823
Views
10
CrossRef citations to date
0
Altmetric
20th Anniversary Issue

The debate regarding maintenance treatment with antipsychotic drugs in schizophrenia

El debate en relación con el tratamiento de mantenimiento con antipsicóticos en la esquizofrenia

Le maintien du traitement par antipsychotiques dans la schizophrénie en débat

REFERENCES

  • López-MuñozF.AlamoC.CuencaE.ShenWW.ClervoyP.RubioG.History of the discovery and clinical introduction of chlorpromazine.Ann Clin Psychiatry.200517311313516433053
  • HogartyGE.Prevention of relapse in chronic schizophrenic patients.J Clin Psychiatry.199354suppl1823
  • García-MagallónB.Silva-FernándezL.Andreu-SánchezJL.Update on the use of steroids in rheumatoid arthritis.Reumatol Clin.20139529730223726772
  • LeuchtS.TardyM.KomossaK.et al.Antipsychotic drugs versus placebo for relapse prevention in schizophrenia: a systematic review and meta-analysis.Lancet.201237998312063207122560607
  • HasanA.FalkaiP.WobrockT.LiebermanJ.GlenthojB.GattazWF.ThibautF.MöllerHJ.World Federation of Societies of Biological Psychiatry (WFSBP) Task Force on Treatment Guidelines for Schizophrenia. World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for Biological Treatment of Schizophrenia, part 1: update 2012 on the acute treatment of schizophrenia and the management of treatment resistance.World J Biol Psychiatry.201213531837822834451
  • TakeuchiH.SuzukiT.UchidaH.WatanabeK.MimuraM.Antipsychotic treatment for schizophrenia in the maintenance phase: a systematic review of the guidelines and algorithms.Schizophr Res.20121342-321922522154594
  • KreyenbuhlJ.BuchananRW.DickersonFB.DixonLB.Schizophrenia patient outcomes research team (port), the schizophrenia patient outcomes research team (PORT): updated treatment recommendations 2009.Schizophr Bull.20103619410319955388
  • HasanA.FalkaiP.WobrockT.et al.WFSBP Task force on Treatment Guidelines for Schizophrenia. World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of schizophrenia, part 2: update 2012 on the long-term treatment of schizophrenia and management of antipsychotic-induced side effects.World J Biol Psychiatry.201314124423216388
  • GoffDC.FalkaiP.FleischhackerWW.et al.The long-term effects of antipsychotic medication on clinical course in schizophrenia.Am J Psychiatry.2017174984084928472900
  • CorrellCU.SolmiM.VeroneseN.et al.Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls.World Psychiatry20171616318028498599
  • MurrayRM.QuattroneD.NatesanS.et al.Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics?Br J Psychiatry.2016209536136527802977
  • InselT.Former NIMH Director's Blog: Antipsychotics: Taking the Long View. n.d. Retrieved from www.nimh.nih.gov/about/directors/thomas-insel/blog/2013/antipsychotics-taking-the-long-view.shtml.
  • Alvarez-JimenezM.O'DonoghueB.ThompsonA.et al.Beyond clinical remission in first episode psychosis: thoughts on antipsychotic maintenance vs. guided discontinuation in the functional recovery era.CNS Drugs.201630535736827106296
  • GøtzschePC.YoungAH.CraceJ.Does long term use of psychiatric drugs cause more harm than good?BMJ.2015350h243525985333
  • MorganC.LappinJ.HeslinM.et al.Reappraising the long-term course and outcome of psychotic disorders: the AESOP-10 study.Psychol Med.201444132713272625066181
  • LeuchtS.DavisJM.Do antipsychotic drugs lose their efficacy for relapse prevention over time?Br J Psychiatry.2017211312712928864750
  • HuiCLM.HonerWG.LeeEHM.et al.Long-term effects of discontinuation from antipsychotic maintenance following first-episode schizophrenia and related disorders: a 10 year follow-up of a randomized, double-blind trial.Lancet Psychiatry.20185543244229551618
  • BowtellM.RatheeshA.McGorryP.KillackeyE.O'DonoghueB.Clinical and demographic predictors of continuing remission or relapse following discontinuation of antipsychotic medication after a first episode of psychosis. A systematic review.Schizophr Res. 2017 pii: S0920-9964(17)30687-4.
