Rheumatoid arthritis and the role of oral bacteria

References

• Papapanou PN. Periodontal diseases: epidemiology. Ann Periodontol. 1996; 1: 1–36.
   PubMedGoogle Scholar
• Takashiba S, Naruishi K, Murayama Y. Perspective of cytokine regulation for periodontal treatment: fibroblast biology. J Periodontol. 2003; 74: 103–10.
   PubMed Web of Science ®Google Scholar
• Silman AJ, MacGregor AJ, Thompson W, Holligan S, Carthy D, Farhan A, et al.. Twin concordance rates for rheumatoid arthritis: results from a nationwide study. Br J Rheumatol. 1993; 32: 903–7.
   PubMedGoogle Scholar
• Bellamy N, Duffy D, Martin N, Mathews J. Rheumatoid arthritis in twins: a study of aetiopathogenesis based on the Australian twin registry. Ann Rheum Dis. 1992; 51: 588–93.
   PubMed Web of Science ®Google Scholar
• Alamanos Y, Drosos AA. Epidemiology of adult rheumatoid arthritis. Autoimmun Rev. 2005; 4: 130–6.
   PubMed Web of Science ®Google Scholar
• Albani S, Carson DA, Roudier J. Genetic and environmental factors in the immune pathogenesis of rheumatoid arthritis. Rheum Dis Clin North Am. 1992; 18: 729–40.
   PubMed Web of Science ®Google Scholar
• Deng GM, Tarkowski A. The role of bacterial DNA in septic arthritis. Int J Mol Med. 2000; 6: 29–33.
   Web of Science ®Google Scholar
• Deng GM, Tarkowski A. The features of arthritis induced by CpG motifs in bacterial DNA. Arthritis Rheum. 2000; 43: 356–64.
   PubMed Web of Science ®Google Scholar
• Klareskog L, Padyukov L, Lorentzen J, Alfredsson L. Mechanisms of disease: genetic susceptibility and environmental triggers in the development of rheumatoid arthritis. Nat Clin Pract Rheumatol. 2006; 2: 425–33.
   PubMedGoogle Scholar
• Bas S, Griffais R, Kvien TK, Glennas A, Melby K, Vischer TL. Amplification of plasmid and chromosome chlamydia DNA in synovial fluid of patients with reactive arthritis and undifferentiated seronegative oligoarthropathies. Arthritis Rheum. 1995; 38: 1005–13.
   PubMed Web of Science ®Google Scholar
• Branigan PJ, Gerard HC, Hudson AP, Schumacher HR Jr, Pando J. Comparison of synovial tissue and synovial fluid as the source of nucleic acids for detection of Chlamydia trachomatis by polymerase chain reaction. Arthritis Rheum. 1996; 39: 1740–6.
   PubMed Web of Science ®Google Scholar
• Hyrich KL, Inman RD. Infectious agents in chronic rheumatic diseases. Curr Opin Rheumatol. 2001; 13: 300–4.
   Web of Science ®Google Scholar
• Cuchacovich R, Japa S, Huang WQ, Calvo A, Vega L, Vargas RB, et al.. Detection of bacterial DNA in Latin America patients with reactive arthritis by polymerase chain reaction and sequencing analysis. J Rheumatol. 2002; 29: 1426–9.
   PubMed Web of Science ®Google Scholar
• Zhang X, Pacheco-Tena C, Inman R. Microbe hunting in the joints. Arthritis Rheum. 2003; 49: 479–82.
   Web of Science ®Google Scholar
• Cox CJ, Kempsell KE, Hill Gaston JS. Investigation of infectious agents associated with arthritis by reverse transcription PCR of bacterial rRNA. Arthritis Res Ther. 2003; 5: R1–R8.
   Web of Science ®Google Scholar
• Woolley DE, Tetlow LC. Observations on the microenvironmental nature of cartilage degradation in rheumatoid arthritis. Ann Rheum Dis. 1997; 56: 151–61.
