454
Views
7
CrossRef citations to date
0
Altmetric
Original Article

Genomics and the future of psychopharmacology: MicroRNAs offer novel therapeutics


La genómica y el futuro de la psicofarmacología: los microARNs ofrecen nuevas terapias

Génomique et futur de la psychopharmacologie: les nouvelles opportunités thérapeutiques des micro-ARN

REFERENCES

  • AmbrosV.MicroRNAs: tiny regulators with great potential.Cell.2001107782382611779458
  • LeeHCLiLGuWDiverse pathways generate microRNA-like RNAs and Dicer-independent small interfering RNAs in fungi.Mol Cell.201038680381420417140
  • HakeS.MicroRNAs: a role in plant development.Curr Biol.20031321851852
  • McManusMTSharpPA.Gene silencing in mammals by small interfering RNAs.Nat Rev Genet.200231073774712360232
  • YatesLANorburyCJGilbertRJ.The long and short of microRNA.Cell.2013153351651923622238
  • ArtziSKiezunAShomronN.miRNAminer: a tool for homologous microRNA gene search.BMC Bioinformatics.200893918215311
  • AmbrosV.MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing.Cell.2003113667367612809598
  • BaehreckeEH.miRNAs: micro managers of programmed cell death.Curr Biol.20031312R47347512814564
  • XuJWangYTanXJingH.MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis.Autophagy.20128687388222441107
  • SuZYangZXuYChenYYuQ.MicroRNAs in apoptosis, autophagy and necroptosis.Oncotarget.20156118474849025893379
  • GilamACondeJWeissglas-VolkovDLocal microRNA delivery targets Palladin and prevents metastatic breast cancer.Nat Commun.201671286827641360
  • IcliBWaraAKMoslehiJMicroRNA-26a regulates pathological and physiological angiogenesis by targeting BMP/SMAD1 signaling.Circ Res.2013113111231124124047927
  • IcliBWuWOzdemirDMicroRNA- 135a-3p regulates angiogenesis and tissue repair by targeting p38 signaling in endothelial cells.Faseb J.2019fj201802063RR
  • LatreilleMHausserJStutzerIMicroRNA-7a regulates pancreatic beta cell function.J Clin Invest.201412462722273524789908
  • FuXDongBTianYMicroRNA-26a regulates insulin sensitivity and metabolism of 
glucose and lipids.J Clin Invest.201512562497250925961460
  • JansenFSchaferLWangHKinetics of circulating microRNAs in response to cardiac stress in patients with coronary artery disease.J Am Heart Assoc.201768 https://doi.org/10.1161/JAHA.116.005270
  • KanuriSHIpeJKassabKNext generation MicroRNA sequencing to identify coronary artery disease patients at risk of recurrent myocardial infarction.Atherosclerosis.201827823223930336307
  • WuJFanCLMaLJDistinctive expression signatures of serum microRNAs in ischaemic stroke and transient ischaemic attack patients.Thromb Haemost.20171175992100128251236
  • MaQLiGTaoZBlood microRNA-93 as an indicator for diagnosis and prediction of functional recovery of acute stroke patients.J Clin Neurosci.20186212112730579843
  • WeiQSunHSongSMicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury.J Clin Invest.2018128125448546430325740
  • PandeyPWangMBaldwinITPandeySPGrotenK.Complex regulation of microRNAs in roots of competitively-grown isogenic Nicotiana attenuata plants with different capacities to interact with arbuscular mycorrhizal fungi.BMC Genomics.201819193730558527
  • IgazIIgazP.Possible role for microRNAs as inter-species mediators of epigenetic information in disease pathogenesis: is the non-coding dark matter of the genome responsible for epigenetic interindividual or interspecies communication? Med Hypotheses.201584215015425535106
  • PergePNagyZDecmannAIgazIIgazP.Potential relevance of microRNAs in inter-species epigenetic communication, and implications for disease pathogenesis.RNA Biol.201714439140127791594
  • LiangHZenKZhangJZhangCYChenX.New roles for microRNAs in cross-species communication.RNA Biol.201310336737023364352
  • Villarroya-BeltriCGutierrez-VazquezCSanchez-CaboFSumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs.Nat Commun.20134298024356509
  • GurwitzD.Exosomal microRNAs in tissue crosstalkDrug Dev Res201576625926226303125
  • KalluriR.The biology and function of exosomes in cancer.J Clin Invest.201612641208121527035812
  • RaynerKJHennessyEJ.Extracellular communication via microRNA: lipid particles have a new message.J Lipid Res.20135451174118123505318
