106
Views
6
CrossRef citations to date
0
Altmetric
Clinical Features

Clinical Strategies to Address Patients' Concerns in Osteoporosis Management with Bisphosphonates

, DO, CCD
Pages 131-144 | Published online: 13 Mar 2015

References

  • . US Department of Health and Human Services. Bone health and osteoporosis: a report of the surgeon general. http://www.surgeongeneral.gov/library/bonehealth/. Accessed August 31, 2010
  • . National Osteoporosis Foundation. Clinician's guide to prevention and treatment of osteoporosis. http://www.nof.org/professionals/NOF_Clinicians_Guide.pdf. Accessed August 31, 2010
  • . Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res. 2007;22(3):465–475
  • . Becker DJ, Yun H, Kilgore ML, . Health services utilization after fractures: evidence from Medicare. J Gerontol A Biol Sci Med Sci. 2010;65(9):1012–1020
  • . National Osteoporosis Foundation. Fast facts on osteoporosis. http://www.nof.org/osteoporosis/diseasefacts.htm#top. Accessed September 8, 2009
  • . Chrischilles EA, Butler CD, Davis CS, Wallace RB. A model of lifetime osteoporosis impact. Arch Intern Med. 1991;151(10):2026–2032
  • . Federal Interagency Forum on Aging-Related Statistics. Older Americans 2008: key indicators of well-being. http://www.agingstats.gov/agingstatsdotnet/main_site/data/2008_Documents/Population.aspx. Accessed March 1, 2010
  • . Iacono MV. Osteoporosis: a national public health priority. J Perianesth Nurs. 2007;22(3):175–180; quiz 181–172
  • . Feldstein A, Elmer PJ, Orwoll E, Herson M, Hillier T. Bone mineral density measurement and treatment for osteoporosis in older individuals with fractures: a gap in evidence-based practice guideline implementation. Arch Intern Med. 2003;163(18):2165–2172
  • . Martens MG, Shaw H. Maximizing effectiveness of bisphosphonate therapy for osteoporosis. South Med J. 2008;101(8):824–830
  • . Baim S, Binkley N, Bilezikian JP, . Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development Conference. J Clin Densitom. 2008;11(1):75–91
  • . Kanis JA, Burlet N, Cooper C, ; European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). European guidance for the diagnosis and management of osteoporosis in postmenopausal women. Osteoporos Int. 2008;19(4):399–428
  • . World Health Organization. WHO Scientific Group on the Assessment of Osteoporosis at the Primary Health Care Level: summary meeting report; Brussels, Belgium; May 5–7, 2004. http://www.who.int/chp/topics/Osteoporosis.pdf. Accessed September 24, 2010
  • . National Osteoporosis Foundation. BMD testing: what the numbers mean. http://www.nof.org/osteoporosis/bmdtest.htm#Index. Accessed June 24, 2010
  • . Siris ES, Miller PD, Barrett-Connor E, . Identification and fracture outcomes of undiagnosed low bone mineral density in postmenopausal women: results from the National Osteoporosis Risk Assessment. JAMA. 2001;286(22):2815–2822
  • . Kanis JA. FRAX®: WHO Fracture Risk Assessment Tool. http://www.sheffield.ac.uk/FRAX/. Accessed August 31, 2010
  • . Kanis JA. WHO Fracture Risk Assessment Tool: FRAX® release notes. http://www.sheffield.ac.uk/FRAX/pdfs/FRAX_Release_Notes.pdf. Accessed August 31, 2010
  • . Kanis JA, Oden A, Johansson H, Borgström F, Strom O, McCloskey E. FRAX® and its applications to clinical practice. Bone. 2009;44(5):734–743
  • . Sinaki M, Pfeifer M, Preisinger E, . The role of exercise in the treatment of osteoporosis. Curr Osteoporos Rep. 2010;8(3):138–144
  • . Kanis JA, Borgstrom F, De Laet C, . Assessment of fracture risk. Osteoporos Int. 2005;16(6):581–589
  • . Tsuang YH, Sun JS, Chen LT, Sun SC, Chen SC. Direct effects of caffeine on osteoblastic cells metabolism: the possible causal effect of caffeine on the formation of osteoporosis. J Orthop Surg Res. 2006;1:7
  • . Tinetti ME. Clinical practice. Preventing falls in elderly persons. N Engl J Med. 2003;348(1):42–49
