REFERENCES

• ZuckerNL.LoshM.BulikCM.LaBarKS.PivenJ.PelphreyKA.Anorexia nervosa and autism spectrum disorders: guided investigation of social cognitive endophenotypes.Psychol Bull.20071336976100617967091
   PubMed Web of Science ®Google Scholar
• de JongJJ.de GelderB.HodiamontPP.Sensory processing, neurocognition, and social cognition in schizophrenia: towards a cohesive cognitive model.Schizophr Res.20131461-320921623522906
   PubMed Web of Science ®Google Scholar
• MiskovicV.SchmidtLA.Social tearfulness in the human brain.Neurosci Biobehav Rev.20123645947821855571
   PubMed Web of Science ®Google Scholar
• ValkanovaV.RhodesF.AllanCL.Diagnosis and management of autism in adults.Practitioner.201325717611316
   PubMedGoogle Scholar
• American Psychiatric AssociationDiagnostic and Statistical Manual of Mental Disorders. 5th ed. Washington, DC: American Psychiatric Press.2013
   Google Scholar
• Al-AsadiAM.KleinB.Multiple comorbidities of 21 psychological disorders and relationships with psychosocial variables: a study of the online assessment and diagnostic system within a web-based population.J Med Internet Res.2015172e5525803420
   PubMedGoogle Scholar
• AchimAM.MaziadeM.RaymondE.OliverD.MeretteC.RoyMA.How prevalent are anxiety disorders in schizophrenia? A meta-analysis and critical review on a significant association.Schizophr Bull.201137481182119959704
   PubMed Web of Science ®Google Scholar
• BeidelDC.TurnerSM.Shy Children, Phobic Adults: Nature and Treatment of Social Anxiety Disorder. 2nd ed. Washington, DC: American Psychological Association.2013
   Google Scholar
• FoxAS.KalinNH.A translational neuroscience approach to understanding the development of social anxiety disorder and its pathophysiology.Am J Psychiatry.2014171111162117325157566
   PubMed Web of Science ®Google Scholar
• PillingS.Mayo-WilsonE.MavranezouliI.KewK.TaylorC.ClarkDM.Guideline Development Group. Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance.BMJ.2013346f254123697669
   PubMedGoogle Scholar
• SteinMB.SteinDJ.Social anxiety disorder.Lancet.200837196181115112518374843
   PubMed Web of Science ®Google Scholar
• RhodesCH.MorriellJI.PfaffDW.Irnmunohistochemical analysis of magnocellular elements in rat hypothalamus: distribution and numbers of cells containing neurophysin, oxytocin, and vasopressin.J Comp Neurol.1981198145647014660
   PubMed Web of Science ®Google Scholar
• VieroC.ShibuyaI.KitamuraN.et alOxytocin: crossing the bridge between basic science and pharmacotherapy.CNS Neurosci Ther.2010165e138e15620626426
   PubMed Web of Science ®Google Scholar
• LeeHJ.MacbethAH.PaganiJ.YoungWS.Oxytocin: the great facilitator of life.Prog Neurobiol.200988212715119482229
   PubMed Web of Science ®Google Scholar
• YamasueH.YeeJR.HurlemannR.RillingJK.ChenFS.Meyer-LindenbergA.Integrative approaches utilizing oxytocin to enhance prosocial behavior: from animal and human social behavior to autistic social dysfunction.J Neurosci.20123241141091411723055480
   PubMed Web of Science ®Google Scholar
• CarterCS.Neuroendocrine perspectives on social attachment and love.Psychoneuroendocrinology.19982387798189924738
   PubMed Web of Science ®Google Scholar
• PorgesSW.The polyvagal theory: phylogenetic contributions to social behavior.Physiol Behav.200379350351312954445
   PubMed Web of Science ®Google Scholar
• PedersenCA.PrangeAJ.Induction of maternal behavior in virgin rats after intracerebroventricular administration of oxytocin.Proc Natl Acad Sci U S A.1979761266616665293752
   PubMed Web of Science ®Google Scholar