  • GotfredsenDR.WilsRS.HjorthøjC.et al.Stability and development of psychotic symptoms and the use of antipsychotic medication - long-term follow-up.Psychol Med.201747122118212928382874
  • HusaAP.RannikkoI.MoilanenJ.et al.Lifetime use of antipsychotic medication and its relation to change of verbal learning and memory in midlife schizophrenia - An observational 9-year follow-up study.Schizophr Res.20141581-313414125034761
  • TorgalsbøenAK.Sustaining full recovery in schizophrenia after 15 years: does resilience matter?Clin Schizophr Relat Psychoses.20125419320022182456
  • HarrowM.JobeTH.Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?Schizophr Bull.201339596296523512950
  • MoilanenJM.HaapeaM.JääskeläinenE.et al.Long-term antipsychotic use and its association with outcomes in schizophrenia - the Northern Finland Birth Cohort 1966.Eur Psychiatry.20163671427311102
  • WunderinkL.NieboerRM.WlersmaD.SytemaS.NienhuisFJ.Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial.JAMA Psychiatry.201370991392023824214
  • VolavkaJ.VeveraJ.Very long-term outcome of schizophrenia.Int J Clin Pract.201824e13094
  • WilsRS.GotfredsenDR.HjorthøjC.et al.Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis.Schizophr Res.2017182424828277310
  • MorrisonAP.HuttonP.WardleM.et al.Cognitive therapy for people with a schizophrenia spectrum diagnosis not taking antipsychotic medication: an exploratory trial.Psychol Med.20124251049105621914252
  • McGorryP.Alvarez-JimenezM.KillackeyE.Antipsychotic medication during the critical period following remission from first-episode psychosis: less is more.JAMA Psychiatry.201370989890023824206
  • EackSM.NewhillCE.AndersonCM.RotondiAJ.Quality of life for persons living with schizophrenia: more than just symptoms.Psychiatr Rehabil J.200730321922217269273
  • ChouinardG.JonesBD.Neuroleptic-induced supersensitivity psychosis: clinical and pharmacologic characteristics.Am J Psychiatry.1980137116216101522
  • MullerP.SeemanP.Dopaminergic supersensitivity after neuroleptics: time-course and specificity.Psychopharmacology (Berl).197860111132574
  • MoncrieffJ.Antipsychotic maintenance treatment: time to rethink?PLoS Med.2015128e100186126241954
  • ShiovitzTM.WelkeTL.TigelPD.et al.Cholinergic rebound and rapid onset psychosis following abrupt clozapine withdrawal.Schizophr Bull.19962245915958938913
  • TiihonenJ.TanskanenA.TaipaleH.20-year nationwide follow-up study on discontinuation of antipsychotic treatment in first-episode schizophrenia.Am J Psychiatry.2018appiajp201817091001
  • HoBC.AndreasenNC.ZiebellS.PiersonR.MagnottaV.Long-term antipsychotic treatment and brain volumes: a longitudinal study of first-episode schizophrenia.Arch Gen Psychiatry.201168212813721300943
  • Fusar-PoliP.SmieskovaR.KemptonMJ.HoBC.AndreasenNC.BorgwardtS.Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies.Neurosci Biobehav Rev.20133781680169123769814
  • HuhtaniskaS.JääskeläinenE.HirvonenN.et al.Long-term antipsychotic use and brain changes in schizophrenia - a systematic review and meta-analysis.Hum Psychopharmacol.2017322
  • AndreasenNC.NopoulosP.MagnottaV.PiersonR.ZiebellS.HoBC.Progressive brain change in schizophrenia: a prospective longitudinal study of first-episode schizophrenia.Biol Psychiatry.201170767267921784414