   Web of Science ®Google Scholar
• Haynes DR, Crotti TN, Loric M, Atkins GJ, Findlay DM. Osteoprotegerin and receptor activator of nuclear factor kappaB ligand (RANKL) regulate osteoclast formation by cells in the human rheumatoid arthritic joint. Rheumatology. 2001; 40: 623–30.
   PubMed Web of Science ®Google Scholar
• Chu CQ, Field M, Allard S, Abney E, Feldmann M, Maini RN. Detection of cytokines at the cartilage/pannus junctions in patients with rheumatoid arthritis: implications for the role of cytokines in cartilage destruction and repair. Br J Rheumatol. 1992; 31: 653–61.
   PubMedGoogle Scholar
• Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies). J Reumatol. 1999; 26: 1650–3.
   PubMed Web of Science ®Google Scholar
• Rosenstein ED, Greenwald RA, Kushner LJ, Weissmann G. Hyphothesis: the humoral immune response to oral bacteria provides a stimulus for the development of rheumatoid arthritis. Inflammation. 2004; 28: 311–8.
   PubMed Web of Science ®Google Scholar
• Ebringer A, Wilson C. HLA molecules, bacteria and autoimmunity. J Med Microbiol. 2000; 49: 305–11.
   PubMed Web of Science ®Google Scholar
• Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005; 76: 2066–74.
   PubMed Web of Science ®Google Scholar
• Carty SM, Snowden N, Silman AJ. Should infection still be considered as the most likely triggering factor for rheumatoid arthritis?. Ann Rheum Dis. 2003; 30: 425–9.
   Google Scholar
• Mercado F, Marshall RI, Klestov AC, Bartold PM. Is there a relationship between rheumatoid arthritis and periodontal disease?. J Clin Periodontol. 2000; 27: 267–72.
   PubMed Web of Science ®Google Scholar
• Pischon N, Pischon T, Kröger J, Gülmez E, Kleber BM, Bernimoulin JP, et al.. Association among rheumatoid arthritis, oral hygiene, and periodontitis. J Periodontol. 2008; 79: 979–86.
   PubMed Web of Science ®Google Scholar
• Carty SM, Snowden N, Silman AJ. Should infection still be considered as the most likely triggering factor for rheumatoid arthritis?. Ann Rheum Dis. 2004; 63: ii46–ii49.
   PubMed Web of Science ®Google Scholar
• Schett G, Redlich K, Xu Q, Bizan P, Groger M, Tohidast-Akrad M, et al.. Enhanced expression of heat shock protein 70 (hsp70) and heat shock factor (HSF1) activation in rheumatoid arthritis synovial tissue. Differential regulation of hsp70 expression and hsf1 activation in synovial fibroblasts by proinflammatory cytokines, shear stress, and antiinflammatory drugs. J Clin Invest. 1998; 102: 301–11.
   Web of Science ®Google Scholar
• Yoshida A, Nakano Y, Yamashita T, Oho T, Ito H, Kondo M, et al.. Immunodominant region of Actinobacillus actinomycetemcomitans 40-kilodalton heat shock protein in patients with rheumatoid arthritis. J Dent Res. 2001; 80: 346–50.
   PubMed Web of Science ®Google Scholar
• Weyand CM, Goronzy JJ. Association of MHC and rheumatoid arthritis. HLA polymorphisms in phenotypic variants of rheumatoid arthritis. Arthritis Res. 2000; 2: 203–4.
   Google Scholar
• Marotte H, Farge P, Gaudin P, Alexandre C, Mougin B, Miossec P. The association between periodontal disease and joint destruction in rheumatoid arthritis extends the link between the HLA-DR shared epitope and severity of bone destruction. Ann Rheum Dis. 2006; 65: 905–9.
