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Original Articles

Grain Foods and Health: A Primer for Clinicians

, PhD, CNS, LN & , MD
Pages 18-33 | Published online: 19 Jun 2015

References

  • Trowell H. Definition of dietary fiber and hypotheses that it is a protective factor in certain diseases. Am J Clin Nutr. 1976; 29(4): 417–427.
  • Food and Drug Administration. 21 CFR Parts 136, 137, and 139, Food Standards: Amendment of Standards of Identity For Enriched, Grain Products to Require Addition of Folic Acid. 1996; 61(44):8781–8797.
  • Centers for Disease Control and Prevention. Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR Recomm Rep. 1992; 41(RR-14): 1–7.
  • Mills JL, Signore C. Neural tube defect rates before and after food fortification with folic acid. Birth Defects Res A Clin Mol Teratol. 2004; 70(11): 844–845.
  • Jacobs DR Jr, Meyer KA, Kushi LH, Folsom AR. Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women's Health Study. Am J Public Health. 1999; 89(3): 322–329.
  • Liu S. Intake of refined carbohydrates and whole grain foods in relation to risk of type 2 diabetes mellitus and coronary heart disease. J Am Coll Nutr. 2002; 21(4): 298–306.
  • Fung TT, Hu FB, Pereira MA, et al. Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr. 2002; 76(3): 535–540.
  • McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002; 76(2): 390–398.
  • Jones JM. Fiber, whole grains and disease prevention. In: Hamaker BR, ed. Technology of Functional Cereal Products. New York, NY: CRC Press; 2008: 46–62.
  • Qi L, van Dam RM, Liu S, Franz M, Mantzoros C, Hu FB. Whole-grain, bran, and cereal fiber intakes and markers of systemic inflammation in diabetic women. Diabetes Care. 2006; 29(2): 207–211.
  • Adom KK, Sorrells ME, Liu RH. Phytochemicals and antioxidant activity of milled fractions of different wheat varieties. J Agric Food Chem. 2005; 53(6): 2297–2306.
  • Lopez-Ridaura R, Willett WC, Rimm EB, et al. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 2004; 27(1): 134–140.
  • Dietary Guidelines for Americans. Eating right and being physically active aren't just a “diet” or a “program”—they are keys to a healthy lifestyle. www.health.gov/dietaryguidelines/. Updated October 16, 2006. Accessed June 1,2008.
  • American Heart Association Nutrition Committee, Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation. 2006; 114(1): 82–96.
  • American Diabetes Association, Bantle JP, Wylie-Rosett J, Albright AL, et al. Nutrition recommendations and interventions for diabetes: a position statement of the American Diabetes Association. Diabetes Care. 2008; 31(suppl 1): S61–S78.
  • Kushi LH, Byers T, Doyle C, et al. American Cancer Society 2006 Nutrition and Physical Activity Guidelines Advisory Committee. American Cancer Society Guidelines on Nutrition and Physical Activity for cancer prevention: reducing the risk of cancer with healthy food choices and physical activity. CA Cancer J Clin. 2006; 56(5): 254–281.
  • US Department of Health and Human Services. Office of Disease Prevention and Health Promotion. Healthy People 2010. www.healthypeople.gov/Document/. Accessed June 1,2008.
  • United States Department of Agriculture (USDA). My Pyramid, www.MyPyramid.gov. Accessed June 1, 2008.
  • Marquart L, Jones JM, Cohen EA, Poutanen K. The future of whole grains. In: Marquart L, Jacobs DD Jr, Mcintosh GH, Poutanen K, Reicks M, eds. Whole Grains and Health. Ames, LA: Blackwell Publishing; 2007.
  • Jones JM, Reicks M, Adams J, Fulcher G, Marquart L. Becoming Proactive With the Whole-Grains Message. Nutr Today. 2004; 39(1): 10–17.
  • Jones JM, Reicks M, Adams J, et al. The importance of promoting a whole grain foods message. J Am Coll Nutr. 2002; 21(4): 293–297.
  • Cleveland LE, Moshfegh AJ, Albertson AM, Goldman J. Dietary intake of whole grains. J Am Coll Nutr. 2000; 19(3 suppl): 331S–338S.
