REFERENCES

• Centers for Disease Control and Prevention (CDC). Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years - Autism and Developmental Disabilities Monitoring Network, 11 sites. United States, 2010.MMWR Surveill Summ.2014632121
   Google Scholar
• American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders. 5th ed. Arlington, VA: American Psychiatric Association;2013
   Google Scholar
• RogersSJ.What are infant siblings teaching us about autism in infancy?Autism Res.20092312513719582867
   PubMed Web of Science ®Google Scholar
• OzonoffS.losifAM.BaguioF.et al.A prospective study of the emergence of early behavioral signs of autism.J Am Acad Child Adolesc Psychiatry.20104932566620410715
   PubMed Web of Science ®Google Scholar
• LandaRJ.GrossAL.StuartEA.FahertyA.Developmental trajectories in children with and without autism spectrum disorders: the first 3 years.Child Dev.201384242944223110514
   PubMed Web of Science ®Google Scholar
• ZwaigenbaumL.BrysonS.RogersT.RobertsW.BrianJ.SzatmariP.Behavioral manifestations of autism in the first year of life.Int J Dev Neurosci.2005232-314315215749241
   PubMed Web of Science ®Google Scholar
• DawsonG.RogersS.MunsonJ.et al.Randomized, controlled trial of an intervention for toddlers with autism: the Early Start Denver Model.Pediatrics.20101251e17e2319948568
   PubMed Web of Science ®Google Scholar
• RogersSJ.VismaraLA.Evidence-based comprehensive treatments for early autism J Clin Child Adolesc Psychol.200837183818444052
   PubMed Web of Science ®Google Scholar
• ClarkMLE.VinenZ.BarbaroJ.DissanayakeC.School age outcomes of children diagnosed early and later with autism spectrum disorder.J Autism Dev Disord. 2017 Sep 14. doi:10.1007/s10803-017-3279-x.
   Google Scholar
• OzonoffS.YoungGS.CarterA.et al.Recurrence risk for autism spectrum disorders: a Baby Siblings Research Consortium study.Pediatrics.20111283e488e49521844053
   PubMed Web of Science ®Google Scholar
• ConstantinoJN.ZhangY.FrazierT.AbbacchiAM.LawP.Sibling recurrence and the genetic epidemiology of autism.Am J Psychiatry.2010167111349135620889652
   PubMed Web of Science ®Google Scholar
• GamlielI.YirmiyaN.SigmanM.The development of young siblings of children with autism from 4 to 54 months.J Autism Dev Disord.200737117118317203244
   PubMed Web of Science ®Google Scholar
• GeorgiadesS.SzatmariP.ZwaigenbaumL.et al.A prospective study of autistic-like traits in unaffected siblings of probands with autism spectrum disorder.JAMA Psychiatry.2013701424722945359
   PubMed Web of Science ®Google Scholar
• OzonoffS.HeungK.ByrdR.HansenR.Hertz-PicciottoI.The onset of autism: patterns of symptom emergence in the first years of life.Autism Res.20081632032819360687
   PubMed Web of Science ®Google Scholar
• ElisonJT.WolffJJ.ReznickJS.et al.Repetitive behavior in 12-month-olds later classified with autism spectrum disorder.J Am Acad Child Adolesc Psychiatry.201453111216122425440311
   PubMed Web of Science ®Google Scholar
• WolffJJ.BotteronKN.DagerSR.et al.Longitudinal patterns of repetitive behavior in toddlers with autism.J Child Psychol Psychiatry.201455894595324552513
   PubMed Web of Science ®Google Scholar
• FilliterJH.LongardJ.LawrenceMA.et al.Positive affect in infant siblings of children diagnosed with autism spectrum disorder.J Abnorm Child Psychol.2014433567575
   Web of Science ®Google Scholar
• EstesA.ZwaigenbaumL.GuH.et al.Behavioral, cognitive, and adaptive development in infants with autism spectrum disorder in the first 2 years of life.J Neurodev Disord.2015712426203305
   PubMedGoogle Scholar
• FlanaganJE.LandaR.BhatA.BaumanM.Head lag in infants at risk for autism: a preliminary study.Am J Occup Ther.201266557758522917124
   PubMed Web of Science ®Google Scholar
• SwansonMR.ShenMD.WolffJJ.et al.Subcortical brain and behavior phenotypes differentiate infants with autism versus language delay.Biol Psychiatry Cogn Neurosci Neuroimaging.201728664672
   PubMedGoogle Scholar
• ChawarskaK.MacariS.ShicF.Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders.Biol Psychiatry.201374319520323313640
