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Italian Journal of Animal Science Volume 8, 2009 - Issue sup2: Proceedings of the 18th ASPA Congress, Palermo, June 9-12, 2009
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Article

Role of alpha-tocopherol in counteracting DNA damage induced by Ochratoxin A in primary porcine fibroblasts

Eleonora FusiDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, ItalyCorrespondence[email protected]
,
Federica CheliDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
,
Raffaella RebucciDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
,
Chiara PecoriniDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
,
Filippo GalanteDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
,
Luciana RossiDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
,
Luciano PinottiDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
&
Antonella BaldiDipartimento Scienze e Tecnologie Veterinarie per la Sicurezza Alimentare, Università di Milano, Italy
 show all
Pages 301-303 | Published online: 07 Mar 2016

References

  • Azzi, A. 2007 Molecular mechanism of α-tocopherol action. Free Rad. Biol. Med. 43: 16–21.
  • Baldi, A., Losio, M.N., Cheli, F., Rebucci, R., Sangalli, L., Fusi, E., Bertasi, B., Pavoni, E., Carli, S., Politis I. 2004. Evaluation of the protective effects of α-tocopherol and retinol against ochratoxin A cytotoxicity. Brit. J. Nutr. 91: 507–512.
  • Fusi, E., Rebucci, R., Pecorini, C., Rossi, L., D’Ambrosio, F., Baldi A. 2008. Evaluation of the damage induced by ochratoxin A and the protective role of α-tocopherol in cultured bovine mammary epithelial cells. Vet. Res. Comm. 32: 343–345.
  • O’Brien, E., Dietrich, D.R. 2005. Ochratoxin A: the continuing enigma. Crit. Rev. Toxicol. 35: 33–60.
  • Ringot, D., Chango, A., Schneider, Y-J., Larondelle, Y. 2006. Toxicokinetics and toxicodynamics of ochratoxin A, an update. Chem.-Biol. Interac. 159: 18–46.
  • Sandau, K., Pfeilschifter, J., and Brüne, B. 1997. Nitric oxide and superoxide induced p53 and Bax accumulation during mesangial cell apoptosis. Kidney Int. 52: 378–386. SAS, 1999.
  • SAS User's Guide: Statistics, Version 8.2. SAS Inst. Inc., Cary, NC, USA.
  • Schaaf, G.J., Nijmeijer, S.M., Maas, R.F.M., Roestenberg, P., de Groene, E.M., Fink-Gremmels, J. 2002. The role of oxidative stress in the ochratoxin A-mediated toxicity in proximal tubular cells. Biochim. Acta 1588: 149–158.
  • Traber, M.G., Atkinson, J. 2007. Vitamin E, antioxidant and nothing more. Free Rad. Biol. Med. 43: 4–15.

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