  • Chase K, Reicks M, Jones JM. Applying the theory of planned behavior to promotion of whole-grain foods by dietitians. J Am Diet Assoc. 2003; 103(12): 1639–1642.
  • Pfeiffer CM, Johnson CL, Jain RB, et al. Trends in blood folate and vitamin B-12 concentrations in the United States, 1988 2004. Am J Clin Nutr. 2007; 86(3): 718–727.
  • Quinlivan EP, Gregory JF 3rd. Reassessing folic acid consumption patterns in the United States (1999 2004): potential effect on neural tube defects and overexposure to folate. Am J Clin Nutr. 2007; 86(6): 1773–1779.
  • American Association of Cereal Chemists International Whole Grains Task Force. Letter submitted to the FDA in response to docket 2006 D-0066. http://www.aaccnet.org/definitions/pdfs/AACCIntlWholeGrainComments.pdf. Updated April 17,2006. Accessed June 1, 2008.
  • American Association of Cereal Chemists. Press Release: AACC Members Agree on Definition of Whole Grain, http://www.aaccnet.org/news/pdfs/wgPR.pdf. Accessed June 1, 2008.
  • Sanjoaquin MA, Appleby PN, Spencer EA, Key TJ. Nutrition and lifestyle in relation to bowel movement frequency: a cross-sectional study of20630 men and women in EPIC-Oxford. Public Health Nutr. 2004; 7(1): 77–83.
  • Aldoori W, Ryan-Harshman M. Preventing diverticular disease. Review of recent evidence on high-fibre diets. Can Fam Physician. 2002; 48: 1632–1637.
  • La Vecchia C, Chatenoud L, Negri E, Franceschi S. Session: whole cereal grains, fibre and human cancer wholegrain cereals and cancer in Italy. Proc Nutr Soc. 2003; 62(1): 45–49.
  • Wakai K, Hirose K, Matsuo K, et al. Dietary risk factors for colon and rectal cancers: a comparative case-control study. J Epidemiol. 2006; 16(3): 125–135.
  • Bingham SA, Day NE Luben R, et al. European Prospective Investigation into Cancer and Nutrition. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet. 2003; 361(9368): 1496–1501.
  • Alberts DS, Martínez ME, Roe DJ, et al. Lack of effect of a high-fiber cereal supplement on the recurrence of colorectal adenomas. Phoenix Colon Cancer Prevention Physicians” Network. N Engl J Med. 2000; 342(16): 1156–1162.
  • Fuchs CS, Giovannucci EL, Colditz GA, et al. Dietary fiber and the risk of colorectal cancer and adenoma in women. N Engl J Med. 1999; 340(3): 169–176.
  • Park Y, Hunter DJ, Spiegelman D, et al. Dietary fiber intake and risk of colorectal cancer: a pooled analysis of prospective cohort studies. JAMA. 2005; 294(22): 2849–2857.
  • Fraser GE. Associations between diet and cancer, ischemic heart disease, and all-cause mortality in non-Hispanic white California Seventh-day Adventists. Am J Clin Nutr. 1999; 70(3 suppl): 532S–538S.
  • Chatenoud L, La Vecchia C, Franceschi S, et al. Refined-cereal intake and risk of selected cancers in Italy. Am J Clin Nutr. 1999; 70(6): 1107–1110.
  • Jacobs DR Jr, Marquart L, Slavin J, Kushi LH. Whole-grain intake and cancer: an expanded review and meta-analysis. Nutr Cancer. 1998; 30(2): 85–96.
  • Schatzkin A, Mouw T, Park Y, et al. Dietary fiber and whole-grain consumption in relation to colorectal cancer in the NIH-AARP Diet and Health Study. Am J Clin Nutr. 2007; 85(5): 1353–1360.
  • Slattery ML, Curtin KP, Edwards SL, Schaffer DM. Plant foods, fiber, and rectal cancer. Am J Clin Nutr. 2004; 79(2): 274–281.
  • Larsson SC, Giovannucci E, Bergkvist L, Wolk A. Whole grain consumption and risk of colorectal cancer: a population-based cohort of 60,000 women. Br J Cancer. 2005; 92(9): 1803–1807.