  • GuoJY.HuhtaniskaS.MiettunenJ.et al.Longitudinal regional brain volume loss in schizophrenia: relationship to antipsychotic medication and change in social function.Schizophr Res.20151681-229730426189075
  • VeijolaJ.GuoJY.MoilanenJS.et al.Longitudinal changes in total brain volume in schizophrenia: relation to symptom severity, cognition and antipsychotic medication.PLoS One.201497e10168925036617
  • WeinmannS.ReadJ.AderholdV.Influence of antipsychotics on mortality in schizophrenia: systematic review.Schizophr Res.2009113111119524406
  • LiebermanJA.Metabolic changes associated with antipsychotic use.Prim Care Companion J Clin Psychiatry.20046Suppl 281316001095
  • RayWA.ChungCP.MurrayKT.HallK.SteinCM.Atypical antipsychotic drugs and the risk of sudden cardiac death.N Engl J Med.2009360322523519144938
  • VermeulenJ.van RooijenG.DoedensP.NumminenE.van TrichtM.de HaanL.Antipsychotic medication and long-term mortality risk in patients with schizophrenia; a systematic review and meta-analysis.Psychol Med.201747132217222828397632
  • LeuchtS.HeresS.HamannJ.KaneJM.Methodological issues in current antipsychotic drug trials.Schizophr Bull.200834227528518234700
  • BebbingtonPE.AngermeyerM.AzorinJM.MarwahaS.MarteauF.ToumiM.Side-effects of antipsychotic medication and health-related quality of life in schizophrenia.Acta Psychiatr Scand Suppl.2009 438222819132963
  • FeldhausT.FalkeS.von GruchallaL.et al.The impact of self-stigmatization on medication attitude in schizophrenia patients.Psychiatry Res.201826139139929353769
  • MoncrieffJ.Magic bullets for mental disorders: the emergence of the concept of an “antipsychotic” drug.J Hist Neurosci.2013221304623323530
  • GaebelW.RiesbeckM.WölwerW.et al.Rates and predictors of remission in first-episode schizophrenia within 1 year of antipsychotic maintenance treatment. Results of a randomized controlled trial within the German Research Network on Schizophrenia.Schizophr Res.20141522347848623643327
  • KirschnerM.AlemanA.KaiserS.Secondary negative symptoms - A review of mechanisms, assessment and treatment.Schizophr Res.2017186293827230288
  • ArtaloytiaJF.ArangoC.LahtiA.et al.Negative signs and symptoms secondary to antipsychotics: a double-blind, randomized trial of a single dose of placebo, haloperidol, and risperidone in healthy volunteers.Am J Psychiatry.2006163348849316513871
  • KotovR.FochtmannL.LiK.et al.Declining clinical course of psychotic disorders over the two decades following first hospitalization: evidence from the Suffolk county mental health project.Am J Psychiatry.2017174111064107428774193
  • SzczypińskiJJ.GolaM.Dopamine dysregulation hypothesis: the common basis for motivational anhedonia in major depressive disorder and schizophrenia?Rev Neurosci. 2018. pii: /j/revneuro.ahead-of-print/revneuro-2017-0091/revneuro-2017-0091.xml. doi: 10.1515/revneuro-2017-0091. [Epub ahead of print].
  • GraceAA.GomesFV.The circuitry of dopamine system regulation and its disruption in schizophrenia: insights into treatment and prevention.Schizophr Bull. 2018 Jan 29.: 10.1093/schbul/sbx199. [Epub ahead of print].