  • . Cummings SR, Martin JS, McClung MR, ; FREEDOM Trial. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med. 2009;361(8):756–765
  • . Reclast [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corp; 2009
  • . Boniva [package insert]. South San Francisco, CA: Genentech USA, Inc; 2010
  • . Actonel [package insert]. Norwich, NY: Norwich Pharmaceuticals, Inc; 2010
  • . Fosamax [package insert]. Whitehouse Station, NJ: Merck and Co, Inc; 2010
  • . Bushardt RL, Turner JL, Ragucci KR, Askins DG Jr. Non-estrogen treatments for osteoporosis: an evidence-based review. JAAPA. 2006;19(12):25–30
  • . Sontag A, Wan X, Krege JH. Benefits and risks of raloxifene by vertebral fracture status. Curr Med Res Opin. 2010;26(1):71–76
  • . Gilchrist N. Antiresorptive agents, raloxifene, and PHARMAC. N Z Med J. 2006;119(1230):U1885
  • . Prolia [package insert]. Thousand Oaks, CA: Amgen Inc; 2010
  • . Deal C. Potential new drug targets for osteoporosis. Nat Clin Pract Rheumatol. 2009;5(1):20–27
  • . Sweet MG, Sweet JM, Jeremiah MP, Galazka SS. Diagnosis and treatment of osteoporosis. Am Fam Physician. 2009;79(3):193–200
  • . Bock O, Felsenberg D. Bisphosphonates in the management of postmenopausal osteoporosis–optimizing efficacy in clinical practice. Clin Interv Aging. 2008;3(2):279–297
  • . Atelvia [package insert]. Rockaway, NJ: Warner-Chilcott; 2010
  • . Vermeire E, Hearnshaw H, Van Royen P, Denekens J. Patient adherence to treatment: three decades of research. A comprehensive review. J Clin Pharm Ther. 2001;26(5):331–342
  • . Cole RE, Harris ST. Preventing nonvertebral osteoporotic fractures with extended-interval bisphosphonates: regimen selection and clinical application. Medscape J Med. 2009;11(1):12
  • . Cramer JA, Lynch NO, Gaudin AF, Walker M, Cowell W. The effect of dosing frequency on compliance and persistence with bisphosphonate therapy in postmenopausal women: a comparison of studies in the United States, the United Kingdom, and France. Clin Ther. 2006;28(10):1686–1694
  • . Emkey R, Koltun W, Beusterien K, . Patient preference for once-monthly ibandronate versus once-weekly alendronate in a randomized, open-label, cross-over trial: the Boniva Alendronate Trial in Osteoporosis (BALTO). Curr Med Res Opin. 2005;21(12):1895–1903
  • . Reginster JY, Rabenda V. Patient preference in the management of postmenopausal osteoporosis with bisphosphonates. Clin Interv Aging. 2006;1(4):415–423
  • . Simon JA, Lewiecki EM, Smith ME, Petruschke RA, Wang L, Palmisano JJ. Patient preference for once-weekly alendronate 70 mg versus once-daily alendronate 10 mg: a multicenter, randomized, open-label, crossover study. Clin Ther. 2002;24(11):1871–1886
  • . Cotte FE, Fardellone P, Mercier F, Gaudin AF, Roux C. Adherence to monthly and weekly oral bisphosphonates in women with osteoporosis. Osteoporos Int. 2010;21(1):145–155
  • . Briesacher BA, Andrade SE, Harrold LR, Fouayzi H, Yood RA. Adoption of once-monthly oral bisphosphonates and the impact on adherence. Am J Med. 2010;123(3):275–280
  • . Lewiecki EM, Babbitt AM, Piziak VK, Ozturk ZE, Bone HG. Adherence to and gastrointestinal tolerability of monthly oral or quarterly intravenous ibandronate therapy in women with previous intolerance to oral bisphosphonates: a 12-month, open-label, prospective evaluation. Clin Ther. 2008;30(4):605–621
  • . Cramer JA, Silverman S, Cziraky MJ, Barr CE, Poston S. Women are more persistent with monthly ibandronate vs. weekly bisphosphonates: results from a retrospective database. Value Health. 2007;10(3):A98
  • . Weiss TW, Henderson SC, McHorney CA, Cramer JA. Persistence across weekly and monthly bisphosphonates: analysis of US retail pharmacy prescription refills. Curr Med Res Opin. 2007;23(9):2193–2203
  • . Lareau SC, Yawn BP. Improving adherence with inhaler therapy in COPD. Int J Chron Obstruct Pulmon Dis. 2010;5:401–406
