  • McCartyM.AveryOT.Studies on the chemical nature of the substance inducing transformation of pneumococcal types: II. Effect of desoxyribonuclease on the biological activity of the transforming substance.J Exp Med.1946838996
  • Newell-PriceJ.ClarkAJ.KingP.DNA methylation and silencing of gene expression.Trends Endocrinol Metab.20001114214810754536
  • BibikovaM.BarnesB.TsanC.et alHigh density DNA methylation array with single CpG site resolution.Genomics.20119828829521839163
  • MurgatroydC.WuY.BockmuhlY.SpenglerD.Genes learn from stress: How infantile trauma programs us for depression.Epigenetics.2010519419920339319
  • JaenischR.BirdA.Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals.Nat Genet.200333(suppl)24525412610534
  • WeberM.SchubelerD.Genomic patterns of DNA methylation: targets and function of an epigenetic mark.Curr Opin Ceil Biol.200719273280
  • KimJK.SamaranayakeM.PradhanS.Epigenetic mechanisms in mammals.Cell Mol Life Sci.20096659661218985277
  • WuH.ZhangY.Reversing DNA methylation: mechanisms, genomics, and biological functions.Cell.2014156456824439369
  • FeldmannA.IvanekR.MurrR.GaidatzisD.BurgerL.SchubelerD.Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions.PLoS Genet.20139e100399424367273
  • LevensonJM.SweattJD.Epigenetic mechanisms in memory formation.Nat Rev Neurosci.2005610811815654323
  • MaddoxSA.SchafeGE.ResslerKJ.Exploring epigenetic regulation of fear memory and biomarkers associated with post-traumatic stress disorder.Front Psychiatry.201346223847551
  • MillerCA.SweattJD.Covalent modification of DNA regulates memory formation.Neuron.20075385786917359920
  • MitchellAC.BharadwajR.WhittleC.et alThe genome in three dimensions: a new frontier in human brain research.Biol Psychiatry.20137596196923958183
  • MillJ.PetronisA.Molecular studies of major depressive disorder: the epigenetic perspective.Mol Psychiatry.20071279981417420765
  • ProvencalN.SudermanMJ.GuilleminC.et alThe signature of maternal rearing in the methylome in rhesus macaque prefrontal cortex and T cells.J Neurosci.201232156261564223115197
  • KlengelT.MehtaD.AnackerC.et alAllele-specific FKBP5 DNA demethyiation mediates gene-childhood trauma interactions.Nat Neurosci.201316334123201972
  • SudermanM.McGowanPO.SasakiA.et alConserved epigenetic sensitivity to early life experience in the rat and human hippocampus.Proc Natl Acad Sci US A.2012109(suppl 2)1726617272
  • PerroudN.Paoloni-GiacobinoA.PradaP.et alIncreased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma.Transl Psychiatry.20111e5922832351
  • LabonteB.SudermanM.MaussionG.et alGenome-wide epigenetic regulation by early-life trauma.Arch Gen Psychiatry.20126972273122752237
  • McGowanPO.SasakiA.D'AlessioAC.et alEpigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse.Nat Neurosci.20091234234819234457
  • MelasPA.WeiY.WongCC.et alGenetic and epigenetic associations of MAOAand NR3C1 with depression and childhood adversities.Int J Neuropsychopharmacol.2013161513152823449091
  • McCormickJA.LyonsV.JacobsonMD.et al5'-heterogeneity of glucocorticoid receptor messenger RNA is tissue specific: differential regulation of variant transcripts by early-life events.Mol Endocrinol.20001450651710770488
  • WeaverIC.CervoniN.ChampagneFA.et alEpigenetic programming by maternal behavior.Nat Neurosci.2004784785415220929
  • BinderEB.BradleyRG.LiuW.et alAssociation of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults.JAMA.20082991291130518349090
  • TyrkaAR.PriceLH.MarsitC.WaltersOC.CarpenterLL.Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults.PLoS One.20127e3014822295073
  • AltSR.TurnerJD.KlokMD.et alDifferential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed.Psychoneuroendocrinology .20103554455619782477
  • AlasaariJS.LagusM.OllilaHM.et alEnvironmental stress affects DNA methylation of a CpG rich promoter region of serotonin transporter gene in a nurse cohort.PLoS One.20127e4581323029256
  • KangHJ.KimJM.StewartR.et alAssociation of SLC6A4 methylation with early adversity, characteristics and outcomes in depression.Prog Neuropsychopharmacol Biol Psychiatry.201344232823333376
  • ZhaoJ.GoldbergJ.BremnerJD.VaccarinoV.Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study.Psychosom Med.20137552352923766378
  • KimJM.StewartR.KangHJ.et alA longitudinal study of SLC6A4 DNA promoter methylation and poststroke depression.J Psychiatr Res.2013471222122723702251