  • MaiaTV.FrankMJ.An integrative perspective on the role of dopamine in schizophrenia.Biol Psychiatry.2017811526627452791
  • LevineSZ.RabinowitzJ.EngelR.EtschelE.LeuchtS.Extrapolation between measures of symptom severity and change: an examination of the PANSS and CGI.Schizophr Res.2008981-331832217949948
  • LeuchtS.KaneJM.KisslingW.HamannJ.EtschelE.EngelRR.What does the PANSS mean?Schizophr Res.2005792-323123815982856
  • LeuchtS.KaneJM.KisslingW.HamannJ.EtschelE.EngelR.Clinical implications of Brief Psychiatric Rating Scale scores.Br J Psychiatry.200518736637116199797
  • LeppingP.SambhiRS.WhittingtonR.LaneS.PooleR.Clinical relevance of findings in trials of antipsychotics: systematic review.Br J Psychiatry.2011198534134521525517
  • DavidsonM.KaparaO.GoldbergS.YoffeR.NoyS.WeiserM.A nation-wide study on the percentage of schizophrenia and bipolar disorder patients who earn minimum wage or above.Schizophr Bull.201642244344725796051
  • LallyJ.AjnakinaO.Di FortiM.et al.Two distinct patterns of treatment resistance: clinical predictors of treatment resistance in first-episode schizophrenia spectrum psychoses.Psychol Med.201646153231324027605254
  • VanesLD.MouchlianitisE.CollierT.AverbeckBB.ShergillSS.Differential neural reward mechanisms in treatment-responsive and treatment-resistant schizophrenia.Psychol Med.201814110
  • HowesOD.McCutcheonR.AgidO.et al.Treatment-resistant schizophrenia: treatment response and resistance in psychosis (trrip) working group consensus guidelines on diagnosis and terminology.Am J Psychiatry.2017174321622927919182
  • HarrowM.JobeTH.FaullRN.Does treatment of schizophrenia with antipsychotic medications eliminate or reduce psychosis? A 20-year multi-follow-up study.Psychol Med.201444143007301625066792
  • De HertM.SermonJ.GeertsP.VansteelandtK.PeuskensJ.DetrauxJ.The use of continuous treatment versus placebo or intermittent treatment strategies in stabilized patients with schizophrenia: a systematic review and meta-analysis of randomized controlled trials with first- and second-generation antipsychotics.CNS Drugs.201529863765826293744
  • GilbertPL.HarrisMJ.McAdamsLA.JesteDV.Neuroleptic withdrawal in schizophrenic patients. A review of the literature.Arch Gen Psychiatry.19955231731887872841
  • LiebermanJA.KoreenAR.ChakosM.et al.Factors influencing treatment response and outcome of first-episode schizophrenia: implications for understanding the pathophysiology of schizophrenia.J Clin Psychiatry.199657Suppl 959
  • GilbertPL.HarrisMJ.McAdamsLA.JesteDV.Neuroleptic withdrawal in schizophrenic patients. A review of the literature.Arch Gen Psychiatry.19955231731887872841
  • EmsleyR.NuamahI.HoughD.GopalS.Treatment response after relapse in a placebo-controlled maintenance trial in schizophrenia.Schizophr Res.20121381293422446143
  • HarrowM.JobeTH.Does long-term treatment of schizophrenia with antipsychotic medications facilitate recovery?Schizophr Bull.201339596296523512950
  • EngelhardtDM.RosenB.FreedmanN.MargolisR.Phenothiazines in prevention of psychiatric hospitalization. IV. Delay or prevention of hospitalization - a reevaluation.Arch Gen Psychiatry.1967161981015333777
  • WilsRS.GotfredsenDR.HjorthøjC.et al.Antipsychotic medication and remission of psychotic symptoms 10 years after a first-episode psychosis.Schizophr Res.2017182424828277310
  • MoilanenJ.HaapeaM.MiettunenJ.et al.Characteristics of subjects with schizophrenia spectrum disorder with and without antipsychotic medication - a 10-year follow-up of the Northern Finland 1966 Birth Cohort study.Eur Psychiatry.2013281535821920710
  • HarrowM.JobeTH.Factors involved in outcome and recovery in schizophrenia patients not on antipsychotic medications: a 15-year multi-follow-up study.J Nerv Ment Dis.2007195540641417502806
  • VolavkaJ.VeveraJ.Very long-term outcome of schizophrenia.Int J Clin Pract.2018e1309429691957
  • WunderinkL.NieboerRM.WiersmaD.SytemaS.NienhuisFJ.Recovery in remitted first-episode psychosis at 7 years of follow-up of an early dose reduction/discontinuation or maintenance treatment strategy: long-term follow-up of a 2-year randomized clinical trial.JAMA Psychiatry.201370991392023824214