• InselTR.YoungL.WangZ.Molecular aspects of monogamy.Ann N Y Acad Sci.19978073023169071359
   PubMed Web of Science ®Google Scholar
• WilliamsJR.InselTR.HarbaughCR.CarterCS.Oxytocin administered centrally facilitates formation of a partner preference in female prairie voles (Microtus ochrogaster). J Neuroendocrinol.1994632472507920590
   PubMed Web of Science ®Google Scholar
• YoungLJ.WangZ.The neurobiology of pair bonding.Nat Neurosci.20047101048105415452576
   PubMed Web of Science ®Google Scholar
• CarterCS.GrippoAJ.Pournajafi-NazarlooH.RuscioMG.PorgesSW.Oxytocin, vasopressin and sociality.Prog Brain Res.200817033133618655893
   PubMed Web of Science ®Google Scholar
• YoungLJ.LimMM.GingrichB.InselTR.Cellular mechanisms of social attachment.Horm Behav.200140213313811534973
   PubMed Web of Science ®Google Scholar
• RossHE.YoungLJ.Oxytocin and the neural mechanisms regulating social cognition and affiliative behavior.Front Neuroendocrinol.200930453454719481567
   PubMed Web of Science ®Google Scholar
• LukasM.NeumannID.Oxytocin and vasopressin in rodent behaviors related to social dysfunctions in autism spectrum disorders.Behav Brain Res.2013251859422981649
   PubMed Web of Science ®Google Scholar
• BenelliA.BertoliniA.PoggioliR.MenozziB.BasagliaR.ArlettiR.Polymodal dose-response curve for oxytocin in the social recognition test.Neuropeptides.19952842512557596490
   PubMed Web of Science ®Google Scholar
• EngelmannM.EbnerK.WotjakCT.LandgrafR.Endogenous oxytocin is involved in short-term olfactory memory in female rats.Behav Brain Res.199890189949520216
   PubMed Web of Science ®Google Scholar
• LukasM.TothI.VeenemaAH.NeumannID.Oxytocin mediates rodent social memory within the lateral septum and the medial amygdala depending on the relevance of the social stimulus: male juvenile versus female adult conspecifics.Psychoneuroendocrinology.201338691692623102690
   PubMed Web of Science ®Google Scholar
• van WimersmaGreidanus TB.MaigretC.The role of limbic vasopressin and oxytocin in social recognition.Brain Res.19967131-21531598724986
   PubMed Web of Science ®Google Scholar
• PopikP.van ReeJM.Oxytocin but not vasopressin facilitates social recognition following injection into the medial preoptic area of the rat brain.Eur Neuropsychopharmacol.1991145555601668316
   PubMedGoogle Scholar
• PopikP.VosPE.Van ReeJM.Neurohypophyseal hormone receptors in the septum are implicated in social recognition in the rat.Behav Pharmacol.19923435135811224137
   PubMed Web of Science ®Google Scholar
• DluzenDE.MuraokaS.EngelmannM.LandgrafR.The effects of infusion of arginine vasopressin, oxytocin, or their antagonists into the olfactory bulb upon social recognition responses in male rats.Peptides.199819699910059700747
   PubMed Web of Science ®Google Scholar
• Larrazolo-LopezA.KendrickKM.Aburto-ArciniegaM.et alVaginocervical stimulation enhances social recognition memory in rats via oxytocin release in the olfactory bulb.Neuroscience.2008152358559318304743
   PubMed Web of Science ®Google Scholar
• CholerisE.LittleSR.MongJA.PuramSV.LangerR.PfaffDW.Microparticle-based delivery of oxytocin receptor antisense DNA in the medial amygdala blocks social recognition in female mice.Proc Natl Acad Sci U S A.2007104114670467517360582
   PubMed Web of Science ®Google Scholar
• EngelmannM.WotjakCT.NeumannI.LudwigM.LandgrafR.Behavioral consequences of intracerebral vasopressin and oxytocin: focus on learning and memory.Neurosci Biobehav Rev.19962033413588880728
   PubMed Web of Science ®Google Scholar