  • Charalampopoulos D, Pandiella SS, Webb C. Evaluation of the effect of malt, wheat and barley extracts on the viability of potentially probiotic lactic acid bacteria under acidic conditions. Int J Food Microbiol. 2003; 82(2): 133–141.
  • Charalampopoulos D, Pandiella SS, Webb C. Growth studies of potentially probiotic lactic acid bacteria in cereal-based substrates. J Appl Microbiol. 2002; 92(5): 851–859.
  • Pool-Zobel BL, Sauer J. Overview of experimental data on reduction of colorectal cancer risk by inulin-type fructans. J Nutr. 2007; 137(11 suppl): 2580S–2584S.
  • Charalampopoulos D, Wang R, Pandiella SS, Webb C. Application of cereals and cereal components in functional foods: a review. Int J Food Microbiol. 2002; 79(1 -2): 131–141.
  • Kim YS, Milner JA. Dietary modulation of colon cancer risk. J Nutr. 2007; 137(11 Suppl): 2576S–2579S.
  • Grasten SM, Juntunen KS, Poutanen KS, Gylling HK, Miettinen TA, Mykkänen HM. Rye bread improves bowel function and decreases the concentrations of some compounds that are putative colon cancer risk markers in middle-aged women and men J Nutr. 2000; 130(9): 2215–2221.
  • Levy RD, Segal I, Hassan H, Saadia R. Stool weight and faecal pH in two South African populations with a dissimilar colon cancer risk. S Afr J Surg. 1994; 32(4): 127–128.
  • Bird AR, Vuaran MS, King RA, et al. Wholegrain foods made from a novel high-amylose barley variety (Himalaya 292) improve indices of bowel health in human subjects. Br J Nutr. 2008; 99(5): 1032–1040.
  • Reddy S, Sanders TA, Owen RW, Thompson MH. Fecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. Br J Nutr. 1998; 79(6): 495–500.
  • Alberts DS, Einspahr JG, Earnest DL, et al. Fecal bile acid concentrations in a subpopulation of the wheat bran fiber colon polyp trial. Cancer Epidemiol Biomarkers Prev. 2003; 12(3): 197–200.
  • McGarr SE, Ridlon JM, Hylemon PB. Diet, anaerobic bacterial metabolism, and colon cancer: a review of the literature. J Clin Gastroenterol. 2005; 39(2): 98–109.
  • van Bennekum AM, Nguyen DV, Schulthess G, Hauser H, Phillips MC. Mechanisms of cholesterol-lowering effects of dietary insoluble fibres: relationships with intestinal and hepatic cholesterol parameters. Br J Nutr. 2005; 94(3): 331–337.
  • Hongisto SM, Paajanen L, Saxelin M, Korpela R. A combination of fibre-rich rye bread and yoghurt containing Lactobacillus GG improves bowel function in women with self-reported constipation. Eur J Clin Nutr. 2006; 60(3): 319–324.
  • Muir JG, Yeow EG, Keogh J, et al. Combining wheat bran with resistant starch has more beneficial effects on fecal indexes than does wheat bran alone. Am J Clin Nutr. 2004; 79(6): 1020–1028.
  • Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem. 2002; 50(21): 6182–6187.
  • Adlercreutz H. Lignans and human health. Crit Rev Clin Lab Sci. 2007; 44(5–6): 483–525.
  • Kuijsten A, Arts IC, Hollman PC, van't Veer P, Kampman E. Plasma enterolignans are associated with lower colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev. 2006; 15(6): 1132–1136.
  • Hallmans G, Zhang JX, Lundin E, et al. Rye, lignans and human health. Proc Nutr Soc. 2003; 62(1): 193–199.
  • Adom KK, Sorrells ME, Liu RH. Phytochemicals and antioxidant activity of milled fractions of different wheat varieties. J Agric Food Chem. 2005; 53(6): 2297–2306.
  • Adom KK, Liu RH. Antioxidant activity of grains. J Agric Food Chem. 2002; 50(21): 6182–6187.
  • Slavin JL. Dietary fiber and body weight. Nutrition. 2005; 21(3): 411–418.
  • McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002; 76(2): 390–398.