  • RaoofRJimenez-MateosEMBauerSCerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus.Sci Rep.201771332828607431
  • GoldieBJDunMDLinMActivity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.Nucleic Acids Res.201442149195920825053844
  • ChivetMJavaletCLaulagnierKBlotBHemmingFJSadoulR.Exosomes secreted by cortical neurons upon glutamatergic synapse activation specifically interact with neurons.J Extracell Vesicles.201432472225398455
  • BahriniISongJHDiezDHanayamaR.Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia.Sci Rep.20155798925612542
  • WangSCescaFLoersGSynapsin I is an oligomannose-carrying glycoprotein, acts as an oligomannose-binding lectin, and promotes neurite outgrowth and neuronal survival when released via glia-derived exosomes.J Neurosci.201131207275729021593312
  • FruhbeisCFrohlichD Kramer-AlbersEM.Emerging roles of exosomes in neuron-glia communicationFront Physiol2012311922557979
  • HuangSGeXYuJIncreased miR-124-3p in microglial exosomes following traumatic brain injury inhibits neuronal inflammation and contributes to neurite outgrowth via their transfer into neurons.Faseb J.201832151252828935818
  • MirraPRacitiGANigroCCirculating miRNAs as intercellular messengers, potential biomarkers and therapeutic targets for Type 2 diabetes.Epigenomics. 20157465366726111035
  • KimJKrichevskyAGradYIdentification of many microRNAs that copurify with polyribosomes in mammalian neurons.Proc Natl Acad Sci U S A.2004101136036514691248
  • KyeMJLiuTLevySFSomatodendritic microRNAs identified by laser capture and multiplex RT-PCR.Rna.20071381224123417592044
  • ParkCSTangSJ.Regulation of microRNA expression by induction of bidirectional synaptic plasticity.J Mol Neurosci.2009381505618998061
  • KocerhaJFaghihiMALopez-ToledanoMAMicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction.Proc Natl Acad Sci U S A.200910693507351219196972
  • RajgorDSandersonTMAmiciMCollingridgeGLHanleyJG.NMDAR-dependent Argonaute 2 phosphorylation regulates miRNA activity and dendritic spine plasticity.Embo J.20183711
  • AttardoAFitzgeraldJESchnitzerMJ.Impermanence of dendritic spines in live adult CA1 hippocampus.Nature.2015523756259259626098371
  • GotoYYangCROtaniS.Functional and dysfunctional synaptic plasticity in prefrontal cortex: roles in psychiatric disorders.Biol Psychiatry.201067319920719833323
  • KennyPJ.Epigenetics, microRNA, and addiction.Dialogues Clin Neurosci.201416333534425364284
  • IsslerOHaramatiSPaulEDMicroRNA 135 is essential for chronic stress resiliency, antidepressant efficacy, and intact serotonergic activity.Neuron.201483234436024952960
  • HuZYuDGuQHmiR-191 and miR-135 are required for long-lasting spine remodelling associated with synaptic long-term depression.Nat Commun.20145326324535612
  • LopezJPLimRCruceanuCmiR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.Nat Med.201420776476824908571
  • OvedKMoragAPasmanik-ChorMRehavi MShomronNGurwitzD.Genome-wide expression profiling of human lymphoblastoid cell lines implicates integrin beta-3 in the mode of action of antidepressantsTransl Psychiatry20133e313
  • OvedKFarberovLGilamAMicroRNA-mediated regulation of ITGB3 and CHL1 is 
implicated in SSRI action.Front Mol Neurosci.20171035529163031
  • WanYLiuYWangXIdentification of differential microRNAs in cerebrospinal fluid and serum of patients with major depressive disorderPLoS One2015103e012197525763923
  • EnatescuVRPapavaIEnatescuICirculating plasma micro RNAs in patients with major depressive disorder treated with antidepressants: a pilot study.Psychiatry Investig.2016135549557
  • LianNNiuQLeiYLiXLiYSongX.MiR-221 is involved in depression by regulating Wnt2/CREB/BDNF axis in hippocampal neurons.Cell Cycle.2018111
  • PapiolSSchulzeTGAldaM.Genetics of lithium response in bipolar disorder.Pharmacopsychiatry.201851520621129579760
  • DuanJShiJFiorentinoAA rare functional noncoding variant at the GWAS-implicated MIR137/MIR2682 locus might confer risk to schizophrenia and bipolar disorder.Am J Hum Genet.201495674475325434007
