References
- Jalali-Heravi M , ArrastiaM, GomezFA. How chemometrics can improve microfluidic research?Anal. Chem. 87, 3544–3555 (2015).
- Neuzil P , GiselbrechtS, LangeK, HuangTJ, ManzA. Revisiting lab-on-a-chip technology for drug discovery. Nat. Rev. Drug Discov. 11, 620–632 (2012).
- Wu M-H , HuangS-B, LeeG-B. Microfluidic cell culture systems for drug research. Lab Chip10, 939–956 (2010).
- Beaudette P , BatemanKP. Discovery stage pharmacokinetics using dried blood spots. J. Chromatog. B809, 153–158 (2004).
- Timmerman P , WhiteS, CobbZ, de VriesR, ThomasE, van BaarB. Update of the EBF Recommendation for the use of dried blood spots in regulated bioanalysis towards the conclusions from the EBF DBS micro sampling consortium. Bioanalysis5 (17), 2129–2136 (2013).
- Spooner N , LadR, BarfieldM. Dried blood spots as a sample collections technique for the determination of pharmacokinetics in clinical studies: considerations for the validation of a quantitative bioanlaytical method. Anal. Chem. 81 (4), 1557–1563 (2009).
- Mini Focus Issue: Dried blood spots. Bioanalysis5 (17), (2013).
- Ishihama Y . Proteomic LC–MS system using nanoscale liquid chromatography with tandem mass spectrometry. J. Chromatogr. A1067 (1), 73–83 (2005).
- Köhler T , PichlerP, De PraM, RieuxL, SwartR, MechtlerK. Development and performance evaluation of an ultralow flow nanoliquid chromatographic-tandem mass spectrometry set-up. Proteomics14 (17–18), 1999–2007 (2014).
- Agilent Technologies, HPLC-Chip Cube MS Interface. www.chem.agilent.com.
- Eksigent cHiPLC systems. www.eksigent.com.
- Waters ionKey/MS system. www.waters.com.
- Wilffert D , AsselmanA, DonzelliRet al. Highly sensitive antibody-free μLC–MS/MS quantification of rhTRAIL in serum. Bioanalysis8 (9), 881–890 (2016).
- Kleinnijenhuis A . Quantitative analysis of infliximab in serum using μLC–MS/MS. Bioanalysis8 (9), 891–904 (2016).
- Schultz GA , McCardleK, NeubertH. Large-scale implementation of sequential protein and peptide immunoaffinity enrichment LC/nanoLC–MS/MS for human β-nerve growth factor. Bioanalysis8 (8), 753–764 (2016).
- Chambers EE , LameME, RainvillePD, MurphyJ, JohnsonJ, FountainKJ, PlumbRS, ClaiseP, SmithNW. Practical applications of integrated microfluidics for peptide quantification. Bioanalysis7 (7), 857–867 (2015).
- Lubin A , VereykenL, de VriesRet al. Ultra high sensitivity bioanalysis by improved ionization and 2D-microUHPLC applying chip technology. Presented at : The 63rd ASMS Conference on Mass Spectrometry. MO, USA, 31 May–4 June 2015.
- Stauber J . Quantitation by MS imaging: needs and challenges in pharmacueticals. Bioanalysis4 (17), 2095–2098 (2012).
- Timmerman P , HendersonN, SmeragliaJet al. Managing scientific, technical and regulatory innovation in regulated bioanalysis: a discussion paper from the European Bioanalysis Forum. Bioanalysis5 (2), 139–145 (2013).
- Kwapiszewska K , MichalczukA, RybkaM, KwapiszewskiR, BrzózkaZ. A microfluidic-based platform for tumour spheroid culture, monitoring and drug screening. Lab Chip14, 2096–2104 (2014).
- Bhatia SN , IngberDE. Microfluidic organs on chips. Nat. Biotechnol. 8, 760–772 (2014).
- Jang KJ , MehrAP, HamiltonGAet al. Human kidney proximal tubule-on-a-chip for drug transport and nephrotoxicity assessment. Integr. Biol. 9, 1119–1129 (2013).
- Huh D , MatthewsBD, MammotoA, Montoya-ZavalaM, HongYH, IngberDE. Reconstituting organ-level lung functions on a chip. Science328, 1662–1668 (2010).