  • . Donovan JL, Blake DR. Patient non-compliance: deviance or reasoned decision-making? Social Sci Med (1982). 1992;34(5):507–513
  • . Khosla S, Burr D, Cauley J, ; American Society for Bone and Mineral Research. Bisphosphonate-associated osteonecrosis of the jaw: report of a Task Force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2007;22(10):1479–1491
  • . Pendrys DG, Silverman SL. Osteonecrosis of the jaws and bisphosphonates. Curr Osteoporos Rep. 2008;6(1):31–38
  • . Woo SB, Hellstein JW, Kalmar JR. Narrative [corrected] review: bisphosphonates and osteonecrosis of the jaws. Ann Int Med. 2006;144(10):753–761
  • . Zavras AI, Zhu S. Bisphosphonates are associated with increased risk for jaw surgery in medical claims data: is it osteonecrosis? J Oral Maxillofac Surg. 2006;64(6):917–923
  • . Baim S, Miller PD. Assessing the clinical utility of serum CTX in postmenopausal osteoporosis and its use in predicting risk of osteonecrosis of the jaw. J Bone Miner Res. 2009;24(4):561–574
  • . Advisory Task Force on Bisphosphonate-Related Osteonecrosis of the Jaws, American Association of Oral and Maxillofacial Surgeons. American Association of Oral and Maxillofacial Surgeons (AAOMS). American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 2007;65(3):369–376
  • . American Dental Association Council on Scientific Affairs. Dental management of patients receiving oral bisphosphonate therapy: expert panel recommendations. J Am Dent Assoc. 2006;137(8):1144–1150
  • . Schneider JP. Bisphosphonates and low-impact femoral fractures: current evidence on alendronate-fracture risk. Geriatrics. 2009;64(1):18–23
  • . Neviaser AS, Lane JM, Lenart BA, Edobor-Osula F, Lorich DG. Low-energy femoral shaft fractures associated with alendronate use. J Orthop Trauma. 2008;22(5):346–350
  • . Lenart BA, Lorich DG, Lane JM. Atypical fractures of the femoral diaphysis in postmenopausal women taking alendronate. N Engl J Med. 2008;358(12):1304–1306
  • . Lee P, Seibel MJ. More on atypical fractures of the femoral diaphysis. N Engl J Med. 2008;359(3):317; author reply 317–318
  • . Kwek EB, Koh JS, Howe TS. More on atypical fractures of the femoral diaphysis. N Engl J Med. 2008;359(3):316–317; author reply 317–318
  • . Breglia MD, Carter JD. Atypical insufficiency fracture of the tibia associated with long-term bisphosphonate therapy. J Clin Rheumatol. 2010;16(2):76–78
  • . Abrahamsen B, Eiken P, Eastell R. Subtrochanteric and diaphyseal femur fractures in patients treated with alendronate: a register-based national cohort study. J Bone Miner Res. 2009;24(6):1095–1102
  • . Kwek EB, Goh SK, Koh JS, Png MA, Howe TS. An emerging pattern of subtrochanteric stress fractures: a long-term complication of alendronate therapy? Injury. 2008;39(2):224–231
  • . Visekruna M, Wilson D, McKiernan FE. Severely suppressed bone turnover and atypical skeletal fragility. J Clin Endocrinol Metab. 2008;93(8):2948–2952
  • . Black DM, Kelly MP, Genant HK, . Bisphosphonates and fractures of the subtrochanteric or diaphyseal femur. N Engl J Med. 2010;362:1761–1771
  • . Giusti A, Hamdy NA, Papapoulos SE. Atypical fractures of the femur and bisphosphonate therapy: a systematic review of case/case series studies. Bone. 2010;47(2):169–180
  • . Rizzoli R, Akesson K, Bouxsein M, . Subtrochanteric fractures after long-term treatment with bisphosphonates: a European Society on Clinical and Economic Aspects of Osteoporosis and Osteoarthritis, and International Osteoporosis Foundation Working Group Report. Osteoporos Int. 2011;22(2):373–390
  • . Shane E, Burr D, Ebeling PR, . Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2010;25(11):2267–2294
  • . US Food and Drug Administration. FDA drug safety communication: ongoing safety review of oral bisphosphonates and atypical subtrochanteric femur fractures. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm203891.htm. Accessed August 31, 2010