  • EmsleyR.Discontinuing antipsychotic treatment after a first-episode of psychosis: Who, when and how?Schizophr Res. 2017 Nov 9. pii: S09209964(17)30675-8. doi:10. 1016/j.schres.2017.10.047
  • CzoborP.Van DornRA.CitromeL.KahnRS.FleischhackerWW.VolavkaJ.Treatment adherence in schizophrenia: a patient-level meta-analysis of combined CATIE and EUFEST studies.Eur Neuropsychopharmacol.201 52581158116626004980
  • CzoborP.VolavkaJ.DerksEM.et al.Insight and hostility as predictors and correlates of nonadherence in the European First Episode Schizophrenia Trial.J Clin Psychopharmacol.201333225826123422388
  • MohamedS.RosenheckR.McEvoyJ.SwartzM.StroupS.LiebermanJA.Cross-sectional and longitudinal relationships between insight and attitudes toward medication and clinical outcomes in chronic schizophrenia.Schizophr Bull.200935233634618586692
  • XavierRM.VorderstrasseA.KeefeRSE.DunganJR.Genetic correlates of insight in schizophrenia.Schizophr Res.201819529029729054485
  • FreseFJ 3rd.StanleyJ.KressK.Vogel-ScibiliaS.Integrating evidence-based practices and the recovery model.Psychiatr Serv.200152111462146811684741
  • SaadTC.The history of autonomy in medicine from antiquity to principlism.Med Health Care Philos.201821112513728601921
  • MorantN.AzamK.JohnsonS.MoncrieffJ.The least worst option: user experiences of antipsychotic medication and lack of involvement in medication decisions in a UK community sample.J Ment Health.201717
  • Bartels-VelthuisAA.VisserE.ArendsJ.et al.Towards a comprehensive routine outcome monitoring program for people with psychotic disorders: The Pharmacotherapy Monitoring and Outcome Survey (PHAMOUS).Schizophr Res. 2018 Jan 26. pii: 50920-9964(18)30036-7. doi: 10.1016/j. schres. 2018.01.016. [Epub ahead of print].
  • MorrisonAP.HuttonP.ShiersD.TurkingtonD.Antipsychotics: is it time to introduce patient choice?Br J Psychiatry .2012201838422859572
  • VolavkaJ.VeveraJ.Very long-term outcome of schizophrenia,Int J Clin Pract.2018e1309429691957
  • CaveE.Protecting patients from their bad decisions: rebalancing rights, relationships, and risk.Med Law Rev.201725452755328082611
  • TverskyA.KahnemanD.Availability: A heuristic for judging frequency and probability.Cogn Psychol.197352207232
  • LeuchtS.Is there compelling evidence that schizophrenia long-term treatment guidelines should be changed?World Psychiatry.20181716616729856564
  • SaposnikG.RedelmeierD.RuffCC.ToblerPN.Cognitive biases associated with medical decisions: a systematic review.BMC Med Inform Decis Mak.201616113827809908
  • SohlerN.AdamsBG.BarnesDM.CohenGH.PrinsSJ.SchwartzS.Weighing the evidence for harm from long-term treatment with antipsychotic medications: A systematic review.Am J Orthopsychiatry.201686547748526652608
  • NishikawaT.HayashiT.KogaI.UchidaY.Neuroleptic withdrawal with remitted schizophrenics: a naturalistic follow-up study.Psychiatry.2007701687917492913
  • PrataD.MechelliA.KapurS.Clinically meaningful biomarkers for psychosis: a systematic and quantitative review.Neurosci Biobehav Rev.2014451344124877683
  • CassidyCM.NormanR.ManchandaR.SchmitzN.MallaA.Testing definitions of symptom remission in first-episode psychosis for prediction of functional outcome at 2 years.Schizophr Bull.20103651001100819321629
  • DavidsonM.SaoudJ.StanerC.et al.Efficacy and safety of min-101: a 12-week randomized, double-blind, placebo-controlled trial of a new drug in development for the treatment of negative symptoms in schizophrenia.Am J Psychiatry.2017174121195120228750582
  • GarayRP.BourinM.de PailletteE.SamalinL.HamegA.LlorcaPM.Potential serotonergic agents for the treatment of schizophrenia.Expert Opin Investig Drugs.2016252159170
  • VanoverK.DmitrienkoA.GlassS.et al.Lumateperone (ITI-007) for the treatment of schizophrenia: placebo-controlled clinical trials and an open-label safety switching.Schizophr Bull.201844Suppl 1S341
  • AnandR.ForrestEC.HartmanRD.GrahamSM.FaravelliL.Antipsychotic efficacy of evenamide (NW-3509) is due to modulation of glutamatergic dysregulation.Schizophr Bull.201844Suppl 1S132