• CarterCS.AltemusM.Integrative functions of lactational hormones in social behavior and stress management.Ann N Y Acad Sci.19978071641749071349
   PubMed Web of Science ®Google Scholar
• YoungLJ.The neurobiology of social recognition, approach, and avoidance.Biol Psychiatry.2002511182611801228
   PubMed Web of Science ®Google Scholar
• OlffM.FrijlingJL.KubzanskyLD.et alThe role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences.Psychoneuroendocrinology.20133891883189423856187
   PubMed Web of Science ®Google Scholar
• NeumannID.KrömerSA.ToschiN.EbnerK.Brain oxytocin inhibits the (re)activity of the hypothalamo-pituitary-adrenal axis in male rats: involvement of hypothalamic and limbic brain regions.Regul Pept.2000961-2313811102649
   PubMedGoogle Scholar
• NeumannID.Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.Prog Brain Res.200213914716212436933
   PubMed Web of Science ®Google Scholar
• HuberD.VeinanteP.StoopR.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala.Science.2005308571924524815821089
   PubMed Web of Science ®Google Scholar
• VivianiD.CharletA.van den Burg E.et alOxytocin selectively gates fear responses through distinct outputs from the central amygdala.Science.2011333603810410721719680
   PubMed Web of Science ®Google Scholar
• GibbsDM.Dissociation of oxytocin, vasopressin, and corticotropin secretion during different types of stress.Life Sci.19843554874916087065
   PubMed Web of Science ®Google Scholar
• WilliamsTD.CarterDA.LightmanSL.Sexual dimorphism in the posterior pituitary response to stress in the rat.Endocrinology.198511627387403967625
   PubMed Web of Science ®Google Scholar
• LangRE.HeilJW.GantenD.HermannK.UngerT.RascherW.Oxytocin unlike vasopressin is a stress hormone in the rat.Neuroendocrinology.19833743143166633820
   PubMed Web of Science ®Google Scholar
• OnakaT.YagiK.Effects of novelty stress on vasopressin and oxytocin secretion by the pituitary in the rat.J Neuroendocrinol.1993543653698401560
   PubMed Web of Science ®Google Scholar
• JezovaD.SkultetyovaI.TokarevDI.BakosP.VigasM.Vasopressin and oxytocin in stress.Ann N Y Acad Sci.19957711922038597399
   PubMed Web of Science ®Google Scholar
• WotjakCT.GansterJ.KohlG.HolsboerF.LandgrafR.EngelmannM.Dissociated central and peripheral release of vasopressin, but not oxytocin, in response to repeated swim stress: new insights into the secretory capacities of peptidergic neurons.Neuroscience.1998854120912229681958
   PubMed Web of Science ®Google Scholar
• NeumannID.SlatteryDA.Oxytocin in general anxiety and social fear: a translational approach.Biol Psychiatry.201679321322126208744
   PubMed Web of Science ®Google Scholar
• BaleTL.DavisAM.AugerAP.DorsaDM.McCarthyMM.CNS regions-pecific oxytocin receptor expression: importance in regulation of anxiety and sex behavior.J Neurosci.20012172546255211264328
   PubMed Web of Science ®Google Scholar
• BlumeA.BoschOJ.MiklosS.et alOxytocin reduces anxiety via ERK1/2 activation: local effect within the rat hypothalamic paraventricular nucleus.Eur J Neurosci.20082781947195618412615
   PubMed Web of Science ®Google Scholar
• JurekB.SlatteryDA.MaloumbyR.et alDifferential contribution of hypothalamic MAPK activity to anxiety-like behaviour in virgin and lactating rats.PLoS One.201275e3706022615888
   PubMed Web of Science ®Google Scholar
• SabihiS.DuroskoNE.DongSM.LeunerB.Oxytocin in the prelimbic medial prefrontal cortex reduces anxiety-like behavior in female and male rats.Psychoneuroendocrinology.201445314224845174
   PubMed Web of Science ®Google Scholar