  • . Wysowski DK, Chang JT. Alendronate and risedronate: reports of severe bone, joint, and muscle pain. Arch Intern Med. 2005;165(3):346–347
  • . Bisphosphonates: bone, muscle and joint pain. Prescrire Int. 2009;18(99):23
  • . US Food and Drug Administration. Information for healthcare professionals: bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa). http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm124165.htm. Accessed August 20, 2010
  • . Caplan L, Pittman CB, Zeringue AL, . An observational study of musculoskeletal pain among patients receiving bisphosphonate therapy. Mayo Clin Proc. 2010;85(4):341–348
  • . Black DM, Delmas PD, Eastell R, ; HORIZON Pivotal Fracture Trial. Once-yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med. 2007;356(18):1809–1822
  • . Mak A, Cheung MW, Ho RC, Cheak AA, Lau CS. Bisphosphonates and atrial fibrillation: Bayesian meta-analyses of randomized controlled trials and observational studies. BMC Musculoskelet Disord. 2009;10:113
  • . Loke YK, Jeevanantham V, Singh S. Bisphosphonates and atrial fibrillation: systematic review and meta-analysis. Drug Saf. 2009;32(3):219–228
  • . Grosso A, Douglas I, Hingorani A, MacAllister R, Smeeth L. Oral bisphosphonates and risk of atrial fibrillation and flutter in women: a self-controlled case-series safety analysis. PLoS One. 2009;4(3):e4720
  • . Bunch TJ, Anderson JL, May HT, . Relation of bisphosphonate therapies and risk of developing atrial fibrillation. Am J Cardiol. 2009;103(6):824–828
  • . Abrahamsen B, Eiken P, Brixen K. Atrial fibrillation in fracture patients treated with oral bisphosphonates. J Intern Med. 2009;265(5):581–592
  • . Osteoporosis drugs not linked to atrial fibrillation. Harv Heart Lett. 2009;19(8):6
  • . Heckbert SR, Li G, Cummings SR, Smith NL, Psaty BM. Use of alendronate and risk of incident atrial fibrillation in women. Arch Intern Med. 2008;168(8):826–831
  • . Cummings SR, Schwartz AV, Black DM. Alendronate and atrial fibrillation. N Engl J Med. 2007;356(18):1895–1896
  • . Huang WF, Tsai YW, Wen YW, Hsiao FY, Kuo KN, Tsai CR. Osteoporosis treatment and atrial fibrillation: alendronate versus raloxifene. Menopause. 2010;17(1):57–63
  • . Karam R, Camm J, McClung M. Yearly zoledronic acid in postmenopausal osteoporosis. N Engl J Med. 2007;357(7):712–713; author reply 714–715
  • . Lewiecki EM, Cooper C, Thompson E, Hartl F, Mehta D, Papapoulos SE. Ibandronate does not increase risk of atrial fibrillation in analysis of pivotal clinical trials. Int J Clin Pract. 2010;64(6):821–826
  • . Black DM, Cummings SR, Karpf DB, . Randomised trial of effect of alendronate on risk of fracture in women with existing vertebral fractures. Fracture Intervention Trial Research Group. Lancet. 1996;348(9041):1535–1541
  • . Chesnut CH, Ettinger MP, Miller PD, . Ibandronate produces significant, similar antifracture efficacy in North American and European women: new clinical findings from BONE. Curr Med Res Opin. 2005;21(3):391–401
  • . Cummings SR, Black DM, Thompson DE, . Effect of alendronate on risk of fracture in women with low bone density but without vertebral fractures: results from the Fracture Intervention Trial. JAMA. 1998;280(24):2077–2082
  • . McClung MR, Geusens P, Miller PD, ; Hip Intervention Program Study Group. Effect of risedronate on the risk of hip fracture in elderly women: Hip Intervention Program Study Group. N Engl J Med. 2001;344(5):333–340
  • . Reginster J, Minne HW, Sorensen OH, . Randomized trial of the effects of risedronate on vertebral fractures in women with established postmenopausal osteoporosis. Vertebral Efficacy with Risedronate Therapy (VERT) Study Group. Osteoporos Int. 2000;11(1):83–91
  • . Marcus R, Wong M, Heath H 3rd, Stock JL. Antiresorptive treatment of postmenopausal osteoporosis: comparison of study designs and outcomes in large clinical trials with fracture as an endpoint. Endocr Rev. 2002;23(1):16–37