   PubMed Web of Science ®Google Scholar
• Trombone AP, Claudino M, Colavite P, de Assis GF, Avila-Campos MJ, Silva JS, et al.. Periodontitis and arthritis interaction in mice involves a shared hyper-inflammatory genotype and functional immunological interferences. Genes Immun. 2010; 11: 479–89.
   PubMed Web of Science ®Google Scholar
• Arend WP, Dayer JM. Cytokines and cytokine or antagonists in rheumatoid arthritis. Arthritis Rheum. 1990; 33: 305–15.
   PubMed Web of Science ®Google Scholar
• Tolo K, Jorkjend L. Serum antibodies and loss of periodontal bone in patients with rheumatoid arthritis. J Clin Periodontol. 1990; 17: 288–91.
   PubMed Web of Science ®Google Scholar
• Yusof Z, Porter SR, Greenman J, Scully C. Levels of serum IgG against Porphyromonas gingivalis in patients with rapidly progressive periodontitis, rheumatoid arthritis and adult periodontitis. J Nihon Univ Sch Dent. 1995; 37: 197–200.
   Google Scholar
• Wilbrink B, van de Heijden IM, Schouls LM, van Embden JDA, Hazez JMW, Breedveld FC, et al.. Detection of bacterial DNA in joint samples from patients with undifferentiated arthritis and reactive arthritis, using polymerase chain reaction with universal 16S ribosomal RNA primers. Arthritis Rheum. 1998; 41: 535–43.
   PubMed Web of Science ®Google Scholar
• Braun J, Tuszewski M, Eggens U, Mertz A, Schauer-Petrowskaja C, Doring E, et al.. Nested polymerase chain reaction strategy simultaneously targeting DNA sequences of multiple bacterial species in inflammatory joint diseases. I. Screening of synovial fluid samples of patients with spondyloarthropathies and other arthritides. J Rheumatol. 1997; 24: 1092–100.
   Web of Science ®Google Scholar
• Gerard HC, Wang Z, Feng Wang G, El-Gabalawy H, Goldbach-Mansky R, Li Y, et al.. Chromosomal DNA from a variety of bacterial species is present in synovial tissue from patients with various forms of arthritis. Arthritis Rheum. 2001; 44: 1689–97.
   PubMed Web of Science ®Google Scholar
• Ogrendik M, Kokino S, Ozdemir F, Bird PS, Hamlet S. Serum antibodies to oral anaerobic bacteria in patients with rheumatoid arthritis. Med Gen Med. 2005; 7: 2.
   PubMedGoogle Scholar
• Moen K, Brun JG, Valen M, Skartveit L, Eribe EK, Olsen I, et al.. Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs. Clin Exp Rheumatol. 2006; 24: 656–63.
   PubMed Web of Science ®Google Scholar
• Mikuls TR, Ayne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, et al.. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009; 9: 38–42.
   PubMed Web of Science ®Google Scholar
• Martinez-Martinez RE, Abud-Mendoza C, Patiño-Marin N, Rizo-Rodriguez JC, Little JW, Loyola-Rodriguez JP. Detection of periodontal bacterial DNA in serum and synovial fluid in refractory rheumatoid arthritis patients. J Clin Periodontol. 2009; 36: 1004–10.
   PubMed Web of Science ®Google Scholar
• Kinane DF, Riggio MP, Walker KF, MacKenzie D, Shearer B. Bacteraemia following periodontal procedures. J Clin Periodontol. 2005; 32: 708–13.
   PubMed Web of Science ®Google Scholar
• de Pablo P, Chapple ILC, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009; 5: 218–24.
   PubMed Web of Science ®Google Scholar
• Pierce DL, Nishiyama S, Liang S, Wang M, Triantafilou M, Triantafilou K, et al.. Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis. Infect Immun. 2009; 77: 3294–301.
   Web of Science ®Google Scholar
• Moen K, Brun JG, Madland TM, Tynning T, Jonsson R. Immunoglobulin G and A antibody responses to Bacteroides forsythus and Prevotella intermedia in sera and synovial fluids of arthritis patients. Clin Diag Lab Immnunol. 2003; 10: 1043–50.