   PubMed Web of Science ®Google Scholar
• JonesW.KlinA.Attention to eyes is present but in decline in 2-6-month-old infants later diagnosed with autism.Nature.20145047480427431
   Web of Science ®Google Scholar
• ShicF.MacariS.ChawarskaK.Speech disturbs face scanning in 6-month-old infants who develop autism spectrum disorder.Biol Psychiatry.201475323123723954107
   PubMed Web of Science ®Google Scholar
• OzonoffS.YoungGS.SteinfeldMB.et al.How early do parent concerns predict later autism diagnosis?J Dev Behav Pediatr.200930536737519827218
   PubMed Web of Science ®Google Scholar
• ChawarskaK.ShicF.MacariS.et al.18-Month predictors of later outcomes in younger siblings of children with autism spectrum disorder: a Baby Siblings Research Consortium Study.J Am Acad Child Adolesc Psychiatry.2014531213171327.e125457930
   PubMed Web of Science ®Google Scholar
• RobinsDL.FeinD.BartonML.GreenJA.The Modified Checklist for Autism in Toddlers: an initial study investigating the early detection of autism and pervasive developmental disorders.J Autism Dev Disord.200131213114411450812
   PubMed Web of Science ®Google Scholar
• PandeyJ.VerbalisA.RobinsDL.et al.Screening for autism in older and younger toddlers with the Modified Checklist for Autism in Toddlers.Autism.200812551353518805945
   PubMed Web of Science ®Google Scholar
• ZwaigenbaumL.BrysonS.LordC.et al.Clinical assessment and management of toddlers with suspected autism spectrum disorder: insights from studies of high-risk infants.Pediatrics.200912351383139119403506
   PubMed Web of Science ®Google Scholar
• HazlettHC.PoeMD.GerigG.et al.Early brain overgrowth in autism associated with an increase in cortical surface area before age 2 years.Arch Gen Psychiatry.201168546721536976
   PubMed Web of Science ®Google Scholar
• HazlettHC.PoeM.GerigG.et al.Magnetic resonance imaging and head circumference study of brain size in autism: birth through age 2 years.Arch Gen Psychiatry.200562121366137616330725
   PubMed Web of Science ®Google Scholar
• CourchesneE.KarnsCM.DavisHR.et al.Unusual brain growth patterns in early life in patients with autistic disorder: an MRI study.Neurology.200157224525411468308
   PubMed Web of Science ®Google Scholar
• NordahlCW.LangeN.LiDD.et al.Brain enlargement is associated with regression in preschool-age boys with autism spectrum disorders.Proc Natl Acad Sci U S A.201110850201952020022123952
   PubMed Web of Science ®Google Scholar
• SparksBF.FriedmanSD.ShawDW.et al.Brain structural abnormalities in young children with autism spectrum disorder.Neurology.200259218412136055
   PubMed Web of Science ®Google Scholar
• ShenMD.NordahlCW.YoungGS.et al.Early brain enlargement and elevated extra-axial fluid in infants who develop autism spectrum disorder.Brain.2013136pt 92825283523838695
   PubMed Web of Science ®Google Scholar
• HazlettHC.GuH.MunsellBC.et al.Early brain development in infants at high risk for autism spectrum disorder.Nature.2017542764134835128202961
   PubMed Web of Science ®Google Scholar
• PanizzonMS.Fennema-NotestineC.EylerLT.et al.Distinct genetic influences on cortical surface area and cortical thickness.Cerebral Cortex.200919112728273519299253
   PubMed Web of Science ®Google Scholar
• OhtaH.NordahlCW.IosifAM.LeeA.RogersS.AmaralDG.Increased surface area, but not cortical thickness, in a subset of young boys with autism spectrum disorder.Autism Res.20169223224826184828
   PubMed Web of Science ®Google Scholar
• ShenMD.KimSH.McKinstryRC.et al.Increased extra-axial cerebrospinal fluid in high-risk infants who later develop autism.Biol Psychiatry.201782318619328392081
   PubMed Web of Science ®Google Scholar
• ElisonJT.PatersonSJ.WolffJJ.et al.White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism.Am J Psychiatry.2013170889990823511344
   PubMed Web of Science ®Google Scholar
• JohansonCE.DuncanJA.KlingePM.BrinkerT.StopaEG.SilverbergGD.Multiplicity of cerebrospinal fluid functions: new challenges in health and disease.Cerebrospinal Fluid Res.200851018479516
   PubMedGoogle Scholar
