Advanced search
Publication Cover
Postgraduate Medicine Volume 121, 2009 - Issue 2
Submit an article Journal homepage
675
Views
20
CrossRef citations to date
0
Altmetric
Clinical Features

OxyContin® Abuse and Overdose

Christopher T. Aquina University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Department of Medical Education, New Brunswick, NJ
, BS,
Andreia Marques-Baptista University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, NJ
, MD,
Patrick Bridgeman Ernest Mayo School of Pharmacy, Rutgers University, Piscataway, NJ
, PharmD &
Mark A. Merlin University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Department of Emergency Medicine, New Brunswick, NJCorrespondence[email protected]
, DO, EMT-P, FACEP
Pages 163-167 | Published online: 13 Mar 2015

References

  • . OxyContin [package insert]. Stamford, CT: Purdue Pharma, LP; 2007. http://www.pharma.com/html/our_products/our_products.htm. Accessed September 12, 2008
  • . Trescot AM, Datta S, Lee M, Hansen H. Opioid pharmacology. Pain Physician. 2008;11( 2 suppl):S133–S153
  • . Gossop M, Griffiths P, Powis B, Strang J. Cocaine: patterns of use, route of administation, and severity of dependence. Br J Psychiatry. 1994;164(5):660–664
  • . Marsch LA, Bickel WF, Badger WJ,. Effects of infusion rate of intravenously administered morphine on physiological, pscyhomotor, and self-reported measures in humans. J Pharmacol Exp Ther. 2001;299(3):1056–1065
  • . Oldendorf WH. Some relationships between addiction and drug delivery to the brain. NIDA Res Monogr. 1992;120:13–25
  • . Roset PN, Farré M, de la Torre R,. Modulation of rate of onset and intensity of drug effects reduces abuse potential in healthy males. Drug Alcohol Depend. 2001;64(3):285–298
  • . Cicero TJ, Inciardi JA, Muñoz A. Trends in abuse of Oxycontin and other opioid analgesics in the United States: 2002–2004. J Pain. 2005;6(10):662–672
  • . Roche T. The potent perils of a miracle drug. Time. 2001;157(1):47
  • . Jayawant SS, Balkrishnan R. The controversy surrounding OxyContin abuse: issues and solutions. Ther Clin Risk Manag. 2005;1(2):77–82
  • . Suffett WL. OxyContin abuse. J Ky Med Assoc. 2001;99(2):72
  • . Tunnell KD. The OxyContin epidemic and crime panic in rural Kentucky. Contemporary Drug Problems. 2005;32(2):225
  • . US Department of Health and Human Services. CSAT Advisory. OxyContin: prescription drug abuse. April 1, 2001
  • . Katz DA, Hays LR. Adolescent OxyContin Abuse. J Am Acad Child Adolesc Psychiatry. 2004;43(2):231–234
  • . US Department of Justice, Drug Enforcement Administration. Office of Diversion Control. Drugs and chemicals of concern: summary of medical examiner reports on oxycodone-related deaths. http://www.deadiversion.usdoj.gov/drugs_concern/oxycodone/oxycontin7.htm. Published July 21, 2008. Accessed October 1, 2008
  • . Substance Abuse and Mental Health Services Administration. Drug Abuse Warning Network, 2005: national estimates of drug-related emergency department visits. DAWN Series D-29, 2007. Rockville, MD: SAMHSA; 2007
  • . Cone EJ, Frant RV, Rohay JM,. Oxycodone involvement in drug abuse deaths: a DAWN-based classification scheme applied to an oxycodone postmortem database containing over 1000 cases. J Anal Toxicol. 2003;27(2):57–67
  • . Drummer OH, Surkamem ML, Phelan M, Cordner SM. A study of deaths involving oxycodone. J Forensic Sci. 1994;39(4):1069–1075
  • . Substance Abuse and Mental Health Services Administration. The DAWN Report: oxycodone, hydrocodone, and polydrug use, 2002. Rockville, MD: SAMHSA; July 2004
  • . Arnold C. Teen abuse of painkiller OxyContin on the rise. All Things Considered. National Public Radio. 2005. http://www.npr.org/templates/story/story.php?storyId=5061674. Accessed October 1, 2008
  • . Goldfrank L, Flomenbaum NE, Lewin N,. Goldfrank's Toxicologic Emergencies. 8th ed. New York, NY: The McGraw-Hill Companies, Inc; 2006
  • . Schneir AB, Vadeboncoeur TF, Offerman SR,. Massive OxyContin ingestion refractory to naloxone therapy. Ann Emerg Med. 2002;40(4):425–28
  • . Weil JV, McCullough RE, Kline JS, Sodal IE. Diminished ventilatory response to hypoxia and hypercapnia after morphine in normal man. N Engl J Med. 1975;292(21):1103–1106
  • . Osler W. Oedema of left lung-Morphia poisoning. Montreal General Hospital Reports. Vol 1. Montreal, Canada: Dawson Bros Publishers; 1880:291–293
  • . Ward JM, McGrath RL, Weil JV. Effects of morphine on the peripheral vascular response to sympathetic stimulation. Am J Cardiol. 1972;29(5):659–666
  • . Fahmy NR, Sunder N, Soter NA. Role of histamine in the hemodynamic and plasma catecholamine responses to morphine. Clin Pharmacol Ther. 1983;33(5):615–620
  • . Barke KE, Hough LB. Opiates, mast cells and histamine release. Life Sci. 1993;53(18):1391–1399
  • . Lee HK, Wang SC. Mechanism of morphine-induced miosis in the dog. J Pharmacol Exp Ther. 1975;192(2):415–431
  • . Greene D. Total necrosis of the intranasal structures and soft palate as a result of nasal inhalation of crushed OxyContin. Ear Nose Throat Journal. 2005;84(8):512, 514, 516
  • . Davis MP, Varga J, Dickerson D,. Normal release and controlled release oxycodone: pharmacokinetics, pharmacodynamics and controversy. Support Care Cancer. 2003;11(2):84–92
  • . Bracken MB, Shepard MJ, Collins WF,. A randomized, controlled trial of methylprednisolone or naloxone in the treatment of acute spinal-cord injury. Results of the Second National Acute Spinal Cord Injury Study. N Engl J Med. 1990;322(20):1405–1411
  • . Buajordet I, Naess AC, Jacobsen D, Brors D. Adverse events after naloxone treatment of episodes of suspected acute opioid overdose. Eur J Emerg Med. 2004;11(1):19–23

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.