40
Views
6
CrossRef citations to date
0
Altmetric
Original Articles

Microcirculatory Alterations in the Critically Ill

, MD, PhD & , MD, PhD
Pages 107-112 | Published online: 24 Jun 2015

References

  • Gomersall CD, Joynt GM, Freebairn RC, Hung V, Buckley TA, Oh TE. Resuscitation of critically ill patients based on the results of gastric tonometry: a prospective, randomized, controlled trial. Crit Care Med. 2000; 28(3): 607–614.
  • Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med. 2004; 32(9): 1825–1831.
  • Trzeciak S, Dellinger RP, Parrillo JE, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med. 2007; 49(1): 88–98.
  • Groner W, Winkelman JW, Harris AG, et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med. 1999; 5(1): 1209–1212.
  • Ince C. The microcirculation is the motor of sepsis. Crit Care. 2005; (9 suppl 4): S13–S19.
  • De Backer D, Hollenberg S, Boerma C, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care. 2007; 11(5): R101.
  • De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med. 2002; 166(1): 98–104.
  • Boerma EC, Mathura KR, van der Voort PH, Spronk PE, Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care. 2005; 9(6): R601–R606.
  • Verdant CL, De Backer D, Bruhn A, et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med. 2009; 37(11): 2875–2181.
  • De Backer D, Creteur J, Dubois MJ, Sakr Y, Vincent JL. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J. 2004; 147(1): 91–99.
  • Jung C, Ferrari M, Rödiger C, et al. Evaluation of the sublingual microcirculation in cardiogenic shock. Clin Hemorheol Microcirc. 2009; 42(2): 141–148.
  • Goldman D, Bateman RM, Ellis CG. Effect of decreased O2 supply on skeletal muscle oxygenation and O2 consumption during sepsis: role of heterogeneous capillary spacing and blood flow. Am J Physiol Heart Circ Physiol. 2006; 290(6): H2277–H2285.
  • Trzeciak S, McCoy JV, Phillip DR, et al. Microcirculatory Alterations in Resuscitation and Shock (MARS) investigators. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med. 2008; 34(12): 2210–2217.
  • Jhanji S, Lee C, Watson D, Hinds C, Pearse RM. Microvascular flow and tissue oxygenation after major abdominal surgery: association with post-operative complications. Intensive Care Med. 2009; 35(4): 671–677.
  • Machiedo GW, Powell RJ, Rush BF Jr, Swislocki NI, Dikdan G. The incidence of decreased red blood cell deformability in sepsis and the association with oxygen free radical damage and multiple-system organ failure. Arch Surg. 1989; 124(12): 1386–1389.
  • Sakr Y, Chierego M, Piagnerelli M, et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med. 2007; 35(7): 1639–1644.
  • Creteur J, Neves AP, Vincent JL. NIRS technique to evaluate the effects of red blood cell transfusion on tissue oxygenation. Crit Care. In press.
  • Zhang H, Benlabed M, Spapen H, Nguyen DN, Vincent JL. Prostaglandin El increases oxygen extraction capabilities in experimental sepsis. J Surg Res. 1994; 57(4): 470–479.
  • Spronk PE, Ince C, Gardien MJ, Mathura KR, Oudemans-van Straaten HM, Zandstra DF. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet. 2002; 360(9343): 1395–1396.
  • Boerma EC, Koopmans M, Konijn A, et al. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial [published online ahead of print August 27,2009], Crit Care Med.
  • Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med. 2009; 37(6): 1961–1966.
  • Dubin A, Pozo MO, Casabella CA, et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care. 2009; 13(3): R92.
  • De Backer D, Creteur J, Dubois MJ, et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med. 2006; 34(2): 403–408.
  • Dubois MJ, De Backer D, Creteur J, Anane S, Vincent JL. Effect of vasopressin on sublingual microcirculation in a patient with distributive shock. Intensive Care Med. 2003; 29(6): 1020–1023.
  • Boerma EC, van der Voort PH, Ince C. Sublingual microcirculatory flow is impaired by the vasopressin-analogue terlipressin in a patient with catecholamine-resistant septic shock. Acta Anaesthesiol Scand. 2005; 49(9): 1387–1390.
  • Koch M, De Backer D, Vincent JL, Barvais L, Hennart D, Schmartz D. Effects of propofol on human microcirculation. Br J Anaesth. 2008; 101(4): 473–478.
  • De Backer D, Verdant C, Chierego M, Koch M, Gullo A, Vincent JL. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med. 2006; 34(7): 1918–1924.
  • Büchele GL, Silva E, Ospina-Tascón GA, Vincent JL, De Backer D. Effects of hydrocortisone on microcirculatory alterations in patients with septic shock. Crit Care Med. 2009; 37(4): 1341–1347.
  • Ospina-Tascon G, Neves AP, Occhipinti G, et al. The microvascular effects of fluids in the early and late phases of severe sepsis (abstract). Intensive Care Med. 2008; 34(suppl 1): S58.
  • De Backer D, Ospina-Tascon G, Neves AP, et al. The effects of crystalloids and albumin on microcirculatory alterations in patients with severe sepsis (abstract). Chest. 2009; 134:69001.
  • Arnold RC, Parrillo JE, Phillip Dellinger R, et al. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med. 2009; 35(10): 1761–1766.
  • Myers DE, Anderson LD, Seifert RP, et al. Noninvasive method for measuring local hemoglobin oxygen saturation in tissue using wide gap second derivative near-infrared spectroscopy. J Biomed Opt. 2005; 10(3): 034017.
  • Skarda DE, Mulier KE, Myers DE, Taylor JH, Beilman GJ. Dynamic near-infrared spectroscopy measurements in patients with severe sepsis. Shock. 2007; 27(4): 348–353.
  • Creteur J. Muscle StO2 in critically ill patients. Curr Opin Crit Care. 2008; 14(3): 361–366.
  • De Blasi RA, Palmisani S, Alampi D, et al. Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock. Intensive Care Med. 2005; 31(12): 1661–1668.
  • Doerschug KC, Delsing AS, Schmidt GA, Haynes WG. Impairments in microvascular reactivity are related to organ failure in human sepsis. Am J Physiol Heart Circ Physiol. 2007; 293(2): H1065–H1071.
  • Creteur J, Carello T, Soldati G, Buchele G, De Backer D, Vincent JL. The prognostic value of muscle StO2, in septic patients. Intensive Care Med. 2007; 33(9): 1549–1556.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.