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Original Articles

A multi-ingredient, pre-workout supplement is apparently safe in healthy males and females

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Article: 27470 | Received 02 Feb 2015, Accepted 26 May 2015, Published online: 16 Jun 2015

References

  • Dickinson A, Blatman J, El-Dash N, Franco JC. Consumer usage and reasons for using dietary supplements: report of a series of surveys. J Am Coll Nutr. 2014; 33: 176–82. [PubMed Abstract].
  • Kerksick C, Harvey T, Stout J, Campbell B, Wilborn C, Kreider R, etal. International Society of Sports Nutrition position stand: nutrient timing. J Int Soc Sports Nutr. 2008; 5: 17. [PubMed Abstract] [PubMed CentralFull Text].
  • Spradley BD, Crowley KR, Tai CY, Kendall KL, Fukuda DH, Esposito EN, etal. Ingesting a pre-workout supplement containing caffeine, B-vitamins, amino acids, creatine, and beta-alanine before exercise delays fatigue while improving reaction time and muscular endurance. Nutr Metabol. 2012; 9: 28.
  • Lowery RP, Joy JM, Dudeck JE, Oliveira de Souza E, McCleary SA, Wells S, etal. Effects of 8 weeks of Xpand(R) 2X pre workout supplementation on skeletal muscle hypertrophy, lean body mass, and strength in resistance trained males. J Int Soc Sports Nutr. 2013; 10: 44. [PubMed Abstract] [PubMed CentralFull Text].
  • Kraemer WJ, Hatfield DL, Spiering BA, Vingren JL, Fragala MS, Ho JY, etal. Effects of a multi-nutrient supplement on exercise performance and hormonal responses to resistance exercise. Eur J Appl Physiol. 2007; 101: 637–46. [PubMed Abstract].
  • Kedia AW, Hofheins JE, Habowski SM, Ferrando AA, Gothard MD, Lopez HL. Effects of a pre-workout supplement on lean mass, muscular performance, subjective workout experience and biomarkers of safety. Int J Med Sci. 2014; 11: 116–26. [PubMed Abstract] [PubMed CentralFull Text].
  • Kendall KL, Moon JR, Fairman CM, Spradley BD, Tai C-Y, Falcone PH. Ingesting a preworkout supplement containing caffeine, creatine, β-alanine, amino acids, and B vitamins for 28 days is both safe and efficacious in recreationally active men. Nutr Res. 2014; 34: 442–449. [PubMed Abstract].
  • Cermak NM, Gibala MJ, van Loon LJ. Nitrate supplementation's improvement of 10-km time-trial performance in trained cyclists. Int J Sport Nutr Exerc Metabol. 2012; 22: 64–71.
  • Lansley KE, Winyard PG, Bailey SJ, Vanhatalo A, Wilkerson DP, Blackwell JR, etal. Acute dietary nitrate supplementation improves cycling time trial performance. Med Sci Sports Exerc. 2011; 43: 1125–31. [PubMed Abstract].
  • Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, etal. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol. 2010; 109: 135–48. [PubMed Abstract].
  • Fulford J, Winyard PG, Vanhatalo A, Bailey SJ, Blackwell JR, Jones AM. Influence of dietary nitrate supplementation on human skeletal muscle metabolism and force production during maximum voluntary contractions. Pflugers Arch. 2013; 465: 517–28. [PubMed Abstract].
  • Joy J, Lowery RP, Falcone PH, Mosman MM, Vogel RM, Carson LR, etal. 28 Days of creatine nitrate supplementation is apparently safe in healthy individuals. J Int Soc Sports Nutr. 2014; 11: 60. [PubMed Abstract] [PubMed CentralFull Text].
  • Norton LE, Layman DK. Leucine regulates translation initiation of protein synthesis in skeletal muscle after exercise. J Nutr. 2006; 136: 533S–7S. [PubMed Abstract].
  • Howatson G, Hoad M, Goodall S, Tallent J, Bell PG, French DN. Exercise-induced muscle damage is reduced in resistance-trained males by branched chain amino acids: a randomized, double-blind, placebo controlled study. J Int Soc Sports Nutr. 2012; 9: 20. [PubMed Abstract] [PubMed CentralFull Text].
  • Carlstrom M, Persson AE, Larsson E, Hezel M, Scheffer PG, Teerlink T, etal. Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res. 2011; 89: 574–85. [PubMed Abstract].
  • Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, etal. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension. 2010; 56: 274–81. [PubMed Abstract].
  • Derave W, Taes Y. Beware of the pickle: health effects of nitrate intake. J Appl Physiol. 2009; 107: 1677. [PubMed Abstract] author reply 8.
  • Lijinsky W, Epstein SS. Nitrosamines as environmental carcinogens. Nature. 1970; 225: 21–3. [PubMed Abstract].
  • Weir JP. Quantifying test-retest reliability using the intraclass correlation coefficient and the SEM. J Strength Cond Res. 2005; 19: 231–40. [PubMed Abstract].
  • Delaney HD, Vargha A. The effect of non-normality on student's two-sample t-test. 2000. Paper presented at the Annual Meeting of the American Educational Research Association, New Orleans..
  • Karagiannidis C, Hense G, Rueckert B, Mantel PY, Ichters B, Blaser K, etal. High-altitude climate therapy reduces local airway inflammation and modulates lymphocyte activation. Scand J Immunol. 2006; 63: 304–10. [PubMed Abstract].
  • Shelmadine B, Cooke M, Buford T, Hudson G, Redd L, Leutholtz B, etal. Effects of 28 days of resistance exercise and consuming a commercially available pre-workout supplement, NO-Shotgun(R), on body composition, muscle strength and mass, markers of satellite cell activation, and clinical safety markers in males. J Int Soc Sports Nutr. 2009; 6: 16. [PubMed Abstract] [PubMed CentralFull Text].
  • Schmitz SM, Hofheins JE, Lemieux R. Nine weeks of supplementation with a multi-nutrient product augments gains in lean mass, strength, and muscular performance in resistance trained men. J Int Soc Sports Nutr. 2010; 7: 40. [PubMed Abstract] [PubMed CentralFull Text].
  • Sindelar JJ, Milkowski AL. Human safety controversies surrounding nitrate and nitrite in the diet. Nitric Oxide. 2012; 26: 259–66. [PubMed Abstract].
  • Hoon MW, Johnson NA, Chapman PG, Burke LM. The effect of nitrate supplementation on exercise performance in healthy individuals: a systematic review and meta-analysis. Int J Sport Nutr Exerc Metabol. 2013; 23: 522–32.
  • Larsen FJ, Weitzberg E, Lundberg JO, Ekblom B. Effects of dietary nitrate on oxygen cost during exercise. Acta Physiol. 2007; 191: 59–66.
  • Vanhatalo A, Bailey SJ, Blackwell JR, DiMenna FJ, Pavey TG, Wilkerson DP, etal. Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010; 299: R1121–31. [PubMed Abstract].
  • Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, etal. Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension. 2008; 51: 784–90. [PubMed Abstract] [PubMed CentralFull Text].
  • Bailey SJ, Winyard P, Vanhatalo A, Blackwell JR, Dimenna FJ, Wilkerson DP, etal. Dietary nitrate supplementation reduces the O2 cost of low-intensity exercise and enhances tolerance to high-intensity exercise in humans. J Appl Physiol. 2009; 107: 1144–55. [PubMed Abstract].