  • . McCarus DC. Fracture prevention in postmenopausal osteoporosis: a review of treatment options. Obstet Gynecol Surv. 2006;61(1):39–50
  • . Schnitzer T, Bone HG, Crepaldi G, . Therapeutic equivalence of alendronate 70 mg once-weekly and alendronate 10 mg daily in the treatment of osteoporosis. Alendronate Once-Weekly Study Group. Aging (Milano). 2000;12(1):1–12
  • . Delmas PD, Benhamou CL, Man Z, . Monthly dosing of 75 mg risedronate on 2 consecutive days a month: efficacy and safety results. Osteoporos Int. 2008;19(7):1039–1045
  • . Delmas PD, McClung MR, Zanchetta JR, . Efficacy and safety of risedronate 150 mg once a month in the treatment of postmenopausal osteoporosis. Bone. 2008;42(1):36–42
  • . Eisman JA, Civitelli R, Adami S, . Efficacy and tolerability of intravenous ibandronate injections in postmenopausal osteoporosis: 2-year results from the DIVA study. J Rheumatol. 2008;35(3):488–497
  • . Reginster JY, Adami S, Lakatos P, . Efficacy and tolerability of once-monthly oral ibandronate in postmenopausal osteoporosis: 2 year results from the MOBILE study. Ann Rheum Dis. 2006;65(5):654–661
  • . Watts NB, Brown JP, Cline G. Risedronate on 2 consecutive days a month reduced vertebral fracture risk at 1year compared with historical placebo. J Clin Densitom. 2010;13(1):56–62
  • . Harris ST, Blumentals WA, Miller PD. Ibandronate and the risk of non-vertebral and clinical fractures in women with postmenopausal osteoporosis: results of a meta-analysis of phase III studies. Curr Med Res Opin. 2008;24(1):237–245
  • . Cranney A, Wells GA, Yetisir E, . Ibandronate for the prevention of nonvertebral fractures: a pooled analysis of individual patient data. Osteoporos Int. 2009;20(2):291–297
  • . MacLean C, Newberry S, Maglione M, . Systematic review: comparative effectiveness of treatments to prevent fractures in men and women with low bone density or osteoporosis. Ann Int Med. 2008;148(3):197–213
  • . Recker R, Stakkestad JA, Chesnut CH 3rd, . Insufficiently dosed intravenous ibandronate injections are associated with sub-optimal antifracture efficacy in postmenopausal osteoporosis. Bone. 2004;34(5):890–899
  • . Miller P, Recker R, Harris ST, . Long-term fracture efficacy with continued ibandronate treatment: pooled analysis of DIVA and MOBILE long-term extension studies. J Bone Miner Res. 2009;24( suppl 1):Abstract A09002020
  • . Bianchi G, Felsenberg D, Czerwinski E, . Efficacy of IV ibandronate is maintained over 5 years: the DIVA LTE study. Ann Rheum Dis. 2009;68( suppl 3):494
  • . Miller PD, Epstein S, Sedarati F, Reginster JY. Once-monthly oral ibandronate compared with weekly oral alendronate in postmenopausal osteoporosis: results from the head-to-head MOTION study. Curr Med Res Opin. 2008;24(1):207–213
  • . Bonnick S, Saag KG, Kiel DP, . Comparison of weekly treatment of postmenopausal osteoporosis with alendronate versus risedronate over two years. J Clin Endocrinol Metab. 2006;91(7):2631–2637
  • . Silverman SL, Watts NB, Delmas PD, Lange JL, Lindsay R. Effectiveness of bisphosphonates on nonvertebral and hip fractures in the first year of therapy: the RisedronatE and ALendronate (REAL) cohort study. Osteoporos Int. 2007;18(1):25–34
  • . Harris ST, Reginster JY, Harley C, . Risk of fracture in women treated with monthly oral ibandronate or weekly bisphosphonates: The eValuation of IBandronate Efficacy (VIBE) database fracture study. Bone. 2009;44(5):758–765
  • . Curtis JR, Westfall AO, Cheng H, Saag KG, Delzell E. RisedronatE and ALendronate Intervention over Three Years (REALITY): minimal differences in fracture risk reduction. Osteoporos Int. 2009;20(6):973–978
  • . Bone HG, Hosking D, Devogelaer JP, ; Alendronate Phase III Osteoporosis Treatment Study Group. Ten years' experience with alendronate for osteoporosis in postmenopausal women. N Engl J Med. 2004;350(12):1189–1199