  • Newby PK, Muller D, Hallfrisch J, Qiao N, Andres R, Tucker KL. Dietary patterns and changes in body mass index and waist circumference in adults. Am J Clin Nutr. 2003; 77(6): 1417–1425.
  • Rose NE. Whole Grain Intake in College Students and its Association with Body Mass Index. [Masters thesis). Blacksburg, VA: Human Nutrition, Foods, and Exercise, Virginia Polytechnic Institute and State University; 2005.
  • Koh-Banerjee P, Franz M, Sampson L, et al. Changes in whole-grain, bran, and cereal fiber consumption in relation to 8-y weight gain among men. Am J Clin Nutr. 2004; 80(5): 1237–1245.
  • Liu S, Willett WC, Manson JE, Hu FB, Rosner B, Colditz G. Relation between changes in intakes of dietary fiber and grain products and changes in weight and development of obesity among middle-aged women. Am J Clin Nutr. 2003; 78(5): 920–927.
  • Anderson JW. Dietary fiber and associated phytochemicals in prevention and reversal of diabetes. In: Pasupuleti V, Anderson JW, eds. Nutraceuticals, Clycemic Health and Diabetes. Ames, IA: Blackwell Publishing Professional; 2008. In press.
  • Harland JI, Garton LE. Whole-grain intake as a marker of healthy body weight and adiposity. Public Health Nutr. 2008; 11(6): 554–563.
  • van de Vijver LP, van den Bosch LM, van den Brandt PA, Goldbohm RA. Whole-grain consumption, dietary fibre intake and body mass index in the Netherlands cohort study [published online ahead of print September 26, 2007]. Eur J Clin Nutr.
  • Thane CW, Stephen AM, Jebb SA. Whole grains and adiposity: little association among British adults [published online ahead of print September 19, 2007], Eur J Clin Nutr.
  • Anderson JW, Conley SB. Whole grains and diabetes. In: Marquart L, Jacobs DR Jr, Mcintosh GH, Poutanen K, Reicks M, eds. Whole Grains and Health. Ames, LA: Blackwell Publishing Professional; 2007: 29–45.
  • Greenway F, O'Neil CE, Stewart L, Rood J, Keenan M, Martin R. Fourteen weeks of treatment with Viscofiber increased fasting levels of glucagon-like peptide-1 and peptide-YY. J Med Food. 2007; 10(4): 720–724.
  • Berti C, Riso P, Brusamolino A, Porrini M. Effect on appetite control of minor cereal and pseudocereal products. Br J Nutr. 2005; 94(5): 850–858.
  • So PW, Yu WS, Kuo YT, et al. Impact of resistant starch on body fat patterning and central appetite regulation. PLoS ONE. 2007; 2(12): e1309.
  • Skrabanja V, Liljeberg Elmståhl HG, Kreft I, Björck IM. Nutritional properties of starch in buckwheat products: studies in vitro and in vivo. J Agric Food Chem. 2001; 49(1): 490–496.
  • Kaplan RJ, Greenwood CE. Influence of dietary carbohydrates and glycaemic response on subjective appetite and food intake in healthy elderly persons. Int J Food Sci Nutr. 2002; 53(4): 305–316.
  • Esposito K, Mariella R, Ciotola M, et al. Effect of a Mediterranean-style diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA. 2004; 292(12): 1440–1446.
  • Schaefer EJ, Gleason JA, Dansinger ML. The effects of low-fat, high-carbohydrate diets on plasma lipoproteins, weight loss, and heart disease risk reduction. Curr Atheroscler Rep. 2005; 7(6): 421–427.
  • Pereira MA, Ludwig DS. Dietary fiber and body-weight regulation. Observations and mechanisms. Pediatr Clin North Am. 2001; 48(4): 969–980.
  • Anderson J W. Whole grains and coronary heart disease: the whole kernel of truth. Am J Clin Nutr. 2004; 80(6): 1459–1460.
  • Anderson JW. Whole grains protect against atherosclerotic cardiovascular disease. Proc Nutr Soc. 2003; 62(1): 135–142.
  • Anderson JW. Whole-grains intake and risk for coronary heart disease. In: Marquart L, Slavin JL, Fulcher G, eds. Whole Grains in Health and Disease. St. Paul, MN: American Association of Cereal Chemists; 2002: 100–114.
