Advanced search
Publication Cover
Bioanalysis Volume 8, 2016 - Issue 14
Submit an article Journal homepage
162
Views
0
CrossRef citations to date
0
Altmetric
Research Article

Determination of Apremilast in Rat Plasma by UPLC–MS/MS in Esi-Negative Mode to Avoid Adduct Ions Formation

Muzaffar Iqbal1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, KSA;2 Bioavailability Laboratory, College of Pharmacy, King Saud University, Riyadh, 11451, KSACorrespondence[email protected]
,
Essam Ezzeldin1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, KSA;2 Bioavailability Laboratory, College of Pharmacy, King Saud University, Riyadh, 11451, KSA
,
Sara TA Al-Rashood1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, KSA
,
Faisal Imam3 Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Riyadh11451, KSA
&
Khalid A Al-Rashood1 Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, 11451, KSA
Pages 1499-1508 | Received 18 Apr 2016, Accepted 13 Jun 2016, Published online: 28 Jun 2016

References

  • Chiricozzi A , CaposienaD, GarofaloVet al. A new therapeutic for the treatment of moderate to severe plaque psoriasis: apremilast. Expert Rev. Clin. Immunol. 12 (3), 237–249 (2015).
  • Kurd SK , GelfandJM. The prevalence of previously diagnosed and undiagnosed psoriasis in US adults: results from NHANES 2003–2004. J. Am. Acad. Dermatol. 60 (2), 218–224 (2009).
  • Kumar N1 , GoldminzAM, KimN, GottliebAB. Phosphodiesterase 4-targeted treatments for autoimmune diseases. BMC Med. 11, 96 (2013).
  • Schafer P . Apremilast mechanism of action and application to psoriasis and psoriatic arthritis. Biochem. Pharmacol. 83 (12), 1583–1590 (2012).
  • Poole RM , BallantyneAD. Apremilast: first global approval. Drugs74 (7), 825–837 (2014).
  • US prescribing information of OTEZLA® (apremilast), tablets . Celgene Corporation Summit, NJ 07901. December 2015. www.otezla.com/otezla-prescribing-information.pdf.
  • Schafer PH , PartonA, GandhiAKet al. Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. Br. J. Pharmacol. 159 (4), 842–855 (2010).
  • McCann FE , PalfreemanAC, AndrewsMet al. Apremilast, a novel PDE4 inhibitor, inhibits spontaneous production of tumour necrosis factor-alpha from human rheumatoid synovial cells and ameliorates experimental arthritis. Arthritis Res. Ther. 12 (3), R107 (2010).
  • Hoffmann M , KumarG, SchaferPet al. Disposition, metabolism and mass balance of [(14)C]apremilast following oral administration. Xenobiotica41 (12), 1063–1075 (2011).
  • Gottlieb AB , MathesonRT, MenterAet al. Efficacy, tolerability, and pharmacodynamics of apremilast in recalcitrant plaque psoriasis: a Phase II open-label study. J. Drugs Dermatol. 12 (8), 888–897 (2013).
  • Schett G , SloanVS, StevensRM, SchaferP. Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases. Ther. Adv. Musculoskelet. Dis. 2 (5), 271–278 (2010).
  • Liu Y , ZhouS, WanY, WuA, PalmisanoM. The impact of co-administration of ketoconazole and rifampicin on the pharmacokinetics of apremilast in healthy volunteers. Br. J. Clin. Pharmacol. 78 (5), 1050–1057 (2014).
  • Wu A , RohaneP, NgJet al. Safety/tolerability and pharmacokinetics of multiple oral doses of apremilast in healthy male subjects. Clin. Pharmacol. Ther. 91, S26 (2012).
  • Chen LG , WangZ, WangS, LiT, PanY, LaiX. Determination of apremilast in rat plasma by UPLC–MS-MS and its application to a pharmacokinetic study. J. Chromatogr. Sci. doi: 10.1093/chromsci/bmw072 (2016) ( Epub ahead of print).
  • Hirabayashi H , SugimotoH, MatsumotoS, AmanoN, MoriwakiT. Development of a quantification method for digoxin, a typical P-glycoprotein probe in clinical and non-clinical studies, using high performance liquid chromatography-tandem mass spectrometry: the usefulness of negative ionization mode to avoid competitive adduct-ion formation. J. Chromatography B. 879 (32), 3837–3844 (2011).
  • Iqbal M , EzzeldinE, Al-RashoodKA, AsiriYA, RezkNL. Rapid determination of canagliflozin in rat plasma by UHPLC–MS/MS using negative ionization mode to avoid adduct-ions formation. Talanta132, 29–36 (2015).
  • Guidance for Industry Bioanalytical Method Validation, U.S. Department of Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER), Editor 2001, US: Rockville, MD, USA. www.fda.gov/downloads/Drugs/Guidance/ucm070107.pdf.
  • EMEA/CHMP/EWP/192217/2009, Guideline on bioanalytical method validation, European Medicines Agency (2012). www.ema.europa.eu/docs/en_GB/document_library/Scientific_guideline/2011/08/WC500109686.pdf.
  • Food and Drug Administration Center for Drug Evaluation and Research (CDER) . NDA Application No. 206088. Pharmacological Review Pharmacokinetic/ADME/Toxicokinetics. www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206088Orig1s000PharmR.
  • Dziadosz M , KlintscharM, TeskeJ. Drug detection by tandem mass spectrometry on the basis of adduct formation. J. Chromatogr. B. 955–956, 108–109 (2014).
  • Mortier KA , ZhangGF, van PeteghemCH, LambertWE. Adduct formation in quantitative bioanalysis: effect of ionization conditions on paclitaxel. J. Am. Soc. Mass. Spectrom. 15 (4), 585–592 (2004).

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.