  • . Ensrud KE, Barrett-Connor EL, Schwartz A, ; Fracture Intervention Trial Long-Term Extension Research Group. Randomized trial of effect of alendronate continuation versus discontinuation in women with low BMD: results from the Fracture Intervention Trial long-term extension. J Bone Miner Res. 2004;19(8):1259–1269
  • . Schwartz AV, Bauer DC, Cummings SR, ; FLEX Research Group. Efficacy of continued alendronate for fractures in women with and without prevalent vertebral fracture: The FLEX trial. J Bone Miner Res. 2010;25(5):976–982
  • . Sorensen OH, Crawford GM, Mulder H, . Long-term efficacy of risedronate: a 5-year placebo-controlled clinical experience. Bone. 2003;32(2):120–126
  • . Mellstrom DD, Sorensen OH, Goemaere S, Roux C, Johnson TD, Chines AA. Seven years of treatment with risedronate in women with postmenopausal osteoporosis. Calcif Tissue Int. 2004;75(6):462–468
  • . Watts NB, Diab DL. Long-term use of bisphosphosphonates in osteoporosis. J Clin Endocrinol Metab. 2010;95(4):1555–1565
  • . Miller PD, Recker RR, Felsenberg D, . 5-year efficacy and safety of oral monthly ibandronate: results of the Mobile Long-Term Extension Study. Osteoporos Int. 2009;20:S199
  • . Devogelaer JP, Brown JP, Burckhardt P, . Zoledronic acid efficacy and safety over five years in postmenopausal osteoporosis. Osteoporos Int. 2007;18(9):1211–1218
  • . Double-Blind Extension of HORIZON Pivotal Fracture Trial (Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis). http://clinicaltrials.gov/ct2/show/NCT00145327?term=00145327&rank=1. Accessed October 15, 2010
  • . Curtis JR, Westfall AO, Cheng H, Delzell E, Saag KG. Risk of hip fracture after bisphosphonate discontinuation: implications for a drug holiday. Osteoporos Int. 2008;19:1613–1620
  • . US Food and Drug Administration. FDA news release: generic Fosamax approved. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2008/ucm116854.htm. Accessed August 31, 2010
  • . Ringe JD, Möller G. Differences in persistence, safety and efficacy of generic and original branded once weekly bisphosphonates in patients with postmenopausal osteoporosis: 1-year results of a retrospective patient chart review analysis. Rheumatol Int. 2009;30(2):213–221
  • . Sheehy O, Kindundu CM, Barbeau M, LeLorier J. Differences in persistence among different weekly oral bisphosphonate medications. Osteoporos Int. 2009;20(8):1369–1376
  • . Grima DT, Papaioannou A, Airia P, Ioannidis G, Adachi JD. Adverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate: a retrospective cohort study. BMC Musculoskelet Disord. 2010;11(1):68
  • . Halkin H, Dushenat M, Silverman B, . Brand versus generic alendronate: gastrointestinal effects measured by resource utilization. Ann Pharmacother. 2007;41(1):29–34
  • . Cramer JA, Amonkar MM, Hebborn A, Altman R. Compliance and persistence with bisphosphonate dosing regimens among women with postmenopausal osteoporosis. Curr Med Res Opin. 2005;21(9):1453–1460
  • . Lombas C, Hakim C, Zanchetta JR. Compliance with alendronate treatment in an osteoporosis clinic. J Bone Miner Res. 2001;16:S529–S529
  • . Penning-van Beest FJ, Goettsch WG, Erkens JA, Herings RM. Determinants of persistence with bisphosphonates: a study in women with postmenopausal osteoporosis. Clin Ther. 2006;28(2):236–242
  • . Siris ES, Harris ST, Rosen CJ, . Adherence to bisphosphonate therapy and fracture rates in osteoporotic women: relationship to vertebral and nonvertebral fractures from 2 US claims databases. Mayo Clin Proc. 2006;81(8):1013–1022
  • . Rossini M, Bianchi G, Di Munno O, ; Treatment of Osteoporosis in Clinical Practice (TOP) Study Group. Determinants of adherence to osteoporosis treatment in clinical practice. Osteoporos Int. 2006;17(6):914–921