• PetersS.SlatteryDA.Uschold-SchmidtN.ReberSO.NeumannID.Dose-dependent effects of chronic central infusion of oxytocin on anxiety, oxytocin receptor binding and stress-related parameters in mice.Psychoneuroendocrinology.20144222523624636519
   PubMed Web of Science ®Google Scholar
• WindleRJ.ShanksN.LightmanSL.IngramCD.Central oxytocin administration reduces stress-induced corticosterone release and anxiety behavior in rats.Endocrinology.19971387282928349202224
   PubMed Web of Science ®Google Scholar
• ChangSW.PlattML.Oxytocin and social cognition in rhesus macaques: implications for understanding and treating human psychopathology.Brain Res.20141580576824231551
   PubMed Web of Science ®Google Scholar
• FreemanSM.InoueK.SmithGoodmanMM.YoungLJ.The neuroanatomical distribution of oxytocin receptor binding and mRNA in the male rhesus macaque (Macaca mulatta).Psychoneuroendocrinology.20144512814124845184
   PubMed Web of Science ®Google Scholar
• WinslowJT.NoblePL.LyonsCK.SterkSM.InselTR.Rearing effects on cerebrospinal fluid oxytocin concentration and social buffering in rhesus monkeys.Neuropsychopharmacology.200328591091812700704
   PubMed Web of Science ®Google Scholar
• ChangSW.BarterJW.EbitzRB.WatsonKK.PlattML.Inhaled oxytocin amplifies both vicarious reinforcement and self reinforcement in rhesus macaques (Macaca mulatta).Proc Natl Acad Sci U S A.2012109395996422215593
   PubMed Web of Science ®Google Scholar
• EbitzRB.WatsonKK.PlattML.Oxytocin blunts social vigilance in the rhesus macaque.Proc Natl Acad Sci U S A.201311028116301163523798448
   PubMed Web of Science ®Google Scholar
• ParrLA.ModiM.SiebertE.YoungLJ.Intranasal oxytocin selectively attenuates rhesus monkeys' attention to negative facial expressions.Psychoneuroendocrinology.20133891748175623490074
   PubMed Web of Science ®Google Scholar
• LaiMC.LombardoMV.Baron-CohenS.Autism.Lancet.20143839920 89691024074734
   PubMed Web of Science ®Google Scholar
• SchneierFR.RodebaughTL.BlancoC.LewinH.LiebowitzMR.Fear and avoidance of eye contact in social anxiety disorder.Compr Psychiatry.2011521818721220069
   PubMed Web of Science ®Google Scholar
• BogelsSM.MansellW.Attention processes in the maintenance and treatment of social phobia: hypervigilance, avoidance and self-focused attention.Clin Psychol Rev.200424782785615501558
   PubMed Web of Science ®Google Scholar
• HymanSE.Stress and the Brain: the Science of Mental Health. London, UK: Taylor & Francis;2013
   Google Scholar
• SimpsonEA.SclafaniV.PauknerA.HamelAF.NovakMA.MeyerJS.Inhaled oxytocin increases positive social behaviors in newborn macaques.Proc Natl Acad Sci U S A.2014111196922692724778211
   PubMed Web of Science ®Google Scholar
• AlvaresGA.ChenNT.BalleineBW.HickieIB.GuastellaAJ.Oxytocin selectively moderates negative cognitive appraisals in high trait anxious males.Psychoneuroendocrinology.201237122022203122613033
   PubMed Web of Science ®Google Scholar
• CardosoC.LinnenAM.JooberR.EllenbogenMA.Coping style moderates the effect of intranasal oxytocin on the mood response to interpersonal stress.Exp Clin Psychopharmacol.2012202849121988218
   PubMed Web of Science ®Google Scholar
• LabuschagneI.PhanKL.WoodA.et alOxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder.Neuropsychopharmacology.201035122403241320720535
   PubMed Web of Science ®Google Scholar
• KawamuraY.LiuX.AkiyamaT.et alThe association between oxytocin receptor gene (OXTR) polymorphisms and affective temperaments, as measured by TEMPS-A.J Affect Disord.20101271-3313720488544