  • PortelaA.EstellerM.Epigenetic modifications and human disease.Nat Biotechnol.2010281057106820944598
  • ShuklaS.KavakE.GregoryM.et alCTCF-promoted RNA polymerase II pausing links DNA methylation to splicing.Nature.2011479747921964334
  • MehtaD.KlengelT.ConneelyKN.et alChildhood maltreatment is associated with distinct genomic and epigenetic profiles in posttraumatic stress disorder.Proc Natl Acad Sci U S A.20131108302830723630272
  • HuangEJ.ReichardtLF.Neurotrophins: roles in neuronal development and function.Annu Rev Neurosci20012467773611520916
  • MurphyGM Jr.SarginsonJE.RyanHS.O'HaraR.SchatzbergAF.LazzeroniLC.BDNF and CREB1 genetic variants interact to affect antidepressant treatment outcomes in geriatric depressionPharmacogenet Genomics.20132330131323619509
  • MenkeA.Gene expression: biomarker of antidepressant therapy?Int Rev Psychiatry.20132557959124151803
  • KangHJ.KimJM.LeeJY.et alBDNF promoter methylation and suicidal behavior in depressive patients.J Affect Disord.201315167968523992681
  • KellerS.SarchiaponeM.ZarrilliF.et alIncreased BDNF promoter methylation in the Wernicke area of suicide subjects.Arch Gen Psychiatry.20106725826720194826
  • FuchikamiM.MorinobuS.SegawaM.et alDNA methylation profiles of the brain-derived neurotrophic factor (BDNF) gene as a potent diagnostic biomarker in major depression.PLoS One.20116e2388121912609
  • PerroudN.SalzmannA.PradaP.et alResponse to psychotherapy in borderline personality disorder and methylation status of the BDNF gene.Transl Psychiatry.20133e20723422958
  • SzyfM.The early life environment and the epigenome.Biochim Biophys Acta.2009179087888519364482
  • PerisicT.ZimmermannN.KirmeierT.et alValproate and amitriptyline exert common and divergent influences on global and gene promoter-specific chromatin modifications in rat primary astrocytes.Neuropsychopharmacology.20103579280519924110
  • ZimmermannN.ZschockeJ.PerisicT.YuS.HolsboerF.ReinT.Antidepressants inhibit DNA methyltransferase 1 through reducing G9a levels.Biochem J.20124489310222880885
  • Alonso-AperteE.UbedaN.AchonM.Perez-MiguelsanzJ.Varela-MoreirasG.Impaired methionine synthesis and hypomethylation in rats exposed to valproate during gestation.Neurology.19995275075610078722
  • DetichN.BovenziV.SzyfM.Valproate induces replication-independent active DNA demethyiation.J Biol Chem.2003278275862759212748177
  • DongE.NelsonM.GraysonDR.CostaE.GuidottiA.Clozapine and sulpiride but not haloperidol or olanzapine activate brain DNA demethyiation.Proc Natl Acad Sci U S A.2008105136141361918757738
  • MolendijkML.BusBA.SpinhovenP.et alSerum levels of brainderived neurotrophic factor in major depressive disorder: state-trait issues, clinical features and pharmacological treatment.Mol Psychiatry.2011161088109520856249
  • TadicA.WagnerS.SchlichtKF.et alThe early non-increase of serum BDNF predicts failure of antidepressant treatment in patients with major depression: a pilot study.Prog Neuropsychopharmacol Biol Psychiatry.20113541542020732374
  • TadicA.Muller-EnglingL.SchlichtKF.et alMethylation of the promoter of brain-derived neurotrophic factor exon IV and antidepressant response in major depression.Mol Psychiatry.20131928128323670489
  • LopezJP.MamdaniF.LabonteB.et alEpigenetic regulation of BDNF expression according to antidepressant response.Mol Psychiatry.20131839839922547115
  • YehudaR.DaskalakisNP.DesarnaudF.et alEpigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD.Front Psychiatry.2013411824098286
  • YehudaR.Status of glucocorticoid alterations in post-traumatic stress disorder.Ann N Y Acad Sci.20091 179566919906232
  • DomschkeK.TidowN.SchwarteK.et alSerotonin transporter gene hypomethylation predicts impaired antidepressant treatment response.Int J Neuropsychopharmacol.2014171167117624679990
  • UherR.PerroudN.NgMY.et alGenome-wide pharmacogenetics of antidepressant response in the GENDEP project.Am J Psychiatry.201016755556420360315
  • UherR.Huezo-DiazP.PerroudN.et alGenetic predictors of response to antidepressants in the GENDEP project.Pharmacogenornics J.20099225233
  • PowellTR.SmithRG.HackingerS.et alDNA methylation in interleukin-11 predicts clinical response to antidepressants in GENDEP.Transl Psychiatry.20133e30024002086
  • WaterlandRA.JirtleRL.Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases.Nutrition.200420636814698016
  • MorrisDW.TrivediMH.RushAJ.Folate and unipolar depression.J Altern Complement Med.20081427728518370582
