Anticryptococcal cytotoxicity of murine nonadherent cells is perforin and nonperforin mediated

LITERATURE CITED

• Abbas AK, Lichtman AH. 2003. Cellular and molecular immunology. 5th ed. Philadelphia: Saunders. 562 p.
   Google Scholar
• Aguirre K, Crowe J, Haas A, Smith J. 2004. Resistance to Cryptococcus neoformans infection in the absence of CD4+ T cells. Med Mycol 42:15–25.
   Google Scholar
• Arsić V, Kranjčić ZI, Mitrović S, Ramić Z, Mostarica Stojković M. 1993. The role of CD4+ T cells in rat cryptococcosis. J Chemotherapy 5:422–423.
   Google Scholar
• Baronetti JL, Chiapello LS, Aoki MP, Gea S, Masih DT. 2006. Heat-killed cells of Cryptococcus neoformans var. grubii induces protective immunity in rats: immunological and histopathological parameters. Med Mycol 44:493–504.
   Google Scholar
• Byon JY, Ohira T, Hirono I, Aoki T. 2005. Use of a cDNA microarray to study immunity against viral hemorrhagic septicemia (VHS) in Japanese flounder (Paralichthys olivaceus) following DNA vaccination. Fish Shellfish Immunol 18:135–147.
   Google Scholar
• Clayberger C, Krensky AM. 2003. Granulysin. Curr Opin Immunol 15:560–565.
   Google Scholar
• Chang YC, Kwon-Chung KL. 1994. Complementation of a capsule-deficient mutation of Cryptococcus neoformans restores its virulence. Mol Cell Biol 14:4912–4919.
   Google Scholar
• de Rie MA, Schumacher TN, van Schijndel GM, van Lier RA, Miedema F. 1989. Regulatory role of CD19 molecules in B-cell activation and differentiation. Cell Immunol 118:368–381.
   Google Scholar
• Farouk SE, Mincheva-Nilsson L, Krensky AM, Dieli F, Troye-Blomberg M. 2004. Gamma delta T cells inhibit in vitro growth of the asexual blood stages of Plasmodium falciparum by a granule exocytosis-dependent cytotoxic pathway that requires granulysin. Eur J Immunol 34: 2248–2256.
   Google Scholar
• Fromtling RA, Kaplan AM, Shadomy HJ. 1983. Immunization of mice with stable, acapsular, yeast-like mutants of Cryptococcus neoformans. Sabouraudia 21:113–119.
   Google Scholar
• Hidore MR, Murphy JW. 1986. Correlation of natural killer cell activity and clearance of Cryptococcus neoformans from mice after adoptive transfer of splenic nylon wool-nonadherent cells. Infect Immun 51:547–555.
   Google Scholar
• ———, Nabavi N, Reynolds CW, Henkart PA, Murphy JW. 1990. Cytoplasmic components of natural killer cells limit the growth of Cryptococcus neoformans. J Leukoc Biol 48:15–26.
   Google Scholar
• ———, ———, Sonleitner F, Murphy JW. 1991. Murine natural killer cells are fungicidal to Cryptococcus neoformans. Infect Immun 59:1747–1754.
   Google Scholar
• Huffnagle GB, Lipscomb MF, Lovchik JA, Hoag KA, Street NE. 1994. The role of CD4(+) and CD8(+) T cells in the protective inflammatory response to a pulmonary cryptococcal infection. J Leukoc Biol 55:35–42.
   Google Scholar
• ———, Yates JL, Lipscomb MF. 1991. Immunity to a pulmonary Cryptococcus neoformans infection requires both CD4 and CD8 T cells. J Exp Med 173:793–800.
   Google Scholar
• Huysamen C, Brown GD. 2009. The fungal pattern recognition receptor, Dectin-1, and the associated cluster of C-type lectin-like receptors. FEMS Microbiol Lett 290:121–128.
   Google Scholar
• Julius MH, Simpson E, Herzenberg LA. 1973. A rapid method for the isolation of functional thymus derived murine lymphocytes. Eur J Immunol 3:645–649.
   Google Scholar
• Kagi D, Ledermann B, Burki K, Seiler P, Odermatt B, Olsen JK, Podack RE, Zinkernagel MR, Hengartner H. 1994. Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31–37.
   Google Scholar
• Kawakami K, Kohno S, Kadota J, Tohyama M, Teruya K, Kudeken N, Saito A, Hara K. 1995. T cell dependent activation of macrophages and enhancement of their phagocytic activity in the lungs of mice inoculated with heat-killed Cryptococcus neoformans: involvement of IFN-gamma and its protective effect against cryptococcal infection. Microbiol Immunol 39:135–143.
   Google Scholar
• Levitz SM, Dupont MP. 1993. Phenotypic and functional characterization of human lymphocytes activated by interleukin-2 to directly inhibit growth of Cryptococcus neoformans in vitro. J Clin Invest 91:1490–1498.
   Google Scholar
• ———, North EA, Dupont MP, Harrison TS. 1995. Mechanisms of inhibition of Cryptococcus neoformans by human lymphocytes. Infect Immun 63:3550–3554.
   Google Scholar
• Liu CC, Walsh CM, Young JD. 1995. Perforin: structure and function. Immunol Today 16:194–201.