   PubMed Web of Science ®Google Scholar
• LoParoD.WaldmanID.The oxytocin receptor gene (OXTR) is associated with autism spectrum disorder: a meta-analysis.Mol Psychiatry.201520564064625092245
   PubMed Web of Science ®Google Scholar
• Saphire-BernsteinS.WayBM.KimHS.ShermanDK.TaylorSE.Oxytocin receptor gene (OXTR) is related to psychological resources.Proc Natl Acad Sci U S A.2011108371511815112221896752
   PubMed Web of Science ®Google Scholar
• KumstaR.HummelE.ChenFS.HeinrichsM.Epigenetic regulation of the oxytocin receptor gene: implications for behavioral neuroscience.Front Neurosci.201378323734094
   PubMed Web of Science ®Google Scholar
• Saphire-BernsteinS.WayBM.KimHS.ShermanDK.TaylorSE.Oxytocin receptor gene (OXTR) is related to psychological resources.Proc Natl Acad Sci U S A.201110837151181512221896752
   PubMed Web of Science ®Google Scholar
• ZieglerC.DannlowskiU.BräuerD.StevensS.LaegerI.WittmannH.Oxytocin receptor gene methylation: converging multilevel evidence for a role in social anxiety.Neuropsychopharmacology.20154061528153825563749
   PubMed Web of Science ®Google Scholar
• HogeEA.PollackMH.KaufmanRE.ZakPJ.SimonNM.Oxytocin levels in social anxiety disorder.CNS Neurosci Ther.200814316517018801109
   PubMed Web of Science ®Google Scholar
• MarazzitiD.BaroniS.CatenaM.et alA relationship between social anxiety and oxytocin.Eur Psychiatry.200722S281S282
   Web of Science ®Google Scholar
• LabuschagneI.PhanKL.WoodA.et alOxytocin attenuates amygdala reactivity to fear in generalized social anxiety disorder.Neuropsychopharmacology.201035122403241320720535
   PubMed Web of Science ®Google Scholar
• PhanKL.FitzgeraldDA.NathanPJ.TancerME.Association between amygdala hyperactivity to harsh faces and severity of social anxiety in generalised social phobia.Biol Psychiatry.200659442442916256956
   PubMedGoogle Scholar
• HuberD.VeinanteP.StoopR.Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala.Science.2005308571924524815821089
   PubMed Web of Science ®Google Scholar
• LabuschagneI.PhanKL.WoodA.et alMedial frontal hyperactivity to sad faces in generalized social anxiety disorder and modulation by oxytocin.Int J Neuropsychopharmacol.2012157883896
   PubMed Web of Science ®Google Scholar
• GorkaSM.FitzgeraldDA.LabuschagneI.et alOxytocin modulation of amygdala functional connectivity to fearful faces in generalized social anxiety disorder.Neuropsychopharmacology.201540227828624998619
   PubMed Web of Science ®Google Scholar
• DodhiaS.HosanagarA.FitzgeraldDA.LabuschagneI.WoodAG.NathanPJ.Modulation of resting-state amygdala-frontal functional connectivity by oxytocin in generalized social anxiety disorder.Neuropsychopharmacology.20143992061206924594871
   PubMed Web of Science ®Google Scholar
• GuastellaAJ.HowardAL.DaddsMR.MitchellP.CarsonDS.A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder.Psychoneuroendocrinology.200934691792319246160
   PubMed Web of Science ®Google Scholar
• LevinsonCA.RodebaughTL.Social anxiety and eating disorder comorbidity: the role of negative social evaluation fears.Eat Behav.2012131273522177392
   PubMed Web of Science ®Google Scholar
• FoussiasG.AgidO.FervahaG.RemingtonG.Negative symptoms of schizophrenia: clinical features, relevance to real world functioning and specificity versus other CNS disorders.Eur Neuropsychopharmacol.201424569370924275699
   PubMed Web of Science ®Google Scholar
• FeifelD.MacdonaldK.NguyenA.CobbP.WarlanH.GalangueB.Adjunctive intranasal oxytocin reduces symptoms in schizophrenia patients.Biol Psychiatry.201068767868020615494