  • Mozaffarian D, Kumanyika SK, Lemaitre RN, Olson JL, Burke GL, Siscovick DS. Cereal, fruit, and vegetable fiber intake and the risk of cardiovascular disease in elderly individuals. JAMA. 2003; 289(13): 1659–1666.
  • Erkkilä AT, Herrington DM, Mozaffarian D, Lichtenstein AH. Cereal fiber and whole-grain intake are associated with reduced progression of coronary-artery atherosclerosis in postmenopausal women with coronary artery disease. Am Heart J. 2005; 150(1): 94–101.
  • Mellen PB, Liese AD, Tooze JA, Vitolins MZ, Wagenknecht LE, Herrington DM. Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr. 2007; 85(6): 1495–1502.
  • Karmally W, Montez MG, Palmas W, et al. Cholesterol-lowering benefits of oat-containing cereal in Hispanic Americans. J Am Diet Assoc. 2005; 105(6): 967–970.
  • Behall KM, Scholfield DJ, Hallfrisch J. Diets containing barley significantly reduce lipids in mildly hypercholesterolemic men and women. Am J Clin Nutr. 2004; 80(5): 1185–1193.
  • Food and Drug Administration. Food Labeling: Health Claims; Soluable Fiber From Whole Oats and Risks of Coronary Heart Disease, Docket No. 95P-0197. 2008.
  • Marcil V, Delvin E, Garofalo C, Levy E. Butyrate impairs lipid transport by inhibiting microsomal triglyceride transfer protein in Caco-2 cells. J Nutr. 2003; 133(7): 2180–2183.
  • Sayar S, Jannink JL, White PJ. In vitro bile acid binding activity within flour fractions from oat lines with typical and high beta-glucan amounts. J Agric Food Chem. 2006; 54(14): 5142–5148.
  • Chronakis IS, Fredholm A, Triantafyllou AO, Oste R. Complex formation in aqueous medium of partially hydrolysed oat cereal proteins with sodium stearoyl-2 lactylate (SSL) lipid surfactant and implications for bile acids activity. Colloids Surf B Biointerfaces. 2004; 35(3–4):175–184.
  • Lundin EA, Zhang JX, Lairon D, et al. Effects of meal frequency and high-fibre rye-bread diet on glucose and lipid metabolism and ileal excretion of energy and sterols in ileostomy subjects. Eur J Clin Nutr. 2004; 58(10): 1410–1419.
  • Yang JL, Kim YH, Lee HS, Lee MS, Moon YK. Barley beta-glucan lowers serum cholesterol based on the up-regulation of cholesterol 7alpha-hydroxylase activity and mRNA abundance in cholesterol-fed rats. J Nutr Sci Vitaminol (Tokyo). 2003; 49(6): 381–387.
  • Anderson JW. Dietary fiber prevents carbohydrate-induced hypertriglyceridemia. Curr Artheroscler Rep. 2000; 2(6): 536–541.
  • Madhujith T, Shahidi F. Antioxidative and antiproliferative properties of selected barley (Hordeum vulgarae L.) cultivars and their potential for inhibition of low-density lipoprotein (LDL) cholesterol oxidation. J Agric Food Chem. 2007; 55(13): 5018–5024.
  • Kris-Etherton PM, Hecker KD, Bonanome A, et al. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am J Med. 2002; 113 (Suppl 9B): 71S–88S.
  • Djoussé L, Gaziano IM. Breakfast cereals and risk of heart failure in the physicians' health study I. Arch Intern Med. 2007; 167(19): 2080–2085.
  • Esmaillzadeh A, Mirmiran P, Azizi F. Whole-grain consumption and the metabolic syndrome, a favorable association in Tehranian adult. Eur J Clin Nutr. 2005; 59(3): 353–362.
  • Wang L, Gaziano JM, Liu S, Manson JE, Buring JE, Sesso HD. Whole- and refined-grain intakes and the risk of hypertension in women. Am J Clin Nutr. 2007; 86(2): 472–479.
  • Pins JJ, Geleva D, Keenan JM, Frazel C, O'Connor PJ, Cherney LM. Do whole-grain oat cereals reduce the need for antihypertensive medications and improve blood pressure control? J Fam Pract. 2002; 51(4): 353–359.