   PubMedGoogle Scholar
• Wegner N, Lundberg K, Kinloch A, Fisher B, Malmström V, Feldmann M, et al.. Autoimmunity to specific citrullinated proteins gives the first clues to the etiology of rheumatoid arthritis. Immunol Rev. 2010; 233: 34–54.
   PubMed Web of Science ®Google Scholar
• Wegner N, Wait R, Sroka A, Eick S, Nguyen KA, Lundberg K, et al.. Peptidylarginine deiminase from Porphyromonas gingivalis citrullinates human fibrinogen and alpha-enolase: implications for autoimmunity in rheumatoid arthritis. Arthritis Rheum. 2010; 62: 2662–72.
   PubMed Web of Science ®Google Scholar
• Liao F, Li Z, Wang Y, Shi B, Ging Z, Cheng X. Porphyromonas gingivalis may play an important role in the pathogenesis of periodontitis-associated rheumatoid arthritis. Med Hypotheses. 2009; 72: 732–5.
   PubMed Web of Science ®Google Scholar
• Hitchon CA, Chandad F, Ferucci ED, Willemze A, Ioan-Facsinay A, van der Woude D, et al.. Antibodies to Porphyromonas gingivalis are associated with anticitrullinated protein antibodies in patients with rheumatoid arthritis and their relatives. J Rheumatol. 2010; 37: 1105–12.
   PubMed Web of Science ®Google Scholar
• Lundberg K, Kinloch A, Fisher BA, Wegner N, Wait R, Charles P, et al.. Antibodies to citrullinated alpha-enolase peptide 1 are specific for rheumatoid arthritis and cross-react with bacterial enolase. Arthritis Rheum. 2008; 58: 3009–19.
   PubMed Web of Science ®Google Scholar
• Bartold PM, Marino V, Cantley M, Haynes DR. Effect of Porphyromonas gingivalis-induced inflammation on the development of rheumatoid arthritis. J Clin Periodontol. 2010; 37: 405–11.
   PubMed Web of Science ®Google Scholar
• Pischon N, Röhner E, Hocke A, N'Guessan P, Müller HC, Matziolis G, et al.. Effects of Porphyromonas gingivalis on cell cycle progression and apoptosis of primary human chondrocytes. Ann Rheum Dis. 2009; 68: 1902–7.
   PubMed Web of Science ®Google Scholar
• Ghosh A, Park JY, Fenno C, Kapila YL. Porphyromonas gingivalis, gamma interferon, and a proapoptotic fibronectin matrix form a synergistic trio that induces c-Jun N-terminal kinase 1-mediated nitric oxide generation and cell death. Infect Immun. 2008; 76: 5514–23.
   Web of Science ®Google Scholar
• Yu JJ, Ruddy MJ, Conti HR, Boonanantanasarn K, Gaffen SL. The interleukin-17 receptor plays a gender-dependent role in host protection against Porphyromonas gingivalis-induced periodontal bone loss. Infect and Immun. 2008; 76: 4206–13.
   Web of Science ®Google Scholar
• Yu JJ, Gaffen SL. Interleukin-17: a novel inflammatory cytokine that bridges innate and adaptive immunity. Front Biosci. 2008; 13: 170–7.
   PubMed Web of Science ®Google Scholar
• Jacobson JJ, Patel B, Asher G, Woolliscroft JO, Schaberg D. Oral staphylococcus in older subjects with rheumatoid arthritis. J Am Geriatr Soc. 1997; 45: 590–3.
   PubMed Web of Science ®Google Scholar
• Jackson MS, Bagg J, Gupta MN, Sturrock RD. Oral carriage of staphylococci in patients with rheumatoid arthritis. Rheumatol. 1999; 38: 572–5.