  • . Gold DT, McClung B. Approaches to patient education: emphasizing the long-term value of compliance and persistence. Am J Med. 2006;119(4 suppl 1):S32–S37
  • . Ettinger B, Pressman A, Schein J, Chan J, Silver P, Connolly N. Alendronate use among 812 women: prevalence of gastrointestinal complaints, noncompliance with patient instructions, and discontinuation. J Manag Care Pharm. 1998;4(5):488–492
  • . Hiligsmann M, Rabenda V, Gathon HJ, Ethgen O, Reginster JY. Potential clinical and economic impact of nonadherence with osteoporosis medications. Calcif Tissue Int. 2010;86(3):202–210
  • . Caro JJ, Ishak KJ, Huybrechts KF, Raggio G, Naujoks C. The impact of compliance with osteoporosis therapy on fracture rates in actual practice. Osteoporos Int. 2004;15(12):1003–1008
  • . McCombs JS, Thiebaud P, McLaughlin-Miley C, Shi J. Compliance with drug therapies for the treatment and prevention of osteoporosis. Maturitas. 2004;48(3):271–287
  • . Cramer JA, Roy A, Burrell A, . Medication compliance and persistence: terminology and definitions. Value Health. 2008;11(1):44–47
  • . Cramer JA, Silverman SL, Gold DT. Methodological considerations in using claims databases to evaluate persistence with bisphosphonates for osteoporosis. Curr Med Res Opin. 2007;23(10):2369–2377
  • . Gold DT, Safi W, Trinh H. Patient preference and adherence: comparative US studies between two bisphosphonates, weekly risedronate and monthly ibandronate. Curr Med Res Opin. 2006;22(12):2383–2391
  • . Cramer JA, Amonkar MM, Hebborn A, Suppapanya N. Does dosing regimen impact persistence with bisphosphonate therapy among postmenopausal osteoporotic women? Poster presented at: 26th Annual Meeting of the American Society for Bone and Mineral Research; October 1–5, 2004; Seattle, WA
  • . Delmas PD, Vrijens B, Eastell R, ; Improving Measurements of Persistence on Actonel Treatment (IMPACT) Investigators. Effect of monitoring bone turnover markers on persistence with risedronate treatment of postmenopausal osteoporosis. J Clin Endocrinol Metab. 2007;92(4):1296–1304
  • . Bonnick SL, Shulman L. Monitoring osteoporosis therapy: bone mineral density, bone turnover markers, or both? Am J Med. 2006;119(4 suppl 1):S25–S31
  • . Chapurlat RD, Cummings SR. Does follow-up of osteoporotic women treated with antiresorptive therapies improve effectiveness? Osteoporos Int. 2002;13(9):738–744
  • . Clowes JA, Peel NF, Eastell R. The impact of monitoring on adherence and persistence with antiresorptive treatment for postmenopausal osteoporosis: a randomized controlled trial. J Clin Endocrinol Metab. 2004;89(3):1117–1123
  • . Lekkerkerker F. Adherence to treatment of osteoporosis: a need for study. Osteoporos Int. 2007;18( suppl 1):Abstract SY531
  • . Christgau S, Bitsch-Jensen O, Hanover Bjarnason N, . Serum CrossLaps for monitoring the response in individuals undergoing antiresorptive therapy. Bone. 2000;26(5):505–511
  • . Hochberg MC, Silverman SL, Barr CE, Miller PD. The utility of changes in serum levels of C-terminal telopeptide of type I collagen in predicting patient response to oral monthly ibandronate therapy. J Clin Densitom. 13(2):181–189
  • . Donovan JL. Patient decision making. The missing ingredient in compliance research. Int J Technol Assess Health Care. 1995;11(3):443–455
  • . Lau E, Papaioannou A, Dolovich L, . Patients' adherence to osteoporosis therapy: exploring the perceptions of postmenopausal women. Can Fam Physician. 2008;54(3):394–402
  • . Binkley N, Bilezikian JP, Kendler DL, Leib ES, Lewiecki EM, Petak SM. Official positions of the International Society for Clinical Densitometry and Executive Summary of the 2005 Position Development Conference. J Clin Densitom. 2006;9(1):4–14
  • . World Health Organization. Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. Report of a WHO Study Group. World Health Organ Tech Rep Ser. 1994;843:1–129

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.