  • Appel LJ, Moore TJ, Obarzanek E, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997; 336(16): 1117–1124.
  • Qi L, Meigs JB, Liu S, Manson JE, Mantzoros C, Hu FB. Dietary fibers and glycemic load, obesity, and plasma adiponectin levels in women with type 2 diabetes. Diabetes Care. 2006; 29(7): 1501–1505.
  • Kurth T, Moore SC, Gaziano JM, et al. Healthy lifestyle and the risk of stroke in women. Arch Intern Med. 2006; 166(13): 1403–1409.
  • Oh K, Hu FB, Cho E, et al. Carbohydrate intake, glycemic index, glycemic load, and dietary fiber in relation to risk of stroke in women. Am J Epidemiol. 2005; 161(2): 161–169.
  • Ding EL, Mozaffarian D. Optimal dietary habits for the prevention of stroke. Semin Neurol. 2006; 26(1): 11–23.
  • Anderson JW, Pasupuleti V. Future Trends and Directions: Nutraceuticals, Glycemic Health and Type 2 Diabetes. Ames, IA: Blackwell Publishing Professional; 2008. In press.
  • Cameron AJ, Shaw JE, Zimmet PZ. The metabolic syndrome: prevalence in worldwide populations. Endocrinol Metab Clin North Am. 2004; 33(2): 351–375.
  • McKeown NM, Meigs JB, Liu S, Wilson PW, Jacques PF. Whole-grain intake is favorably associated with metabolic risk factors for type 2 diabetes and cardiovascular disease in the Framingham Offspring Study. Am J Clin Nutr. 2002; 76(2): 390–398.
  • Kochar J, Djoussé L, Gaziano JM. Breakfast cereals and risk of type 2 diabetes in the Physicians' Health Study I. Obesity (Silver Spring). 2007; 15(12): 3039–3044.
  • de Munter JS, Hu FB, Spiegelman D, Franz M, van Dam RM. Whole grain, bran, and germ intake and risk of type 2 diabetes: a prospective cohort study and systematic review. PLoS Med. 2007; 4(8): e261.
  • Lutsey PL, Jacobs DR Jr, Kori S, et al. Whole grain intake and its cross-sectional association with obesity, insulin resistance, inflammation, diabetes and subclinical CVD: The MESA Study. Br J Nutr. 2007; 98(2): 397–405.
  • Fung TT, Hu FB, Pereira MA, et al. Whole-grain intake and the risk of type 2 diabetes: a prospective study in men. Am J Clin Nutr. 2002; 76(3): 535–540.
  • Liese AD, Roach AK, Sparks KC, Marquart L, D'Agostino RB Jr, MayerDavis EJ. Whole-grain intake and insulin sensitivity: the Insulin Resistance Atherosclerosis Study. Am J Clin Nutr. 2003; 78(5): 965–971.
  • Pereira MA, Jacobs DR Jr, Pins J J, et al. Effect of whole grains on insulin sensitivity in overweight hyperinsulinemic adults. Am J Clin Nutr. 2002; 75(5): 848–855.
  • Panahi S, Ezatagha A, Temelli F, Vasanthan T, Vuksan V. Beta-glucan from two sources of oat concentrates affect postprandial glycemia in relation to the level of viscosity. J Am Coll Nutr. 2007; 26(6): 639–644.
  • Garcia AL, Otto B, Reich SC, et al. Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr. 2007; 61 (3): 334–341.
  • Lu ZX, Walker KZ, Muir JG, O'Dea K. Arabinoxylan fibre improves metabolic control in people with Type II diabetes. Eur J Clin Nutr. 2004; 58(4): 621–628.
  • Bo S, Pisu E. Role of dietary magnesium in cardiovascular disease prevention, insulin sensitivity and diabetes. Curr Opin Lipidol. 2008; 19(1): 50–56.
  • McCarty MF. Magnesium may mediate the favorable impact of whole grains on insulin sensitivity by acting as a mild calcium antagonist. Med Hypotheses. 2005; 64(3): 619–627.
