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Original Articles

Understanding insulin resistance

What are the clinical implications?

, MD
Pages 41-48 | Published online: 30 Jun 2015

References

  • Reaven GM. Multiple CHD risk factors in type 2 diabetes: beyond hyperglycaemia. Diabetes Obes Metab 2002; 4(Suppl 1): S13–8
  • Wallace TM, Matthews DR. The assessment of insulin resistance in man. Diabet Med 2002; 19(7): 527–34
  • McLaughlin T, Abbasi F, Cheal K, et al. Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 2003; 139(10): 802–9
  • Polonsky KS. Dynamics of insulin secretion in obesity and diabetes. Int J Obes Relat Metab Dis 2000; 24(Suppl 2): S29–31
  • Leahy JL. Natural history of beta-cell dysfunction in NIDDM. Diabetes Care 1990; 13(9): 992–1010
  • DeFronzo RA. Lilly lecture 1987. The triumvirate: beta-cell, muscle, liver. A collusion responsible for NIDDM. Diabetes 1988; 37(6): 667–87
  • Sivitz WI, Wayson SM, Bayless ML, et al. Leptin and body fat in type 2 diabetes and monodrug therapy. J Clin Endocrinol Metab 2003; 88(4): 1543–53
  • DeFronzo RA, Bonadonna RC, Ferrannini E. Pathogenesis of NIDDM: a balanced overview. Diabetes Care 1992; 15(3): 318–68
  • Franks S. Polycystic ovary syndrome. N Engl J Med 1995; 333(13): 853–61 [Erratum, N Engl J Med 1995; 333(21): 1435] [Comment, N Engl J Med 1996; 334(10): 668]
  • Ginsberg HN. Insulin resistance and cardiovascular disease. J Clin Invest 2000; 106(4): 453–8 [Comment, J Clin Invest 2000; 106(5): 629–31]
  • Yokoyama H, Emoto M, Fujiwara S, et al. Quantitative insulin sensitivity check index and the reciprocal index of homeostasis model assessment in normal range weight and moderately obese type 2 diabetic patients. Diabetes Care 2003; 26(8): 2426–32
  • Pacini G, Mari A. Methods for clinical assessment of insulin sensitivity and beta-cell function. Best Pract Res Clin Endocrinol Metab 2003; 17(3): 305–22
  • Flakoll P, Carlson MG, Cherrington A. Physiologic action of insulin. In: LeRoith D, Taylor SI, Olefsky JM, eds. Diabetes mellitus: a fundamental and clinical text. Philadelphia: Lippincott-Raven, 1996: 121–31
  • Sivitz WI. Lipotoxicity and glucotoxicity in type 2 diabetes: effects on development and progression. Postgrad Med 2001; 109(4): 55–64
  • Bonora E. Relationship between regional fat distribution and insulin resistance. Int J Obes Relat Metab Disord 2000; 24(Suppl 2): S32–5
  • Kelley DE, Goodpaster BH. Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance. Diabetes Care 2001; 24(5): 933–41
  • Stewart PM, Tomlinson JW. Cortisol, 11 beta-hydroxysteroid dehydrogenase type 1 and central obesity. Trends Endocrinol Metab 2002; 13(3): 94–6
  • Khan AH, Pessin JE. Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 2002; 45(11): 1475–83
  • Reusch JE. Current concepts in insulin resistance, type 2 diabetes mellitus, and the metabolic syndrome. Am J Cardiol 2002; 90(5A): 19–26G
  • Shepherd PR, Kahn BB. Glucose transporters and insulin action—implications for insulin resistance and diabetes mellitus. N Engl J Med 1999; 341(4): 248–57 [Comment, N Engl J Med 1999; 341(4): 240–6]
  • Hsueh WA, Law RE. PPARgamma and atherosclerosis: effects on cell growth and movement. Arterioscler Thromb Vase Biol 2001; 21(12): 1891–5
  • Kelley DE, Mandarino LJ. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 2000; 49(5): 677–83
  • Shulman GI. Cellular mechanisms of insulin resistance. J Clin Invest 2000; 106(2): 171–6
  • Reaven GM. Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease. J Clin Endocrinol Metab 2003; 88(6): 2399–403
  • Knowler WC, Barrett-Connor E, Fowler SE, et al; Diabetes Prevention Program Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346(6): 393–403
  • Lord JM, Flight IH, Norman RJ. Metformin in polycystic ovary syndrome: systematic review and meta-analysis. BMJ 2003; 327(7421): 951–3

References

  • Pacini G, Marl A. Methods for clinical assessment of insulin sensitivity and beta-cell function. Best Pract Res Clin Endocrinol Metab 2003;17(3): 305–22
  • Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev 1985;6(1): 45–86

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