• XieL.KangH.XuQ.et al.Sleep drives metabolite clearance from the adult brain.Science.2013342615637337724136970
   PubMed Web of Science ®Google Scholar
• Del BigioMR.Neuropathology and structural changes in hydrocephalus.Dev Disabil Res Rev.2010161162220419767
   PubMedGoogle Scholar
• IliffJJ.WangM.LiaoY.et al.A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β.Sci Transl Med.20124147147ra111
   PubMed Web of Science ®Google Scholar
• LehtinenMK.WalshCA.Neurogenesis at the brain-cerebrospinal fluid interface.Annu Rev Cell Dev Biol.20112765367921801012
   PubMed Web of Science ®Google Scholar
• SwansonMR.PivenJ.Neurodevelopment of autism: the first three years of life. In:Autism Imaging and Devices. Casanova MF, El-Baz AS, Suri JS, eds. Boca Raton, FL: Taylor & Francis Group;2016
   Google Scholar
• LehtinenMK.ZappaterraMW.ChenX.et al.The cerebrospinal fluid provides a proliferative niche for neural progenitor cells.Neuron.201169589390521382550
   PubMed Web of Science ®Google Scholar
• MashayekhiF.DraperCE.BannisterCM.PourghasemM.Owen-LynchPJ.MiyanJA.Deficient cortical development in the hydrocephalic Texas (H-Tx) rat: a role for CSF.Brain.2002125pt 81859187412135976
   PubMedGoogle Scholar
• ChazalJ.TanguyA.IrthumB.JannyP.VanneuvilleG.Dilatation of the subarachnoid pericerebral space and absorption of cerebrospinal fluid in the infant.Anat Clin.19857161663994855
   PubMedGoogle Scholar
• BrinerS.BodensteinerJ.Benign subdural collections of infancy.Pediatrics.19816768028046972029
   PubMed Web of Science ®Google Scholar
• WolffJJ.GuH.GerigG.et al.Differences in white matter fiber tract development present from 6 to 24 months in infants with autism.Am J Psychiatry.2012169658960022362397
   PubMed Web of Science ®Google Scholar
• WolffJJ.GerigG.LewisJD.et al.Altered corpus callosum morphology associated with autism over the first 2 years of life.Brain.2015138pt 72046205825937563
   PubMedGoogle Scholar
• WolffJJ.SwansonMR.ElisonJT.et al.Neural circuitry at age 6 months associated with later repetitive behavior and sensory responsiveness in autism.Mol Autism.20178828316772
   PubMed Web of Science ®Google Scholar
• BashatDB.Kronfeld-DueniasV.ZachorDA.et al.Accelerated maturation of white matter in young children with autism: a high b value DWI study.Neuroimage.2007371404717566764
   PubMed Web of Science ®Google Scholar
• SolsoS.XuR.ProudfootJ.et al.Diffusion tensor imaging provides evidence of possible axonal overconnectivity in frontal lobes in autism spectrum disorder toddlers.Biol Psychiatry.201579867668426300272
   PubMed Web of Science ®Google Scholar
• EmersonRW.AdamsC.NishinoT.et al.Functional neuroimaging of high-risk 6-month-old infants predicts a diagnosis of autism at 24 months of age.Sci Transl Med.20179393eaag288228592562
   PubMed Web of Science ®Google Scholar
• ElsabbaghM.MercureE.HudryK.et al.Infant neural sensitivity to dynamic eye gaze is associated with later emerging autism.Curr Biol.201222433834222285033
   PubMed Web of Science ®Google Scholar
• JonesEJ.VenemaK.EarlR.et al.Reduced engagement with social stimuli in 6-month-old infants with later autism spectrum disorder: a longitudinal prospective study of infants at high familial risk.J Neurodev Disord.20168726981158
   PubMed Web of Science ®Google Scholar
• VivantiG.DissanayakeC.Outcome for children receiving the early start Denver model before and after 48 months.J Autism Dev Disord.20164672441244927020055
   PubMed Web of Science ®Google Scholar
• RogersSJ.VismaraL.WagnerAL.McCormickC.YoungG.OzonoffS.Autism treatment in the first year of life: a pilot study of infant start, a parent-implemented intervention for symptomatic infants.J Autism Dev Disord.201444122981299525212413
   PubMed Web of Science ®Google Scholar
• GreenJ.CharmanT.PicklesA.WanMW.Parent-mediated intervention versus no intervention for infants at high risk of autism: a parallel, single-blind, randomised trial.Lancet Psychiatry.20152213314026359749
   PubMed Web of Science ®Google Scholar