  • Jacobs DR Jr, Meyer KA, Kushi LH, Folsom AR. Is whole grain intake associated with reduced total and cause-specific death rates in older women? The Iowa Women's Health Study. Am J Public Health. 1999; 89(3): 322–329.
  • Sahyoun NR, Jacques PF, Zhang XL, Juan W, McKeown NM. Whole-grain intake is inversely associated with the metabolic syndrome and mortality in older adults. Am J Clin Nutr. 2006; 83(1): 124–131.
  • Esmaillzadeh A, Azadbakht L. Whole-grain intake, metabolic syndrome, and mortality in older adults. Am J Clin Nutr. 2006; 83(6): 1439–1440.
  • Steffen LM, Jacobs DR Jr, Stevens J, Shahar E, Carithers T, Folsom AR. Associations of whole-grain, refined-grain, and fruit and vegetable consumption with risks of all-cause mortality and incident coronary artery disease and ischemic stroke: the Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr. 2003; 78(3): 383–390.
  • Hughes SA, Shewry PR, Li L, Gibson GR, Sanz ML, Rastall RA. In vitro fermentation by human fecal microflora of wheat arabinoxylans. J Agric Food Chem. 2007; 55(11): 4589–4595.
  • Fulcher G, Pascoe D, Slavin J. Soluble cereal carbohydrate polymers in foods and nutrition. Annual meeting AACCI San Antonio, 2007. Abstract.
  • Miller HE, Rigelhof F, Marquart L, Prakash A, Kanter M. Antioxidant content of whole grain breakfast cereals, fruits and vegetables. J Am Coll Nutr. 2000; 19 (3 suppl): 312S–319S.
  • Jones JM. Mining whole grains for functional components. Food Science and Technology Bulletin: Functional Foods. 2007; 4(7): 67–86.
  • Nie L, Wise ML, Peterson DM, Meydani M. Avenanthramide, a polyphenol from oats, inhibits vascular smooth muscle cell proliferation and enhances nitric oxide production. Atherosclerosis. 2006; 186(2): 260–266.
  • Hu C, Zawistowski J, Ling W, Kitts DD. Black rice (Oryza sativa L. indica) pigmented fraction suppresses both reactive oxygen species and nitric oxide in chemical and biological model systems. J Agric Food Chem. 2003; 51(18): 5271–5277.
  • Xia M, Ling WH, Ma J, Kitts DD, Zawistowski J. Supplementation of diets with the black rice pigment fraction attenuates atherosclerotic plaque formation in apolipoprotein e deficient mice. J Nutr. 2003; 133(3): 744–751.
  • Bulló M, Casas-Agustench P, Amigó-Correig P, Aranceta J, Salas-Salvadó J. Inflammation, obesity and comorbidities: the role of diet. Public Health Nutr. 2007; 10(10A): 1164–1172.
  • Rader JI, Schneeman BO. Prevalence of neural tube defects, folate status, and folate fortification of enriched cereal-grain products in the United States. Pediatrics. 2006; 117(4): 1394–1399.
  • Canfield MA, Collins JS, Botto LD, et al. National Birth Defects Prevention Network. Changes in the birth prevalence of selected birth defects after grain fortification with folic acid in the United States: findings from a multi-state population-based study. Birth Defects Res A Clin Mol Teratol. 2005; 73(10): 679–689.
  • Zhang SM, Moore SC, Lin J, et al. Folate, vitamin B6, multivitamin supplements, and colorectal cancer risk in women. Am J Epidemiol. 2006; 163(2): 108–115.
  • Yang Q, Botto LD, Erickson JD, et al. Improvement in stroke mortality in Canada and the United States, 1990 to 2002. Circulation. 2006:113(10): 1335–1343.
  • Jones JM, Reicks M, Adams J, Fulcher G, Marquart L. Becoming Proactive With the Whole-Grains Message. Nutr Today. 2004; 39(1): 10–17.
  • Edge MS, Jones JM, Marquart L. A new life for whole grains. J Am Diet Assoc. 2005; 105(12): 1856–1860.
  • USDA Agricultural Research Service. National Nutrient Database for Standard Reference, http://www.nal.usda.gov/fnic/foodcomp/cgi-bin/nut_search_new.pl Accessed June 1, 2008.

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