   PubMed Web of Science ®Google Scholar
• Ortiz P, Bissada NF, Palomo L, Han YW, Al-Zahrani MS, Panneerselvam A, et al.. Periodontal therapy reduces the severity of active rheumatoid arthritis in patients treated with or without tumor necrosis factors inhibitors. J Periodontol. 2009; 80: 535–40.
   PubMed Web of Science ®Google Scholar
• Ribeiro J, Leao A, Novaes AB. Periodontal infection as a possible severity factor for rheumatoid arthritis. J Clin Periodontol. 2005; 32: 412–6.
   Web of Science ®Google Scholar
• Al-Katma MK, Bissada NF, Bordeaux JM, Sue J, Askari AD. Control of periodontal infection reduces the severity of active rheumatoid arthritis. J Clin Rheumatol. 2007; 13: 134–7.
   PubMed Web of Science ®Google Scholar
• Modi DK, Chopra VS, Bhau U. Rheumatoid arthritis and periodontitis: biological links and the emergence of dual purpose therapies. Indian J Den Res. 2009; 20: 86–90.
   PubMedGoogle Scholar
• Fiedorczyk M, Klimiuk PA, Sierakowski S, Gindzienska-Siesiewicz E, Chwiecko J. Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in patients with early rheumatoid arthritis. J Rheumatol. 2007; 34: 890–2.
   Google Scholar
• Stone M, Fortin PR, Pacheco-Tena C, Inman RD. Should tetracycline treatment be used more extensively for rheumatoid arthritis? Meta analysis demonstrates clinical benefit with reduction in disease activity. J Rheumatol. 2003; 30: 2112–22.
   PubMed Web of Science ®Google Scholar
• Sorsa T, Tjaderhane L, Konttinen YT, Lauhio A, Salo T, Lee HM, et al.. Matrix metalloproteinases: contribution to pathogenesis, diagnosis and treatment of periodontal inflammation. Ann Med. 2006; 38: 306–21.
   PubMed Web of Science ®Google Scholar
• Salvi GE, Williams RC, Offenbacher S. Nonsteroidal anti-inflammatory drugs as adjuncts in the management of periodontal diseases and peri-implantitis. Curr Opin Periodontol. 1997; 4: 51–8.
   PubMedGoogle Scholar
• Pillinger MH, Capodici C, Rosenthal P, Kheterpal N, Hanft S, Philips MR, et al.. Modes of action of aspirin-like drugs: salicylates inhibit erk activation and integrin-dependent neutrophil adhesion. Proc Natl Acad Sci USA. 1998; 95: 14540–5.
   PubMed Web of Science ®Google Scholar
• Lavagno L, Gunella G, Bardelli C, Spina S, Fresu LG, Viano I, et al.. Anti-inflammatory drugs and tumor necrosis factor-alpha production from monocytes: role of transcription of factor NF-kappa B and implication for rheumatoid arthritis therapy. Eur J Pharmacol. 2004; 501: 199–208.
   PubMed Web of Science ®Google Scholar
• Albandar JM, DeNardin AM, Adesanya MR, Diehl SR, Winn DM. Association between serum antibody levels to periodontal pathogens and early-onset periodontitis. J Periodontol. 2001; 72: 1463–9.
   Web of Science ®Google Scholar
• Ebersole JL, Cappelli D, Mathys EC, Steffen MJ, Singer RE, Montgomery M, et al.. Periodontitis in humans and non-humans primates: oral-systemic linkage inducing acute phase proteins. Ann Periodontol. 2002; 7: 102–11.
   Google Scholar
• Bassetti S, Wasmer S, Hasler P, Vogt T, Nogarth D, Frei R, et al.. Staphylococcus aureus in patients with rheumatoid arthritis under conventional and anti-tumor necrosis factor-alpha treatment. J Rheumatol. 2005; 32: 2125–9.
   PubMed Web of Science ®Google Scholar