  • BavamianSMelliosNLalondeJDysregulation of miR-34a links neuronal development to genetic risk factors for bipolar disorder.Mol Psychiatry.201520557358425623948
  • HouLHeilbronnerUDegenhardtFGenetic variants associated with response to lithium treatment in bipolar disorder: a genome-
wide association study.Lancet.2016387100231085109326806518
  • Valles-ColomerMFalonyGDarziYThe neuroactive potential of the human gut microbiota in quality of life and depression.Nat Microbiol. In press https://doi.org/10.1038/s41564-018-0337-x
  • MoralesSGulppiFGonzalez-Hormazabal PAssociation of single nucleotide polymorphisms in Pre-miR-27a, Pre-miR-196a2, Pre-miR-423, miR-608 and Pre-miR-618 with breast cancer susceptibility in a South American population.BMC Genet.201617110927421647
  • KwonEWangWTsaiLH.Validation of schizophrenia-associated genes CSMD1, C10orf26, CACNA1C and TCF4 as miR-137 targets.Mol Psychiatry.2013181111222182936
  • SiegertSSeoJKwonEJThe schizophrenia risk gene product miR-137 alters presynaptic plasticity.Nat Neurosci.20151871008101626005852
  • MaJShangSWangJIdentification of miR-22-3p, miR-92a-3p, and miR-137 in peripheral blood as biomarker for schizophrenia.Psychiatry Res.2018265707629684772
  • SakamotoKCrowleyJJ.A comprehensive review of the genetic and biological evidence supports a role for MicroRNA-137 in the etiology of schizophrenia.Am J Med Genet B Neuropsychiatr Genet.2018177224225629442441
  • FernandezBASchererSW.Syndromic autism spectrum disorders: moving from a clinically defined to a molecularly defined approach.Dialogues Clin Neurosci.201719435337129398931
  • WuYEParikshakNNBelgardTGGeschwindDH.Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder.Nat Neurosci.201619111463147627571009
  • CobaMPRamakerMJHoEVDlgap1 knockout mice exhibit alterations of the postsynaptic density and selective reductions in sociability.Sci Rep.201881228129396406
  • PaganCGoubran-BotrosHDelormeRDisruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders.Sci Rep.201771209628522826
  • WilliamsSMAnJYEdsonJAn integrative analysis of non-coding regulatory DNA variations associated with autism spectrum disorder.Mol Psychiatry. In press https://doi.org/10.1038/s41380-018-0049-x
  • KhalifaOPersYMFerreiraRX-Linked miRNAs Associated with gender differences in rheumatoid arthritis.Int J Mol Sci.20161711 pii: E1852
  • SullivanPFNealeMCKendlerKS.Genetic epidemiology of major depression: review and 
meta-analysis.Am J Psychiatry.2000157101552156211007705
  • ChhibberAWoodySKKarim RumiMASoaresMJZhaoL.Estrogen receptor beta deficiency impairs BDNF-5-HT2A signaling in the hippocampus of female brain: A possible mechanism for menopausal depression.Psychoneuroendocrinology.20178210711628544903
  • BeutelMEBrahlerEWiltinkJNew onset of depression in aging women and men: contributions of social, psychological, behavioral, and somatic predictors in the community.Psychol Med.201818
  • CarrelLWillardHF.X-inactivation profile reveals extensive variability in X-linked gene 
expression in females.Nature.2005434703140040415772666
  • HewagamaAGorelikGPatelDOverexpression of X-linked genes in T cells from women with lupus.J Autoimmun.201341607123434382
  • PollexTHeardE.Nuclear positioning and pairing of X-chromosome inactivation centers are not primary determinants during initiation of random X-inactivation.Nat Genet.201951228529530643252
  • PinheiroIDejagerLLibertC.X-chromosome-located microRNAs in immunity: might they explain male/female differences? The X chromosome-genomic context may affect X-located miRNAs and downstream signaling, thereby contributing to the enhanced immune response of females.Bioessays.2011331179180221953569
  • GuoXSuBZhouZShaJ.Rapid evolution of mammalian X-linked testis microRNAs.BMC Genomics.2009109719257908
  • Jimenez-MateosEMEngelTMerino-Serrais PSilencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects.Nat Med.20121871087109422683779
  • TalebiARahnemaMBigdeliMR.Effect of intravenous injection of antagomiR-1 on brain ischemia.Mol Biol Rep. https://doi.org/10.1007/s11033-018-04580-y
  • IsslerOChenA.Determining the role of microRNAs in psychiatric disorders.Nat Rev Neurosci.201516420121225790865