  • FarahA.The role of L-methylfolate in depressive disorders.CMS Spectr.20091427
  • CoppenA.BaileyJ.Enhancement of the antidepressant action of fluoxetine by folic acid: a randomised, placebo controlled trial.J Affect Disord.20006012113010967371
  • GodfreyPS.TooneBK.CarneyMW.et alEnhancement of recovery from psychiatric illness by methylfolate.Lancet.19903363923951974941
  • JacobRA.GretzDM.TaylorPC.et alModerate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women.J Nutr.1998128120412129649607
  • RampersaudGC.KauwellGP.HutsonAD.CerdaJJ.BaileyLB.Genomic DNA methylation decreases in response to moderate folate depletion in elderly women.Am J Clin Nutr.200072998100311010943
  • LenzB.BleichS.BeutlerS.et alHomocysteine regulates expression of Herp by DNA methylation involving the AARE and CREB binding sites.Exp Cell Res.20063124049405517020760
  • MatteC.PereiraLO.Dos SantosTM.et alAcute homocysteine administration impairs memory consolidation on inhibitory avoidance task and decreases hippocampal brain-derived neurotrophic factor immunocontent: prevention by folic acid treatment.Neuroscience.20091631039104519619620
  • de VogelS.WoutersKA.GottschalkRW.et alDietary methyl donors, methyl metabolizing enzymes, and epigenetic regulators: diet-gene interactions and promoter CpG island hypermethylation in colorectal cancer.Cancer Causes Control.20112211220960050
  • FolsteinM.LiuT.PeterI.et alThe homocysteine hypothesis of depression.Am J Psychiatry.200716486186717541043
  • FrielingH.RomerKD.BeyerS.et alDepressive symptoms may explain elevated plasma levels of homocysteine in females with eating disorders.J Psychiatr Res.200842838617182057
  • RakyanVK.DownTA.BaldingDJ.BeckS.Epigenome-wide association studies for common human diseases.Nat Rev Genet.20111252954121747404
  • MichelsKB.BinderAM.DedeurwaerderS.et alRecommendations for the design and analysis of epigenome-wide association studies.Nat Methods.20131094995524076989
  • HeynH.EstellerM.DNA methylation profiling in the clinic: applications and challenges.Nat Rev Genet.20121367969222945394
  • EstellerM.Garcia-FoncillasJ.AndionE.et alInactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.N Engl J Med.20003431350135411070098
  • FouseSD.NagarajanRO.CostelloJF.Genome-scale DNA methylation analysis.Epigenomics.2010210511720657796
  • Ladd-AcostaC.AryeeMJ.OrdwayJM.FeinbergAP.Comprehensive high-throughput arrays for relative methylation (CHARM).Curr Protoc Hum Genet.2010Chapter 20Unit 20. 1. 119
  • DedeurwaerderS.DefranceM.CalonneE.DenisH.SotiriouC.FuksF.Evaluation of the Infinium Methylation 450K technology.Epigenomics.2011377178422126295
  • ZillerMJ.GuH.MullerF.et alCharting a dynamic DNA methylation landscape of the human genome.Nature.201350047748123925113
  • SabunciyanS.AryeeMJ.IrizarryRA.et alGenome-wide DNA methylation scan in major depressive disorder.PLoS One.20127e3445122511943
  • UddinM.KoenenKC.AielloAE.WildmanDE.de los SantosR.GaleaS.Epigenetic and inflammatory marker profiles associated with depression in a community-based epidemiologic sample.Psychol Med.201141997100720836906
  • LabonteB.SudermanM.MaussionG.et alGenome-wide methylation changes in the brains of suicide completers.Am J Psychiatry.201317051152023511308
  • AristizabalMJ.NegriGL.BenschopJJ.HolstegeFC.KroganNJ.KoborMS.High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8.PLoS Genet.20139e1 003758
  • GuintivanoJ.AryeeMJ.KaminskyZA.A cell epigenotype specific model for the correction of brain cellular heterogeneity bias and its application to age, brain region and major depression.Epigenetics.2013829030223426267
  • HousemanEA.AccomandoWP.KoestlerDC.et alDNA methylation arrays as surrogate measures of cell mixture distribution.BMC Bioinformatics.2012138622568884
  • GENDEPInvestigatorsMARSInvestigatorsSTAR*DInvestigatorsCommon genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.Am J Psychiatry.201317020721723377640
  • Garcia-ManeroG.Myelodysplastic syndromes: 2014 update on diagnosis, risk-stratification, and management.Am J Hematol.2014899710824464505
  • SalesAJ.BiojoneC.TercetiMS.GuimaraesFS.GomesMV.JocaSR.Antidepressant-like effect induced by systemic and intra-hippocampal administration of DNA methylation inhibitors.Br J Pharmacol.20111641711172121585346
  • HeimC.BinderEB.Current research trends in early life stress and depression: review of human studies on sensitive periods, gene-environment interactions, and epigenetics.Exp Neurol.201223310211122101006