• JonesEJH.DawsonG.KellyJ.EstesA.Jane WebbS.Parent-delivered early intervention in infants at risk for ASD: effects on electrophysiological and habituation measures of social attention.Autism Res.201710596197228244271
   PubMed Web of Science ®Google Scholar
• NIH Biomarkers Definitions Working Group. Biomarkers and surrogate endpoints: preferred definitions and conceptual framework.Clin Pharmacol Ther.2001693899511240971
   PubMed Web of Science ®Google Scholar
• KnickmeyerRC.GouttardS.KangC.et al.A structural MRI study of human brain development from birth to 2 years.J Neurosci.20082847121761218219020011
   PubMed Web of Science ®Google Scholar
• InselTR.Translating scientific opportunity into public health impact: a strategic plan for research on mental illness.Arch Gen Psychiatry.200966212813319188534
   PubMed Web of Science ®Google Scholar
• OzonoffS.YoungGS.LandaRJ.et al.Diagnostic stability in young children at risk for autism spectrum disorder: a baby siblings research consortium study.J Child Psychol Psychiatry.201556998899825921776
   PubMed Web of Science ®Google Scholar
• ZwaigenbaumL.BrysonSE.BrianJ.et al.Stability of diagnostic assessment for autism spectrum disorder between 18 and 36 months in a high-risk cohort.Autism Res.20169779080026613202
   PubMed Web of Science ®Google Scholar
• BrianJ.BrysonSE.SmithIM.et al.Stability and change in autism spectrum disorder diagnosis from age 3 to middle childhood in a high-risk sibling cohort.Autism.201620788889226685198
   PubMed Web of Science ®Google Scholar
• ChungJ.SmithAL.HughesSC.et al.Twenty-year follow-up of newborn screening for patients with muscular dystrophy.Muscle Nerve.201653457057826260293
   PubMed Web of Science ®Google Scholar
• MacLeodR.BeachA.HenriquesS.KnoppJ.NelsonK.Kerzin-StorrarL.Experiences of predictive testing in young people at risk of Huntington's disease, familial cardiomyopathy or hereditary breast and ovarian cancer.Eur J Hum Genet.201422339640123860040
   PubMed Web of Science ®Google Scholar
• CrozierS.RobertsonN.DaleM.The psychological impact of predictive genetic testing for Huntington's disease: a systematic review of the literature.J Genet Couns.2015241293925236481
   PubMed Web of Science ®Google Scholar
• BroadstockM.MichieS.MarteauT.Psychological consequences of predictive genetic testing: a systematic review.Eur J Hum Genet.200081073173811039571
   PubMed Web of Science ®Google Scholar
• MichieS.BobrowM.MarteauTM.Predictive genetic testing in children and adults: a study of emotional impact.J Med Genet.200138851952611483640
   PubMed Web of Science ®Google Scholar
• SparbelKJ.TluczekA.Patient and family issues regarding genetic testing for cystic fibrosis: a review of prenatal carrier testing and newborn screening.Annu Rev Nurs Res.20112930332922891510
   PubMedGoogle Scholar
• BaileyDB.WheelerA.Berry-KravisE.et al.Maternal consequences of the detection of fragile X carriers in newborn screening.Pediatrics.20151362e433e44026169437
   PubMed Web of Science ®Google Scholar
• HendriksKS.GrosfeldFJ.WildeAA.et al.High distress in parents whose children undergo predictive testing for long QT syndrome.Community Genet.20058210311315925886
   PubMedGoogle Scholar
• LermanC.CroyleRT.TercyakKP.HamannH.Genetic testing: psychological aspects and implications.J Consult Clin Psychol.200270378479712090383
   PubMed Web of Science ®Google Scholar
• BaileyDB.SkinnerD.DavisAM.WhitmarshI.PowellC.Ethical, legal, and social concerns about expanded newborn screening: fragile X syndrome as a prototype for emerging issues.Pediatrics.20081213e693e70418310190
   PubMed Web of Science ®Google Scholar
• GreenRC.RobertsJS.CupplesLA.et al.Disclosure of APOE genotype for risk of Alzheimer's disease.N Engl J Med.2009361324525419605829
   PubMed Web of Science ®Google Scholar
• WalshP.ElsabbaghM.BoltonP.SinghI.In search of biomarkers for autism: scientific, social and ethical challenges.Nat Rev Neurosci.2011121060361221931335
   PubMed Web of Science ®Google Scholar
• InselTR.CuthbertBN.Medicine. Brain disorders? Precisely.Science.2015348623449950025931539
   PubMed Web of Science ®Google Scholar