   Google Scholar
• Ma LL, Spurrell JCL, Wang JF, Neely GG, Epelmant S, Krensky AM, Mody CH. 2002. CD8 T cell-mediated killing of Cryptococcus neoformans requires granulysin and is dependent on CD4 T cells and IL 15. J Immunol 77:2436–2446.
   Google Scholar
• ———, Wang CLC, Neely GG, Epelman S, Krensky AM, Mody CH. 2004. NK cells use perforin rather than granulysin for anticryptococcal activity. J Immunol 173: 3357–3365.
   Google Scholar
• Marr KJ, Jones GJ, Zheng C, Huston SM, Timm-McCann M, Islam A, Berenger BM, Ma LL, Wiseman JC, Mody CH. 2009. Cryptococcus neoformans directly stimulates perforin production and rearms NK cells for enhanced anticryptococcal microbicidal activity. Infect Immun 77:2436–2460.
   Google Scholar
• Mitchell TG, Perfect JR. 1995. Cryptococcosis in the era of AIDS—100 y after the discovery of Cryptococcus neoformans. Clin Microbiol Rev 8:515–548.
   Google Scholar
• Mody CH, Chen GH, Jackson C, Curtis JL, Toews GB. 1994. In vivo depletion of murine CD8 positive T cells impairs survival during infection with a highly virulent strain of Cryptococcus neoformans. Mycopathologia 125: 7–17.
   Google Scholar
• ———, Lipscomb MF, Street NE, Toews GB. 1990. Depletion of CD4+ (L3T4+) lymphocytes in vivo impairs murine host defense to Cryptococcus neoformans. J Immunol 144:1472–1477.
   Google Scholar
• ———, Toews GB, Lipscomb MF. 1989. Treatment of murine cryptococcosis with cyclosporine-A in normal and athymic mice. Am Rev Respir Dis 139:8–13.
   Google Scholar
• ———, Wood CJ, Syme RM, Spurrell JCL. 1999. The cell wall and membrane of Cryptococcus neoformans possess a mitogen for human T lymphocytes. Infect Immun 67: 936–941.
   Google Scholar
• Murphy JW, Schafer F, Casadevall A, Adesina A. 1998. Antigen-induced protective and nonprotective cell-mediated immune components against Cryptococcus neoformans. Infect Immun 66:2632–2639.
   Google Scholar
• Muth MS, Murphy JW. 1995. Direct anticryptococcal activity of lymphocytes from C. neoformans-immunized mice. Infect Immun 63:1637–1644.
   Google Scholar
• Pellicci DG, Hammond KJL, Coquet J, Kyparissoudis K, Brooks AG, Kedzierska K, Keating R, Turner S, Berzins S, Smyth MJ, Godfrey DI. 2005. DX5/CD49b-positive T cells are not synonymous with CD1d-dependent NKT cells. J Immunol 175:4416–4425.
   Google Scholar
• Ramadi BK, Bashir G, Rizvi TA, Fernandez-Cabezudo MJ. 2004. Poor survival but high immunogenicity of IL-2-expressing Salmonella typhimurium in inherently resistant mice. Microbes Infect 6:350–359.
   Google Scholar
• Schapiro JM, Segev Y, Rannon SL, Alkan M, Rager-Zisman B. 1990. Natural killer (NK) cell response after vaccination of volunteers with killed influenza vaccine. J Med Virol 30:196–200.
   Google Scholar
• Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, Froelich CJ, Ganz T, Thoma-Uszvnski S, Melian A, Bogdan C, Poecelli SA, Bloom BR, Krensky AM, Modlin RL. 1998. An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282:121–125.
   Google Scholar
• Trinchieri G. 1989. Biology of natural killer cells. Adv Immunol 47:187–376.
   Google Scholar
• ———. 1995. Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity. Annu Rev Immunol 13:251–276.
   Google Scholar
• Tripathi S, Maiti TK. 2005. Immunomodulatory role of native and heat denatured agglutinin from Abrus precatorius. Int J Biochem Cell Biol 372:451–462.
   Google Scholar
• Vasilevko V, Ghochikyan A, Holterman MJ, Agadjanyan MG. 2002. CD80 (B7-1) and CD86 (B7-2) are functionally equivalent in the initiation and maintenance of CD4+ T-cell proliferation after activation with suboptimal doses of PHA. DNA Cell Biol 21:137–149.
   Google Scholar
• Villena SN, Pinheiro RO, Pinheiro CS, Nunes MP, Takiya CM, DosReis GA, Previato JO, Mendonça-Previato L, Freire-de-Lima CG. 2008. Capsular polysaccharides galactoxylomannan and glucuronoxylomannan from Cryptococcus neoformans induce macrophage apoptosis mediated by Fas ligand. Cell Microbiol 10:1274–1285.
   Google Scholar
• Wozniak KL, Levitz SM. 2009. Isolation and purification of antigenic component of Cryptococcus. Methods Mol Biol 470:71–83.
   Google Scholar
• Yauch LE, Lam JS, Levitz SM. 2006. Direct inhibition of T cell responses by the Cryptococcus capsular polysaccharide glucuronoxylomannan. PLoS Pathog 2:e120.
   Google Scholar
• Zheng CF, Ma LL, Gareth J, Jones JG, Gill JM, Alan M, Krensky MA, Kubes P, Mody CH. 2007. Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients. Blood 109:2049–2057.
   Google Scholar