Outcome Comparison of 600 mg versus 300 mg Loading dose of Clopidogrel for Patients with ST-Elevation Myocardial Infarction: A Meta-Analysis

References

• . Beckerath von N, Taubert D, Pogatsa-Murray G, Schömig E, Kastrati A, Schömig A. Absorption, metabolization, and antiplatelet effects of 300-, 600-, and 900-mg loading doses of clopidogrel: results of the ISAR-CHOICE (Intracoronary Stenting and Antithrombotic Regimen: Choose between 3 High Oral Doses for Immediate Clopidogrel Effect) Trial. Circulation. 2005;112(19):2946–2950
   PubMed Web of Science ®Google Scholar
• . , American College of Emergency Physicians, Society for Cardiovascular Angiography and InterventionsO'Gara PT, . 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2013;61(4):e78–e140
   PubMed Web of Science ®Google Scholar
• . Kushner FG, Hand M, Smith SC, . 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients with ST-Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update). J Am Coll Cardiol. 2009;54(23):2205–2241
   PubMed Web of Science ®Google Scholar
• . Bellemain-Appaix A, O'connor SA, Silvain J, . Association of clopidogrel pretreatment with mortality, cardiovascular events, and major bleeding among patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. JAMA. 2012;308(23):2507–2516
   PubMed Web of Science ®Google Scholar
• . Moher D, Liberati A, Tetzlaff J, Altman DG, Grouppara TP. Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–1012
   PubMed Web of Science ®Google Scholar
• . Downs SH, Black N. The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health. 1998;52(6):377–384
   PubMed Web of Science ®Google Scholar
• . Lemesle G, Delhaye C, Sudre A, . Impact of high loading and maintenance dose of clopidogrel within the first 15 days after percutaneous coronary intervention on patient outcome. Am Heart J. 2009;157(2):375–382
   PubMed Web of Science ®Google Scholar
• . Kim JY, Jeong MH, Moon JH, . Impact of clopidogrel loading dose in patients with chronic kidney disease undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. Am J Cardiol. 2012:1–9
   Google Scholar
• . Mehta SR, Tanguay JF, Eikelboom JW, . Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trial. Lancet. 2010;376(9748):1233–1243
   PubMed Web of Science ®Google Scholar
• . Cannon CP, Harrington RA, James S, . Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study. Lancet. 2010;375(9711):283–293
   PubMed Web of Science ®Google Scholar
• . Song PS, Hahn JY, Song YB, . Effects of 600 mg versus 300 mg loading dose of clopidogrel in asian patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention: long-term follow-up study. Yonsei Med J. 2012;53(5):906
   PubMed Web of Science ®Google Scholar
• . Patti G, Bárczi G, Orlic D, . Outcome comparison of 600- and 300-mg loading doses of clopidogrel in patients undergoing primary percutaneous coronary intervention for ST-segment elevation myocardial infarction. J Am Coll Cardiol. 2011;58(15):1592–1599
   PubMed Web of Science ®Google Scholar
• . Choi CU, Rha SW, Oh DJ, . Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: insights from the Korea Acute Myocardial Infarction Registry. Am Heart J. 2011;161(2):373–382.e1–e3
   PubMed Web of Science ®Google Scholar
• . Steg PG, James S, Harrington RA, . Ticagrelor versus clopidogrel in patients with ST-elevation acute coronary syndromes intended for reperfusion with primary percutaneous coronary intervention: a Platelet Inhibition and Patient Outcomes (PLATO) trial subgroup analysis. Circulation. 2010;122(21):2131–2141
   PubMed Web of Science ®Google Scholar
• . Mangiacapra F, Muller O, Ntalianis A, . Comparison of 600 versus 300-mg clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary coronary angioplasty. Am J Cardiol. 2010;106(9):1208–1211
   PubMed Web of Science ®Google Scholar
• . , CURRENT-OASIS 7 InvestigatorsMehta SR, Bassand JP, . Dose comparisons of clopidogrel and aspirin in acute coronary syndromes. N Engl J Med. 2010;363(10):930–942
   PubMed Web of Science ®Google Scholar
• . Dangas G, Mehran R, Guagliumi G, . Role of clopidogrel loading dose in patients with ST-segment elevation myocardial infarction undergoing primary angioplasty. J Am Coll Cardiol. 2009;54(15):1438–1446
   PubMed Web of Science ®Google Scholar
• . Fefer P, Hod H, Hammerman H, . Usefulness of pretreatment with high-dose clopidogrel in patients undergoing primary angioplasty for ST-elevation myocardial infarction. Am J Cardiol. 2009;104(4):514–518
   PubMed Web of Science ®Google Scholar
• . Jung JH, Min PK, Lee SH, . Clopidogrel pretreatment before primary percutaneous coronary stenting in patients with acute ST-segment elevation myocardial infarction: comparison of high loading dose (600-mg) versus low loading dose (300-mg). Coron Artery Dis. 2009;20(2):150–154
   PubMed Web of Science ®Google Scholar
• . Jennings LK. Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost. 2009;102(2):248–257
   PubMed Web of Science ®Google Scholar
• . Wiviott SD, Antman EM, Braunwald E. Prasugrel. Circulation. 2010;122(4):394–403
   PubMed Web of Science ®Google Scholar
• . Campo G, Valgimigli M, Gemmati D, . Value of platelet reactivity in predicting response to treatment and clinical outcome in patients undergoing primary coronary intervention. J Am Coll Cardiol. 2006;48(11):2178–2185
   PubMed Web of Science ®Google Scholar
• . Sabatine MS, Cannon CP, Gibson CM, . Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevation. N Engl J Med. 2005;352(12):1179–1189
   PubMed Web of Science ®Google Scholar
• . Chen ZM, Jiang LX, Chen YP, . Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trial. Lancet. 2005;366(9497):1607–1621
   PubMed Web of Science ®Google Scholar
• . Hulot JS, Bura A, Villard E, . Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood. 2006;108(7):2244–2247
   PubMed Web of Science ®Google Scholar
• . Müller I, Seyfarth M, Rüdiger S, . Effect of a high loading dose of clopidogrel on platelet function in patients undergoing coronary stent placement. Heart. 2001;85(1):92–93
   PubMed Web of Science ®Google Scholar
• . Gurbel PA, Bliden KP, Hayes KM, Yoho JA, Herzog WR, Tantry US. The relation of dosing to clopidogrel responsiveness and the incidence of high post-treatment platelet aggregation in patients undergoing coronary stenting. J Am Coll Cardiol. 2005;45(9):1392–1396
   PubMed Web of Science ®Google Scholar
• . Siller-Matula JM, Huber K, Christ G, . Impact of clopidogrel loading dose on clinical outcome in patients undergoing percutaneous coronary intervention: a systematic review and meta-analysis. Heart. 2010;97(2):98–105
   PubMed Web of Science ®Google Scholar
• . Wiviott SD, Braunwald E, McCabe CH, . Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357(20):2001–2015
   PubMed Web of Science ®Google Scholar
• . Wallentin L, Becker RC, Budaj A, . Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361(11):1045–1057
   PubMed Web of Science ®Google Scholar