   PubMed Web of Science ®Google Scholar
• FeifelD.ShillingD.MacDonaldK.A review of oxytocin's effects on the positive, negative, and cognitive domains of schizophrenia.Biol Psychiatry.201579322222326410353
   PubMed Web of Science ®Google Scholar
• AverbeckBobinT.EvansS.ShergillSS.Emotion recognition and oxytocin in patients with schizophrenia.Psychol Med.201242225926621835090
   PubMed Web of Science ®Google Scholar
• DavisMC.LeeJ.HoranWP.et alEffects of single dose intranasal oxytocin on social cognition in schizophrenia.Schizophr Res.20131472-339339723676253
   PubMed Web of Science ®Google Scholar
• PretiA.MelisM.SiddiS.VellanteM.DonedduG.FaddaR.Oxytocin and autism: a systematic review of randomized controlled trials.J Child Adolesc Psychopharmacol.2014242546824679173
   PubMed Web of Science ®Google Scholar
• AndariE.DuhamelJR.ZallaT.HerbrechtE.LeboyerM.SiriguA.Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.Proc Natl Acad Sci U S A.201010794389439420160081
   PubMed Web of Science ®Google Scholar
• HollanderE.BartzJ.ChaplinW.et alOxytocin increases retention of social cognition in autism.Biol Psychiatry.200761449850316904652
   PubMed Web of Science ®Google Scholar
• GuastellaAJ.EinfeldSL.GrayKM.et alIntranasal oxytocin improves emotion recognition for youth with autism spectrum disorders.Biol Psychiatry.201067769269419897177
   PubMed Web of Science ®Google Scholar
• de LacyN.KingBH.Revisiting the relationship between autism and schizophrenia: toward an integrated neurobiology.Annu Rev Clin Psychol.2013955558723537488
   PubMed Web of Science ®Google Scholar
• KimYR.KimCH.CardiV.EomJS.SeongY.TreasureJ.Intranasal oxytocin attenuates attentional bias for eating and fat shape stimuli in patients with anorexia nervosa.Psychoneuroendocrinology.20144413314224703429
   PubMed Web of Science ®Google Scholar
• KimYR.KimCH.ParkJH.PyoJ.TreasureJ.The impact of intranasal oxytocin on attention to social emotional stimuli in patients with anorexia nervosa: a double blind within-subject cross-over experiment.PLoS One.201496e9072124603863
   PubMedGoogle Scholar
• KimYR.EomJS.YangJW.KangJ.TreasureJ.The impact of oxytocin on food intake and emotion recognition in patients with eating disorders: a double blind single dose within-subject cross-over design.PLoS One.2015109e013751426402337
   PubMed Web of Science ®Google Scholar
• InselTR.Translating oxytocin neuroscience to the clinic: a national institute of mental health perspective.Biol Psychiatry.201579115315426723108
   PubMedGoogle Scholar
• LawsonEA.HolsenLM.SantinM.et alPostprandial oxytocin secretion is associated with severity of anxiety and depressive symptoms in anorexia nervosa.J Clin Psychiatry.2014745e451e457
   Web of Science ®Google Scholar
• GuastellaAJ.HickieIB.McGuinnessMM.et alRecommendations for the standardisation of oxytocin nasal administration and guidelines for its reporting in human research.Psychoneuroendocrinology.201338561262523265311
   PubMed Web of Science ®Google Scholar
• EvansSL.Dal MonteO.NobleP.AverbeckBB.Intranasal oxytocin effects on social cognition: a critique.Brain Res.20141580697724239931
   PubMed Web of Science ®Google Scholar
• ErmischA.RühleHJ.LandgrafR.HessJ.Blood-brain barrier and peptides.J Cereb Blood Flow Metab.1985533503573897253
   PubMed Web of Science ®Google Scholar
• KellyAM.GoodsonJL.Social functions of individual vasopressin-oxytocin cell groups in vertebrates: what do we really know?Front Neuroendocrinol.201435451252924813923
   PubMed Web of Science ®Google Scholar